Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development
Yue T, Guo Y, Qi X, Zheng W, Zhang H, Wang B, Liu K, Zhou B, Zeng X, Ouzhuluobu, He Y, Su B. Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development. ELife 2024, 12: rp89004. PMID: 38869160, PMCID: PMC11175615, DOI: 10.7554/elife.89004.Peer-Reviewed Original ResearchConceptsExpression divergenceHigh birth weightFull-term placentaDecreased immune responseSyncytial knotsMale newbornsEndoplasmic reticulum stressPlacental trophoblastsFetal developmentUmbilical cordBirth weightHan migrantsNative TibetansUmbilical artery wallImmune responseStudy of human reproductionPlacentaAdaptation of human populationsHistological changesBetween-population differencesReticulum stressMigrantsHuman reproductionBetween-populationReproductive successSex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development
Yue T, Guo Y, Qi X, Zheng W, Zhang H, Wang B, Liu K, Zhou B, Zeng X, Ouzhuluobu, He Y, Su B. Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development. ELife 2024, 12 DOI: 10.7554/elife.89004.5.Peer-Reviewed Original ResearchExpression divergenceHigh birth weightFull-term placentaDecreased immune responseSyncytial knotsMale newbornsEndoplasmic reticulum stressPlacental trophoblastsFetal developmentUmbilical cordBirth weightHan migrantsNative TibetansUmbilical artery wallImmune responseStudy of human reproductionPlacentaAdaptation of human populationsHistological changesBetween-population differencesReticulum stressMigrantsHuman reproductionBetween-populationReproductive successLKB1 prevents ILC2 exhaustion to enhance antitumor immunity
Niu H, Zhang H, Wang D, Zhao L, Zhang Y, Zhou W, Zhang J, Su X, Sun J, Su B, Qiu J, Shen L. LKB1 prevents ILC2 exhaustion to enhance antitumor immunity. Cell Reports 2024, 43: 113579. PMID: 38670109, DOI: 10.1016/j.celrep.2023.113579.Peer-Reviewed Original ResearchAntitumor immunityPD-1Tumor immunityExpression of programmed cell death protein 1Group 2 innate lymphoid cellsBlockade of PD-1Cell death protein 1Lung melanoma metastasesAntitumor immune responseRegulating tumor immunityNuclear factor of activating T cells pathwayT-cell pathwayLiver kinase B1ILC2 functionMelanoma metastasesILC2sLymphoid cellsAllergic inflammationImmune homeostasisEffector functionsInactivating mutationsImmune responseHuman cancersCell pathwaysProtein 1