Comparative single-cell multiome identifies evolutionary changes in neural progenitor cells during primate brain development
Liu Y, Luo X, Sun Y, Chen K, Hu T, You B, Xu J, Zhang F, Cheng Q, Meng X, Yan T, Li X, Qi X, He X, Guo X, Li C, Su B. Comparative single-cell multiome identifies evolutionary changes in neural progenitor cells during primate brain development. Developmental Cell 2024 PMID: 39481377, DOI: 10.1016/j.devcel.2024.10.005.Peer-Reviewed Original ResearchEvolutionary changesDistal regulatory elementsGene regulatory mechanismsExtracellular matrixSingle-cell multiomicsProgenitor cellsTranscriptional divergenceEvolutionary divergenceChromatin regionsChromatin accessibilityNeural progenitorsRegulatory elementsSequence changesTranscriptional rewiringGenetic mechanismsMouse prefrontal cortexRegulatory mechanismsPrefrontal cortexHuman neural progenitorsHuman-specific featuresUpper-layer neuronsNeural progenitor cellsChromatinCellular propertiesProgenitor proliferationWeakened tanning ability is an important mechanism for evolutionary skin lightening in East Asians
Pu Y, Pu S, Chen Y, Kong Q, Liu X, Zhao Q, Xu K, Liu J, Li M, Xu X, Qiao X, Su B, Chen J, Yang Z. Weakened tanning ability is an important mechanism for evolutionary skin lightening in East Asians. Journal Of Genetics And Genomics 2024, 51: 703-713. PMID: 38461943, DOI: 10.1016/j.jgg.2024.03.001.Peer-Reviewed Original ResearchBinding activity of transcription factorsActivation of transcription factorsEast AsiansTranscription factor binding assaysBinding to Smad2Zebrafish embryosHan Chinese individualsEnhanced activityAdaptive allelesAssociated with skin colorAncestral alleleHigh-latitude environmentsHan Chinese malesPigment genesIntronic mutationTanning abilityTranscription factorsGenetic mechanismsSelection signalsT alleleUltraviolet radiation responsesNatural selectionLight skin pigmentationMelanin productionBinding activity