2004
N-linked Glycosylation Is Required for Optimal Function of Kaposi's Sarcoma Herpesvirus–encoded, but Not Cellular, Interleukin 6
Dela Cruz CS, Lee Y, Viswanathan SR, El-Guindy AS, Gerlach J, Nikiforow S, Shedd D, Gradoville L, Miller G. N-linked Glycosylation Is Required for Optimal Function of Kaposi's Sarcoma Herpesvirus–encoded, but Not Cellular, Interleukin 6. Journal Of Experimental Medicine 2004, 199: 503-514. PMID: 14970177, PMCID: PMC2211829, DOI: 10.1084/jem.20031205.Peer-Reviewed Original ResearchConceptsVIL-6Janus tyrosine kinaseSimilar biological functionsActivator of transcriptionGp130 receptor subunitCellular IL-6Distinct functional rolesFunctional homologueBiological functionsSignal transducerTyrosine kinaseFunctional roleKaposi's sarcoma herpesvirusCell proliferation bioassayGlycosylationCell proliferationReceptor subunitsGp130B cell proliferationN89PathwayOptimal functionTranscriptionHomologuesKinase
2002
Breakdown of CTL Tolerance to Self HLA-B*2705 Induced by Exposure to Chlamydia trachomatis
Popov I, Dela Cruz CS, Barber BH, Chiu B, Inman RD. Breakdown of CTL Tolerance to Self HLA-B*2705 Induced by Exposure to Chlamydia trachomatis. The Journal Of Immunology 2002, 169: 4033-4038. PMID: 12244206, DOI: 10.4049/jimmunol.169.7.4033.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedAutoantigensCells, CulturedChlamydia trachomatisCoculture TechniquesCytotoxicity, ImmunologicEpitopes, T-LymphocyteHLA-B AntigensHLA-B27 AntigenHumansL CellsLymphocyte ActivationLymphocyte Culture Test, MixedMiceRatsRats, Inbred LewSelf ToleranceT-Lymphocytes, CytotoxicTransfectionConceptsB27-transgenic ratsSuch immunized animalsGeneration of CTLMHC class IArthritogenic pathogensSelf-HLASeronegative arthritisCTL toleranceHLA-B27Arthritogenic peptidesCTL recognitionImmunized animalsRestriction elementsTransgenic ratsChlamydia trachomatisB27Disease pathogenesisSplenocytesClass IStrong associationCTLIntracellular bacteriaImmunizationChlamydiaRats