1999
Reduction in Potassium Currents in Identified Cutaneous Afferent Dorsal Root Ganglion Neurons After Axotomy
Everill B, Kocsis J. Reduction in Potassium Currents in Identified Cutaneous Afferent Dorsal Root Ganglion Neurons After Axotomy. Journal Of Neurophysiology 1999, 82: 700-708. PMID: 10444667, DOI: 10.1152/jn.1999.82.2.700.Peer-Reviewed Original ResearchConceptsDorsal root ganglion neuronsCutaneous afferent neuronsAfferent neuronsGanglion neuronsPotassium currentWhole-cell patch-clamp recordingsCell patch-clamp recordingsPrimary afferent neuronsEffects of axotomyPatch-clamp recordingsControl cellsAppropriate ion replacementAcute ligationNerve ligationDRG neuronsExcitability changesChannel blockersNeuronal excitabilityPharmacological componentsAxotomyNeuronsLigationBasis of sensitivityCellsBlockers
1996
GABAA-receptor-mediated conductance and action potential waveform in cutaneous and muscle afferent neurons of the adult rat: differential expression and response to nerve injury
Oyelese A, Kocsis J. GABAA-receptor-mediated conductance and action potential waveform in cutaneous and muscle afferent neurons of the adult rat: differential expression and response to nerve injury. Journal Of Neurophysiology 1996, 76: 2383-2392. PMID: 8899611, PMCID: PMC2605353, DOI: 10.1152/jn.1996.76.4.2383.Peer-Reviewed Original ResearchConceptsGABAA receptor-mediated conductanceMuscle afferent neuronsCutaneous afferent neuronsAction potential waveformAfferent neuronsDorsal root gangliaCrush injuryAction potentialsL5 dorsal root gangliaWhole-cell patch-clamp recordingsCell patch-clamp recordingsInjury-induced plasticitySciatic nerve ligationPotential waveformDistal nerve stumpPatch-clamp recordingsGamma-aminobutyric acidPeak GABANerve ligationMuscle afferentsNerve injuryDRG neuronsInjured neuronsNerve stumpRoot ganglia
1995
Enhancement of GABAA receptor-mediated conductances induced by nerve injury in a subclass of sensory neurons
Oyelese A, Eng D, Richerson G, Kocsis J. Enhancement of GABAA receptor-mediated conductances induced by nerve injury in a subclass of sensory neurons. Journal Of Neurophysiology 1995, 74: 673-683. PMID: 7472373, PMCID: PMC2605359, DOI: 10.1152/jn.1995.74.2.673.Peer-Reviewed Original ResearchConceptsDRG neuronsAction potential durationMedium neuronsNerve injurySmall neuronsLarge neuronsAction potentialsGABA conductanceNerve ligationControl neuronsPotential durationAdult rat dorsal root ganglion neuronsGABAA receptor-mediated conductanceRat dorsal root ganglion neuronsWhole-cell patch-clamp recordingsCell patch-clamp recordingsDorsal root ganglion neuronsMean action potential durationShort-duration action potentialsControl DRG neuronsSciatic nerve ligationEffects of axotomyReceptor-mediated conductanceTraumatic nerve injuryPatch-clamp recordingsGabapentin potentiates the conductance increase induced by nipecotic acid in CA1 pyramidal neurons in vitro
Honmou O, Kocsis J, Richerson G. Gabapentin potentiates the conductance increase induced by nipecotic acid in CA1 pyramidal neurons in vitro. Epilepsy Research 1995, 20: 193-202. PMID: 7796791, DOI: 10.1016/0920-1211(94)00076-9.Peer-Reviewed Original ResearchConceptsRelease of GABACA1 pyramidal neuronsNipecotic acidPyramidal neuronsGABAA receptorsWhole-cell patch-clamp recordingsGABA uptake systemRat optic nerveCalcium-free solutionPeriod of hyperexcitabilityPatch-clamp recordingsChloride equilibrium potentialMechanism of actionGabapentin exposurePartial seizuresPressure microejectionOptic nerveAnticonvulsant gabapentinNonvesicular releaseHippocampal slicesNeuronal inhibitionMetabolic effectsSynaptic transmissionWhole-cell conductanceClamp recordings
1994
Retinal ganglion cells express a cGMP-gated cation conductance activatable by nitric oxide donors
Ahmad I, Leinders-Zufall T, Kocsis J, Shepherd G, Zufall F, Barnstable C. Retinal ganglion cells express a cGMP-gated cation conductance activatable by nitric oxide donors. Neuron 1994, 12: 155-165. PMID: 7507337, DOI: 10.1016/0896-6273(94)90160-0.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-3-isobutylxanthine8-Bromo Cyclic Adenosine MonophosphateAnimalsAnimals, NewbornBase SequenceCells, CulturedCyclic GMPCyclic Nucleotide-Gated Cation ChannelsCysteineDNA PrimersElectric ConductivityGene ExpressionIn Situ HybridizationIon ChannelsMembrane PotentialsModels, NeurologicalMolecular Sequence DataNitric OxideNitroprussidePolymerase Chain ReactionRatsRats, WistarRetinal Ganglion CellsRetinal Rod Photoreceptor CellsS-NitrosothiolsTranscription, GeneticConceptsRetinal ganglion cellsGanglion cellsWhole-cell patch-clamp recordingsRat retinal ganglion cellsNitric oxide donor sodium nitroprussideCation channelsGanglion cell activityPatch-clamp recordingsCation conductanceNitric oxide donorDonor sodium nitroprussideNonselective cation channelsAmacrine cellsSodium nitroprussideOxide donorPhosphodiesterase inhibitorCell activityPolymerase chain reaction amplificationNitric oxideChain reaction amplificationReversal potentialOutward rectificationRod photoreceptorsCGMPS-nitrosocysteine