2011
Altered Hematopoiesis in Trisomy 21 As Revealed Through In Vitro Differentiation of Isogenic Human Pluripotent Cells
MacLean G, Menne T, Park I, Daley G, Orkin S. Altered Hematopoiesis in Trisomy 21 As Revealed Through In Vitro Differentiation of Isogenic Human Pluripotent Cells. Blood 2011, 118: 921. DOI: 10.1182/blood.v118.21.921.921.Peer-Reviewed Original ResearchTrisomy 21Trisomic cellsFetal liverAdvisory CommitteeGATA1 mutationsPre-leukemic conditionAcute myeloid leukemiaTransient myeloproliferative disorderTrisomy 21 resultsCell linesDisomic controlsSomatic mutationsCFU-M coloniesColony forming assaysMultilineage hematopoietic progenitor cellsQuantitative RT-PCRHematopoietic progenitor cellsIL-6Myeloid leukemiaMouse modelMyeloproliferative disordersMegakaryoblastic leukemiaProgenitor populationsMyeloid progenitor populationsCD31/CD34
2009
Generation of induced pluripotent stem cells from human blood
Loh YH, Agarwal S, Park IH, Urbach A, Huo H, Heffner GC, Kim K, Miller JD, Ng K, Daley GQ. Generation of induced pluripotent stem cells from human blood. Blood 2009, 113: 5476-5479. PMID: 19299331, PMCID: PMC2689048, DOI: 10.1182/blood-2009-02-204800.Peer-Reviewed Original ResearchConceptsPluripotent stem cellsPluripotent cell-specific genesPatient-specific stem cellsTranscription factorsStem cellsHuman embryonic stem cellsPluripotency-associated transcription factorsEmbryonic stem cellsCell-specific genesInduced pluripotent stem cellsDNA methylation statusEctopic expressionHematopoietic lineagesRetroviral transductionMethylation statusSomatic mutationsHuman dermal fibroblastsHuman bloodDermal fibroblastsCellsHuman peripheral blood cellsExpressionPluripotencyPeripheral blood cellsLineages