A Dual Role of Evi-1 During Developmental Hematopoiesis
Konantz M, Grauer M, Grzywna S, Park I, Daley G, Kanz L, Lengerke C. A Dual Role of Evi-1 During Developmental Hematopoiesis. Blood 2012, 120: 765. DOI: 10.1182/blood.v120.21.765.765.Peer-Reviewed Original ResearchEvi-1Developmental hematopoiesisZebrafish embryosSCL expressionProgenitor cellsHematopoietic cellsPre-mRNA splicingHuman hematopoietic developmentEvi-1 locusMurine hematopoietic cellsHuman iPS cellsPrecise molecular basisSurvival/proliferationEmbryonic myelopoiesisPluripotent stem cellsEvi-1 expressionErythroid progenitor cellsDefinitive hematopoiesisPrimitive erythroid progenitor cellsPrimitive erythropoiesisZebrafish zygotesHSC formationPrimitive hematopoiesisBlood developmentSitu hybridization analysisAltered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells
MacLean GA, Menne TF, Guo G, Sanchez DJ, Park IH, Daley GQ, Orkin SH. Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 17567-17572. PMID: 23045682, PMCID: PMC3491455, DOI: 10.1073/pnas.1215468109.Peer-Reviewed Original ResearchConceptsHuman embryonic stemPluripotent cellsHuman pluripotent cellsFetal liver stageEffects of trisomyPluripotent stem cellsDefinitive hematopoiesisIsogenic originColony-forming potentialColony-forming assaysΓ-globinEmbryonic stemIPS linesDifferentiation conditionsAltered hematopoiesisClonal variationHematopoietic cellsStem cellsHematopoiesisHematopoietic abnormalitiesChromosome 21Two- to fivefold increaseFetal liverTrisomic cellsMyeloid hematopoiesis