2011
Role of Chitin and Chitinase/Chitinase-Like Proteins in Inflammation, Tissue Remodeling, and Injury
Lee CG, Da Silva CA, Dela Cruz CS, Ahangari F, Ma B, Kang MJ, He CH, Takyar S, Elias JA. Role of Chitin and Chitinase/Chitinase-Like Proteins in Inflammation, Tissue Remodeling, and Injury. Annual Review Of Physiology 2011, 73: 479-501. PMID: 21054166, PMCID: PMC3864643, DOI: 10.1146/annurev-physiol-012110-142250.Peer-Reviewed Original ResearchConceptsBRP-39/YKLAdaptive Th2 immunityTissue remodelingChitinase-like proteinsAlternative macrophage activationTh2 inflammationInnate inflammationLung injuryTh2 immunityAcidic mammalian chitinaseAncient gene familyIL-13YKL-40Tissue injuryNumber of chitinasesEffector functionsMacrophage activationFamily of chitinasesInflammationDisease severityInjuryRole of chitinMammalian chitinaseGene familyEndogenous chitin
2010
Transgenic modelling of cytokine polarization in the lung
Dela Cruz CS, Kang M, Cho W, Lee CG. Transgenic modelling of cytokine polarization in the lung. Immunology 2010, 132: 9-17. PMID: 21091906, PMCID: PMC3015070, DOI: 10.1111/j.1365-2567.2010.03376.x.Peer-Reviewed Original ResearchConceptsCytokine polarizationT helper type 17 cytokinesT helper type 2T helper type 1Type 1Type 17 cytokinesHelper type 2Type 2 cytokinesHelper type 1Human lung diseasesVariety of cytokinesCytokine milieuPulmonary inflammationEnvironmental allergensLung diseaseTissue phenotypeInjury modelT-betCommon siteCertain cytokinesEffector functionsTransgenic miceIndividual cytokinesPathophysiological consequencesType 2