2011
The Kinases MEKK2 and MEKK3 Regulate Transforming Growth Factor-β-Mediated Helper T Cell Differentiation
Chang X, Liu F, Wang X, Lin A, Zhao H, Su B. The Kinases MEKK2 and MEKK3 Regulate Transforming Growth Factor-β-Mediated Helper T Cell Differentiation. Immunity 2011, 34: 201-212. PMID: 21333552, PMCID: PMC3073014, DOI: 10.1016/j.immuni.2011.01.017.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow TransplantationCell DifferentiationEnzyme ActivationForkhead Transcription FactorsLymphocyte CountLymphopeniaMAP Kinase Kinase Kinase 2MAP Kinase Kinase Kinase 3MAP Kinase Signaling SystemMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3PhosphorylationProtein Processing, Post-TranslationalProtein Structure, TertiaryReceptors, Antigen, T-CellSmad2 ProteinSmad3 ProteinSpecific Pathogen-Free OrganismsTh17 CellsT-Lymphocytes, Helper-InducerT-Lymphocytes, RegulatoryTransforming Growth Factor betaConceptsTh cell differentiationSevere experimental autoimmune encephalomyelitisGrowth factorExperimental autoimmune encephalomyelitisHelper T cell differentiationT helper cell differentiationCell differentiationT cell differentiationTGF-β signaling pathwaysTransforming Growth FactorHelper cell differentiationTGF-β stimulationCell receptor signalsAutoimmune encephalomyelitisTGF-β responseAbnormal accumulationImpaired phosphorylationReceptor signalsSignaling pathwaysMiceCellsKinase MEKK2DifferentiationWild-type cellsTregs
2005
Identification of MEKK2/3 serine phosphorylation site targeted by the Toll‐like receptor and stress pathways
Zhang D, Facchinetti V, Wang X, Huang Q, Qin J, Su B. Identification of MEKK2/3 serine phosphorylation site targeted by the Toll‐like receptor and stress pathways. The EMBO Journal 2005, 25: 97-107. PMID: 16362041, PMCID: PMC1356356, DOI: 10.1038/sj.emboj.7600913.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibodies, Phospho-SpecificCytokinesEnzyme ActivationInterleukin-6LigandsLipopolysaccharidesMAP Kinase Kinase Kinase 2MAP Kinase Kinase Kinase 3Molecular Sequence DataMutationPhosphoamino AcidsPhosphorylationProtein Kinase InhibitorsSerineTNF Receptor-Associated Factor 6Toll-Like Receptor 4Toll-Like ReceptorsConceptsPhosphorylation sitesSerine phosphorylationMitogen-activated protein kinase kinase kinase (MAP3K) familyMolecular mechanismsProtein kinase kinase kinase familyToll-like receptorsStress pathwaysRegulatory phosphorylation sitesSerine phosphorylation sitesCellular stress responseCellular stress pathwaysNovel molecular mechanismDifferent cellular responsesKey adaptor moleculeMEKK3 phosphorylationRegulatory serineKinase familyAdaptor moleculeStress responseCellular responsesK activationMAPK agonistsPhosphorylationMEKK2Pathway