2011
MEKK3 Regulates IFN-γ Production in T Cells through the Rac1/2-Dependent MAPK Cascades
Wang X, Zhang F, Chen F, Liu D, Zheng Y, Zhang Y, Dong C, Su B. MEKK3 Regulates IFN-γ Production in T Cells through the Rac1/2-Dependent MAPK Cascades. The Journal Of Immunology 2011, 186: 5791-5800. PMID: 21471448, PMCID: PMC3833674, DOI: 10.4049/jimmunol.1002127.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAminoquinolinesAnimalsCD4-Positive T-LymphocytesCell LineFlow CytometryImmunoblottingInterferon-gammaInterleukin-12Interleukin-18Listeria monocytogenesMAP Kinase Kinase Kinase 3MAP Kinase Signaling SystemMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein KinasesPyrimidinesRac GTP-Binding ProteinsRac1 GTP-Binding ProteinReceptors, Antigen, T-CellConceptsSer/Thr proteinMAPK activationMAPK kinase kinase (MAP3K) familyP38 MAPK activationThr proteinMAPK cascadeKinase familyMAPK signalsConditional knockout miceMEKK3 activationMEKK3 deficiencyMEKK3Cell differentiationTCR stimulationTCR signalsTh2 cell differentiationSpecific roleBacterial infectionsT cellsCellsKnockout miceActivationJNKProductionProteinThe Kinases MEKK2 and MEKK3 Regulate Transforming Growth Factor-β-Mediated Helper T Cell Differentiation
Chang X, Liu F, Wang X, Lin A, Zhao H, Su B. The Kinases MEKK2 and MEKK3 Regulate Transforming Growth Factor-β-Mediated Helper T Cell Differentiation. Immunity 2011, 34: 201-212. PMID: 21333552, PMCID: PMC3073014, DOI: 10.1016/j.immuni.2011.01.017.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow TransplantationCell DifferentiationEnzyme ActivationForkhead Transcription FactorsLymphocyte CountLymphopeniaMAP Kinase Kinase Kinase 2MAP Kinase Kinase Kinase 3MAP Kinase Signaling SystemMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3PhosphorylationProtein Processing, Post-TranslationalProtein Structure, TertiaryReceptors, Antigen, T-CellSmad2 ProteinSmad3 ProteinSpecific Pathogen-Free OrganismsTh17 CellsT-Lymphocytes, Helper-InducerT-Lymphocytes, RegulatoryTransforming Growth Factor betaConceptsTh cell differentiationSevere experimental autoimmune encephalomyelitisGrowth factorExperimental autoimmune encephalomyelitisHelper T cell differentiationT helper cell differentiationCell differentiationT cell differentiationTGF-β signaling pathwaysTransforming Growth FactorHelper cell differentiationTGF-β stimulationCell receptor signalsAutoimmune encephalomyelitisTGF-β responseAbnormal accumulationImpaired phosphorylationReceptor signalsSignaling pathwaysMiceCellsKinase MEKK2DifferentiationWild-type cellsTregs
2009
MEKK3 Is Essential for Lymphopenia-Induced T Cell Proliferation and Survival
Wang X, Chang X, Facchinetti V, Zhuang Y, Su B. MEKK3 Is Essential for Lymphopenia-Induced T Cell Proliferation and Survival. The Journal Of Immunology 2009, 182: 3597-3608. PMID: 19265138, PMCID: PMC2923428, DOI: 10.4049/jimmunol.0803738.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationCell ProliferationCell SurvivalCells, CulturedGene Knock-In TechniquesHomeostasisLymphopeniaMAP Kinase Kinase Kinase 3MiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Thymus GlandConceptsT cell proliferationT cell homeostasisT cellsCell proliferationPeripheral T cell numbersSelf-peptide MHCTCR stimulationT cell immunityT cell numbersThymic T cell developmentConditional knockout miceCell homeostasisT cell developmentCell immunityActivity of ERK1/2Knockout miceConditional ablationPeptide-MHCP38 MAPKLymphopeniaCell numberSignificant reductionCell developmentSelective roleProliferation
2007
MEKK3 is required for endothelium function but is not essential for tumor growth and angiogenesis
Deng Y, Yang J, McCarty M, Su B. MEKK3 is required for endothelium function but is not essential for tumor growth and angiogenesis. American Journal Of Physiology - Cell Physiology 2007, 293: c1404-c1411. PMID: 17687003, DOI: 10.1152/ajpcell.00058.2007.Peer-Reviewed Original ResearchMeSH KeywordsAngiopoietin-1AnimalsAortaApoptosisCell ProliferationEmbryo, MammalianEndocardiumEndothelial CellsEndothelium, VascularFemaleMAP Kinase Kinase Kinase 3MiceMice, Inbred StrainsMice, KnockoutMice, NudeMitogen-Activated Protein KinasesMyocardiumNeoplasms, ExperimentalNeoplastic Stem CellsNeovascularization, PathologicPhosphorylationReceptor, TIE-2Vascular Endothelial Growth Factor AConceptsEmbryonic angiogenesisProtein kinase kinase kinase 3Embryonic stem cell linesEarly embryonic developmentCell proliferationStem cell linesTumor angiogenesisTumor growthEmbryonic developmentEndothelial cellsKinase 3ERK5 activationMEKK3Endothelial cell proliferationAng1/Tie2Essential roleCell linesProduction of VEGFCritical roleEmbryosAngiogenesisFactor productionProliferationGrowthCells
2005
Identification of MEKK2/3 serine phosphorylation site targeted by the Toll‐like receptor and stress pathways
Zhang D, Facchinetti V, Wang X, Huang Q, Qin J, Su B. Identification of MEKK2/3 serine phosphorylation site targeted by the Toll‐like receptor and stress pathways. The EMBO Journal 2005, 25: 97-107. PMID: 16362041, PMCID: PMC1356356, DOI: 10.1038/sj.emboj.7600913.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibodies, Phospho-SpecificCytokinesEnzyme ActivationInterleukin-6LigandsLipopolysaccharidesMAP Kinase Kinase Kinase 2MAP Kinase Kinase Kinase 3Molecular Sequence DataMutationPhosphoamino AcidsPhosphorylationProtein Kinase InhibitorsSerineTNF Receptor-Associated Factor 6Toll-Like Receptor 4Toll-Like ReceptorsConceptsPhosphorylation sitesSerine phosphorylationMitogen-activated protein kinase kinase kinase (MAP3K) familyMolecular mechanismsProtein kinase kinase kinase familyToll-like receptorsStress pathwaysRegulatory phosphorylation sitesSerine phosphorylation sitesCellular stress responseCellular stress pathwaysNovel molecular mechanismDifferent cellular responsesKey adaptor moleculeMEKK3 phosphorylationRegulatory serineKinase familyAdaptor moleculeStress responseCellular responsesK activationMAPK agonistsPhosphorylationMEKK2Pathway