2011
MEKK3 Regulates IFN-γ Production in T Cells through the Rac1/2-Dependent MAPK Cascades
Wang X, Zhang F, Chen F, Liu D, Zheng Y, Zhang Y, Dong C, Su B. MEKK3 Regulates IFN-γ Production in T Cells through the Rac1/2-Dependent MAPK Cascades. The Journal Of Immunology 2011, 186: 5791-5800. PMID: 21471448, PMCID: PMC3833674, DOI: 10.4049/jimmunol.1002127.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAminoquinolinesAnimalsCD4-Positive T-LymphocytesCell LineFlow CytometryImmunoblottingInterferon-gammaInterleukin-12Interleukin-18Listeria monocytogenesMAP Kinase Kinase Kinase 3MAP Kinase Signaling SystemMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein KinasesPyrimidinesRac GTP-Binding ProteinsRac1 GTP-Binding ProteinReceptors, Antigen, T-CellConceptsSer/Thr proteinMAPK activationMAPK kinase kinase (MAP3K) familyP38 MAPK activationThr proteinMAPK cascadeKinase familyMAPK signalsConditional knockout miceMEKK3 activationMEKK3 deficiencyMEKK3Cell differentiationTCR stimulationTCR signalsTh2 cell differentiationSpecific roleBacterial infectionsT cellsCellsKnockout miceActivationJNKProductionProteinThe Kinases MEKK2 and MEKK3 Regulate Transforming Growth Factor-β-Mediated Helper T Cell Differentiation
Chang X, Liu F, Wang X, Lin A, Zhao H, Su B. The Kinases MEKK2 and MEKK3 Regulate Transforming Growth Factor-β-Mediated Helper T Cell Differentiation. Immunity 2011, 34: 201-212. PMID: 21333552, PMCID: PMC3073014, DOI: 10.1016/j.immuni.2011.01.017.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow TransplantationCell DifferentiationEnzyme ActivationForkhead Transcription FactorsLymphocyte CountLymphopeniaMAP Kinase Kinase Kinase 2MAP Kinase Kinase Kinase 3MAP Kinase Signaling SystemMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3PhosphorylationProtein Processing, Post-TranslationalProtein Structure, TertiaryReceptors, Antigen, T-CellSmad2 ProteinSmad3 ProteinSpecific Pathogen-Free OrganismsTh17 CellsT-Lymphocytes, Helper-InducerT-Lymphocytes, RegulatoryTransforming Growth Factor betaConceptsTh cell differentiationSevere experimental autoimmune encephalomyelitisGrowth factorExperimental autoimmune encephalomyelitisHelper T cell differentiationT helper cell differentiationCell differentiationT cell differentiationTGF-β signaling pathwaysTransforming Growth FactorHelper cell differentiationTGF-β stimulationCell receptor signalsAutoimmune encephalomyelitisTGF-β responseAbnormal accumulationImpaired phosphorylationReceptor signalsSignaling pathwaysMiceCellsKinase MEKK2DifferentiationWild-type cellsTregs
2010
Sin1-mTORC2 Suppresses rag and il7r Gene Expression through Akt2 in B Cells
Lazorchak AS, Liu D, Facchinetti V, Di Lorenzo A, Sessa WC, Schatz DG, Su B. Sin1-mTORC2 Suppresses rag and il7r Gene Expression through Akt2 in B Cells. Molecular Cell 2010, 39: 433-443. PMID: 20705244, PMCID: PMC2957800, DOI: 10.1016/j.molcel.2010.07.031.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsB-LymphocytesCell Line, TransformedDNA-Binding ProteinsForkhead Box Protein O1Forkhead Transcription FactorsGene Expression RegulationGene Rearrangement, B-LymphocyteHomeodomain ProteinsMiceMice, KnockoutPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktReceptors, Interleukin-7Signal TransductionTOR Serine-Threonine KinasesTranscription FactorsConceptsB cell developmentGene expressionCell developmentRAG gene expressionMTOR complex 2FOXO1 transcriptional activityPI3K signalingMTOR inhibitor rapamycinTranscriptional activityKey regulatorB cellsMolecular mechanismsInhibitor rapamycinK signalingCell survivalFoxO1 phosphorylationMammalian targetRecombinase activityPI3KIL-7 receptorAkt2SignalingRapamycinExpressionCells
2007
MEKK3 is required for endothelium function but is not essential for tumor growth and angiogenesis
Deng Y, Yang J, McCarty M, Su B. MEKK3 is required for endothelium function but is not essential for tumor growth and angiogenesis. American Journal Of Physiology - Cell Physiology 2007, 293: c1404-c1411. PMID: 17687003, DOI: 10.1152/ajpcell.00058.2007.Peer-Reviewed Original ResearchMeSH KeywordsAngiopoietin-1AnimalsAortaApoptosisCell ProliferationEmbryo, MammalianEndocardiumEndothelial CellsEndothelium, VascularFemaleMAP Kinase Kinase Kinase 3MiceMice, Inbred StrainsMice, KnockoutMice, NudeMitogen-Activated Protein KinasesMyocardiumNeoplasms, ExperimentalNeoplastic Stem CellsNeovascularization, PathologicPhosphorylationReceptor, TIE-2Vascular Endothelial Growth Factor AConceptsEmbryonic angiogenesisProtein kinase kinase kinase 3Embryonic stem cell linesEarly embryonic developmentCell proliferationStem cell linesTumor angiogenesisTumor growthEmbryonic developmentEndothelial cellsKinase 3ERK5 activationMEKK3Endothelial cell proliferationAng1/Tie2Essential roleCell linesProduction of VEGFCritical roleEmbryosAngiogenesisFactor productionProliferationGrowthCells