2010
Reprogramming of T Cells from Human Peripheral Blood
Loh YH, Hartung O, Li H, Guo C, Sahalie JM, Manos PD, Urbach A, Heffner GC, Grskovic M, Vigneault F, Lensch MW, Park IH, Agarwal S, Church GM, Collins JJ, Irion S, Daley GQ. Reprogramming of T Cells from Human Peripheral Blood. Cell Stem Cell 2010, 7: 15-19. PMID: 20621044, PMCID: PMC2913590, DOI: 10.1016/j.stem.2010.06.004.Peer-Reviewed Original Research
2009
Generation of functional human hepatic endoderm from human induced pluripotent stem cells
Sullivan GJ, Hay DC, Park I, Fletcher J, Hannoun Z, Payne CM, Dalgetty D, Black JR, Ross JA, Samuel K, Wang G, Daley GQ, Lee J, Church GM, Forbes SJ, Iredale JP, Wilmut I. Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology 2009, 51: 329-335. PMID: 19877180, PMCID: PMC2799548, DOI: 10.1002/hep.23335.Peer-Reviewed Original ResearchCell Culture TechniquesCell DifferentiationCell LineageEndodermFemaleHumansInduced Pluripotent Stem CellsLiverMaleGeneration of induced pluripotent stem cells from human blood
Loh YH, Agarwal S, Park IH, Urbach A, Huo H, Heffner GC, Kim K, Miller JD, Ng K, Daley GQ. Generation of induced pluripotent stem cells from human blood. Blood 2009, 113: 5476-5479. PMID: 19299331, PMCID: PMC2689048, DOI: 10.1182/blood-2009-02-204800.Peer-Reviewed Original ResearchConceptsPluripotent stem cellsPluripotent cell-specific genesPatient-specific stem cellsTranscription factorsStem cellsHuman embryonic stem cellsPluripotency-associated transcription factorsEmbryonic stem cellsCell-specific genesInduced pluripotent stem cellsDNA methylation statusEctopic expressionHematopoietic lineagesRetroviral transductionMethylation statusSomatic mutationsHuman dermal fibroblastsHuman bloodDermal fibroblastsCellsHuman peripheral blood cellsExpressionPluripotencyPeripheral blood cellsLineagesHuman iPS Cell Derivation/Reprogramming
Park I, Daley GQ. Human iPS Cell Derivation/Reprogramming. Current Protocols In Stem Cell Biology 2009, 8: 4a.1.1-4a.1.8. PMID: 19170021, DOI: 10.1002/9780470151808.sc04a01s8.Peer-Reviewed Original ResearchMeSH KeywordsCell Culture TechniquesCell DedifferentiationCell DifferentiationEmbryonic Stem CellsFibroblastsHumansKruppel-Like Factor 4Pluripotent Stem CellsResearch DesignConceptsHES cellsHuman fibroblast cellsInduced pluripotent stem cellsFibroblast cellsHuman iPS cellsPluripotent stem cellsPluripotency genesTranscription factorsEmbryoid bodiesGerm layersIPS cellsStem cell culture conditionsCell coloniesCell culture conditionsStem cellsRetroviral vectorsCulture conditionsCellsReprogrammingGenesDifferentiationColoniesDissection microscope
2008
Generation of human-induced pluripotent stem cells
Park IH, Lerou PH, Zhao R, Huo H, Daley GQ. Generation of human-induced pluripotent stem cells. Nature Protocols 2008, 3: 1180-1186. PMID: 18600223, DOI: 10.1038/nprot.2008.92.Peer-Reviewed Original ResearchMeSH KeywordsCell Culture TechniquesFibroblastsHumansKruppel-Like Factor 4Pluripotent Stem CellsRetroviridaeTranscription FactorsTransduction, GeneticConceptsPluripotent stem cellsEmbryonic stem cellsIPS cellsStem cellsPatient-specific pluripotent stem cellsHuman somatic cellsInduced pluripotent stem cellsHuman iPS cellsHuman-induced pluripotent stem cellsHuman primary fibroblastsTissue replacement therapiesSomatic cellsTranscription factorsPluripotent cellsEctopic expressionRetroviral transductionSource of cellsPrimary fibroblastsHuman fibroblast lineFibroblast linesPrimary human fibroblast linesCellsInvaluable toolTransplantation of cellsImmune rejection