2024
Development and multinational validation of an algorithmic strategy for high Lp(a) screening
Aminorroaya A, Dhingra L, Oikonomou E, Saadatagah S, Thangaraj P, Vasisht Shankar S, Spatz E, Khera R. Development and multinational validation of an algorithmic strategy for high Lp(a) screening. Nature Cardiovascular Research 2024, 3: 558-566. DOI: 10.1038/s44161-024-00469-1.Peer-Reviewed Original ResearchElectronic health recordsAssociated with premature atherosclerotic cardiovascular diseaseElevated Lp(aHealth recordsUK BiobankPremature atherosclerotic cardiovascular diseaseMachine learning modelsAtherosclerotic cardiovascular diseaseCohort studyReal-world settingsTargeted screeningCardiovascular diseaseLearning modelsNovel targeted therapeuticsAlgorithmic strategiesCohortProbability thresholdScreeningClinical featuresValidation cohortElevated lipoproteinRisk inspectionARICLp(a
2023
Association of SGLT‐2 Inhibitors With Treatment Satisfaction and Diabetes‐Specific and General Health Status in Adults With Cardiovascular Disease and Type 2 Diabetes
Ding Q, Spatz E, Bena J, Morrison S, Levay M, Lin H, Grey M, Edwards N, Isaacs D, West L, Combs P, Albert N. Association of SGLT‐2 Inhibitors With Treatment Satisfaction and Diabetes‐Specific and General Health Status in Adults With Cardiovascular Disease and Type 2 Diabetes. Journal Of The American Heart Association 2023, 12: e029058. PMID: 37655510, PMCID: PMC10547320, DOI: 10.1161/jaha.122.029058.Peer-Reviewed Original ResearchConceptsSodium-glucose cotransporter 2 inhibitorsGeneral health statusCardiovascular disease typesType 2 diabetesTreatment satisfactionDiabetes-specific qualityCardiovascular diseaseHealth statusDisease typeProspective observational study designPatient-reported health statusInverse probabilityNoninsulin antidiabetic medicationsSGLT-2i useSGLT-2i usersTreatment-weighted analysisCotransporter 2 inhibitorsSGLT-2 inhibitorsDiabetes treatment satisfactionObservational study designGreater reductionAntidiabetic medicationsDiabetes medicationsSecondary outcomesSymptom burdenAssociation of Population Well-Being With Cardiovascular Outcomes
Spatz E, Roy B, Riley C, Witters D, Herrin J. Association of Population Well-Being With Cardiovascular Outcomes. JAMA Network Open 2023, 6: e2321740. PMID: 37405774, PMCID: PMC10323707, DOI: 10.1001/jamanetworkopen.2023.21740.Peer-Reviewed Original ResearchConceptsPopulation health factorsCVD mortalityCoronary heart diseaseCross-sectional studyHeart diseaseCardiovascular diseaseSecondary outcomesHealth factorsCardiovascular outcomesHeart failureCardiovascular healthMortality rateCounty-level ratesLower CVD mortalityTotal CVD mortalityCardiovascular death ratesAcute myocardial infarctionTotal heart diseaseEffect sizePrimary outcomeHighest quintileLowest quintileMyocardial infarctionNational HealthMAIN OUTCOMEClassification of blood pressure during sleep impacts designation of nocturnal nondipping
Mortazavi B, Martinez-Brockman J, Tessier-Sherman B, Burg M, Miller M, Nowroozilarki Z, Adams O, Maharaj R, Nazario C, Nunez M, Nunez-Smith M, Spatz E. Classification of blood pressure during sleep impacts designation of nocturnal nondipping. PLOS Digital Health 2023, 2: e0000267. PMID: 37310958, PMCID: PMC10263317, DOI: 10.1371/journal.pdig.0000267.Peer-Reviewed Original ResearchAmbulatory blood pressure monitorBlood pressure monitorNocturnal nondippingBlood pressurePressure monitorAmbulatory blood pressure monitoringClinic blood pressure measurementsAmbulatory blood pressureFuture cardiovascular riskBlood pressure monitoringSleep periodBlood pressure measurementsCardiovascular riskHypertension StudyTotal sleep lengthCardiovascular diseaseNondippingSleep qualitySleep efficiencyPressure monitoringSleep patternsSecondary analysisSleep onsetSleep lengthFleiss' kappa
2022
CARDIOVASCULAR DISEASE AND TYPE 2 DIABETES: TREATMENT SATISFACTION, QUALITY OF LIFE AND DIABETES RELATED SYMPTOMS WHEN RECEIVING SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR VERSUS OTHER NONINULIN DIABETES MEDICATIONS
Ding Q, Spatz E, Isaacs D, Bena J, Morrison S, Levay M, West L, Combs P, Albert N. CARDIOVASCULAR DISEASE AND TYPE 2 DIABETES: TREATMENT SATISFACTION, QUALITY OF LIFE AND DIABETES RELATED SYMPTOMS WHEN RECEIVING SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR VERSUS OTHER NONINULIN DIABETES MEDICATIONS. Journal Of The American College Of Cardiology 2022, 79: 1547. DOI: 10.1016/s0735-1097(22)02538-4.Peer-Reviewed Original Research
2019
Phenotypes of Hypertensive Ambulatory Blood Pressure Patterns: Design and Rationale of the ECHORN Hypertension Study.
Spatz ES, Martinez-Brockman JL, Tessier-Sherman B, Mortazavi B, Roy B, Schwartz JI, Nazario CM, Maharaj R, Nunez M, Adams OP, Burg M, Nunez-Smith M. Phenotypes of Hypertensive Ambulatory Blood Pressure Patterns: Design and Rationale of the ECHORN Hypertension Study. Ethnicity & Disease 2019, 29: 535-544. PMID: 31641320, PMCID: PMC6802166, DOI: 10.18865/ed.29.4.535.Peer-Reviewed Original ResearchConceptsAmbulatory blood pressure measurementsABPM patternsBP patternAmbulatory blood pressure patternsMore precision-based approachesAmbulatory BP patternsDiagnosis of HTNTreatment of HTNBlood pressure patternWave 2High-risk populationBlood pressure measurementsCommunity-residing adultsPrecision-based approachesAntihypertensive medicationsBlood pressureProspective studyHypertension StudyHypertensive phenotypeCardiovascular diseaseParent studyHTNEcological momentary assessmentSelf-report surveyHigh rateSevere cardiovascular morbidity in women with hypertensive diseases during delivery hospitalization
Ackerman CM, Platner MH, Spatz ES, Illuzzi JL, Xu X, Campbell KH, Smith GN, Paidas MJ, Lipkind HS. Severe cardiovascular morbidity in women with hypertensive diseases during delivery hospitalization. American Journal Of Obstetrics And Gynecology 2019, 220: 582.e1-582.e11. PMID: 30742823, DOI: 10.1016/j.ajog.2019.02.010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCardiomyopathiesCardiovascular DiseasesCerebrovascular DisordersCohort StudiesEclampsiaEducational StatusElectric CountershockEthnicityFemaleHeart ArrestHeart FailureHospitalizationHumansHypertension, Pregnancy-InducedInformation Storage and RetrievalInsurance, HealthLogistic ModelsMiddle AgedMultivariate AnalysisMyocardial InfarctionNew York CityObesity, MaternalPovertyPre-EclampsiaPregnancyRetrospective StudiesSeverity of Illness IndexVentricular FibrillationYoung AdultConceptsSevere cardiovascular morbidityCardiovascular morbidityDelivery hospitalizationsHypertensive disordersSevere featuresNormotensive womenGestational hypertensionCardiovascular diseaseRetrospective cohort studyClinical risk factorsPregnancy-related deathsMultivariable logistic regressionChronic hypertensionDiligent screeningSingleton gestationsCohort studyHypertensive diseaseDiabetes mellitusMaternal deathsRisk factorsInclusion criteriaDiseases-10HospitalizationMorbidityPreeclampsia
2018
Association Between Financial Burden, Quality of Life, and Mental Health Among Those With Atherosclerotic Cardiovascular Disease in the United States
Annapureddy A, Valero-Elizondo J, Khera R, Grandhi GR, Spatz ES, Dreyer RP, Desai NR, Krumholz HM, Nasir K. Association Between Financial Burden, Quality of Life, and Mental Health Among Those With Atherosclerotic Cardiovascular Disease in the United States. Circulation Cardiovascular Quality And Outcomes 2018, 11: e005180. PMID: 30571331, DOI: 10.1161/circoutcomes.118.005180.Peer-Reviewed Original ResearchIs diabetes mellitus equivalent to atherosclerotic cardiovascular disease from a healthcare cost perspective? Insights from the Medical Expenditure Panel Survey
Feldman DI, Valero-Elizondo J, Salami JA, Rana JS, Ogunmoroti O, Okunrintemi V, Osondu CU, Spatz ES, Virani SS, Blankstein R, Blaha MJ, Veledar E, Nasir K. Is diabetes mellitus equivalent to atherosclerotic cardiovascular disease from a healthcare cost perspective? Insights from the Medical Expenditure Panel Survey. Cardiovascular Endocrinology & Metabolism 2018, 7: 64-67. PMID: 31646284, PMCID: PMC6739895, DOI: 10.1097/xce.0000000000000151.Peer-Reviewed Original ResearchAtherosclerotic cardiovascular diseaseDiabetes mellitusMedical Expenditure Panel SurveyCardiovascular diseaseMajor adverse cardiac eventsAggressive therapeutic managementAdverse cardiac eventsLower healthcare expendituresCardiac eventsSecondary preventionTherapeutic managementHealthcare costsEconomic burdenProper lifestyleHealthcare expendituresHousehold ComponentMellitusPanel SurveyDiseasePriority conditionsResource utilizationCliniciansDiagnosisIndividualsPreventionLife's Simple 7 and the risk of atrial fibrillation: The Multi-Ethnic Study of Atherosclerosis
Ogunmoroti O, Michos ED, Aronis KN, Salami JA, Blankstein R, Virani SS, Spatz ES, Allen NB, Rana JS, Blumenthal RS, Veledar E, Szklo M, Blaha MJ, Nasir K. Life's Simple 7 and the risk of atrial fibrillation: The Multi-Ethnic Study of Atherosclerosis. Atherosclerosis 2018, 275: 174-181. PMID: 29920438, DOI: 10.1016/j.atherosclerosis.2018.05.050.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAtrial FibrillationBlood GlucoseBlood PressureBody Mass IndexDiet, HealthyExerciseFemaleHealth StatusHealthy LifestyleHumansIncidenceLipidsMaleMiddle AgedPrimary PreventionProspective StudiesProtective FactorsRisk AssessmentRisk FactorsRisk Reduction BehaviorSmokingTime FactorsUnited StatesConceptsAtrial fibrillationMulti-Ethnic StudyRace/ethnicityHazard ratioOverall cohortSimple 7Cardiovascular healthCardiovascular diseaseLower riskAmerican Heart Association's LifeBurden of AFFirst AF episodeSimple 7 (LS7) metricsIdeal cardiovascular healthProportional hazard ratiosProspective cohort studyLife's Simple 7Hospital discharge recordsICD-9 codesLS7 metricsCohort studyIncidence rateAF episodesInadequate scoresAssociation's LifeFavorable Modifiable Cardiovascular Risk Profile Is Associated With Lower Healthcare Costs Among Cancer Patients: The 2012–2013 Medical Expenditure Panel Survey
Singh J, Valero‐Elizondo J, Salami JA, Warraich HJ, Ogunmoroti O, Spatz ES, Desai N, Rana JS, Virani SS, Blankstein R, Blaha MJ, Nasir K. Favorable Modifiable Cardiovascular Risk Profile Is Associated With Lower Healthcare Costs Among Cancer Patients: The 2012–2013 Medical Expenditure Panel Survey. Journal Of The American Heart Association 2018, 7: e007874. PMID: 29686026, PMCID: PMC6015292, DOI: 10.1161/jaha.117.007874.Peer-Reviewed Original ResearchConceptsAtherosclerotic cardiovascular diseaseAbsence of ASCVDCancer patientsMedical Expenditure PanelCRF profileRepresentative US adult populationHealthcare expendituresCardiovascular risk profileRisk factor profileBurden of cancerMean annual costAnnual healthcare expendituresMedical Expenditure Panel SurveyUS adult populationLower medical expendituresYears of ageLower healthcare costsCardiovascular managementCardiovascular diseaseHigh prevalenceRepresentative adult sampleUS adultsTwo-part econometric modelHealthcare costsEconomic burdenTraditional Chinese Medicine for Acute Myocardial Infarction in Western Medicine Hospitals in China
Spatz ES, Wang Y, Beckman AL, Wu X, Lu Y, Du X, Li J, Xu X, Davidson PM, Masoudi FA, Spertus JA, Krumholz HM, Jiang L. Traditional Chinese Medicine for Acute Myocardial Infarction in Western Medicine Hospitals in China. Circulation Cardiovascular Quality And Outcomes 2018, 11: e004190. PMID: 29848478, PMCID: PMC5882246, DOI: 10.1161/circoutcomes.117.004190.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionTraditional Chinese medicineTCM useWestern Medicine HospitalMyocardial infarctionHospital bleedingMedicine HospitalChinese medicineCardiovascular risk factorsHospital-level factorsHours of hospitalizationMultivariable hierarchical modelsQuality of careLack of evidenceChart reviewChina PatientRetrospective studySecondary hospitalsEarly managementRisk factorsIntravenous useCardiovascular diseasePatientsSignificant associationHospital
2017
Persistent socioeconomic disparities in cardiovascular risk factors and health in the United States: Medical Expenditure Panel Survey 2002–2013
Valero-Elizondo J, Hong JC, Spatz ES, Salami JA, Desai NR, Rana JS, Khera R, Virani SS, Blankstein R, Blaha MJ, Nasir K. Persistent socioeconomic disparities in cardiovascular risk factors and health in the United States: Medical Expenditure Panel Survey 2002–2013. Atherosclerosis 2017, 269: 301-305. PMID: 29254694, DOI: 10.1016/j.atherosclerosis.2017.12.014.Peer-Reviewed Original ResearchConceptsCardiovascular diseaseSocioeconomic statusWorse cardiovascular risk factor profileCardiovascular risk factor profileHighest prevalence increasePrevalence of CRFCardiovascular risk factorsRisk factor profileHealthy lifestyle behaviorsMedical Expenditure Panel Survey 2002Medical Expenditure Panel SurveyHealth disparity gapRelative percent increasePhysical inactivityLifestyle behaviorsRisk factorsPrevalence increasesHigh burdenHigh prevalenceLow-income groupsProportion of individualsUS adultsFactor profileDisparity gapSocioeconomic disparitiesA systematic review of the associations between HIV/HCV coinfection and biomarkers of cardiovascular disease
Osibogun O, Ogunmoroti O, Michos ED, Spatz ES, Olubajo B, Nasir K, Maziak W. A systematic review of the associations between HIV/HCV coinfection and biomarkers of cardiovascular disease. Reviews In Medical Virology 2017, 28 PMID: 29135056, DOI: 10.1002/rmv.1953.Peer-Reviewed Original ResearchConceptsHIV/HCV coinfectionCarotid intima-media thicknessHuman immunodeficiency virusC-reactive proteinHCV coinfectionHealthy controlsCoinfected individualsCVD biomarkersEndothelial markersHepatitis C virus coinfectionBiomarkers of CVDC virus coinfectionCardiovascular disease riskIntima-media thicknessSignificant lower levelsWeb of ScienceHCV monoinfectionCVD riskVirus coinfectionImmunodeficiency virusProspective studyIL-6Clinical trialsCardiovascular diseaseCarotid plaquesPrimary Prevention with Statins: Strategies to Support Shared Decision-Making
Spatz E, Montori V. Primary Prevention with Statins: Strategies to Support Shared Decision-Making. Current Cardiovascular Risk Reports 2017, 11: 29. DOI: 10.1007/s12170-017-0556-3.Peer-Reviewed Original ResearchStatin therapyPrimary preventionAmerican Heart Association guidelinesPreventive statin therapyHeart Association guidelinesPrimary care cliniciansPatient-centered modelCare cliniciansGuideline recommendationsCholesterol managementLifelong medicationPatient preferencesAssociation guidelinesCardiovascular diseaseClinicians' knowledgeAmerican CollegeHealthcare teamHealth systemPatientsScientific evidenceReviewThis paperTherapyCliniciansPreventionMedicationsLife's Simple 7 and Incident Heart Failure: The Multi‐Ethnic Study of Atherosclerosis
Ogunmoroti O, Oni E, Michos ED, Spatz ES, Allen NB, Rana JS, Virani SS, Blankstein R, Aronis KN, Blumenthal RS, Veledar E, Szklo M, Blaha MJ, Nasir K. Life's Simple 7 and Incident Heart Failure: The Multi‐Ethnic Study of Atherosclerosis. Journal Of The American Heart Association 2017, 6: e005180. PMID: 28655734, PMCID: PMC5669160, DOI: 10.1161/jaha.116.005180.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiomarkersBlood GlucoseBlood PressureBody Mass IndexCholesterolDiet, HealthyExerciseFemaleHealthy LifestyleHeart FailureHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedPrognosisProtective FactorsRisk FactorsRisk Reduction BehaviorSmoking CessationTime FactorsUnited StatesConceptsSimple 7 (LS7) metricsIncident heart failureHeart failureMulti-Ethnic StudyLS7 metricsHazard ratioSimple 7Cardiovascular healthBurden of HFLife's Simple 7 (LS7) metricsIncidence of HFIdeal cardiovascular healthProportional hazard ratiosLife's Simple 7American Heart AssociationRace/ethnicityLS7 scoreHeart AssociationIncidence rateCardiovascular diseaseMultiethnic cohortLower riskInadequate scoresIdeal metricsAtherosclerosisHIV/HCV coinfection and the risk of cardiovascular disease: A meta‐analysis
Osibogun O, Ogunmoroti O, Michos E, Spatz E, Olubajo B, Nasir K, Madhivanan P, Maziak W. HIV/HCV coinfection and the risk of cardiovascular disease: A meta‐analysis. Journal Of Viral Hepatitis 2017, 24: 998-1004. PMID: 28502092, DOI: 10.1111/jvh.12725.Peer-Reviewed Original ResearchConceptsHIV/HCV coinfectionHCV coinfectionHazard ratioCardiovascular diseaseHIV monoinfectionCVD riskHepatitis C virus coinfectionTraditional CVD risk factorsC virus coinfectionImproved antiretroviral therapyAdjusted hazard ratioCVD risk factorsRisk reduction therapyCongestive heart failureCoronary artery diseaseHuman immunodeficiency virusIncreased inflammatory responseRandom-effects modelWeb of ScienceHCV individualsAntiretroviral therapyCohort studyCVD outcomesArtery diseaseHeart failureAssociation Between Modifiable Risk Factors and Pharmaceutical Expenditures Among Adults With Atherosclerotic Cardiovascular Disease in the United States: 2012–2013 Medical Expenditures Panel Survey
Salami JA, Valero‐Elizondo J, Ogunmoroti O, Spatz ES, Rana JS, Virani SS, Blankstein R, Younus A, Arrieta A, Blaha MJ, Veledar E, Nasir K. Association Between Modifiable Risk Factors and Pharmaceutical Expenditures Among Adults With Atherosclerotic Cardiovascular Disease in the United States: 2012–2013 Medical Expenditures Panel Survey. Journal Of The American Heart Association 2017, 6: e004996. PMID: 28600400, PMCID: PMC5669151, DOI: 10.1161/jaha.116.004996.Peer-Reviewed Original ResearchConceptsModifiable risk factorsAtherosclerotic cardiovascular diseaseCardiovascular diseaseRisk factorsPharmaceutical expenditureMedication-related expendituresSignificant marginal increaseSurvey's complex designInadequate physical activityMedical Expenditure Panel SurveyMedical Expenditure PanelHigher healthcare spendingASCVD patientsDiabetes mellitusMost deathsPhysical activityTotal pharmaceutical expenditureAdjusted relationshipMedicationsDiseaseHealthcare spendingMellitusPatientsAssociationAdultsHeterogeneity in Early Responses in ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial)
Dhruva SS, Huang C, Spatz ES, Coppi AC, Warner F, Li SX, Lin H, Xu X, Furberg CD, Davis BR, Pressel SL, Coifman RR, Krumholz HM. Heterogeneity in Early Responses in ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial). Hypertension 2017, 70: 94-102. PMID: 28559399, DOI: 10.1161/hypertensionaha.117.09221.Peer-Reviewed Original ResearchConceptsAntihypertensive therapySystolic blood pressure responseAdverse cardiovascular eventsFavorable initial responseBlood pressure responseHigher hazard ratioCardiovascular eventsCardiovascular outcomesHazard ratioMultivariable adjustmentHeart failureAverage SBPRandomized trialsOdds ratioCardiovascular diseaseSBPStudy participantsRespondersMonthsPressure responseImmediate respondersALLHATEarly responseInitial responseSuperior discriminationPatient–Provider Communication and Health Outcomes Among Individuals With Atherosclerotic Cardiovascular Disease in the United States
Okunrintemi V, Spatz ES, Di Capua P, Salami JA, Valero-Elizondo J, Warraich H, Virani SS, Blaha MJ, Blankstein R, Butt AA, Borden WB, Dharmarajan K, Ting H, Krumholz HM, Nasir K. Patient–Provider Communication and Health Outcomes Among Individuals With Atherosclerotic Cardiovascular Disease in the United States. Circulation Cardiovascular Quality And Outcomes 2017, 10: e003635. PMID: 28373270, DOI: 10.1161/circoutcomes.117.003635.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAspirinAtherosclerosisCommunicationEmergency Service, HospitalFemaleHealth Care CostsHealth Care SurveysHealth ExpendituresHealth StatusHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLength of StayMaleMental HealthMiddle AgedOdds RatioPatient Reported Outcome MeasuresPatient-Centered CarePhysician-Patient RelationsPlatelet Aggregation InhibitorsQuality Indicators, Health CareRisk FactorsUnited StatesYoung AdultConceptsAtherosclerotic cardiovascular diseasePatient-provider communicationHealthcare resource utilizationPatient-reported outcomesCardiovascular diseaseHealth Plans SurveyMedical Expenditure Panel Survey cohortHigher annual healthcare expendituresRepresentative US adult populationHealthcare expendituresAtherosclerotic cardiovascular disease (ASCVD) patientsConsumer AssessmentEmergency room visitsEvidence-based therapiesAnnual healthcare expendituresCardiovascular disease patientsUS adult populationPlans SurveyMental health statusPatient-centered careOutcomes of interestASA useHospital stayRoom visitsPoor outcome