2014
PIWI Proteins Are Dispensable for Mouse Somatic Development and Reprogramming of Fibroblasts into Pluripotent Stem Cells
Cheng EC, Kang D, Wang Z, Lin H. PIWI Proteins Are Dispensable for Mouse Somatic Development and Reprogramming of Fibroblasts into Pluripotent Stem Cells. PLOS ONE 2014, 9: e97821. PMID: 25238487, PMCID: PMC4169525, DOI: 10.1371/journal.pone.0097821.Peer-Reviewed Original ResearchConceptsPIWI proteinsEmbryonic stem cellsInduced pluripotent stem cellsPluripotent stem cellsIPS cellsPiwi genesGermline stem cell maintenanceStem cellsControl iPS cellsDifferentiated somatic cellsStem cell maintenancePIWI protein familyReprogramming of fibroblastsExpression profiling revealsGermline developmentProtein familyKnockout embryosCell maintenanceFemale fertileSomatic cellsEmbryonic fibroblastsDirect reprogrammingProfiling revealsTeratoma assayGerm layers
2011
The microRNA regulation of stem cells
Huang XA, Lin H. The microRNA regulation of stem cells. Wiley Interdisciplinary Reviews Membrane Transport And Signalling 2011, 1: 83-95. PMID: 23024929, PMCID: PMC3459065, DOI: 10.1002/wdev.5.Peer-Reviewed Original ResearchStem cellsMore mRNA targetsAdult tissue stem cellsDistinct expression profilesEmbryonic stem cellsTissue stem cellsMiRNA pathwayNegative feedback loopGene regulationMicroRNA regulationMRNA targetsTranscription factorsGene expressionRegulatory mechanismsEpigenetic factorsExpression profilesBiological processesDifferent miRNAsConcerted controlRegulatory roleIPS cellsMiRNAsSuch regulationRegulationCells