2024
Comparative single-cell multiome identifies evolutionary changes in neural progenitor cells during primate brain development
Liu Y, Luo X, Sun Y, Chen K, Hu T, You B, Xu J, Zhang F, Cheng Q, Meng X, Yan T, Li X, Qi X, He X, Guo X, Li C, Su B. Comparative single-cell multiome identifies evolutionary changes in neural progenitor cells during primate brain development. Developmental Cell 2024 PMID: 39481377, DOI: 10.1016/j.devcel.2024.10.005.Peer-Reviewed Original ResearchEvolutionary changesDistal regulatory elementsGene regulatory mechanismsExtracellular matrixSingle-cell multiomicsProgenitor cellsTranscriptional divergenceEvolutionary divergenceChromatin regionsChromatin accessibilityNeural progenitorsRegulatory elementsSequence changesTranscriptional rewiringGenetic mechanismsMouse prefrontal cortexRegulatory mechanismsPrefrontal cortexHuman neural progenitorsHuman-specific featuresUpper-layer neuronsNeural progenitor cellsChromatinCellular propertiesProgenitor proliferationTWIST1+FAP+ fibroblasts in the pathogenesis of intestinal fibrosis in Crohn’s disease
Zhang Y, Wang J, Sun H, Xun Z, He Z, Zhao Y, Qi J, Sun S, Yang Q, Gu Y, Zhang L, Zhou C, Ye Y, Wu N, Zou D, Su B. TWIST1+FAP+ fibroblasts in the pathogenesis of intestinal fibrosis in Crohn’s disease. Journal Of Clinical Investigation 2024, 134: e179472. PMID: 39024569, PMCID: PMC11405050, DOI: 10.1172/jci179472.Peer-Reviewed Original ResearchExcessive extracellular matrixComplication of Crohn's diseaseDextran sulfate sodium saltSingle-cell RNA sequencingMesenchymal stromal cellsTGF-b signalingScRNA-seqCrohn's diseaseIntestinal fibrosisCell transcriptomic profilingRNA sequencingTranscriptome profilingSingle cell transcriptomic profilingInhibition of Twist1Murine colitis modelPathogenesis of intestinal fibrosisAnti-fibrosis drugsExtracellular matrixPharmacological inhibitionFibrotic intestineFibrotic sitesTwist1 expressionECM productionCD patientsIntestinal obstruction
2023
Brain developmental and cortical connectivity changes in transgenic monkeys carrying the human-specific duplicated gene SRGAP2C
Meng X, Lin Q, Zeng X, Jiang J, Li M, Luo X, Chen K, Wu H, Hu Y, Liu C, Su B. Brain developmental and cortical connectivity changes in transgenic monkeys carrying the human-specific duplicated gene SRGAP2C. National Science Review 2023, 10: nwad281. PMID: 38090550, PMCID: PMC10712708, DOI: 10.1093/nsr/nwad281.Peer-Reviewed Original ResearchTransgenic monkeysDeep layer neuronsFetal neurogenesisMyelination levelsSynaptic maturationLongitudinal MRITransgenic miceSynaptic connectionsBrain developmentConnectivity changesBrain connectivityOccipital regionMolecular pathwaysBrainMotor planningMonkeysEnergy metabolismHuman brainCellular levelEnlarged brainExtracellular matrixPrior studiesHumansNeurogenesisGenes