2024
PROTAC EZH2 degrader-1 overcomes the resistance of podophyllotoxin derivatives in refractory small cell lung cancer with leptomeningeal metastasis
Shi M, Ding X, Tang L, Cao W, Su B, Zhang J. PROTAC EZH2 degrader-1 overcomes the resistance of podophyllotoxin derivatives in refractory small cell lung cancer with leptomeningeal metastasis. BMC Cancer 2024, 24: 504. PMID: 38644473, PMCID: PMC11034131, DOI: 10.1186/s12885-024-12244-3.Peer-Reviewed Original ResearchConceptsSmall cell lung cancerCell lung cancerMouse modelLung cancerRefractory small cell lung cancerNude miceIn vivo drug testingCell linesDrug testingLM cellsSensitivity of cisplatinIn vitro drug testingIncreased in vitroBackgroundLeptomeningeal metastasisLeptomeningeal metastasesSevere neurological disordersAssociated with several neurological disordersDrug sensitivityIn vivo live imagingHistological examinationCarotid arteryEffective treatmentMetastasisDrug trialsExpressing luciferase
2007
MEKK3 is required for endothelium function but is not essential for tumor growth and angiogenesis
Deng Y, Yang J, McCarty M, Su B. MEKK3 is required for endothelium function but is not essential for tumor growth and angiogenesis. American Journal Of Physiology - Cell Physiology 2007, 293: c1404-c1411. PMID: 17687003, DOI: 10.1152/ajpcell.00058.2007.Peer-Reviewed Original ResearchMeSH KeywordsAngiopoietin-1AnimalsAortaApoptosisCell ProliferationEmbryo, MammalianEndocardiumEndothelial CellsEndothelium, VascularFemaleMAP Kinase Kinase Kinase 3MiceMice, Inbred StrainsMice, KnockoutMice, NudeMitogen-Activated Protein KinasesMyocardiumNeoplasms, ExperimentalNeoplastic Stem CellsNeovascularization, PathologicPhosphorylationReceptor, TIE-2Vascular Endothelial Growth Factor AConceptsEmbryonic angiogenesisProtein kinase kinase kinase 3Embryonic stem cell linesEarly embryonic developmentCell proliferationStem cell linesTumor angiogenesisTumor growthEmbryonic developmentEndothelial cellsKinase 3ERK5 activationMEKK3Endothelial cell proliferationAng1/Tie2Essential roleCell linesProduction of VEGFCritical roleEmbryosAngiogenesisFactor productionProliferationGrowthCells