2020
Mural Cell-Specific Deletion of Cerebral Cavernous Malformation 3 in the Brain Induces Cerebral Cavernous Malformations
Wang K, Zhang H, He Y, Jiang Q, Tanaka Y, Park IH, Pober JS, Min W, Zhou HJ. Mural Cell-Specific Deletion of Cerebral Cavernous Malformation 3 in the Brain Induces Cerebral Cavernous Malformations. Arteriosclerosis Thrombosis And Vascular Biology 2020, 40: 2171-2186. PMID: 32640906, DOI: 10.1161/atvbaha.120.314586.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosis Regulatory ProteinsBrainCell CommunicationCell MovementCells, CulturedCoculture TechniquesEndothelial CellsFemaleFocal AdhesionsGene DeletionGenetic Predisposition to DiseaseHemangioma, Cavernous, Central Nervous SystemHumansMaleMembrane ProteinsMice, KnockoutMicrovesselsMyocytes, Smooth MusclePaxillinPericytesPhenotypeProtein StabilityProto-Oncogene ProteinsSignal TransductionConceptsCerebral cavernous malformationsBrain mural cellsCCM lesionsMural cellsCavernous malformationsSevere brain hemorrhageCCM pathogenesisSmooth muscle cellsWeeks of ageCell-specific deletionMural cell coverageBrain pericytesBrain hemorrhageNeonatal stageBrain vasculatureLesionsEntire brainMuscle cellsCerebral cavernous malformation 3Endothelial cellsMicePericytesSpecific deletionAdhesion formationPathogenesis
2015
Correction: Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice
Tucker BA, Park IH, Qi SD, Klassen HJ, Jiang C, Yao J, Redenti S, Daley GQ, Young MJ. Correction: Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice. PLOS ONE 2015, 10: e0125947. PMID: 25950705, PMCID: PMC4423907, DOI: 10.1371/journal.pone.0125947.Peer-Reviewed Original Research
2014
In Vivo Roles of a Patient-Derived Induced Pluripotent Stem Cell Line (HD72-iPSC) in the YAC128 Model of Huntington’s Disease
Jeon I, Choi C, Lee N, Im W, Kim M, Oh SH, Park IH, Kim HS, Song J. In Vivo Roles of a Patient-Derived Induced Pluripotent Stem Cell Line (HD72-iPSC) in the YAC128 Model of Huntington’s Disease. International Journal Of Stem Cells 2014, 7: 43-47. PMID: 24921027, PMCID: PMC4049731, DOI: 10.15283/ijsc.2014.7.1.43.Peer-Reviewed Original ResearchHuntington's diseaseHD pathologyNeural precursorsAvailable therapeutic optionsHD mouse modelsYAC128 transgenic miceSignificant behavioral improvementCAG repeatsVivo roleYAC128 modelGrafted miceTherapeutic optionsGrafted cellsPatient-derived iPSCsMouse modelTransgenic miceBehavioral improvementDiseaseNovel therapeuticsMiceCell linesPluripotent stem cell linePathologyStem cellsNeurodegenerative genetic disease
2012
Role of Pluripotent Stem Cells in Regenerative Medicine
Hysolli E, Zhou X, Liu R, Kim J, Adams B, Sullivan G, Park I. Role of Pluripotent Stem Cells in Regenerative Medicine. 2012, 21-37. DOI: 10.1201/b11937-3.Peer-Reviewed Original ResearchBone marrow cellsStem cellsMarrow cellsInjection of bone marrow cellsDifferentiation potentialProperties of stem cellsInner cell massMultipotent stem cellsPluripotent stem cellsSingle bone marrow cellsIrradiated miceHematopoietic coloniesSpleen coloniesSelf-renewalTotipotent zygoteGerm layersBlastocystCell massRegenerative medicineSpleenMultiple lineagesCellsTissue typesDifferentiationMice
2011
Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice
Tucker BA, Park IH, Qi SD, Klassen HJ, Jiang C, Yao J, Redenti S, Daley GQ, Young MJ. Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice. PLOS ONE 2011, 6: e18992. PMID: 21559507, PMCID: PMC3084746, DOI: 10.1371/journal.pone.0018992.Peer-Reviewed Original ResearchConceptsRetinal functionNormal retinal physiologyOuter nuclear layerRetinal precursorsC-MycRetinal degenerative diseasesRetinal outer nuclear layerDelivery of neurotransmittersRetinal degenerative (rd) miceRetinal transplantationSubretinal transplantationNuclear layerAdult miceDsRed miceTransplantationRetinal structureRetinal physiologyPhotoreceptor markersDegenerative diseasesMiceRetroviral inductionFunctional anatomyPhotoreceptor precursorsPhotoreceptor cellsFibroblast-derived iPSCs