2024
Exploring the Impact of Age, Frailty, and Multimorbidity on the Effect of ICU Interventions: A Systematic Review of Randomized Controlled Trials.
Perrella A, Geen O, Ahuja M, Scott S, Kaushik R, Ferrante L, Brummel N, Muscedere J, Rochwerg B. Exploring the Impact of Age, Frailty, and Multimorbidity on the Effect of ICU Interventions: A Systematic Review of Randomized Controlled Trials. Critical Care Medicine 2024 PMID: 38661459, DOI: 10.1097/ccm.0000000000006315.Peer-Reviewed Original ResearchCritical care interventionsRandomized controlled trialsCare interventionsOlder adultsCluster randomized controlled trialStatistically significant effect modificationSubgroup effectsIll older adultsControlled trialsCritically ill older adultsSystematic review of randomized controlled trialsSignificant effect modificationReview of randomized controlled trialsCritical care randomized controlled trialsCritical care journalsStatistically significant subgroup effectsIndividual patient preferencesSubgroups of ageIntervention effectsMultimorbidityEffect modificationFrailty subgroupsICU interventionsStudy characteristicsGeneral medicine
2020
Prediction Models for Physical, Cognitive, and Mental Health Impairments After Critical Illness: A Systematic Review and Critical Appraisal
Haines KJ, Hibbert E, McPeake J, Anderson BJ, Bienvenu OJ, Andrews A, Brummel NE, Ferrante LE, Hopkins RO, Hough CL, Jackson J, Mikkelsen ME, Leggett N, Montgomery-Yates A, Needham DM, Sevin CM, Skidmore B, Still M, van Smeden M, Collins GS, Harhay MO. Prediction Models for Physical, Cognitive, and Mental Health Impairments After Critical Illness: A Systematic Review and Critical Appraisal. Critical Care Medicine 2020, 48: 1871-1880. PMID: 33060502, PMCID: PMC7673641, DOI: 10.1097/ccm.0000000000004659.Peer-Reviewed Original ResearchConceptsCritical illnessMental health impairmentSystematic reviewHealth impairmentBias assessment toolRisk of biasStudy eligibility criteriaPrediction model RiskComposite outcomeAdult patientsTrial enrollmentCochrane LibraryPatient recoveryIndependent reviewersHigh riskEligibility criteriaOutcome measurementsStandardized outcomesAdult survivorsStudy characteristicsIllnessStudy designSystematic searchImpairmentCandidate predictors