2015
Histone Deacetylases Positively Regulate Transcription through the Elongation Machinery
Greer CB, Tanaka Y, Kim YJ, Xie P, Zhang MQ, Park IH, Kim TH. Histone Deacetylases Positively Regulate Transcription through the Elongation Machinery. Cell Reports 2015, 13: 1444-1455. PMID: 26549458, PMCID: PMC4934896, DOI: 10.1016/j.celrep.2015.10.013.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationCell Cycle ProteinsCell Line, TumorEpigenesis, GeneticHistone Deacetylase InhibitorsHistone DeacetylasesHSP90 Heat-Shock ProteinsHumansKineticsNuclear ProteinsProtein BindingProtein Processing, Post-TranslationalRNA Polymerase IITranscription Elongation, GeneticTranscription FactorsConceptsNegative elongation factorElongation factorEnhancer activityHeat shock protein 90 (HSP90) activityEnhancer RNA productionRNA polymerase IISame genomic siteElongation machinerySmall molecule inhibitorsGene bodiesTranscription elongationPolymerase IINascent transcriptionGenomic sitesIntergenic regionGene activationRNA productionEfficient elongationMolecule inhibitorsProtein 4TranscriptionPromoterHDACsEnhancerElongation
2008
Regulatory networks define phenotypic classes of human stem cell lines
Müller FJ, Laurent LC, Kostka D, Ulitsky I, Williams R, Lu C, Park IH, Rao MS, Shamir R, Schwartz PH, Schmidt NO, Loring JF. Regulatory networks define phenotypic classes of human stem cell lines. Nature 2008, 455: 401-405. PMID: 18724358, PMCID: PMC2637443, DOI: 10.1038/nature07213.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsArtificial IntelligenceCell DifferentiationCell LineComputational BiologyDatabases, FactualEmbryonic Stem CellsGene Expression ProfilingHumansMiceMultipotent Stem CellsOligonucleotide Array Sequence AnalysisOocytesPhenotypePluripotent Stem CellsProtein BindingStem CellsConceptsStem cell linesStem cellsCell linesCell typesProtein-protein networkHuman stem cell linesDifferent human cell linesSpecific molecular networksPluripotent stem cell lineHuman stem cellsHuman cell linesRegulatory networksTranscriptional profilesBioinformatics analysisPhenotypic classesMolecular networksNeural stem cell lineLimited repertoireTight controlCellsCell samplesPluripotencyEmbryosLinesBroad range