2024
Multiple intravenous infusions versus a single infusion of mesenchymal stem cells in a rat model of cerebral ischemia.
Yokoyama T, Sasaki M, Nagahama H, Kataoka-Sasaki Y, Ukai R, Oka S, Kocsis J, Honmou O. Multiple intravenous infusions versus a single infusion of mesenchymal stem cells in a rat model of cerebral ischemia. Journal Of Neurosurgery 2024, 1-9. PMID: 39454218, DOI: 10.3171/2024.6.jns241111.Peer-Reviewed Original ResearchInfusion of mesenchymal stem cellsMiddle cerebral artery occlusionMiddle cerebral artery occlusion inductionMesenchymal stem cellsCorpus callosumSystemic infusion of mesenchymal stem cellsMultiple infusionsAcute phaseMesenchymal stem cell infusionCerebral ischemiaStem cellsMultiple intravenous infusionsRat model of cerebral ischemiaHigh-dose infusionPermanent middle cerebral artery occlusionIschemic lesion volumeModels of cerebral ischemiaCC thicknessRandomized clinical trialsCerebral artery occlusionNeural tractsAcute cerebral strokeFunctional recovery outcomesMRI diffusion tensor imagingMSC-3
2006
Neuroprotection by PlGF gene-modified human mesenchymal stem cells after cerebral ischaemia
Liu H, Honmou O, Harada K, Nakamura K, Houkin K, Hamada H, Kocsis J. Neuroprotection by PlGF gene-modified human mesenchymal stem cells after cerebral ischaemia. Brain 2006, 129: 2734-2745. PMID: 16901914, PMCID: PMC2605397, DOI: 10.1093/brain/awl207.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridaeAnimalsApoptosisBrain IschemiaGenetic VectorsHumansImage Processing, Computer-AssistedInfarction, Middle Cerebral ArteryMagnetic Resonance ImagingMaleMesenchymal Stem Cell TransplantationMesenchymal Stem CellsModels, AnimalNeovascularization, PathologicNeuropsychological TestsPlacenta Growth FactorPregnancy ProteinsRatsRats, Sprague-DawleyTransduction, GeneticConceptsMiddle cerebral artery occlusionCerebral ischaemiaMesenchymal stem cellsIntravenous deliveryPermanent middle cerebral artery occlusionHuman MSCsControl sham groupLimb placement testRats 3 hCerebral artery occlusionTreadmill stress testPlacental growth factorIntraluminal vascular occlusionEnzyme-linked immunosorbentNon-neural tissuesHuman mesenchymal stem cellsStem cellsAdult bone marrowArtery occlusionInfarcted hemisphereSham groupFunctional outcomeVascular occlusionFunctional deficitsInfarction size
2005
I.v. infusion of brain-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat
Nomura T, Honmou O, Harada K, Houkin K, Hamada H, Kocsis J. I.v. infusion of brain-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat. Neuroscience 2005, 136: 161-169. PMID: 16229956, PMCID: PMC2605391, DOI: 10.1016/j.neuroscience.2005.06.062.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorMesenchymal stem cell groupBrain-derived neurotrophic factor contributesMiddle cerebral artery occlusionStem cell groupCerebral artery occlusionCerebral ischemia modelMesenchymal stem cellsNeurotrophic factorArtery occlusionCell groupsIschemia modelPermanent middle cerebral artery occlusionRat cerebral ischemia modelHuman mesenchymal stem cellsBrain-derived neurotrophic factor (BDNF) geneStem cellsControl sham groupTreadmill stress testRats 6 hFactor contributesNeurotrophic factor geneIntraluminal vascular occlusionAdult bone marrowCerebral ischemia