2020
Sexual Dimorphisms in Adult Human Brown Adipose Tissue
Fletcher L, Kim K, Leitner B, Cassimatis T, O’Mara A, Johnson J, Halprin M, McGehee S, Brychta R, Cypess A, Chen K. Sexual Dimorphisms in Adult Human Brown Adipose Tissue. Obesity 2020, 28: 241-246. PMID: 31970907, PMCID: PMC6986330, DOI: 10.1002/oby.22698.Peer-Reviewed Original ResearchMeSH KeywordsAdipose Tissue, BrownAdiposityAdolescentAdultFemaleFluorodeoxyglucose F18HumansMaleObesitySex CharacteristicsYoung AdultConceptsBrown adipose tissueF-fluorodeoxyglucose uptakeBAT volumeAdipose tissueAdult human brown adipose tissueCold-activated brown adipose tissueInterscapular brown adipose tissueGlucose uptakeTotal BAT volumeHuman brown adipose tissueBAT glucose uptakeBody weight regulationPositron emission tomographyOvert shiveringDistribution of BATLean womenAnatomical distributionBAT depotsWeight regulationHours of exposureHuman newbornsComputerized tomographyEmission tomographyYoung womenWomen
2019
Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT.
Kim K, Huang S, Fletcher LA, O'Mara AE, Tal I, Brychta RJ, Cypess AM, Chen KY, Leitner BP. Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT. Journal Of Visualized Experiments 2019 PMID: 30985755, DOI: 10.3791/58469.Peer-Reviewed Original ResearchMeSH KeywordsAdipose Tissue, BrownAlgorithmsFluorodeoxyglucose F18HumansImage Processing, Computer-AssistedPositron Emission Tomography Computed TomographyConceptsHuman brown adipose tissueBrown adipose tissueAdipose tissueF-FDG PET/CT scanF-fluorodeoxyglucose positron emission tomographyPET/CT scansThermogenic capacityBAT thermogenic capacityActive adipose tissuePET/CTPositron emission tomographyBAT volumeTomography scanNovel therapiesAnatomical distributionCT scanMetabolic disordersPharmacological activationEmission tomographyPotential targetWhole bodyBody temperatureTissueScansRegional quantification
2018
Kinetics of human brown adipose tissue activation and deactivation
Leitner BP, Weiner LS, Desir M, Kahn PA, Selen DJ, Tsang C, Kolodny GM, Cypess AM. Kinetics of human brown adipose tissue activation and deactivation. International Journal Of Obesity 2018, 43: 633-637. PMID: 29795459, PMCID: PMC6252171, DOI: 10.1038/s41366-018-0104-3.Peer-Reviewed Original ResearchConceptsBrown adipose tissueBAT volumeMetabolic diseasesBrown adipose tissue activationActive brown adipose tissueCold exposureHuman BAT thermogenesisBAT glucose uptakePrevention of obesityPET/CT imagingBAT activationBAT thermogenesisClinical trialsAdipose tissueHealthy adultsCold stimulationTissue activationCT imagingGlucose uptakeDuration of stimuliPotential targetCessation of coolingObesityDiseaseActivation