Seth Herzon, PhD
Milton Harris ’29 Ph.D. Professor of ChemistryCards
About
Research
Overview
Anti-Markovnikov Hydration and Reductive Hydration of Alkynes; Diazofluorenes; Guanidinium Alkaloids’ Husbanan and Acutumine Akaloids; Huperzine A; Pleuromutilins; (Pre)Colibactins; Reduction and Hydrofunctionalization of Alkenes by Hydrogen Atom Transfer
Publications
2025
Genome-scale CRISPR/Cas9 screening reveals the role of PSMD4 in colibactin-mediated cell cycle arrest
Dougherty M, Hoffmann R, Hernandez M, Airan Y, Gharaibeh R, Herzon S, Yang Y, Jobin C. Genome-scale CRISPR/Cas9 screening reveals the role of PSMD4 in colibactin-mediated cell cycle arrest. MSphere 2025, 10: e00692-24. PMID: 39918307, PMCID: PMC11934320, DOI: 10.1128/msphere.00692-24.Peer-Reviewed Original ResearchConceptsCell cycle arrestCycle arrestCRISPR/Cas9 screenDNA damageGenome-scale CRISPR/Cas9 screensGenome-wide CRISPR/Cas9 knockout screenRegulating cell cycle arrestRNA polymerase IIIRNA processing factorsCRISPR/Cas9 knockout screenG2-M cell cycle arrestGenotoxic secondary metabolitesHT-29 cellsHost response pathwaysPolymerase IIIKnockout screenHost pathwaysCell fateProteasome subunitsColony sizeColibactin-producing bacteriaColibactinRNA sequencingColony formation rateGene expressionA Stereoselective Oxidative Dimerization En Route to (−)-Lomaiviticin A
DiBello M, Xu Z, Palazzo A, Herzon S. A Stereoselective Oxidative Dimerization En Route to (−)-Lomaiviticin A. Organic Letters 2025, 27: 937-941. PMID: 39846772, PMCID: PMC11883818, DOI: 10.1021/acs.orglett.4c04098.Peer-Reviewed Original Research
2024
Colibactin Exerts Androgen-dependent and -independent Effects on Prostate Cancer
Agrawal R, Al-Hiyari S, Hugh-White R, Hromas R, Patel Y, Williamson E, Mootor M, Gonzalez A, Fu J, Haas R, Jordan M, Wickes B, Mohammed G, Tian M, Doris M, Jobin C, Wernke K, Pan Y, Yamaguchi T, Herzon S, Boutros P, Liss M. Colibactin Exerts Androgen-dependent and -independent Effects on Prostate Cancer. European Urology Oncology 2024 PMID: 39547899, DOI: 10.1016/j.euo.2024.10.015.Peer-Reviewed Original ResearchProstate cancerInduction of genomic instabilityPC diagnosisPC etiologyColibactin-producing Escherichia coliEtiology of prostate cancerProstate cancer cellsProstate cancer diagnosisSomatic point mutationsCombination in vitroGenomic instabilityAndrogen-dependentColon cancerPatient populationProstateClinical cohortInitial cancerSomatic mutationsCancer cellsDihydrotestosteroneGenetic dysfunctionSingle cell lineCancerCell linesDiagnosisIntramolecular oxyalkylation of unactivated alkenes
Xu Z, Airan Y, Tomanik M, Yang A, Bhak N, Herzon S. Intramolecular oxyalkylation of unactivated alkenes. Tetrahedron 2024, 161: 134070. PMID: 38911481, PMCID: PMC11192504, DOI: 10.1016/j.tet.2024.134070.Peer-Reviewed Original ResearchMechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers
Huseman E, Lo A, Fedorova O, Elia J, Gueble S, Lin K, Sundaram R, Oh J, Liu J, Menges F, Rees M, Ronan M, Roth J, Batista V, Crawford J, Pyle A, Bindra R, Herzon S. Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers. Journal Of The American Chemical Society 2024, 146: 18241-18252. PMID: 38815248, PMCID: PMC11409917, DOI: 10.1021/jacs.3c06483.Peer-Reviewed Original ResearchDNA repair capacityDifferential DNA repair capacityDNA interstrand cross-linksRepair capacityInterstrand cross-linksDisplacement of fluorideDNA repairCross-linkingAberrant DNA repairLesionsHealthy tissueBrain cancerRing openingHealthy cellsMGMTSelective chemotherapyGenotoxic agentsTumorChemical DNA modificationsCancerMultistep processRepair1073 GENOME-SCALE CRISPR/CAS9 SCREENING REVEALS THE ROLE OF PSMD4 IN COLIBACTIN-MEDIATED CELL CYCLE ARREST
Dougherty M, Hoffmann R, Airan Y, Gharaibeh R, Herzon S, Yang Y, Jobin C. 1073 GENOME-SCALE CRISPR/CAS9 SCREENING REVEALS THE ROLE OF PSMD4 IN COLIBACTIN-MEDIATED CELL CYCLE ARREST. Gastroenterology 2024, 166: s-253. DOI: 10.1016/s0016-5085(24)01066-7.Peer-Reviewed Original ResearchAn oxidative photocyclization approach to the synthesis of Securiflustra securifrons alkaloids
Alexander B, Bartfield N, Gupta V, Mercado B, Del Campo M, Herzon S. An oxidative photocyclization approach to the synthesis of Securiflustra securifrons alkaloids. Science 2024, 383: 849-854. PMID: 38386756, DOI: 10.1126/science.adl6163.Peer-Reviewed Original ResearchConceptsFunctional group manipulationsMicrocrystal electron diffractionOxidative photocyclizationAdvanced intermediateGroup manipulationsHeterocyclic residuesOxide ringSynthetic accessibilityElectron diffractionTarget identification studiesReactive alkenesModular assemblyCytotoxic alkaloidFlexible routeAlkenesIdentification studiesAlkaloidsPhotocycleDiffractionStructural complexityStructureRingIntermediateChemistrySynthesis
News & Links
News
- February 28, 2025Source: Yale Ventures
YSM Faculty Win Awards From the Blavatnik Fund for Innovation at Yale
- February 11, 2025
Yale Advances in Treating Primary Brain Cancers Benefit Patients and Science
- January 09, 2025
Seth Herzon, PhD and Smita Krishnaswamy, PhD, Recipients of Yale Cancer Center Class of ‘61 Cancer Research Awards
- October 23, 2024Source: Yale Ventures
Yale Spinout Modifi Biosciences Acquired by Merck
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