2011
MEKK3 Regulates IFN-γ Production in T Cells through the Rac1/2-Dependent MAPK Cascades
Wang X, Zhang F, Chen F, Liu D, Zheng Y, Zhang Y, Dong C, Su B. MEKK3 Regulates IFN-γ Production in T Cells through the Rac1/2-Dependent MAPK Cascades. The Journal Of Immunology 2011, 186: 5791-5800. PMID: 21471448, PMCID: PMC3833674, DOI: 10.4049/jimmunol.1002127.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAminoquinolinesAnimalsCD4-Positive T-LymphocytesCell LineFlow CytometryImmunoblottingInterferon-gammaInterleukin-12Interleukin-18Listeria monocytogenesMAP Kinase Kinase Kinase 3MAP Kinase Signaling SystemMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein KinasesPyrimidinesRac GTP-Binding ProteinsRac1 GTP-Binding ProteinReceptors, Antigen, T-CellConceptsSer/Thr proteinMAPK activationMAPK kinase kinase (MAP3K) familyP38 MAPK activationThr proteinMAPK cascadeKinase familyMAPK signalsConditional knockout miceMEKK3 activationMEKK3 deficiencyMEKK3Cell differentiationTCR stimulationTCR signalsTh2 cell differentiationSpecific roleBacterial infectionsT cellsCellsKnockout miceActivationJNKProductionProtein
2009
MEKK3 Is Essential for Lymphopenia-Induced T Cell Proliferation and Survival
Wang X, Chang X, Facchinetti V, Zhuang Y, Su B. MEKK3 Is Essential for Lymphopenia-Induced T Cell Proliferation and Survival. The Journal Of Immunology 2009, 182: 3597-3608. PMID: 19265138, PMCID: PMC2923428, DOI: 10.4049/jimmunol.0803738.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationCell ProliferationCell SurvivalCells, CulturedGene Knock-In TechniquesHomeostasisLymphopeniaMAP Kinase Kinase Kinase 3MiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Thymus GlandConceptsT cell proliferationT cell homeostasisT cellsCell proliferationPeripheral T cell numbersSelf-peptide MHCTCR stimulationT cell immunityT cell numbersThymic T cell developmentConditional knockout miceCell homeostasisT cell developmentCell immunityActivity of ERK1/2Knockout miceConditional ablationPeptide-MHCP38 MAPKLymphopeniaCell numberSignificant reductionCell developmentSelective roleProliferation