The research on catechol-O-methyltransferase (COMT) proposed in Dr. Ding’s FIRST award and DOD breast cancer grant provides links between basic neuroscience and drug research, drug development and oncology. Our recent data that showed relatively higher COMT activities in tumor tissue, as compared to normal tissue from breast cancer patients, support the promise of future PET investigation of this disease.
We have successfully translated several radiotracers from pre-clinical studies in animals to clinical investigations in humans; for example, we developed C-11 labeled methylphenidate (Ritalin, a drug for the treatment of ADHD) and its active enantiomer, [11C]d-threo-methylphenidate, as ligands (t1/2 of 11C: 20 min) for the dopamine transporter. This development work allows the first studies of this drug in the human brain leading to a better understanding of the reinforcing abilities of psychostimulant drugs, and also has initiated investigations in drug abuse, alcoholism, obesity, Parkinson’s disease and normal aging.
Our recent development of potent and selective radioligands to carry out PET imaging studies of nicotinic acetylcholine receptor (nAChR) and norepinephrine transporter (NET) systems in humans should provide an opportunity to better understand their roles in various CNS disorders, such as substance abuse, depression, ADHD, Parkinson’s disease and Alzheimer’s disease.