2001
Gα16 Couples Chemoattractant Receptors to NF-κB Activation
Yang M, Sang H, Rahman A, Wu D, Malik A, Ye R. Gα16 Couples Chemoattractant Receptors to NF-κB Activation. The Journal Of Immunology 2001, 166: 6885-6892. PMID: 11359849, DOI: 10.4049/jimmunol.166.11.6885.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusAmino Acid SubstitutionCell NucleusEnzyme ActivationGenes, ReporterGlutamineGTP-Binding Protein alpha Subunits, Gq-G11HeLa CellsHeterotrimeric GTP-Binding ProteinsHumansIsoenzymesLeucineLuciferasesNF-kappa BPhospholipase C betaReceptors, ChemokineReceptors, Formyl PeptideReceptors, ImmunologicReceptors, PeptideSignal TransductionTrans-ActivatorsTransfectionType C PhospholipasesConceptsNF-kappaB activationFormyl peptide receptorChemoattractant receptorsPeptide receptorCXC chemokine receptor 2NF-kappaB.Chemokine receptor 2Regulatory protein alpha subunitNF-κB activationLuciferase activityProtein kinase CKappaB-luciferase activityPhosphorylation of IkappaBalphaPhospholipase C-beta activityC3a receptorReceptor 2Seven-membrane-spanning receptorsAgonist stimulationConventional PKC isoformsPharmacological inhibitorsLuciferase reporterReceptorsHemopoietic cellsProtein alpha subunitsCell model systemDeficient long‐term synaptic depression in the rostral cerebellum correlated with impaired motor learning in phospholipase C β4 mutant mice
Miyata M, Kim H, Hashimoto K, Lee T, Cho S, Jiang H, Wu Y, Jun K, Wu D, Kano M, Shin H. Deficient long‐term synaptic depression in the rostral cerebellum correlated with impaired motor learning in phospholipase C β4 mutant mice. European Journal Of Neuroscience 2001, 13: 1945-1954. PMID: 11403688, DOI: 10.1046/j.0953-816x.2001.01570.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtaxiaBlinkingCalcium SignalingCerebellumConditioning, PsychologicalIsoenzymesLearningLong-Term PotentiationMiceMice, KnockoutMotor ActivityMutationNerve FibersNeural InhibitionPhospholipase C betaPurkinje CellsReceptors, Metabotropic GlutamateReference ValuesSynapsesSynaptic TransmissionType C PhospholipasesConceptsLong-term depressionRostral cerebellumMutant micePurkinje cellsMetabotropic glutamate receptor subtype 1Parallel fiber-Purkinje cell synapseParallel fiber-Purkinje cell synapsesLong-term synaptic depressionFiber-Purkinje cell synapseFiber-Purkinje cell synapsesMotor learningReceptor subtype 1Voltage-gated Ca2Wild-type miceParallel fiber stimulationEyeblink responseMost Purkinje cellsUnconditioned stimulusImpaired motorCell synapsesCaudal cerebellumSynaptic depressionCell synapseFiber stimulationSubtype 1
2000
Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction
Li Z, Jiang H, Xie W, Zhang Z, Smrcka A, Wu D. Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction. Science 2000, 287: 1046-1049. PMID: 10669417, DOI: 10.1126/science.287.5455.1046.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesChemokine CCL4Chemotactic FactorsChemotaxis, LeukocyteImmunoglobulin lambda-ChainsIsoenzymesMacrophage Inflammatory ProteinsMiceN-Formylmethionine Leucyl-PhenylalanineNeutrophil InfiltrationNeutrophilsPeritonitisPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPhospholipase C betaPhosphorylationSignal TransductionSkin UlcerSuperoxidesType C PhospholipasesClimbing fiber synapse elimination during postnatal cerebellar development requires signal transduction involving Gαq and phospholipase Cβ4
Hashimoto K, Watanabe M, Kurihara H, Offermanns S, Jiang H, Wu Y, Jun K, Shin H, Inoue Y, Wu D, Simon M, Kano M. Climbing fiber synapse elimination during postnatal cerebellar development requires signal transduction involving Gαq and phospholipase Cβ4. Progress In Brain Research 2000, 124: 31-48. PMID: 10943115, DOI: 10.1016/s0079-6123(00)24006-5.Peer-Reviewed Original ResearchAge FactorsAnimalsAtaxiaCell SizeCerebellumExcitatory Postsynaptic PotentialsGene Expression Regulation, DevelopmentalGene Expression Regulation, EnzymologicGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding ProteinsIsoenzymesMiceMice, Neurologic MutantsMicroscopy, ElectronNerve FibersOrgan Culture TechniquesPhospholipase C betaPurkinje CellsRNA, MessengerSignal TransductionSynapsesType C Phospholipases
1999
Genetic alteration of phospholipase C β3 expression modulates behavioral and cellular responses to μ opioids
Xie W, Samoriski G, McLaughlin J, Romoser V, Smrcka A, Hinkle P, Bidlack J, Gross R, Jiang H, Wu D. Genetic alteration of phospholipase C β3 expression modulates behavioral and cellular responses to μ opioids. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 10385-10390. PMID: 10468617, PMCID: PMC17897, DOI: 10.1073/pnas.96.18.10385.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCalcium ChannelsCell MembraneEnkephalin, Ala(2)-MePhe(4)-Gly(5)-EnkephalinsGanglia, SpinalGene Expression RegulationGene Expression Regulation, EnzymologicIsoenzymesMembrane PotentialsMiceMice, KnockoutMorphineNeurons, AfferentPainPhospholipase C betaReceptors, Opioid, deltaReceptors, Opioid, kappaReceptors, Opioid, muType C PhospholipasesConceptsBeta3-null miceDorsal root ganglion neuronsPLC-beta3Mu-opioid responseOpioid receptor numberSpecific mu agonistPrimary sensory neuronsPhospholipase CDelta-opioid receptorsWild-type neuronsBeta3-deficient miceProtein kinase CDAMGO responseMicro opioidsOpioid responseOpioid regulationMu agonistsOpioid sensitivityGanglion neuronsΜ-opioidOpioid receptorsReceptor numberSensory neuronsKinase CNumber of intracellular
1998
Phospholipase Cβ4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum
Kano M, Hashimoto K, Watanabe M, Kurihara H, Offermanns S, Jiang H, Wu Y, Jun K, Shin H, Inoue Y, Simon M, Wu D. Phospholipase Cβ4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 15724-15729. PMID: 9861037, PMCID: PMC28111, DOI: 10.1073/pnas.95.26.15724.Peer-Reviewed Original ResearchConceptsCF synapse eliminationSynapse eliminationType 1 metabotropic glutamate receptorFiber synapse eliminationMultiple CF innervationMetabotropic glutamate receptorsPurkinje cell synapsesCF innervationCell synapsesGlutamate receptorsCaudal cerebellumCerebellar vermisRostral portionClimbing fibresRostral cerebellumCerebellar histologyPurkinje cellsSynapse formationMutant miceLocomotor ataxiaBasic electrophysiologyPhospholipase C isoformsPhospholipase Cβ4CerebellumDevelopmental eliminationIdentification of a Structural Element in Phospholipase C β2 That Interacts with G Protein βγ Subunits*
Sankaran B, Osterhout J, Wu D, Smrcka A. Identification of a Structural Element in Phospholipase C β2 That Interacts with G Protein βγ Subunits*. Journal Of Biological Chemistry 1998, 273: 7148-7154. PMID: 9507029, DOI: 10.1074/jbc.273.12.7148.Peer-Reviewed Original Research
1997
Roles of phospholipase C β2 in chemoattractant-elicited responses
Jiang H, Kuang Y, Wu Y, Xie W, Simon M, Wu D. Roles of phospholipase C β2 in chemoattractant-elicited responses. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 7971-7975. PMID: 9223297, PMCID: PMC21539, DOI: 10.1073/pnas.94.15.7971.Peer-Reviewed Original Research
1996
Phospholipase C β4 is involved in modulating the visual response in mice
Jiang H, Lyubarsky A, Dodd R, Vardi N, Pugh E, Baylor D, Simon M, Wu D. Phospholipase C β4 is involved in modulating the visual response in mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 14598-14601. PMID: 8962098, PMCID: PMC26179, DOI: 10.1073/pnas.93.25.14598.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsIsoenzymesMiceMice, KnockoutMutationPhospholipase C betaRetinaType C PhospholipasesVisual PathwaysConceptsPLC-beta 4Beta 4Phospholipase C beta 4Cell-cell interactionsC beta 4Phototransduction cascadePLC-betaRod photoreceptorsPhysiological significanceMouse linesLateral geniculate nucleusPhospholipase C β4Wild-type littermatesElectroretinographic resultsVisual functionGeniculate nucleusLittermate controlsSuperior colliculusRod aRetinal cellsBehavioral testsLight microscopyB-wave componentVisual responsesMice