TWIST1+FAP+ fibroblasts in the pathogenesis of intestinal fibrosis in Crohn’s disease
Zhang Y, Wang J, Sun H, Xun Z, He Z, Zhao Y, Qi J, Sun S, Yang Q, Gu Y, Zhang L, Zhou C, Ye Y, Wu N, Zou D, Su B. TWIST1+FAP+ fibroblasts in the pathogenesis of intestinal fibrosis in Crohn’s disease. Journal Of Clinical Investigation 2024, 134: e179472. PMID: 39024569, PMCID: PMC11405050, DOI: 10.1172/jci179472.Peer-Reviewed Original ResearchExcessive extracellular matrixComplication of Crohn's diseaseDextran sulfate sodium saltSingle-cell RNA sequencingMesenchymal stromal cellsTGF-b signalingScRNA-seqCrohn's diseaseIntestinal fibrosisCell transcriptomic profilingRNA sequencingTranscriptome profilingSingle cell transcriptomic profilingInhibition of Twist1Murine colitis modelPathogenesis of intestinal fibrosisAnti-fibrosis drugsExtracellular matrixPharmacological inhibitionFibrotic intestineFibrotic sitesTwist1 expressionECM productionCD patientsIntestinal obstructionCrosstalk between CD8+ T cells and mesenchymal stromal cells in intestine homeostasis and immunity
Chen Y, Sun H, Luo Z, Mei Y, Xu Z, Tan J, Xie Y, Li M, Xia J, Yang B, Su B. Crosstalk between CD8+ T cells and mesenchymal stromal cells in intestine homeostasis and immunity. Advances In Immunology 2024, 162: 23-58. PMID: 38866438, DOI: 10.1016/bs.ai.2024.02.001.Peer-Reviewed Original ResearchCD8+ T cellsMesenchymal stromal cell populationT cellsStromal cell populationsMHC II moleculesMesenchymal stromal cellsStromal cellsFunction of CD8+ T cellsCD103+ dendritic cellsMHC-IIIntestinal homeostasisCell populationsPotential pathophysiological impactGut-associated lymphoid tissueIgA+ plasma cellsDiseases of inflammationDead cell debrisTissue residencyDendritic cellsFood antigensIL-33Plasma cellsIntestinal toleranceLymphoid tissueImmunostimulatory agents