2024
Identifying Variation in Intraoperative Management of Brain-Dead Organ Donors and Opportunities for Improvement: A Multicenter Perioperative Outcomes Group Analysis
Lele A, Vail E, O’Reilly-Shah V, DeGraw X, Domino K, Walters A, Fong C, Gomez C, Naik B, Mori M, Schonberger R, Deshpande R, Souter M, Mathis M. Identifying Variation in Intraoperative Management of Brain-Dead Organ Donors and Opportunities for Improvement: A Multicenter Perioperative Outcomes Group Analysis. Anesthesia & Analgesia 2024 DOI: 10.1213/ane.0000000000007001.Peer-Reviewed Original ResearchIntraclass correlation coefficientMulticenter Perioperative Outcomes GroupOrgan procurement organization regionBrain-dead organ donorsNon-Hispanic whitesPoisson regression analysisOrgan procurement organizationsIntraoperative eventsUS hospitalsYears of ageMedication useIncidence of hypotensionOrgan donorsManagement of brain-dead donorsPrimary outcomeManagement of brain-dead organ donorsMixed-effects Poisson regression analysisIntravenous heparinVasoactive medicationsBrain-dead donorsMulticenter cohortIntraoperative managementTransplant outcomesCase volumeMm HgPreoperative Blood Pressures and the Physician Anesthesiologist
Schonberger R. Preoperative Blood Pressures and the Physician Anesthesiologist. Anesthesiology 2024, 141: 208-210. PMID: 38980164, PMCID: PMC11239125, DOI: 10.1097/aln.0000000000005101.Peer-Reviewed Original ResearchAnesthesia Techniques for Vitreoretinal Surgery in the United States: A Report from the Multicenter Perioperative Outcomes Group Research Consortium
Chauhan M, SOLIMAN M, Pace N, Mathis M, Schonberger R, Sallam A, Group M. Anesthesia Techniques for Vitreoretinal Surgery in the United States: A Report from the Multicenter Perioperative Outcomes Group Research Consortium. American Journal Of Ophthalmology 2024, 267: 30-40. PMID: 38871268, DOI: 10.1016/j.ajo.2024.06.010.Peer-Reviewed Original ResearchMonitored anesthesia careVR surgeryMulticenter Perioperative Outcomes GroupGeneral anesthesiaAmerican Society of Anesthesiologists (ASAHistory of drug abuseChronic pulmonary diseaseType of anesthesiaMonitored anesthesia care casesAlcohol abuse disordersMultivariate mixed-effects modelRandom-effects modelRetinal detachmentSB surgeryVitreoretinal surgeryYounger patientsAnesthesia useSurgery casesOutcome groupAnesthesia techniquesPrimary outcomeSurgeryLiver diseaseSecondary outcomesPulmonary diseaseSame-Day Primary Care Referral Versus Usual Care for Patients With Elevated Blood Pressures Seen in a Preoperative Clinic
Butler S, Holt N, Dai F, Quick C, Kravetz J, Perrino A, Schonberger R. Same-Day Primary Care Referral Versus Usual Care for Patients With Elevated Blood Pressures Seen in a Preoperative Clinic. Cureus 2024, 16: e58401. PMID: 38756290, PMCID: PMC11098054, DOI: 10.7759/cureus.58401.Peer-Reviewed Original ResearchPrimary care referralsPrimary care groupsCare referralUsual careCare groupPreoperative clinicQuality improvementCare coordination effortsLong-term health outcomesPrimary care visitsPrimary care appointmentsCohort of US veteransMonths post-interventionSame-day referralElectronic health recordsBlood pressureSurgical care episodesHypertension treatmentProspective QI projectPreoperative evaluation clinicImprove BP controlQI projectCare appointmentsPreoperative clinic visitPrimary care
2023
Perioperative Mortality of the COVID-19 Recovered Patient Compared to a Matched Control: A Multicenter Retrospective Cohort Study
Aziz M, Schenning K, Koike S, O’Glasser A, O’Reilly-Shah V, Sera V, Mathis M, Naik B, Taicher B, Colquhoun D, Freundlich R, Schonberger R, Domino K, Chen L, Pace N. Perioperative Mortality of the COVID-19 Recovered Patient Compared to a Matched Control: A Multicenter Retrospective Cohort Study. Anesthesiology 2023, 140: 195-206. PMID: 37844271, DOI: 10.1097/aln.0000000000004809.Peer-Reviewed Original ResearchConceptsAcute kidney injuryPulmonary complicationsKidney injuryIncreased riskPerioperative mortalityExposed patientsCOVID-19 infectionIncreased 30-day mortality riskElective surgeryIncreased risk of acute kidney injuryIncreased risk of pulmonary complicationsRisk of acute kidney injuryMortality riskPositive testRisk of pulmonary complicationsRisk of perioperative mortalityRetrospective observational cohort studyThirty-day mortalityCOVID-19-recovered patientsCohort of patientsExposure to COVID-19 infectionIncreased risk of mortalityAssociated with increased mortality riskObservational cohort studyElective inpatient surgeryPatient-, Clinician-, and Institution-level Variation in Inotrope Use for Cardiac Surgery: A Multicenter Observational Analysis
Mathis M, Janda A, Kheterpal S, Schonberger R, Pagani F, Engoren M, Mentz G, Shook D, Muehlschlegel J, Cassidy R, Clark D, Colquhoun D, Freundlich R, Jewell E. Patient-, Clinician-, and Institution-level Variation in Inotrope Use for Cardiac Surgery: A Multicenter Observational Analysis. Anesthesiology 2023, 139: 122-141. PMID: 37094103, PMCID: PMC10524016, DOI: 10.1097/aln.0000000000004593.Peer-Reviewed Original ResearchConceptsInotrope useCardiac surgeryHome medicationsAdjusted median odds ratioPulmonary circulation disordersAdult cardiac surgeryMechanical circulatory supportMedian odds ratioMedical school affiliationHome inotropesInotrope infusionInotrope therapyInotropic therapyCardiopulmonary bypassHeart failureMulticenter cohortPrimary outcomeCirculatory supportBlack raceCirculation disordersOdds ratioCommunity hospitalObservational studySame patientPatientsAssociation of adherence to individual components of Society of Thoracic Surgeons cardiac surgery antibiotic guidelines and postoperative infections
Bardia A, Michel G, Farela A, Fisher C, Mori M, Huttler J, Lang A, Geirsson A, Schonberger R. Association of adherence to individual components of Society of Thoracic Surgeons cardiac surgery antibiotic guidelines and postoperative infections. Journal Of Thoracic And Cardiovascular Surgery 2023, 167: 2170-2176.e5. PMID: 37075942, PMCID: PMC10579454, DOI: 10.1016/j.jtcvs.2023.03.031.Peer-Reviewed Original ResearchWeight-adjusted dosingPostoperative infectionAntibiotic guidelinesIncidence of nonadherenceCoronary artery bypassTertiary care hospitalAssociation of adherenceCohort of patientsRetrospective observational studyPost-operative infectionIntraoperative redosingValvular surgeryAntibiotic timingArtery bypassCoronary revascularizationPostoperative complicationsPostoperative sepsisAdult patientsFirst doseAntibiotic choiceCardiac surgeryCardiopulmonary bypassCare hospitalDose adjustmentPrimary outcomeSystemic Effects of Perineural Glucocorticoids on Fasting Serum Glucose, Potassium, and White Blood Cell Count in Total Hip Arthroplasty
Sharma A, Dai F, Tseng L, Effraim P, Zhou B, Schonberger R, Li J. Systemic Effects of Perineural Glucocorticoids on Fasting Serum Glucose, Potassium, and White Blood Cell Count in Total Hip Arthroplasty. Journal Of Pain Research 2023, 16: 553-561. PMID: 36846205, PMCID: PMC9946012, DOI: 10.2147/jpr.s395336.Peer-Reviewed Original ResearchWhite blood cell countTotal hip arthroplastyBlood cell countSerum glucosePAI groupSerum potassiumPOD 2Hip arthroplastySystemic effectsCell countTertiary academic medical centerPrimary total hip arthroplastyRetrospective cohort studyPostoperative day 1Immediate postoperative periodLocal anesthetic injectionPeripheral nerve blocksAcademic medical centerPotential systemic effectsElectronic health recordsPreoperative baselineCohort studyPostoperative periodSecondary outcomesPOD 3Perioperative Complications in Patients with Systemic Sclerosis: A Comparative Cohort Analysis
Carr Z, Yan L, Yanez N, Schonberger R, Bohorquez M, He Z, Li F, Hines R, Treggiari M. Perioperative Complications in Patients with Systemic Sclerosis: A Comparative Cohort Analysis. Medical Research Archives 2023, 11: 10.18103/mra.v11i10.4606. PMID: 38037571, PMCID: PMC10688569, DOI: 10.18103/mra.v11i10.4606.Peer-Reviewed Original ResearchMajor adverse cardiac eventsSystemic sclerosisLength of stayPerioperative complicationsSSc patientsComparative cohort analysisSSc cohortPerioperative outcomesControl cohortCohort analysisCormack-Lehane grade 3Limited cervical rangeAdverse cardiac eventsRare autoimmune disorderComparative cohort studySurgical site infectionBetween-group differencesQuaternary care institutionMultiple organ systemsHigh rateAirway complicationsComposite infectionHospital complicationsCardiac eventsCohort study
2022
Geospatial analysis of patients’ social determinants of health for health systems science and disparity research
Pearson J, Jacobson C, Ugochukwu N, Asare E, Kan K, Pace N, Han J, Wan N, Schonberger R, Andreae M. Geospatial analysis of patients’ social determinants of health for health systems science and disparity research. International Anesthesiology Clinics 2022, 61: 49-62. PMID: 36480649, PMCID: PMC10107426, DOI: 10.1097/aia.0000000000000389.Peer-Reviewed Original ResearchEfficacy and Safety of Sugammadex to Shorten Time-to-Extubation Following Cardiac Surgery: A Single-Center Randomized Placebo-Controlled Trial
Bardia A, Treggiari M, Dai F, Johnson C, Singh M, Kunze K, Tickoo M, Tantawy H, Giersson A, Darr U, Schonberger R. Efficacy and Safety of Sugammadex to Shorten Time-to-Extubation Following Cardiac Surgery: A Single-Center Randomized Placebo-Controlled Trial. Critical Care Explorations 2022, 4: e0821. PMID: 36601562, PMCID: PMC9788969, DOI: 10.1097/cce.0000000000000821.Peer-Reviewed Original ResearchAortic valve replacementCardiac surgeryNeuromuscular blockadeCombined Aortic Valve ReplacementElective aortic valve replacementEfficacy of sugammadexStudy drug administrationCoronary artery bypassPlacebo-controlled trialPrimary study endpointResidual neuromuscular blockadeUse of sugammadexArtery bypassPlacebo groupSugammadex groupBaseline characteristicsValve replacementAnesthetic medicationsStudy endpointMechanical ventilationModifiable factorsCardiothoracic ICUICU settingNMB reversalPatientsOxygen administration during surgery and postoperative organ injury: observational cohort study
McIlroy D, Shotwell M, Lopez M, Vaughn M, Olsen J, Hennessy C, Wanderer J, Semler M, Rice T, Kheterpal S, Billings F, Group M, Cuff G, Freundlich R, Kurz A, Naik B, Mathis M, Schonberger R. Oxygen administration during surgery and postoperative organ injury: observational cohort study. The BMJ 2022, 379: e070941. PMID: 36450405, PMCID: PMC9710248, DOI: 10.1136/bmj-2022-070941.Peer-Reviewed Original ResearchConceptsAcute kidney injuryObservational cohort studyLung injuryKidney injuryMyocardial injuryOxygen administrationGreater oddsCohort studyMedian age 59 yearsHospital discharge diagnosis codesGlobal Outcomes criteriaAge 59 yearsHours of surgeryDischarge diagnosis codesPotential confounding variablesHemoglobin oxygen saturationPostoperative kidneyPrimary endpointAdult patientsMedian durationOrgan injurySerum troponinEndotracheal intubationGeneral anesthesiaKidney diseaseAssociation between choice of reversal agent for neuromuscular block and postoperative pulmonary complications in patients at increased risk undergoing non-emergency surgery: STIL-STRONGER, a multicentre matched cohort study
Colquhoun D, Vaughn M, Bash L, Janda A, Shah N, Ghaferi A, Sjoding M, Mentz G, Kheterpal S, Committee M, Craft R, Domino K, Freundlich R, Mathis M, McCormick P, Naik B, Ruiz J, Schonberger R, Schroeder R, Stewart A, Taicher B, Tingle S, Togioka B, Urman R, Vachhani S. Association between choice of reversal agent for neuromuscular block and postoperative pulmonary complications in patients at increased risk undergoing non-emergency surgery: STIL-STRONGER, a multicentre matched cohort study. British Journal Of Anaesthesia 2022, 130: e148-e159. PMID: 35691703, PMCID: PMC9875908, DOI: 10.1016/j.bja.2022.04.023.Peer-Reviewed Original ResearchConceptsPostoperative pulmonary complicationsPulmonary complicationsNon-emergency surgeryRespiratory failureCohort studyNeuromuscular blockReversal agentsAnesthesiologists physical status 3Primary composite outcomeCohort of patientsUse of sugammadexIntra-abdominal surgeryOccurrence of pneumoniaBody mass indexSource of morbidityNeuromuscular blocking agentsStatus 3Complication outcomesComposite outcomeMajor surgeryPrimary outcomeMass indexTracheal intubationGeneral anesthesiaMulticenter Perioperative Outcomes Group
2019
Chasing Ghosts: Unexplained Artifactual Echogenicity on the Aortic Valve Leading to Unwarranted Surgery
Blitz D, Mahmood F, Tickoo M, Schonberger R, Bardia A. Chasing Ghosts: Unexplained Artifactual Echogenicity on the Aortic Valve Leading to Unwarranted Surgery. Case 2019, 3: 107-109. PMID: 31286089, PMCID: PMC6588731, DOI: 10.1016/j.case.2019.01.002.Peer-Reviewed Original ResearchPreoperative chlorhexidine mouthwash to reduce pneumonia after cardiac surgery: A systematic review and meta-analysis
Bardia A, Blitz D, Dai F, Hersey D, Jinadasa S, Tickoo M, Schonberger RB. Preoperative chlorhexidine mouthwash to reduce pneumonia after cardiac surgery: A systematic review and meta-analysis. Journal Of Thoracic And Cardiovascular Surgery 2019, 158: 1094-1100. PMID: 30826096, DOI: 10.1016/j.jtcvs.2019.01.014.Peer-Reviewed Original ResearchConceptsPreoperative chlorhexidine mouthwashChlorhexidine gluconate mouthwashPostoperative pneumoniaCardiac surgeryChlorhexidine mouthwashHealth care burdenQuality of evidenceComprehensive systematic searchRandom-effects modelPreoperative chlorhexidineRecommendations AssessmentCommon complicationPrimary outcomePreoperative protocolPatient morbidityRisk ratioPatient outcomesCare burdenReduced riskIndependent reviewersCumulative IndexPneumoniaNLM PubMedChlorhexidine gluconatePatientsSuccinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment: Database Analyses and Systematic Review.
Larach MG, Klumpner TT, Brandom BW, Vaughn MT, Belani KG, Herlich A, Kim TW, Limoncelli J, Riazi S, Sivak EL, Capacchione J, Mashman D, Kheterpal S, Kooij F, Wilczak J, Soto R, Berris J, Price Z, Lins S, Coles P, Harris JM, Cummings KC, Berman MF, Nanamori M, Adelman BT, Wedeven C, LaGorio J, McCormick PJ, Tom S, Aziz MF, Coffman T, Ellis TA, Molina S, Peterson W, Mackey SC, van Klei WA, Ginde AA, Biggs DA, Neuman MD, Craft RM, Pace NL, Paganelli WC, Durieux ME, Nair BJ, Wanderer JP, Miller SA, Helsten DL, Turnbull ZA, Schonberger RB. Succinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment: Database Analyses and Systematic Review. Anesthesiology 2019, 130: 41-54. PMID: 30550426, DOI: 10.1097/ALN.0000000000002490.Peer-Reviewed Original Research
2018
Elevated preoperative blood pressures in adult surgical patients are highly predictive of elevated home blood pressures
Schonberger RB, Nwozuzu A, Zafar J, Chen E, Kigwana S, Monteiro MM, Charchaflieh J, Sophanphattana S, Dai F, Burg MM. Elevated preoperative blood pressures in adult surgical patients are highly predictive of elevated home blood pressures. International Journal Of Cardiology Cardiovascular Risk And Prevention 2018, 12: 303-310. PMID: 29486981, PMCID: PMC5938112, DOI: 10.1016/j.jash.2018.01.012.Peer-Reviewed Original ResearchElevated home blood pressuresHome blood pressureClinic blood pressureTreatment of hypertensionBlood pressurePositive predictive valuePresurgical assessmentPredictive valueDiastolic home blood pressureSystolic home blood pressureAmerican Heart Association guidelinesHome blood pressure monitorPreoperative blood pressurePreoperative pain scoreAdult surgical patientsHeart Association guidelinesDay of surgeryUpper arm deviceIndex clinic visitBlood pressure measurementsBlood pressure monitorAntihypertensive treatmentBP controlPain scoresClinic visitsQuantification of Postmembrane Gaseous Microembolization During Venoarterial Extracorporeal Membrane Oxygenation
Jiao Y, Gipson KE, Bonde P, Mangi A, Hagberg R, Rosinski DJ, Gross JB, Schonberger RB. Quantification of Postmembrane Gaseous Microembolization During Venoarterial Extracorporeal Membrane Oxygenation. ASAIO Journal 2018, 64: 31-37. PMID: 28557862, DOI: 10.1097/mat.0000000000000598.Peer-Reviewed Original ResearchConceptsVenoarterial extracorporeal membrane oxygenationVA-ECMO patientsExtracorporeal membrane oxygenationGaseous microemboliVA-ECMOECMO patientsMembrane oxygenationCardiopulmonary bypassAdult VA-ECMO patientsExtracorporeal membrane oxygenation circuitEnd-organ dysfunctionInstitutional review board approvalRoutine patient careMembrane oxygenation circuitPatient care eventsPatient care activitiesReview board approvalOrgan dysfunctionEmbolic rateClinical eventsObservational studyIntravenous injectionEnd organsGME volumeBoard approval
2017
Postcardiotomy Venoarterial Extracorporeal Membrane Oxygenation (VA ECMO) in Adult Patients – Many Questions, Few Answers, and Hard Choices
Bardia A, Schonberger RB. Postcardiotomy Venoarterial Extracorporeal Membrane Oxygenation (VA ECMO) in Adult Patients – Many Questions, Few Answers, and Hard Choices. Journal Of Cardiothoracic And Vascular Anesthesia 2017, 32: 1183-1184. PMID: 29276089, DOI: 10.1053/j.jvca.2017.10.037.Peer-Reviewed Original ResearchThe effect of race on postsurgical ambulatory medical follow-up among United States Veterans
Schonberger RB, Dai F, Brandt C, Burg MM. The effect of race on postsurgical ambulatory medical follow-up among United States Veterans. Journal Of Clinical Anesthesia 2017, 40: 55-61. PMID: 28625448, PMCID: PMC5490668, DOI: 10.1016/j.jclinane.2016.11.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAmbulatory CareBlack or African AmericanComorbidityContinuity of Patient CareFemaleFollow-Up StudiesHealthcare DisparitiesHumansLong-Term CareMaleMiddle AgedPatient Acceptance of Health CareRetrospective StudiesSurgical Procedures, OperativeUnited StatesVeteransVeterans HealthYoung AdultConceptsAfrican American raceAfrican American patientsInternal medicineAmerican patientsAmbulatory internal medicineAmerican raceUS Veterans Affairs hospitalsYear of surgeryDay of surgeryVeterans Affairs hospitalUnited States veteransQuality improvement initiativesRetrospective observationalUS veteransHispanic ethnicityInpatient daysStates veteransSurgeryDecreased likelihoodEffect of raceImprovement initiativesVeteransFurther studiesPatientsAfrican Americans