PET Center Publications

2023

Differences in Quantification of the Metabotropic Glutamate Receptor 5 Across Bipolar Disorder and Major Depressive Disorder.Holmes SE, Asch RH, Davis MT, DellaGioia N, Pashankar N, Gallezot JD, Nabulsi N, Matuskey D, Sanacora G, Carson RE, Blumberg HP, Esterlis I. Biol Psychiatry. 2023 Jun 15; 2022 Nov 8. PMID: 36764853.
Preclinical evaluation of a brain penetrant PARP PET imaging probe in rat glioblastoma and nonhuman primates.Chen B, Ojha DP, Toyonaga T, Tong J, Pracitto R, Thomas MA, Liu M, Kapinos M, Zhang L, Zheng MQ, Holden D, Fowles K, Ropchan J, Nabulsi N, De Feyter H, Carson RE, Huang Y, Cai Z. Eur J Nucl Med Mol Imaging. 2023 Jun; 2023 Feb 28. PMID: 36849748.
In vivo synaptic density loss correlates with impaired functional and related structural connectivity in Alzheimer's disease.Zhang J, Wang J, Xu X, You Z, Huang Q, Huang Y, Guo Q, Guan Y, Zhao J, Liu J, Xu W, Deng Y, Xie F, Li B. J Cereb Blood Flow Metab. 2023 Jun; 2023 Jan 30. PMID: 36718002.
Clustering of KOR PET images separates people with AUD into distinct responses to naltrexone.Hoye J, Key J, de Laat B, Cosgrove KP, Krishnan-Sarin S, Papademetris X, Morris ED. Brain Imaging Behav. 2023 Jun; 2023 Jan 25. PMID: 36695971.
Reductions in synaptic marker SV2A in early-course Schizophrenia.Yoon JH, Zhang Z, Mormino E, Davidzon G, Minzenberg MJ, Ballon J, Kalinowski A, Hardy K, Naganawa M, Carson RE, Khalighi M, Park JH, Levinson DF, Chin FT. J Psychiatr Res. 2023 May; 2023 Feb 23. PMID: 36934603.
Synaptic Loss in Spinocerebellar Ataxia Type 3 Revealed by SV2A Positron Emission Tomography.Chen Z, Liao G, Wan N, He Z, Chen D, Tang Z, Long Z, Zou G, Peng L, Wan L, Wang C, Peng H, Shi Y, Tang Y, Li J, Li Y, Long T, Hou X, He L, Qiu R, Chen D, Wang J, Guo J, Shen L, Huang Y, Ashizawa T, Klockgether T, Tang B, Zhou M, Hu S, Jiang H. Mov Disord. 2023 Apr 6; 2023 Apr 6. PMID: 37023261.
Lower Dopamine D2/3 Receptor Availability is Associated With Worse Verbal Learning and Memory in People Who Smoke Cigarettes.Zakiniaeiz Y, Gueorguieva R, Peltier MR, Roberts W, Verplaetse TL, Burke C, Morris ED, McKee SA, Cosgrove KP. Nicotine Tob Res. 2023 Apr 6. PMID: 36107715.
(18)F-Labeled o‑aminopyridyl alkynyl radioligands targeting colony-stimulating factor 1 receptor for neuroinflammation imaging.An X, Wang J, Tong L, Zhang X, Fu H, Zhang J, Xie H, Huang Y, Jia H. Bioorg Med Chem. 2023 Apr 1; 2023 Mar 8. PMID: 36933438.
ImmunoPET Imaging Identifies the Optimal Timepoint for Combination Therapy in Xenograft Models of Triple-Negative Breast Cancer.Li Z, Belitzky E, Blaha O, Cavaliere A, Katz SR, Aboian M, Melegari L, Rajabimoghadam K, Kurpiewski S, Zhu X, Marquez-Nostra B. Cancers (Basel). 2023 Mar 3; 2023 Mar 3. PMID: 36900378.
Cholinergic system adaptations are associated with cognitive function in people recently abstinent from smoking: a (-)-[(18)F]flubatine PET study.Calakos KC, Hillmer AT, Anderson JM, LeVasseur B, Baldassarri SR, Angarita GA, Matuskey D, Kapinos M, Zheng MQ, Huang Y, Cosgrove KP. Neuropsychopharmacology. 2023 Mar; 2023 Jan 21. PMID: 36681758.
Positron Emission Tomography of Neuroimmune Responses in Humans: Insights and Intricacies.Raval NR, Wetherill RR, Wiers CE, Dubroff JG, Hillmer AT. Semin Nucl Med. 2023 Mar; 2022 Oct 19. PMID: 36270830.
Linking resting-state network fluctuations with systems of coherent synaptic density: A multimodal fMRI and (11)C-UCB-J PET study.Fang XT, Volpi T, Holmes SE, Esterlis I, Carson RE, Worhunsky PD. Front Hum Neurosci. 2023; 2023 Feb 23. PMID: 36908710.
Nicotine Use and Metabotropic Glutamate Receptor 5 in Individuals With Major Depressive and Posttraumatic Stress Disorders.Baldassarri SR, Asch RH, Hillmer AT, Pietrzak RH, DellaGioia N, Esterlis I, Davis MT. Chronic Stress (Thousand Oaks). 2023 Jan-Dec; 2023 Feb 9. PMID: 36843572.
Decreased synaptic vesicle glycoprotein 2A binding in a rodent model of familial Alzheimer's disease detected by [(18)F]SDM-16.Zheng C, Toyonaga T, Chen B, Nicholson L, Mennie W, Liu M, Spurrier J, Deluca K, Strittmatter SM, Carson RE, Huang Y, Cai Z. Front Neurol. 2023; 2023 Feb 8. PMID: 36846134.
Investigating CNS distribution of PF-05212377, a P-glycoprotein substrate, by translation of 5-HT(6) receptor occupancy from non-human primates to humans.Sawant-Basak A, Chen L, Lockwood P, Boyden T, Doran AC, Mancuso J, Zasadny K, McCarthy T, Morris ED, Carson RE, Esterlis I, Huang Y, Nabulsi N, Planeta B, Fullerton T. Biopharm Drug Dispos. 2023 Feb; 2023 Mar 13. PMID: 36825693.
Serotonin transporter availability in physically aggressive personality disordered patients: associations with trait and state aggression, and response to fluoxetine.Rosell DR, Slifstein M, Thompson J, Xu X, Perez-Rodriguez MM, McClure MM, Hazlett EA, New AS, Nabulsi N, Huang Y, Carson RE, Siever LS, Abi-Dargham A, Koenigsberg HW. Psychopharmacology (Berl). 2023 Feb; 2023 Jan 14. PMID: 36640190.
Neurotransmitter transporter occupancy following administration of centanafadine sustained-release tablets: A phase 1 study in healthy male adults.Matuskey D, Gallezot JD, Nabulsi N, Henry S, Torres K, Dias M, Angarita GA, Huang Y, Shoaf SE, Carson RE, Mehrotra S. J Psychopharmacol. 2023 Feb; 2022 Dec 14. PMID: 36515395.
In Vivo Imaging and Kinetic Modeling of Novel Glycogen Synthase Kinase-3 Radiotracers [(11)C]OCM-44 and [(18)F]OCM-50 in Non-Human Primates.Smart K, Zheng MQ, Holden D, Felchner Z, Zhang L, Han Y, Ropchan J, Carson RE, Vasdev N, Huang Y. Pharmaceuticals (Basel). 2023 Jan 28; 2023 Jan 28. PMID: 37259346.
Joint motion estimation and penalized image reconstruction algorithm with anatomical priors for gated TOF-PET/CT.Tsai YJ, Liu C. Phys Med Biol. 2023 Jan 13; 2023 Jan 13. PMID: 36549009.
The metabotropic glutamate receptor 5 as a biomarker for psychiatric disorders.Asch RH, Hillmer AT, Baldassarri SR, Esterlis I. Int Rev Neurobiol. 2023; 2022 Nov 18. PMID: 36868631.
Noninvasive Quantitative PET Imaging in Humans of the Pancreatic Beta-Cell Mass Biomarkers VMAT2 and Dopamine D2/D3 Receptors In Vivo.Bini J, Carson RE, Cline GW. Methods Mol Biol. 2023. PMID: 36507985.
PET imaging of kappa opioid receptors and receptor expression quantified in neuron-derived extracellular vesicles in socially housed female and male cynomolgus macaques.Johnson BN, Kumar A, Su Y, Singh S, Sai KKS, Nader SH, Li S, Reboussin BA, Huang Y, Deep G, Nader MA. Neuropsychopharmacology. 2023 Jan; 2022 Sep 13. PMID: 36100655.
D3 Receptors and PET Imaging.Koohsari S, Yang Y, Matuskey D. Curr Top Behav Neurosci. 2023. PMID: 35711027.

2022

An objective evaluation method for head motion estimation in PET-Motion corrected centroid-of-distribution.Sun C, Revilla EM, Zhang J, Fontaine K, Toyonaga T, Gallezot JD, Mulnix T, Onofrey JA, Carson RE, Lu Y. Neuroimage. 2022 Dec 1; 2022 Oct 17. PMID: 36261057.
Age, gender and body-mass-index relationships with in vivo CB(1) receptor availability in healthy humans measured with [(11)C]OMAR PET.Radhakrishnan R, Worhunsky PD, Zheng MQ, Najafzadeh S, Gallezot JD, Planeta B, Henry S, Nabulsi N, Ranganathan M, Skosnik PD, Pittman B, Cyril D'Souza D, Carson RE, Huang Y, Potenza MN, Matuskey D. Neuroimage. 2022 Dec 1; 2022 Oct 13. PMID: 36243269.
Evaluation of (rac)-, (R)-, and (S)-(18)F-OF-NB1 for Imaging GluN2B Subunit-Containing N-Methyl-d-Aspartate Receptors in Nonhuman Primates.Ahmed H, Zheng MQ, Smart K, Fang H, Zhang L, Emery PR, Gao H, Ropchan J, Haider A, Tamagnan G, Carson RE, Ametamey SM, Huang Y. J Nucl Med. 2022 Dec; 2022 Jun 16. PMID: 35710735.
Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [(11) C]UCB-J.Mecca AP, O'Dell RS, Sharp ES, Banks ER, Bartlett HH, Zhao W, Lipior S, Diepenbrock NG, Chen MK, Naganawa M, Toyonaga T, Nabulsi NB, Vander Wyk BC, Arnsten AFT, Huang Y, Carson RE, van Dyck CH. Alzheimers Dement. 2022 Dec; 2022 Feb 17. PMID: 35174954.
Real-world assessment of the clinical utility of whole body 18F-FDG PET/CT in the diagnosis of infection.Medvedeva N, Radcliffe C, Malinis M, Chen MK, Azar MM. PLoS One. 2022; 2022 Nov 14. PMID: 36374789.
Poly (ADP-ribose) polymerases as PET imaging targets for central nervous system diseases.Tong J, Chen B, Tan PW, Kurpiewski S, Cai Z. Front Med (Lausanne). 2022; 2022 Nov 10. PMID: 36438061.
Drug characteristics derived from kinetic modeling: combined (11)C-UCB-J human PET imaging with levetiracetam and brivaracetam occupancy of SV2A.Naganawa M, Gallezot JD, Finnema SJ, Maguire RP, Mercier J, Nabulsi NB, Kervyn S, Henry S, Nicolas JM, Huang Y, Chen MK, Hannestad J, Klitgaard H, Stockis A, Carson RE. EJNMMI Res. 2022 Nov 8; 2022 Nov 8. PMID: 36346513.
Mapping neurotransmitter systems to the structural and functional organization of the human neocortex.Hansen JY, Shafiei G, Markello RD, Smart K, Cox SML, Nørgaard M, Beliveau V, Wu Y, Gallezot JD, Aumont É, Servaes S, Scala SG, DuBois JM, Wainstein G, Bezgin G, Funck T, Schmitz TW, Spreng RN, Galovic M, Koepp MJ, Duncan JS, Coles JP, Fryer TD, Aigbirhio FI, McGinnity CJ, Hammers A, Soucy JP, Baillet S, Guimond S, Hietala J, Bedard MA, Leyton M, Kobayashi E, Rosa-Neto P, Ganz M, Knudsen GM, Palomero-Gallagher N, Shine JM, Carson RE, Tuominen L, Dagher A, Misic B. Nat Neurosci. 2022 Nov; 2022 Oct 27. PMID: 36303070.
Systemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers.Zakiniaeiz Y, Hoye J, Ryan Petrulli J, LeVasseur B, Stanley G, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Chen MK, Matuskey D, Barron DS, Kelmendi B, Fulbright RK, Hampson M, Cosgrove KP, Morris ED. Brain Behav Immun. 2022 Nov; 2022 Sep 1. PMID: 36058419.
Nicotine Patch Alters Patterns of Cigarette Smoking-Induced Dopamine Release: Patterns Relate to Biomarkers Associated With Treatment Response.Zakiniaeiz Y, Liu H, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Matuskey D, Chen MK, Cosgrove KP, Morris ED. Nicotine Tob Res. 2022 Oct 17. PMID: 35100429.
Editorial: Translational advances in Alzheimer's, Parkinson's, and other dementia: Molecular mechanisms, biomarkers, diagnosis, and therapies, volume II.Jiang J, Shi K, Huang YH, Hsu CY, Hettie KS, Kung WM. Front Aging Neurosci. 2022; 2022 Oct 10. PMID: 36299613.
Detection of changes in synaptic density in amyotrophic lateral sclerosis patients using (18) F-SynVesT-1 positron emission tomography.Tang Y, Liu P, Li W, Liu Z, Zhou M, Li J, Yuan Y, Fang L, Wang M, Shen L, Huang Y, Tang B, Wang J, Hu S. Eur J Neurol. 2022 Oct; 2022 Jul 6. PMID: 35708508.
PET Image Denoising using a Deep-Learning Method for Extremely Obese Patients.Liu H, Yousefi H, Mirian N, Lin M, Menard D, Gregory M, Aboian M, Boustani A, Chen MK, Saperstein L, Pucar D, Kulon M, Liu C. IEEE Trans Radiat Plasma Med Sci. 2022 Sep; 2021 Dec 2. PMID: 37284026.
Perspectives on nuclear chemistry, radiochemistry, PET/SPECT imaging and radiotherapy.Bongarzone S, Cai Z, Caillé F, Deri M, Ekoume FP, Shegani A, Radchenko V. Nucl Med Biol. 2022 Sep-Oct; 2022 Aug 3. PMID: 36028382.
Virtual high-count PET image generation using a deep learning method.Liu J, Ren S, Wang R, Mirian N, Tsai YJ, Kulon M, Pucar D, Chen MK, Liu C. Med Phys. 2022 Sep; 2022 Aug 13. PMID: 35880541.
Imaging the fetal nonhuman primate brain with SV2A positron emission tomography (PET).Rossano S, Toyonaga T, Berg E, Lorence I, Fowles K, Nabulsi N, Ropchan J, Li S, Ye Y, Felchner Z, Kukis D, Huang Y, Benveniste H, Tarantal AF, Groman S, Carson RE. Eur J Nucl Med Mol Imaging. 2022 Sep; 2022 May 28. PMID: 35633376.
Nuclear Medicine and Artificial Intelligence: Best Practices for Evaluation (the RELAINCE Guidelines).Jha AK, Bradshaw TJ, Buvat I, Hatt M, Kc P, Liu C, Obuchowski NF, Saboury B, Slomka PJ, Sunderland JJ, Wahl RL, Yu Z, Zuehlsdorff S, Rahmim A, Boellaard R. J Nucl Med. 2022 Sep; 2022 May 26. PMID: 35618476.
Unsupervised inter-frame motion correction for whole-body dynamic PET using convolutional long short-term memory in a convolutional neural network.Guo X, Zhou B, Pigg D, Spottiswoode B, Casey ME, Liu C, Dvornek NC. Med Image Anal. 2022 Aug; 2022 Jun 25. PMID: 35797734.
Comparison of three novel radiotracers for GluN2B-containing NMDA receptors in non-human primates: (R)-[(11)C]NR2B-Me, (R)-[(18)F]of-Me-NB1, and (S)-[(18)F]of-NB1.Smart K, Zheng MQ, Ahmed H, Fang H, Xu Y, Cai L, Holden D, Kapinos M, Haider A, Felchner Z, Ropchan JR, Tamagnan G, Innis RB, Pike VW, Ametamey SM, Huang Y, Carson RE. J Cereb Blood Flow Metab. 2022 Aug; 2022 Feb 25. PMID: 35209743.
Translational PET Imaging of Spinal Cord Injury with the Serotonin Transporter Tracer [(11)C]AFM.Fang H, Rossano S, Wang X, Nabulsi N, Kelley B, Fowles K, Ropchan J, Strittmatter SM, Carson RE, Huang Y. Mol Imaging Biol. 2022 Aug; 2022 Jan 12. PMID: 35020138.
Cortical abnormalities of synaptic vesicle protein 2A in focal cortical dysplasia type II identified in vivo with (18)F-SynVesT-1 positron emission tomography imaging.Tang Y, Yu J, Zhou M, Li J, Long T, Li Y, Feng L, Chen D, Yang Z, Huang Y, Hu S. Eur J Nucl Med Mol Imaging. 2022 Aug; 2022 Jan 3. PMID: 34978594.
A personalized deep learning denoising strategy for low-count PET images.Liu Q, Liu H, Mirian N, Ren S, Viswanath V, Karp J, Surti S, Liu C. Phys Med Biol. 2022 Jul 13; 2022 Jul 13. PMID: 35697017.
Differences in the association between kappa opioid receptors and pain among Black and White adults with alcohol use disorders.de Laat B, Nabulsi N, Huang Y, O'Malley SS, Morris ED, Krishnan-Sarin S. Alcohol Clin Exp Res. 2022 Jul; 2022 Jun 24. PMID: 35633151.
Deep learning-based attenuation correction for whole-body PET - a multi-tracer study with (18)F-FDG, (68) Ga-DOTATATE, and (18)F-Fluciclovine.Toyonaga T, Shao D, Shi L, Zhang J, Revilla EM, Menard D, Ankrah J, Hirata K, Chen MK, Onofrey JA, Lu Y. Eur J Nucl Med Mol Imaging. 2022 Jul; 2022 Mar 12. PMID: 35277742.
Deep-learning-based methods of attenuation correction for SPECT and PET.Chen X, Liu C. J Nucl Cardiol. 2022 Jun 9; 2022 Jun 9. PMID: 35680755.
Imaging of Synaptic Density in Neurodegenerative Disorders.Carson RE, Naganawa M, Toyonaga T, Koohsari S, Yang Y, Chen MK, Matuskey D, Finnema SJ. J Nucl Med. 2022 Jun. PMID: 35649655.
Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q.Spurrier J, Nicholson L, Fang XT, Stoner AJ, Toyonaga T, Holden D, Siegert TR, Laird W, Allnutt MA, Chiasseu M, Brody AH, Takahashi H, Nies SH, Pérez-Cañamás A, Sadasivam P, Lee S, Li S, Zhang L, Huang YH, Carson RE, Cai Z, Strittmatter SM. Sci Transl Med. 2022 Jun; 2022 Jun 1. PMID: 35648810.
Characterization in nonhuman primates of (R)-[(18)F]OF-Me-NB1 and (S)-[(18)F]OF-Me-NB1 for imaging the GluN2B subunits of the NMDA receptor.Zheng M, Ahmed H, Smart K, Xu Y, Holden D, Kapinos M, Felchner Z, Haider A, Tamagnan G, Carson RE, Huang Y, Ametamey SM. Eur J Nucl Med Mol Imaging. 2022 Jun; 2022 Feb 2. PMID: 35107627.
PET Imaging in Animal Models of Alzheimer's Disease.Chen B, Marquez-Nostra B, Belitzky E, Toyonaga T, Tong J, Huang Y, Cai Z. Front Neurosci. 2022; 2022 May 24. PMID: 35685772.
Adaptive data-driven motion detection and optimized correction for brain PET.Revilla EM, Gallezot JD, Naganawa M, Toyonaga T, Fontaine K, Mulnix T, Onofrey JA, Carson RE, Lu Y. Neuroimage. 2022 May 15; 2022 Mar 4. PMID: 35257856.
Feasibility of imaging synaptic density in the human spinal cord using [(11)C]UCB-J PET.Rossano S, Toyonaga T, Bini J, Nabulsi N, Ropchan J, Cai Z, Huang Y, Carson RE. EJNMMI Phys. 2022 May 3; 2022 May 3. PMID: 35503134.
Multimodal neuroimaging of metabotropic glutamate 5 receptors and functional connectivity in alcohol use disorder.Smart K, Worhunsky PD, Scheinost D, Angarita GA, Esterlis I, Carson RE, Krystal JH, O'Malley SS, Cosgrove KP, Hillmer AT. Alcohol Clin Exp Res. 2022 May; 2022 Apr 21. PMID: 35342968.
Clinical Evaluation of Nuclear Imaging Agents in Breast Cancer.Li Z, Aboian MS, Zhu X, Marquez-Nostra B. Cancers (Basel). 2022 Apr 23; 2022 Apr 23. PMID: 35565232.
Harmonization of [(11)C]raclopride brain PET images from the HR+ and HRRT: method development and validation in human subjects.Hoye J, Toyonaga T, Zakiniaeiz Y, Stanley G, Hampson M, Morris ED. EJNMMI Phys. 2022 Apr 13; 2022 Apr 13. PMID: 35416555.
Low-Dose Augmentation With Buprenorphine for Treatment-Resistant Depression: A Multisite Randomized Controlled Trial With Multimodal Assessment of Target Engagement.Lee HH, Blumberger DM, Lenze EJ, Anderson SJ, Barch DM, Black KJ, Cristancho P, Daskalakis ZJ, Eisenstein SA, Huang Y, Li S, Lissemore J, McConathy J, Mulsant BH, Rajji TK, Reynolds CF 3rd, Su Y, Tu Z, Voineskos D, Karp JF. Biol Psychiatry Glob Open Sci. 2022 Apr; 2021 Oct 1. PMID: 36325158.
Imaging the effect of ketamine on synaptic density (SV2A) in the living brain.Holmes SE, Finnema SJ, Naganawa M, DellaGioia N, Holden D, Fowles K, Davis M, Ropchan J, Emory P, Ye Y, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Mol Psychiatry. 2022 Apr; 2022 Feb 15. PMID: 35165397.
A metabolically stable PET tracer for imaging synaptic vesicle protein 2A: synthesis and preclinical characterization of [(18)F]SDM-16.Zheng C, Holden D, Zheng MQ, Pracitto R, Wilcox KC, Lindemann M, Felchner Z, Zhang L, Tong J, Fowles K, Finnema SJ, Nabulsi N, Carson RE, Huang Y, Cai Z. Eur J Nucl Med Mol Imaging. 2022 Apr; 2021 Nov 11. PMID: 34761284.
Imaging Pituitary Vasopressin 1B Receptor in Humans with the PET Radiotracer (11)C-TASP699.Naganawa M, Nabulsi NB, Matuskey D, Henry S, Ropchan J, Lin SF, Gao H, Pracitto R, Labaree D, Zhang MR, Suhara T, Nishino I, Sabia H, Ozaki S, Huang Y, Carson RE. J Nucl Med. 2022 Apr; 2021 Aug 12. PMID: 34385336.
Recently Abstinent Smokers Exhibit Mood-Associated Dopamine Dysfunction in the Ventral Striatum Compared to Nonsmokers: A [11C]-(+)-PHNO PET Study.Calakos KC, Hillmer AT, Angarita GA, Baldassarri SR, Najafzadeh S, Emery PR, Matuskey D, Huang Y, Cosgrove KP. Nicotine Tob Res. 2022 Mar 26. PMID: 34628508.
PET Imaging of Synaptic Density: Challenges and Opportunities of Synaptic Vesicle Glycoprotein 2A PET in Small Animal Imaging.Toyonaga T, Fesharaki-Zadeh A, Strittmatter SM, Carson RE, Cai Z. Front Neurosci. 2022; 2022 Mar 8. PMID: 35345546.
Target occupancy study and whole-body dosimetry with a MAGL PET ligand [(11)C]PF-06809247 in non-human primates.Arakawa R, Takano A, Nag S, Jia Z, Amini N, Maresca KP, Zhang L, Keliher EJ, Butler CR, Piro JR, Samad TA, Smith D, Nason D, O'Neil S, Trapa P, Fonseca KR, Litchfield J, McCarthy T, Carson RE, Halldin C. EJNMMI Res. 2022 Mar 4; 2022 Mar 4. PMID: 35244788.
PET-BIDS, an extension to the brain imaging data structure for positron emission tomography.Norgaard M, Matheson GJ, Hansen HD, Thomas A, Searle G, Rizzo G, Veronese M, Giacomel A, Yaqub M, Tonietto M, Funck T, Gillman A, Boniface H, Routier A, Dalenberg JR, Betthauser T, Feingold F, Markiewicz CJ, Gorgolewski KJ, Blair RW, Appelhoff S, Gau R, Salo T, Niso G, Pernet C, Phillips C, Oostenveld R, Gallezot JD, Carson RE, Knudsen GM, Innis RB, Ganz M. Sci Data. 2022 Mar 2; 2022 Mar 2. PMID: 35236846.
Discovery and development of brain-penetrant (18)F-labeled radioligands for neuroimaging of the sigma-2 receptors.Zhang Y, Wang T, Zhang X, Deuther-Conrad W, Fu H, Cui M, Zhang J, Brust P, Huang Y, Jia H. Acta Pharm Sin B. 2022 Mar; 2021 Sep 4. PMID: 35530149.
[89Zr]ZrDFO-CR011 PET Correlates with Response to Glycoprotein Nonmetastatic Melanoma B-targeted Therapy in Triple-negative Breast Cancer.Lee S, Cavaliere A, Gallezot JD, Keler T, Michelhaugh SK, Belitzky E, Liu M, Mulnix T, Maher SE, Bothwell ALM, Li F, Phadke M, Mittal S, Marquez-Nostra B. Mol Cancer Ther. 2022 Mar 1. PMID: 35027482.
Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's disease.Mecca AP, Chen MK, O'Dell RS, Naganawa M, Toyonaga T, Godek TA, Harris JE, Bartlett HH, Zhao W, Banks ER, Ni GS, Rogers K, Gallezot JD, Ropchan J, Emery PR, Nabulsi NB, Vander Wyk BC, Arnsten AFT, Huang Y, Carson RE, van Dyck CH. Neurobiol Aging. 2022 Mar; 2021 Nov 20. PMID: 34963063.
Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory (11) C-UCB-J positron emission tomography study in humans.Angarita GA, Worhunsky PD, Naganawa M, Toyonaga T, Nabulsi NB, Li CR, Esterlis I, Skosnik PD, Radhakrishnan R, Pittman B, Gueorguieva R, Potenza MN, Finnema SJ, Huang Y, Carson RE, Malison RT. Addict Biol. 2022 Mar; 2021 Dec 1. PMID: 34852401.
EC(50) images, a novel endpoint from PET target occupancy studies, reveal spatial variation in apparent drug affinity.de Laat B, Hoye J, Liu H, Morris ED. Eur J Nucl Med Mol Imaging. 2022 Mar; 2021 Oct 12. PMID: 34636937.
Relationships between dopamine D2/3 receptor availability and social-environmental factors in humans.Calakos KC, Rusowicz A, Pittman B, Gallezot JD, Potenza MN, Cosgrove KP, Matuskey D. Neurosci Lett. 2022 Feb 6; 2022 Jan 17. PMID: 35051435.
PET respiratory motion correction: quo vadis?Lamare F, Bousse A, Thielemans K, Liu C, Merlin T, Fayad H, Visvikis D. Phys Med Biol. 2022 Feb 1; 2022 Feb 1. PMID: 34915465.
Feasibility study of PET dynamic imaging of [(18)F]DHMT for quantification of reactive oxygen species in the myocardium of large animals.Wu J, Boutagy NE, Cai Z, Lin SF, Zheng MQ, Feher A, Stendahl JC, Kapinos M, Gallezot JD, Liu H, Mulnix T, Zhang W, Lindemann M, Teng JK, Miller EJ, Huang Y, Carson RE, Sinusas AJ, Liu C. J Nucl Cardiol. 2022 Feb; 2020 May 15. PMID: 32415628.
Glia Imaging Differentiates Multiple System Atrophy from Parkinson's Disease: A Positron Emission Tomography Study with [(11) C]PBR28 and Machine Learning Analysis.Jucaite A, Cselényi Z, Kreisl WC, Rabiner EA, Varrone A, Carson RE, Rinne JO, Savage A, Schou M, Johnström P, Svenningsson P, Rascol O, Meissner WG, Barone P, Seppi K, Kaufmann H, Wenning GK, Poewe W, Farde L. Mov Disord. 2022 Jan; 2021 Oct 5. PMID: 34609758.
Lower synaptic density is associated with psychiatric and cognitive alterations in obesity.Asch RH, Holmes SE, Jastreboff AM, Potenza MN, Baldassarri SR, Carson RE, Pietrzak RH, Esterlis I. Neuropsychopharmacology. 2022 Jan; 2021 Jul 22. PMID: 34294874.

2021

Validation of SV2A-Targeted PET Imaging for Noninvasive Assessment of Neuroendocrine Differentiation in Prostate Cancer.Guan B, Zhou N, Wu CY, Li S, Chen YA, Debnath S, Hofstad M, Ma S, Raj GV, He D, Hsieh JT, Huang Y, Hao G, Sun X. Int J Mol Sci. 2021 Dec 3; 2021 Dec 3. PMID: 34884893.
TSPO imaging in animal models of brain diseases.Van Camp N, Lavisse S, Roost P, Gubinelli F, Hillmer A, Boutin H. Eur J Nucl Med Mol Imaging. 2021 Dec; 2021 Jul 10. PMID: 34245328.
In vivo evidence of lower synaptic vesicle density in schizophrenia.Radhakrishnan R, Skosnik PD, Ranganathan M, Naganawa M, Toyonaga T, Finnema S, Hillmer AT, Esterlis I, Huang Y, Nabulsi N, Carson RE, D'Souza DC. Mol Psychiatry. 2021 Dec; 2021 Jun 16. PMID: 34135473.
Looking Back at the Next 40 Years of ASD Neuroscience Research.McPartland JC, Lerner MD, Bhat A, Clarkson T, Jack A, Koohsari S, Matuskey D, McQuaid GA, Su WC, Trevisan DA. J Autism Dev Disord. 2021 Dec; 2021 May 27. PMID: 34043128.
Kinetic modeling and parameter estimation of TSPO PET imaging in the human brain.Wimberley C, Lavisse S, Hillmer A, Hinz R, Turkheimer F, Zanotti-Fregonara P. Eur J Nucl Med Mol Imaging. 2021 Dec; 2021 Mar 11. PMID: 33693967.
Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography.Smart K, Yttredahl A, Oquendo MA, Mann JJ, Hillmer AT, Carson RE, Miller JM. Transl Psychiatry. 2021 Nov 27; 2021 Nov 27. PMID: 34839360.
Determining the minimal ultra-low dose CT for reliable attenuation correction of (18)F-FDG PET-CT: a phantom study.Cheng D, Ghita M, Menard D, Chen MK. J Nucl Med Technol. 2021 Nov 8; 2021 Nov 8. PMID: 34750234.
Pitfalls on PET/CT Due to Artifacts and Instrumentation.Tsai YJ, Liu C. Semin Nucl Med. 2021 Nov; 2021 Jul 7. PMID: 34243906.
Further Investigation of Synaptic Vesicle Protein 2A (SV2A) Ligands Designed for Positron Emission Tomography and Single-Photon Emission Computed Tomography Imaging: Synthesis and Structure-Activity Relationship of Substituted Pyridinylmethyl-4-(3,5-difluorophenyl)pyrrolidin-2-ones.Pracitto R, Wilcox KC, Lindemann M, Tong J, Zheng C, Li S, Finnema SJ, Huang Y, Cai Z. ACS Omega. 2021 Oct 26; 2021 Oct 8. PMID: 34722967.
Preliminary In Vivo Evidence of Reduced Synaptic Density in Human Immunodeficiency Virus (HIV) Despite Antiretroviral Therapy.Weiss JJ, Calvi R, Naganawa M, Toyonaga T, Farhadian SF, Chintanaphol M, Chiarella J, Zheng MQ, Ropchan J, Huang Y, Pietrzak RH, Carson RE, Spudich S. Clin Infect Dis. 2021 Oct 20. PMID: 34050746.
Imaging brain cortisol regulation in PTSD with a target for 11β-hydroxysteroid dehydrogenase type 1.Bhatt S, Hillmer AT, Rusowicz A, Nabulsi N, Matuskey D, Angarita GA, Najafzadeh S, Kapinos M, Southwick SM, Krystal JH, Carson RE, Huang Y, Cosgrove KP. J Clin Invest. 2021 Oct 15. PMID: 34651587.
Novel Reversible-Binding PET Ligands for Imaging Monoacylglycerol Lipase Based on the Piperazinyl Azetidine Scaffold.Rong J, Mori W, Xia X, Schafroth MA, Zhao C, Van RS, Yamasaki T, Chen J, Xiao Z, Haider A, Ogasawara D, Hiraishi A, Shao T, Zhang Y, Chen Z, Pang F, Hu K, Xie L, Fujinaga M, Kumata K, Gou Y, Fang Y, Gu S, Wei H, Bao L, Xu H, Collier TL, Shao Y, Carson RE, Cravatt BF, Wang L, Zhang MR, Liang SH. J Med Chem. 2021 Oct 14; 2021 Sep 27. PMID: 34569803.
Artificial Intelligence-Based Image Enhancement in PET Imaging: Noise Reduction and Resolution Enhancement.Liu J, Malekzadeh M, Mirian N, Song TA, Liu C, Dutta J. PET Clin. 2021 Oct. PMID: 34537130.
Assessment of transient dopamine responses to smoked cannabis.Calakos KC, Liu H, Lu Y, Anderson JM, Matuskey D, Nabulsi N, Ye Y, Skosnik PD, D'Souza DC, Morris ED, Cosgrove KP, Hillmer AT. Drug Alcohol Depend. 2021 Oct 1; 2021 Jul 29. PMID: 34399137.
Generation of parametric K(i) images for FDG PET using two 5-min scans.Wu J, Liu H, Ye Q, Gallezot JD, Naganawa M, Miao T, Lu Y, Chen MK, Esserman DA, Kyriakides TC, Carson RE, Liu C. Med Phys. 2021 Sep; 2021 Aug 13. PMID: 34287939.
Generation of synthetic PET images of synaptic density and amyloid from (18) F-FDG images using deep learning.Wang R, Liu H, Toyonaga T, Shi L, Wu J, Onofrey JA, Tsai YJ, Naganawa M, Ma T, Liu Y, Chen MK, Mecca AP, O'Dell RS, van Dyck CH, Carson RE, Liu C. Med Phys. 2021 Sep; 2021 Jul 27. PMID: 34224153.
Partial volume correction analysis for (11)C-UCB-J PET studies of Alzheimer's disease.Lu Y, Toyonaga T, Naganawa M, Gallezot JD, Chen MK, Mecca AP, van Dyck CH, Carson RE. Neuroimage. 2021 Sep; 2021 Jun 11. PMID: 34119639.
Effect of age on brain metabotropic glutamate receptor subtype 5 measured with [(18)F]FPEB PET.Mecca AP, Rogers K, Jacobs Z, McDonald JW, Michalak HR, DellaGioia N, Zhao W, Hillmer AT, Nabulsi N, Lim K, Ropchan J, Huang Y, Matuskey D, Esterlis I, Carson RE, van Dyck CH. Neuroimage. 2021 Sep; 2021 May 27. PMID: 34052464.
Comparison of [(11)C]UCB-J and [(18)F]FDG PET in Alzheimer's disease: A tracer kinetic modeling study.Chen MK, Mecca AP, Naganawa M, Gallezot JD, Toyonaga T, Mondal J, Finnema SJ, Lin SF, O'Dell RS, McDonald JW, Michalak HR, Vander Wyk B, Nabulsi NB, Huang Y, Arnsten AF, van Dyck CH, Carson RE. J Cereb Blood Flow Metab. 2021 Sep; 2021 Mar 24. PMID: 33757318.
Occupancy of the kappa opioid receptor by naltrexone predicts reduction in drinking and craving.de Laat B, Nabulsi N, Huang Y, O'Malley SS, Froehlich JC, Morris ED, Krishnan-Sarin S. Mol Psychiatry. 2021 Sep; 2020 Jun 15. PMID: 32541931.
Detecting and classifying neurotransmitter signals from ultra-high sensitivity PET data: the future of molecular brain imaging.Liu H, Morris ED. Phys Med Biol. 2021 Aug 24; 2021 Aug 24. PMID: 34330107.
Identifying brain networks in synaptic density PET ((11)C-UCB-J) with independent component analysis.Fang XT, Toyonaga T, Hillmer AT, Matuskey D, Holmes SE, Radhakrishnan R, Mecca AP, van Dyck CH, D'Souza DC, Esterlis I, Worhunsky PD, Carson RE. Neuroimage. 2021 Aug 15; 2021 May 15. PMID: 34000404.
Standardization and quantification is a key to the future of atherosclerosis FDG PET/CT imaging.Pucar D, Liu C. J Nucl Cardiol. 2021 Aug; 2019 Oct 7. PMID: 31591696.
Multiparametric cardiac(18)F-FDG PET in humans: pilot comparison of FDG delivery rate with(82)Rb myocardial blood flow.Zuo Y, López JE, Smith TW, Foster CC, Carson RE, Badawi RD, Wang G. Phys Med Biol. 2021 Jul 30; 2021 Jul 30. PMID: 34280905.
Multi-Tracer Positron Emission Tomography Quantification of Sympathetic Innervation: Tracer Similarity But Not Equivalence.Sinusas AJ, Liu C. JACC Cardiovasc Imaging. 2021 Jul; 2020 Nov 18. PMID: 33221231.
Preliminary in vivo evidence of lower hippocampal synaptic density in cannabis use disorder.D'Souza DC, Radhakrishnan R, Naganawa M, Ganesh S, Nabulsi N, Najafzadeh S, Ropchan J, Ranganathan M, Cortes-Briones J, Huang Y, Carson RE, Skosnik P. Mol Psychiatry. 2021 Jul; 2020 Sep 24. PMID: 32973170.
Quantification of SV2A Binding in Rodent Brain Using [(18)F]SynVesT-1 and PET Imaging.Sadasivam P, Fang XT, Toyonaga T, Lee S, Xu Y, Zheng MQ, Spurrier J, Huang Y, Strittmatter SM, Carson RE, Cai Z. Mol Imaging Biol. 2021 Jun; 2020 Nov 30. PMID: 33258040.
A local-neighborhood Lassen plot filter for creating occupancy and non-displaceable binding images.de Laat B, Morris ED. J Cereb Blood Flow Metab. 2021 Jun; 2020 Oct 13. PMID: 33050827.
PET Imaging Estimates of Regional Acetylcholine Concentration Variation in Living Human Brain.Smart K, Naganawa M, Baldassarri SR, Nabulsi N, Ropchan J, Najafzadeh S, Gao H, Navarro A, Barth V, Esterlis I, Cosgrove KP, Huang Y, Carson RE, Hillmer AT. Cereb Cortex. 2021 May 10. PMID: 33442731.
PET Neuroimaging of Alzheimer's Disease: Radiotracers and Their Utility in Clinical Research.Bao W, Xie F, Zuo C, Guan Y, Huang YH. Front Aging Neurosci. 2021; 2021 May 6. PMID: 34025386.
Assessment of test-retest reproducibility of [(18)F]SynVesT-1, a novel radiotracer for PET imaging of synaptic vesicle glycoprotein 2A.Li S, Naganawa M, Pracitto R, Najafzadeh S, Holden D, Henry S, Matuskey D, Emery PR, Cai Z, Ropchan J, Nabulsi N, Carson RE, Huang Y. Eur J Nucl Med Mol Imaging. 2021 May; 2021 Jan 8. PMID: 33416954.
Binding of the synaptic vesicle radiotracer [(11)C]UCB-J is unchanged during functional brain activation using a visual stimulation task.Smart K, Liu H, Matuskey D, Chen MK, Torres K, Nabulsi N, Labaree D, Ropchan J, Hillmer AT, Huang Y, Carson RE. J Cereb Blood Flow Metab. 2021 May; 2020 Aug 5. PMID: 32757741.
Preclinical Advances in Theranostics for the Different Molecular Subtypes of Breast Cancer.Fang H, Cavaliere A, Li Z, Huang Y, Marquez-Nostra B. Front Pharmacol. 2021; 2021 Apr 27. PMID: 33986665.
Evaluation of quantitative modeling methods in whole-body, dynamic [(11)C]-erlotinib PET.Petrulli JR, Zheng M, Huang Y, Nabulsi NB, Goldberg SB, Contessa JN, Morris ED. Am J Nucl Med Mol Imaging. 2021; 2021 Apr 15. PMID: 34079641.
First-in-Human Assessment of (11)C-LSN3172176, an M1 Muscarinic Acetylcholine Receptor PET Radiotracer.Naganawa M, Nabulsi N, Henry S, Matuskey D, Lin SF, Slieker L, Schwarz AJ, Kant N, Jesudason C, Ruley K, Navarro A, Gao H, Ropchan J, Labaree D, Carson RE, Huang Y. J Nucl Med. 2021 Apr; 2020 Aug 28. PMID: 32859711.
First-in-Human Evaluation of (18)F-SynVesT-1, a Radioligand for PET Imaging of Synaptic Vesicle Glycoprotein 2A.Naganawa M, Li S, Nabulsi N, Henry S, Zheng MQ, Pracitto R, Cai Z, Gao H, Kapinos M, Labaree D, Matuskey D, Huang Y, Carson RE. J Nucl Med. 2021 Apr; 2020 Aug 28. PMID: 32859701.
FDG PET imaging of vascular inflammation in post-traumatic stress disorder: A pilot case-control study.Toczek J, Hillmer AT, Han J, Liu C, Peters D, Emami H, Wu J, Esterlis I, Cosgrove KP, Sadeghi MM. J Nucl Cardiol. 2021 Apr; 2019 May 9. PMID: 31073848.
Dopamine D(2/3) receptor availability in cocaine use disorder individuals with obesity as measured by [(11)C]PHNO PET.Matuskey D, Angarita GA, Worhunsky P, Koohsari S, Gravel P, Pittman B, Gaiser EC, Gallezot JD, Nabulsi N, Huang Y, Carson RE, Potenza MN, Malison RT. Drug Alcohol Depend. 2021 Mar 1; 2021 Jan 8. PMID: 33454626.
Nondisplaceable Binding Is a Potential Confounding Factor in (11)C-PBR28 Translocator Protein PET Studies.Laurell GL, Plavén-Sigray P, Jucaite A, Varrone A, Cosgrove KP, Svarer C, Knudsen GM, Ogden RT, Zanderigo F, Cervenka S, Hillmer AT, Schain M. J Nucl Med. 2021 Mar; 2020 Jul 17. PMID: 32680926.
Simplified Quantification of (11)C-UCB-J PET Evaluated in a Large Human Cohort.Naganawa M, Gallezot JD, Finnema SJ, Matuskey D, Mecca A, Nabulsi NB, Labaree D, Ropchan J, Malison RT, D'Souza DC, Esterlis I, Detyniecki K, van Dyck CH, Huang Y, Carson RE. J Nucl Med. 2021 Mar; 2020 Jul 9. PMID: 32646875.
Development of [(89)Zr]ZrDFO-amivantamab bispecific to EGFR and c-MET for PET imaging of triple-negative breast cancer.Cavaliere A, Sun S, Lee S, Bodner J, Li Z, Huang Y, Moores SL, Marquez-Nostra B. Eur J Nucl Med Mol Imaging. 2021 Feb; 2020 Aug 8. PMID: 32770372.
Association of Aβ deposition and regional synaptic density in early Alzheimer's disease: a PET imaging study with [(11)C]UCB-J.O'Dell RS, Mecca AP, Chen MK, Naganawa M, Toyonaga T, Lu Y, Godek TA, Harris JE, Bartlett HH, Banks ER, Kominek VL, Zhao W, Nabulsi NB, Ropchan J, Ye Y, Vander Wyk BC, Huang Y, Arnsten AFT, Carson RE, van Dyck CH. Alzheimers Res Ther. 2021 Jan 5; 2021 Jan 5. PMID: 33402201.
The Therapeutic Potential of Purinergic Receptors in Alzheimer's Disease and Promising Therapeutic Modulators.Pan L, Ma Y, Li Y, Wu H, Huang R, Cai Z, Wu X. Mini Rev Med Chem. 2021. PMID: 33302833.
Prediction of post-radiotherapy locoregional progression in HPV-associated oropharyngeal squamous cell carcinoma using machine-learning analysis of baseline PET/CT radiomics.Haider SP, Sharaf K, Zeevi T, Baumeister P, Reichel C, Forghani R, Kann BH, Petukhova A, Judson BL, Prasad ML, Liu C, Burtness B, Mahajan A, Payabvash S. Transl Oncol. 2021 Jan; 2020 Oct 16. PMID: 33075658.
Multimodal investigation of dopamine D(2)/D(3) receptors, default mode network suppression, and cognitive control in cocaine-use disorder.Worhunsky PD, Angarita GA, Zhai ZW, Matuskey D, Gallezot JD, Malison RT, Carson RE, Potenza MN. Neuropsychopharmacology. 2021 Jan; 2020 Oct 2. PMID: 33007778.
Acute neuroimmune stimulation impairs verbal memory in adults: A PET brain imaging study.Woodcock EA, Hillmer AT, Sandiego CM, Maruff P, Carson RE, Cosgrove KP, Pietrzak RH. Brain Behav Immun. 2021 Jan; 2020 Sep 28. PMID: 33002632.
Longitudinal imaging of metabotropic glutamate 5 receptors during early and extended alcohol abstinence.Hillmer AT, Angarita GA, Esterlis I, Anderson JM, Nabulsi N, Lim K, Ropchan J, Carson RE, Krystal JH, Malley SSO, Cosgrove KP. Neuropsychopharmacology. 2021 Jan; 2020 Sep 12. PMID: 32919411.

2020

Quantitative Cerebral Blood Flow with PET in the 1980s: Going with the Flow.Carson RE. J Nucl Med. 2020 Dec. PMID: 33293455.
Patient motion correction for dynamic cardiac PET: Current status and challenges.Lu Y, Liu C. J Nucl Cardiol. 2020 Dec; 2018 Nov 12. PMID: 30421380.
Assessment of population-based input functions for Patlak imaging of whole body dynamic (18)F-FDG PET.Naganawa M, Gallezot JD, Shah V, Mulnix T, Young C, Dias M, Chen MK, Smith AM, Carson RE. EJNMMI Phys. 2020 Nov 23; 2020 Nov 23. PMID: 33226522.
Dysregulation of Decision Making Related to Metabotropic Glutamate 5, but Not Midbrain D(3), Receptor Availability Following Cocaine Self-administration in Rats.Groman SM, Hillmer AT, Liu H, Fowles K, Holden D, Morris ED, Lee D, Taylor JR. Biol Psychiatry. 2020 Nov 15; 2020 Jun 29. PMID: 32826065.
Midbrain D(3) Receptor Availability Predicts Escalation in Cocaine Self-administration.Groman SM, Hillmer AT, Liu H, Fowles K, Holden D, Morris ED, Lee D, Taylor JR. Biol Psychiatry. 2020 Nov 15; 2020 Feb 27. PMID: 32312578.
The rate of dasotraline brain entry is slow following intravenous administration.Lew R, Constantinescu CC, Holden D, Carson RE, Carroll V, Galluppi G, Koblan KS, Hopkins SC. Psychopharmacology (Berl). 2020 Nov; 2020 Aug 19. PMID: 32813030.
Reply: (11)C-(+)-PHNO Trapping Reversibility for Quantitative PET Imaging of β-Cell Mass in Patients with Type 1 Diabetes.Bini J, Carson RE, Cline GW. J Nucl Med. 2020 Nov; 2020 Jul 3. PMID: 32620703.
Kinetic Modeling and Test-Retest Reproducibility of (11)C-EKAP and (11)C-FEKAP, Novel Agonist Radiotracers for PET Imaging of the κ-Opioid Receptor in Humans.Naganawa M, Li S, Nabulsi N, Lin SF, Labaree D, Ropchan J, Gao H, Mei M, Henry S, Matuskey D, Carson RE, Huang Y. J Nucl Med. 2020 Nov; 2020 Mar 13. PMID: 32169917.
Measuring the effects of ketamine on mGluR5 using [(18)F]FPEB and PET.Holmes SE, Gallezot JD, Davis MT, DellaGioia N, Matuskey D, Nabulsi N, Krystal JH, Javitch JA, DeLorenzo C, Carson RE, Esterlis I. J Cereb Blood Flow Metab. 2020 Nov; 2019 Nov 19. PMID: 31744389.
Reduced synaptic vesicle protein 2A binding in temporal lobe epilepsy: A [(11) C]UCB-J positron emission tomography study.Finnema SJ, Toyonaga T, Detyniecki K, Chen MK, Dias M, Wang Q, Lin SF, Naganawa M, Gallezot JD, Lu Y, Nabulsi NB, Huang Y, Spencer DD, Carson RE. Epilepsia. 2020 Oct; 2020 Sep 18. PMID: 32944949.
Inverse changes in raphe and cortical 5-HT(1B) receptor availability after acute tryptophan depletion in healthy human subjects.Baldassarri SR, Park E, Finnema SJ, Planeta B, Nabulsi N, Najafzadeh S, Ropchan J, Huang Y, Hannestad J, Maloney K, Bhagwagar Z, Carson RE. Synapse. 2020 Oct; 2020 May 7. PMID: 32324935.
Accuracy of arterial [(18)F]-Fluorodeoxyglucose uptake quantification: A kinetic modeling study.Toczek J, Wu J, Hillmer AT, Han J, Esterlis I, Cosgrove KP, Liu C, Sadeghi MM. J Nucl Cardiol. 2020 Oct; 2020 Feb 10. PMID: 32043239.
Noise reduction with cross-tracer and cross-protocol deep transfer learning for low-dose PET.Liu H, Wu J, Lu W, Onofrey JA, Liu YH, Liu C. Phys Med Biol. 2020 Sep 14; 2020 Sep 14. PMID: 32924973.
Data-Driven Motion Detection and Event-by-Event Correction for Brain PET: Comparison with Vicra.Lu Y, Naganawa M, Toyonaga T, Gallezot JD, Fontaine K, Ren S, Revilla EM, Mulnix T, Carson RE. J Nucl Med. 2020 Sep; 2020 Jan 31. PMID: 32005770.
Assessment of a white matter reference region for (11)C-UCB-J PET quantification.Rossano S, Toyonaga T, Finnema SJ, Naganawa M, Lu Y, Nabulsi N, Ropchan J, De Bruyn S, Otoul C, Stockis A, Nicolas JM, Martin P, Mercier J, Huang Y, Maguire RP, Carson RE. J Cereb Blood Flow Metab. 2020 Sep; 2019 Sep 30. PMID: 31570041.
Body Mass Index and Age Effects on Brain 11β-Hydroxysteroid Dehydrogenase Type 1: a Positron Emission Tomography Study.Bini J, Bhatt S, Hillmer AT, Gallezot JD, Nabulsi N, Pracitto R, Labaree D, Kapinos M, Ropchan J, Matuskey D, Sherwin RS, Jastreboff AM, Carson RE, Cosgrove K, Huang Y. Mol Imaging Biol. 2020 Aug. PMID: 32133575.
Guidelines for the content and format of PET brain data in publications and archives: A consensus paper.Knudsen GM, Ganz M, Appelhoff S, Boellaard R, Bormans G, Carson RE, Catana C, Doudet D, Gee AD, Greve DN, Gunn RN, Halldin C, Herscovitch P, Huang H, Keller SH, Lammertsma AA, Lanzenberger R, Liow JS, Lohith TG, Lubberink M, Lyoo CH, Mann JJ, Matheson GJ, Nichols TE, Nørgaard M, Ogden T, Parsey R, Pike VW, Price J, Rizzo G, Rosa-Neto P, Schain M, Scott PJ, Searle G, Slifstein M, Suhara T, Talbot PS, Thomas A, Veronese M, Wong DF, Yaqub M, Zanderigo F, Zoghbi S, Innis RB. J Cereb Blood Flow Metab. 2020 Aug; 2020 Feb 16. PMID: 32065076.
Tobacco Smoking in People Is Not Associated with Altered 18-kDa Translocator Protein Levels: A PET Study.Hillmer AT, Matuskey D, Huang Y, Nabulsi N, Ropchan J, Carson RE, O'Malley SS, Cosgrove KP. J Nucl Med. 2020 Aug; 2020 Jan 31. PMID: 32005773.
Preclinical In Vitro and In Vivo Characterization of Synaptic Vesicle 2A-Targeting Compounds Amenable to F-18 Labeling as Potential PET Radioligands for Imaging of Synapse Integrity.Patel S, Knight A, Krause S, Teceno T, Tresse C, Li S, Cai Z, Gouasmat A, Carroll VM, Barret O, Gottmukkala V, Zhang W, Xiang X, Morley T, Huang Y, Passchier J. Mol Imaging Biol. 2020 Aug. PMID: 31728839.
Methods for Quantifying Neurotransmitter Dynamics in the Living Brain With PET Imaging.Ceccarini J, Liu H, Van Laere K, Morris ED, Sander CY. Front Physiol. 2020; 2020 Jul 21. PMID: 32792972.
Synthesis and evaluation of new 1-oxa-8-azaspiro[4.5]decane derivatives as candidate radioligands for sigma-1 receptors.Tian J, He Y, Deuther-Conrad W, Fu H, Xie F, Zhang Y, Wang T, Zhang X, Zhang J, Brust P, Huang Y, Jia H. Bioorg Med Chem. 2020 Jul 15; 2020 May 23. PMID: 32616183.
Human adult and adolescent biodistribution and dosimetry of the synaptic vesicle glycoprotein 2A radioligand (11)C-UCB-J.Bini J, Holden D, Fontaine K, Mulnix T, Lu Y, Matuskey D, Ropchan J, Nabulsi N, Huang Y, Carson RE. EJNMMI Res. 2020 Jul 14; 2020 Jul 14. PMID: 32666239.
In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET.Mecca AP, Chen MK, O'Dell RS, Naganawa M, Toyonaga T, Godek TA, Harris JE, Bartlett HH, Zhao W, Nabulsi NB, Wyk BCV, Varma P, Arnsten AFT, Huang Y, Carson RE, van Dyck CH. Alzheimers Dement. 2020 Jul; 2020 May 13. PMID: 32400950.
Separating dopamine D(2) and D(3) receptor sources of [(11)C]-(+)-PHNO binding potential: Independent component analysis of competitive binding.Smart K, Gallezot JD, Nabulsi N, Labaree D, Zheng MQ, Huang Y, Carson RE, Hillmer AT, Worhunsky PD. Neuroimage. 2020 Jul 1; 2020 Mar 19. PMID: 32201327.
Positron Emission Tomography Imaging Evaluation of a Novel (18)F-Labeled Sigma-1 Receptor Radioligand in Cynomolgus Monkeys.Jia H, Cai Z, Holden D, He Y, Lin SF, Li S, Baum E, Shirali A, Kapinos M, Gao H, Ropchan J, Huang Y. ACS Chem Neurosci. 2020 Jun 3; 2020 May 20. PMID: 32356969.
PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies.Bhatt S, Hillmer AT, Girgenti MJ, Rusowicz A, Kapinos M, Nabulsi N, Huang Y, Matuskey D, Angarita GA, Esterlis I, Davis MT, Southwick SM, Friedman MJ, Duman RS, Carson RE, Krystal JH, Pietrzak RH, Cosgrove KP. Nat Commun. 2020 May 12; 2020 May 12. PMID: 32398677.
Imaging Mechanisms of Disease Progression in Multiple Sclerosis: Beyond Brain Atrophy.Bagnato F, Gauthier SA, Laule C, Moore GRW, Bove R, Cai Z, Cohen-Adad J, Harrison DM, Klawiter EC, Morrow SA, Öz G, Rooney WD, Smith SA, Calabresi PA, Henry RG, Oh J, Ontaneda D, Pelletier D, Reich DS, Shinohara RT, Sicotte NL. J Neuroimaging. 2020 May. PMID: 32418324.
Norepinephrine transporter availability in brown fat is reduced in obesity: a human PET study with [(11)C] MRB.Sanchez-Rangel E, Gallezot JD, Yeckel CW, Lam W, Belfort-DeAguiar R, Chen MK, Carson RE, Sherwin R, Hwang JJ. Int J Obes (Lond). 2020 Apr; 2019 Oct 21. PMID: 31636373.
PET Imaging of Pancreatic Dopamine D(2) and D(3) Receptor Density with (11)C-(+)-PHNO in Type 1 Diabetes.Bini J, Sanchez-Rangel E, Gallezot JD, Naganawa M, Nabulsi N, Lim K, Najafzadeh S, Shirali A, Ropchan J, Matuskey D, Huang Y, Herold KC, Harris PE, Sherwin RS, Carson RE, Cline GW. J Nucl Med. 2020 Apr; 2019 Oct 10. PMID: 31601695.
Quantification of PET infusion studies without true equilibrium: A tissue clearance correction.Hillmer AT, Carson RE. J Cereb Blood Flow Metab. 2020 Apr; 2019 May 14. PMID: 31088233.
First in-human PET study and kinetic evaluation of [(18)F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1.Bhatt S, Nabulsi NB, Li S, Cai Z, Matuskey D, Bini J, Najafzadeh S, Kapinos M, Ropchan JR, Carson RE, Cosgrove KP, Huang Y, Hillmer AT. J Cereb Blood Flow Metab. 2020 Apr; 2019 Mar 21. PMID: 30895878.
Quantification of [(11)C]PBR28 data after systemic lipopolysaccharide challenge.Woodcock EA, Schain M, Cosgrove KP, Hillmer AT. EJNMMI Res. 2020 Mar 12; 2020 Mar 12. PMID: 32166497.
Synaptic Changes in Parkinson Disease Assessed with in vivo Imaging.Matuskey D, Tinaz S, Wilcox KC, Naganawa M, Toyonaga T, Dias M, Henry S, Pittman B, Ropchan J, Nabulsi N, Suridjan I, Comley RA, Huang Y, Finnema SJ, Carson RE. Ann Neurol. 2020 Mar; 2020 Feb 5. PMID: 31953875.
Further in vivo characterization of [(11) C]-(+)-PHNO uptake into a retina-like region of interest in humans.Caravaggio F, Worhunsky P, Graff-Guerrero A, Matuskey D. Synapse. 2020 Mar; 2019 Sep 29. PMID: 31553807.
Synthesis and Preclinical Evaluation of an (18)F-Labeled Synaptic Vesicle Glycoprotein 2A PET Imaging Probe: [(18)F]SynVesT-2.Cai Z, Li S, Zhang W, Pracitto R, Wu X, Baum E, Finnema SJ, Holden D, Toyonaga T, Lin SF, Lindemann M, Shirali A, Labaree DC, Ropchan J, Nabulsi N, Carson RE, Huang Y. ACS Chem Neurosci. 2020 Feb 19; 2020 Feb 4. PMID: 31961649.
Clinical brain PET research must embrace multi-centre collaboration and data sharing or risk its demise.Matheson GJ, Plavén-Sigray P, Tuisku J, Rinne J, Matuskey D, Cervenka S. Eur J Nucl Med Mol Imaging. 2020 Feb; 2019 Nov 12. PMID: 31713656.
In vivo 5-HT(6) and 5-HT(2A) receptor availability in antipsychotic treated schizophrenia patients vs. unmedicated healthy humans measured with [(11)C]GSK215083 PET.Radhakrishnan R, Matuskey D, Nabulsi N, Gaiser E, Gallezot JD, Henry S, Planeta B, Lin SF, Ropchan J, Huang Y, Carson RE, D'Souza DC. Psychiatry Res Neuroimaging. 2020 Jan 30; 2019 Nov 12. PMID: 31760336.
Approaches to PET Imaging of Glioblastoma.Drake LR, Hillmer AT, Cai Z. Molecules. 2020 Jan 28; 2020 Jan 28. PMID: 32012954.
PET imaging of mGluR5 in Alzheimer's disease.Mecca AP, McDonald JW, Michalak HR, Godek TA, Harris JE, Pugh EA, Kemp EC, Chen MK, Salardini A, Nabulsi NB, Lim K, Huang Y, Carson RE, Strittmatter SM, van Dyck CH. Alzheimers Res Ther. 2020 Jan 18; 2020 Jan 18. PMID: 31954399.
[(11)C]Methionine and [(11)C]PBR28 as PET Imaging Tracers to Differentiate Metastatic Tumor Recurrence or Radiation Necrosis.Tran TT, Gallezot JD, Jilaveanu LB, Zito C, Turcu G, Lim K, Nabulsi N, Huang H, Huttner A, Kluger HM, Chiang VL, Carson R. Mol Imaging. 2020 Jan-Dec. PMID: 33147119.
Sex and the dopaminergic system: Insights from addiction studies.Woodcock EA, Zakiniaeiz Y, Morris ED, Cosgrove KP. Handb Clin Neurol. 2020. PMID: 33008522.

2019

Binge alcohol use is not associated with alterations in striatal dopamine receptor binding or dopamine release.Wai JM, Grassetti A, Slifstein M, Matuskey D, Nabulsi N, Ropchan J, Labaree D, Huang Y, Martinez D. Drug Alcohol Depend. 2019 Dec 1; 2019 Oct 17. PMID: 31669800.
The Kappa Opioid Receptor Is Associated With Naltrexone-Induced Reduction of Drinking and Craving.de Laat B, Goldberg A, Shi J, Tetrault JM, Nabulsi N, Zheng MQ, Najafzadeh S, Gao H, Kapinos M, Ropchan J, O'Malley SS, Huang Y, Morris ED, Krishnan-Sarin S. Biol Psychiatry. 2019 Dec 1; 2019 Jun 8. PMID: 31399255.
Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers.Zakiniaeiz Y, Hillmer AT, Matuskey D, Nabulsi N, Ropchan J, Mazure CM, Picciotto MR, Huang Y, McKee SA, Morris ED, Cosgrove KP. Neuropsychopharmacology. 2019 Dec; 2019 Jul 3. PMID: 31269510.
In Vivo Synaptic Density Imaging with (11)C-UCB-J Detects Treatment Effects of Saracatinib in a Mouse Model of Alzheimer Disease.Toyonaga T, Smith LM, Finnema SJ, Gallezot JD, Naganawa M, Bini J, Mulnix T, Cai Z, Ropchan J, Huang Y, Strittmatter SM, Carson RE. J Nucl Med. 2019 Dec; 2019 May 17. PMID: 31101744.
Reproducibility of the correlative triad among aging, dopamine receptor availability, and cognition.Juarez EJ, Castrellon JJ, Green MA, Crawford JL, Seaman KL, Smith CT, Dang LC, Matuskey D, Morris ED, Cowan RL, Zald DH, Samanez-Larkin GR. Psychol Aging. 2019 Nov; 2019 Oct 7. PMID: 31589058.
Effects of age, BMI and sex on the glial cell marker TSPO - a multicentre [(11)C]PBR28 HRRT PET study.Tuisku J, Plavén-Sigray P, Gaiser EC, Airas L, Al-Abdulrasul H, Brück A, Carson RE, Chen MK, Cosgrove KP, Ekblad L, Esterlis I, Farde L, Forsberg A, Halldin C, Helin S, Kosek E, Lekander M, Lindgren N, Marjamäki P, Rissanen E, Sucksdorff M, Varrone A, Collste K, Gallezot JD, Hillmer A, Huang Y, Höglund CO, Johansson J, Jucaite A, Lampa J, Nabulsi N, Pittman B, Sandiego CM, Stenkrona P, Rinne J, Matuskey D, Cervenka S. Eur J Nucl Med Mol Imaging. 2019 Oct; 2019 Jul 30. PMID: 31363804.
Quantification of Positron Emission Tomography Data Using Simultaneous Estimation of the Input Function: Validation with Venous Blood and Replication of Clinical Studies.Bartlett EA, Ananth M, Rossano S, Zhang M, Yang J, Lin SF, Nabulsi N, Huang Y, Zanderigo F, Parsey RV, DeLorenzo C. Mol Imaging Biol. 2019 Oct. PMID: 30535672.
Anti-edema and antioxidant combination therapy for ischemic stroke via glyburide-loaded betulinic acid nanoparticles.Deng G, Ma C, Zhao H, Zhang S, Liu J, Liu F, Chen Z, Chen AT, Yang X, Avery J, Zou P, Du F, Lim KP, Holden D, Li S, Carson RE, Huang Y, Chen Q, Kimberly WT, Simard JM, Sheth KN, Zhou J. Theranostics. 2019; 2019 Sep 21. PMID: 31660082.
Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study.Martinez D, Slifstein M, Matuskey D, Nabulsi N, Zheng MQ, Lin SF, Ropchan J, Urban N, Grassetti A, Chang D, Salling M, Foltin R, Carson RE, Huang Y. Neuropsychopharmacology. 2019 Sep; 2019 Apr 26. PMID: 31026862.
Social status and demographic effects of the kappa opioid receptor: a PET imaging study with a novel agonist radiotracer in healthy volunteers.Matuskey D, Dias M, Naganawa M, Pittman B, Henry S, Li S, Gao H, Ropchan J, Nabulsi N, Carson RE, Huang Y. Neuropsychopharmacology. 2019 Sep; 2019 Mar 30. PMID: 30928993.
Quantitative PET Imaging in Drug Development: Estimation of Target Occupancy.Naganawa M, Gallezot JD, Rossano S, Carson RE. Bull Math Biol. 2019 Sep; 2017 Dec 11. PMID: 29230702.
An investigation of quantitative accuracy for deep learning based denoising in oncological PET.Lu W, Onofrey JA, Lu Y, Shi L, Ma T, Liu Y, Liu C. Phys Med Biol. 2019 Aug 21; 2019 Aug 21. PMID: 31307019.
Event-by-event non-rigid data-driven PET respiratory motion correction methods: comparison of principal component analysis and centroid of distribution.Ren S, Lu Y, Bertolli O, Thielemans K, Carson RE. Phys Med Biol. 2019 Aug 21; 2019 Aug 21. PMID: 30822762.
Synthesis and in vivo evaluation of [(18)F]UCB-J for PET imaging of synaptic vesicle glycoprotein 2A (SV2A).Li S, Cai Z, Zhang W, Holden D, Lin SF, Finnema SJ, Shirali A, Ropchan J, Carre S, Mercier J, Carson RE, Nabulsi N, Huang Y. Eur J Nucl Med Mol Imaging. 2019 Aug; 2019 Jun 7. PMID: 31175396.
Imaging the Enzyme 11β-Hydroxysteroid Dehydrogenase Type 1 with PET: Evaluation of the Novel Radiotracer (11)C-AS2471907 in Human Brain.Gallezot JD, Nabulsi N, Henry S, Pracitto R, Planeta B, Ropchan J, Lin SF, Labaree D, Kapinos M, Shirali A, Lara-Jaime T, Gao H, Matuskey D, Walzer M, Marek GJ, Bellaire S, Yuan N, Carson RE, Huang Y. J Nucl Med. 2019 Aug; 2019 Mar 15. PMID: 30877174.
Evaluation of (11)C-LSN3172176 as a Novel PET Tracer for Imaging M(1) Muscarinic Acetylcholine Receptors in Nonhuman Primates.Nabulsi NB, Holden D, Zheng MQ, Bois F, Lin SF, Najafzadeh S, Gao H, Ropchan J, Lara-Jaime T, Labaree D, Shirali A, Slieker L, Jesudason C, Barth V, Navarro A, Kant N, Carson RE, Huang Y. J Nucl Med. 2019 Aug; 2019 Feb 7. PMID: 30733324.
In vivo imaging of D(2) receptors and corticosteroids predict behavioural responses to captivity stress in a wild bird.Lattin CR, Merullo DP, Riters LV, Carson RE. Sci Rep. 2019 Jul 18; 2019 Jul 18. PMID: 31320692.
Development and In Vivo Evaluation of a κ-Opioid Receptor Agonist as a PET Radiotracer with Superior Imaging Characteristics.Li S, Zheng MQ, Naganawa M, Kim S, Gao H, Kapinos M, Labaree D, Huang Y. J Nucl Med. 2019 Jul; 2019 Jan 10. PMID: 30630942.
(18) F-Labeled benzylpiperazine derivatives as highly selective ligands for imaging σ(1) receptor with positron emission tomography.Ye J, Wang L, Deuther-Conrad W, Chen Y, Zhang X, Zhang J, Huang Y, Brust P, Jia H. J Labelled Comp Radiopharm. 2019 Jun 30. PMID: 30991462.
Human Positron Emission Tomography Neuroimaging.Hooker JM, Carson RE. Annu Rev Biomed Eng. 2019 Jun 4. PMID: 31167104.
In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation.Davis MT, Hillmer A, Holmes SE, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Carson RE, Krystal JH, Esterlis I. Proc Natl Acad Sci U S A. 2019 Jun 4; 2019 May 13. PMID: 31085640.
Imaging Biomarkers of the Neuroimmune System among Substance Use Disorders: A Systematic Review.Woodcock EA, Hillmer AT, Mason GF, Cosgrove KP. Mol Neuropsychiatry. 2019 Jun; 2019 May 9. PMID: 31312635.
A Novel (18)F-Labeled Radioligand for Positron Emission Tomography Imaging of 11β-Hydroxysteroid Dehydrogenase (11β-HSD1): Synthesis and Preliminary Evaluation in Nonhuman Primates.Baum E, Zhang W, Li S, Cai Z, Holden D, Huang Y. ACS Chem Neurosci. 2019 May 15; 2019 Feb 19. PMID: 30689943.
A single-center, open-label positron emission tomography study to evaluate brivaracetam and levetiracetam synaptic vesicle glycoprotein 2A binding in healthy volunteers.Finnema SJ, Rossano S, Naganawa M, Henry S, Gao H, Pracitto R, Maguire RP, Mercier J, Kervyn S, Nicolas JM, Klitgaard H, DeBruyn S, Otoul C, Martin P, Muglia P, Matuskey D, Nabulsi NB, Huang Y, Kaminski RM, Hannestad J, Stockis A, Carson RE. Epilepsia. 2019 May; 2019 Mar 29. PMID: 30924924.
Imaging of HER2 with [(89)Zr]pertuzumab in Response to T-DM1 Therapy.Massicano AVF, Lee S, Crenshaw BK, Aweda TA, El Sayed R, Super I, Bose R, Marquez-Nostra BV, Lapi SE. Cancer Biother Radiopharm. 2019 May; 2019 Jan 24. PMID: 30676778.
Partial-volume correction increases estimated dopamine D2-like receptor binding potential and reduces adult age differences.Smith CT, Crawford JL, Dang LC, Seaman KL, San Juan MD, Vijay A, Katz DT, Matuskey D, Cowan RL, Morris ED, Zald DH, Samanez-Larkin GR. J Cereb Blood Flow Metab. 2019 May; 2017 Nov 1. PMID: 29090626.
Lower synaptic density is associated with depression severity and network alterations.Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Nat Commun. 2019 Apr 4; 2019 Apr 4. PMID: 30948709.
Neuroimaging in Dementias.Mahalingam S, Chen MK. Semin Neurol. 2019 Apr; 2019 Mar 29. PMID: 30925612.
Novel Kappa Opioid Receptor Agonist as Improved PET Radiotracer: Development and in Vivo Evaluation.Li S, Zheng MQ, Naganawa M, Gao H, Pracitto R, Shirali A, Lin SF, Teng JK, Ropchan J, Huang Y. Mol Pharm. 2019 Apr 1; 2019 Feb 28. PMID: 30726092.
Toward whole-brain dopamine movies: a critical review of PET imaging of dopamine transmission in the striatum and cortex.Liu H, Zakiniaeiz Y, Cosgrove KP, Morris ED. Brain Imaging Behav. 2019 Apr. PMID: 29071465.
Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman Primates.Li S, Cai Z, Wu X, Holden D, Pracitto R, Kapinos M, Gao H, Labaree D, Nabulsi N, Carson RE, Huang Y. ACS Chem Neurosci. 2019 Mar 20; 2018 Nov 16. PMID: 30396272.
Data-driven voluntary body motion detection and non-rigid event-by-event correction for static and dynamic PET.Lu Y, Gallezot JD, Naganawa M, Ren S, Fontaine K, Wu J, Onofrey JA, Toyonaga T, Boutagy N, Mulnix T, Panin VY, Casey ME, Carson RE, Liu C. Phys Med Biol. 2019 Mar 8; 2019 Mar 8. PMID: 30695768.
Positron emission tomography imaging of the γ-aminobutyric acid system.Andersson JD, Matuskey D, Finnema SJ. Neurosci Lett. 2019 Jan 19; 2018 Aug 10. PMID: 30102960.
PET imaging of synaptic density: A new tool for investigation of neuropsychiatric diseases.Cai Z, Li S, Matuskey D, Nabulsi N, Huang Y. Neurosci Lett. 2019 Jan 19; 2018 Jul 31. PMID: 30075287.
Imaging sigma receptors in the brain: New opportunities for diagnosis of Alzheimer's disease and therapeutic development.Jia H, Zhang Y, Huang Y. Neurosci Lett. 2019 Jan 19; 2018 Jul 21. PMID: 30040970.
Small Molecule Natural Products and Alzheimer's Disease.Wu X, Cai H, Pan L, Cui G, Qin F, Li Y, Cai Z. Curr Top Med Chem. 2019. PMID: 30714527.

2018

PET imaging reveals lower kappa opioid receptor availability in alcoholics but no effect of age.Vijay A, Cavallo D, Goldberg A, de Laat B, Nabulsi N, Huang Y, Krishnan-Sarin S, Morris ED. Neuropsychopharmacology. 2018 Dec; 2018 Sep 6. PMID: 30188515.
Clinical and scientific value in the pursuit of quantification of beta cells in the pancreas by PET imaging.Cline GW, McCarthy TJ, Carson RE, Calle RA. Diabetologia. 2018 Dec; 2018 Aug 22. PMID: 30136144.
Decreased VMAT2 in the pancreas of humans with type 2 diabetes mellitus measured in vivo by PET imaging.Cline GW, Naganawa M, Chen L, Chidsey K, Carvajal-Gonzalez S, Pawlak S, Rossulek M, Zhang Y, Bini J, McCarthy TJ, Carson RE, Calle RA. Diabetologia. 2018 Dec; 2018 May 2. PMID: 29721633.
The Importance of Drug and Sex Effects in Psychiatric Research.Hillmer AT. Biol Psychiatry. 2018 Nov 15. PMID: 30360777.
Kinetic evaluation and test-retest reproducibility of [(11)C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans.Finnema SJ, Nabulsi NB, Mercier J, Lin SF, Chen MK, Matuskey D, Gallezot JD, Henry S, Hannestad J, Huang Y, Carson RE. J Cereb Blood Flow Metab. 2018 Nov; 2017 Aug 9. PMID: 28792356.
Sex differences in the nicotinic acetylcholine and dopamine receptor systems underlying tobacco smoking addiction.Verplaetse TL, Morris ED, McKee SA, Cosgrove KP. Curr Opin Behav Sci. 2018 Oct; 2018 Apr 26. PMID: 31341936.
Automated radiosynthesis of [(18)F]FBEM, a sulfhydryl site specific labeling agent for peptides and proteins.Lim K, Ropchan J, Kiesewetter DO, Chen X, Huang Y. Appl Radiat Isot. 2018 Oct; 2018 Jul 29. PMID: 30098587.
Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging.Chen MK, Mecca AP, Naganawa M, Finnema SJ, Toyonaga T, Lin SF, Najafzadeh S, Ropchan J, Lu Y, McDonald JW, Michalak HR, Nabulsi NB, Arnsten AFT, Huang Y, Carson RE, van Dyck CH. JAMA Neurol. 2018 Oct 1. PMID: 30014145.
Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [(18)F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes.Naganawa M, Lim K, Nabulsi NB, Lin SF, Labaree D, Ropchan J, Herold KC, Huang Y, Harris P, Ichise M, Cline GW, Carson RE. Mol Imaging Biol. 2018 Oct. PMID: 29468404.
Dose-Related Target Occupancy and Effects on Circuitry, Behavior, and Neuroplasticity of the Glycine Transporter-1 Inhibitor PF-03463275 in Healthy and Schizophrenia Subjects.D'Souza DC, Carson RE, Driesen N, Johannesen J, Ranganathan M, Krystal JH. Biol Psychiatry. 2018 Sep 15; 2018 Jan 31. PMID: 29499855.
Improved discrimination between benign and malignant LDCT screening-detected lung nodules with dynamic over static (18)F-FDG PET as a function of injected dose.Ye Q, Wu J, Lu Y, Naganawa M, Gallezot JD, Ma T, Liu Y, Tanoue L, Detterbeck F, Blasberg J, Chen MK, Casey M, Carson RE, Liu C. Phys Med Biol. 2018 Sep 6; 2018 Sep 6. PMID: 30095083.
High Single Doses of Radiation May Induce Elevated Levels of Hypoxia in Early-Stage Non-Small Cell Lung Cancer Tumors.Kelada OJ, Decker RH, Nath SK, Johung KL, Zheng MQ, Huang Y, Gallezot JD, Liu C, Carson RE, Oelfke U, Carlson DJ. Int J Radiat Oncol Biol Phys. 2018 Sep 1; 2018 Jun 1. PMID: 30102194.
Kappa opioid receptor binding in major depression: A pilot study.Miller JM, Zanderigo F, Purushothaman PD, DeLorenzo C, Rubin-Falcone H, Ogden RT, Keilp J, Oquendo MA, Nabulsi N, Huang YH, Parsey RV, Carson RE, Mann JJ. Synapse. 2018 Sep; 2018 Jul 17. PMID: 29935119.
Age-Related Change in 5-HT(6) Receptor Availability in Healthy Male Volunteers Measured with (11)C-GSK215083 PET.Radhakrishnan R, Nabulsi N, Gaiser E, Gallezot JD, Henry S, Planeta B, Lin SF, Ropchan J, Williams W, Morris E, D'Souza DC, Huang Y, Carson RE, Matuskey D. J Nucl Med. 2018 Sep; 2018 Apr 6. PMID: 29626125.
Respiratory Motion Compensation for PET/CT with Motion Information Derived from Matched Attenuation-Corrected Gated PET Data.Lu Y, Fontaine K, Mulnix T, Onofrey JA, Ren S, Panin V, Jones J, Casey ME, Barnett R, Kench P, Fulton R, Carson RE, Liu C. J Nucl Med. 2018 Sep; 2018 Feb 9. PMID: 29439015.
Evaluation of PET Brain Radioligands for Imaging Pancreatic β-Cell Mass: Potential Utility of (11)C-(+)-PHNO.Bini J, Naganawa M, Nabulsi N, Huang Y, Ropchan J, Lim K, Najafzadeh S, Herold KC, Cline GW, Carson RE. J Nucl Med. 2018 Aug; 2018 Jan 25. PMID: 29371405.
In Vivo Reactive Oxygen Species Detection With a Novel Positron Emission Tomography Tracer, (18)F-DHMT, Allows for Early Detection of Anthracycline-Induced Cardiotoxicity in Rodents.Boutagy NE, Wu J, Cai Z, Zhang W, Booth CJ, Kyriakides TC, Pfau D, Mulnix T, Liu Z, Miller EJ, Young LH, Carson RE, Huang Y, Liu C, Sinusas AJ. JACC Basic Transl Sci. 2018 Jun; 2018 May 30. PMID: 30062224.
Noradrenergic Activity in the Human Brain: A Mechanism Supporting the Defense Against Hypoglycemia.Belfort-DeAguiar R, Gallezot JD, Hwang JJ, Elshafie A, Yeckel CW, Chan O, Carson RE, Ding YS, Sherwin RS. J Clin Endocrinol Metab. 2018 Jun 1. PMID: 29590401.
Evaluation of [(89)Zr]trastuzumab-PET/CT in differentiating HER2-positive from HER2-negative breast cancer.Dehdashti F, Wu N, Bose R, Naughton MJ, Ma CX, Marquez-Nostra BV, Diebolder P, Mpoy C, Rogers BE, Lapi SE, Laforest R, Siegel BA. Breast Cancer Res Treat. 2018 Jun; 2018 Feb 13. PMID: 29442264.
The Effect of Treatment with Guanfacine, an Alpha2 Adrenergic Agonist, on Dopaminergic Tone in Tobacco Smokers: An [(11)C]FLB457 PET Study.Sandiego CM, Matuskey D, Lavery M, McGovern E, Huang Y, Nabulsi N, Ropchan J, Picciotto MR, Morris ED, McKee SA, Cosgrove KP. Neuropsychopharmacology. 2018 Apr; 2017 Sep 25. PMID: 28944773.
Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [(11)C]ABP688 and PET imaging study in depression.Esterlis I, DellaGioia N, Pietrzak RH, Matuskey D, Nabulsi N, Abdallah CG, Yang J, Pittenger C, Sanacora G, Krystal JH, Parsey RV, Carson RE, DeLorenzo C. Mol Psychiatry. 2018 Apr; 2017 Apr 11. PMID: 28397841.
Bridging from Brain to Tumor Imaging: (S)-(-)- and (R)-(+)-[(18)F]Fluspidine for Investigation of Sigma-1 Receptors in Tumor-Bearing Mice.Kranz M, Bergmann R, Kniess T, Belter B, Neuber C, Cai Z, Deng G, Fischer S, Zhou J, Huang Y, Brust P, Deuther-Conrad W, Pietzsch J. Molecules. 2018 Mar 20; 2018 Mar 20. PMID: 29558382.
Use of Electronic Cigarettes Leads to Significant Beta2-Nicotinic Acetylcholine Receptor Occupancy: Evidence From a PET Imaging Study.Baldassarri SR, Hillmer AT, Anderson JM, Jatlow P, Nabulsi N, Labaree D, Cosgrove KP, O'Malley SS, Eissenberg T, Krishnan-Sarin S, Esterlis I. Nicotine Tob Res. 2018 Mar 6. PMID: 28460123.
Evaluation of (-)-[(18) F]Flubatine-specific binding: Implications for reference region approaches.Bhatt S, Hillmer AT, Nabulsi N, Matuskey D, Lim K, Lin SF, Esterlis I, Carson RE, Huang Y, Cosgrove KP. Synapse. 2018 Mar; 2017 Nov 17. PMID: 29105121.
Protective and restorative effects of the traditional Chinese medicine Jitai tablet against methamphetamine-induced dopaminergic neurotoxicity.Xu S, Tu S, Gao J, Liu J, Guo Z, Zhang J, Liu X, Liang J, Huang Y, Han M. BMC Complement Altern Med. 2018 Feb 23; 2018 Feb 23. PMID: 29475448.
Cardiac-gated parametric images from (82) Rb PET from dynamic frames and direct 4D reconstruction.Germino M, Carson RE. Med Phys. 2018 Feb; 2017 Dec 30. PMID: 29205378.
Evaluation of the Lysophosphatidic Acid Receptor Type 1 Radioligand (11)C-BMT-136088 for Lung Imaging in Rhesus Monkeys.Gallezot JD, Nabulsi NB, Holden D, Lin SF, Labaree D, Ropchan J, Najafzadeh S, Donnelly DJ, Cao K, Bonacorsi S, Seiders J, Roppe J, Hayes W, Huang Y, Du S, Carson RE. J Nucl Med. 2018 Feb; 2017 Sep 1. PMID: 28864634.
Targeting HER2 in Nuclear Medicine for Imaging and Therapy.Massicano AVF, Marquez-Nostra BV, Lapi SE. Mol Imaging. 2018 Jan-Dec. PMID: 29357745.
Cortical β-amyloid burden, gray matter, and memory in adults at varying APOE ε4 risk for Alzheimer's disease.Mecca AP, Barcelos NM, Wang S, Brück A, Nabulsi N, Planeta-Wilson B, Nadelmann J, Benincasa AL, Ropchan J, Huang Y, Gelernter J, Van Ness PH, Carson RE, van Dyck CH. Neurobiol Aging. 2018 Jan; 2017 Oct 6. PMID: 29111487.
A 3D-printed modular device for imaging the brain of small birds.Lattin CR, Emerson MA, Gallezot JD, Mulnix T, Brown JE, Carson RE. J Neurosci Methods. 2018 Jan 1; 2017 Oct 6. PMID: 28988856.
Novel (18)F-Labeled κ-Opioid Receptor Antagonist as PET Radiotracer: Synthesis and In Vivo Evaluation of (18)F-LY2459989 in Nonhuman Primates.Li S, Cai Z, Zheng MQ, Holden D, Naganawa M, Lin SF, Ropchan J, Labaree D, Kapinos M, Lara-Jaime T, Navarro A, Huang Y. J Nucl Med. 2018 Jan; 2017 Jul 26. PMID: 28747521.

2017

Human biodistribution and dosimetry of [(18)F]nifene, an α4β2* nicotinic acetylcholine receptor PET tracer.Betthauser TJ, Hillmer AT, Lao PJ, Ehlerding E, Mukherjee J, Stone CK, Christian BT. Nucl Med Biol. 2017 Dec; 2017 Aug 17. PMID: 28963927.
Microglial depletion and activation: A [(11)C]PBR28 PET study in nonhuman primates.Hillmer AT, Holden D, Fowles K, Nabulsi N, West BL, Carson RE, Cosgrove KP. EJNMMI Res. 2017 Dec; 2017 Jul 24. PMID: 28741281.
Quantification of Tumor Hypoxic Fractions Using Positron Emission Tomography with [(18)F]Fluoromisonidazole ([(18)F]FMISO) Kinetic Analysis and Invasive Oxygen Measurements.Kelada OJ, Rockwell S, Zheng MQ, Huang Y, Liu Y, Booth CJ, Decker RH, Oelfke U, Carson RE, Carlson DJ. Mol Imaging Biol. 2017 Dec. PMID: 28409339.
In vivo imaging of translocator protein, a marker of activated microglia, in alcohol dependence.Hillmer AT, Sandiego CM, Hannestad J, Angarita GA, Kumar A, McGovern EM, Huang Y, O'Connor KC, Carson RE, O'Malley SS, Cosgrove KP. Mol Psychiatry. 2017 Dec; 2017 Feb 28. PMID: 28242869.
Preclinical PET imaging of glycoprotein non-metastatic melanoma B in triple negative breast cancer: feasibility of an antibody-based companion diagnostic agent.Marquez-Nostra BV, Lee S, Laforest R, Vitale L, Nie X, Hyrc K, Keler T, Hawthorne T, Hoog J, Li S, Dehdashti F, Ma CX, Lapi SE. Oncotarget. 2017 Nov 28; 2017 Nov 1. PMID: 29262642.
A modification to improve the reliability of [(11) C]CN(-) production in the GE radiochemistry system.Labaree DC, Ropchan JR, Nabulsi N, Huang Y. J Labelled Comp Radiopharm. 2017 Oct; 2017 Sep 21. PMID: 28833348.
Reduced dopamine receptors and transporters but not synthesis capacity in normal aging adults: a meta-analysis.Karrer TM, Josef AK, Mata R, Morris ED, Samanez-Larkin GR. Neurobiol Aging. 2017 Sep; 2017 May 12. PMID: 28599217.
Estradiol modulates neural response to conspecific and heterospecific song in female house sparrows: An in vivo positron emission tomography study.Lattin CR, Stabile FA, Carson RE. PLoS One. 2017; 2017 Aug 23. PMID: 28832614.
Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence.Holmes SE, Girgenti MJ, Davis MT, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Duman RS, Carson RE, Krystal JH, Esterlis I. Proc Natl Acad Sci U S A. 2017 Aug 1; 2017 Jul 17. PMID: 28716937.
[(18) F]Nifene test-retest reproducibility in first-in-human imaging of α4β2* nicotinic acetylcholine receptors.Lao PJ, Betthauser TJ, Tudorascu DL, Barnhart TE, Hillmer AT, Stone CK, Mukherjee J, Christian BT. Synapse. 2017 Aug; 2017 Apr 26. PMID: 28420041.
In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [(11)C]ABP688 and [(18)F]FPEB.DeLorenzo C, Gallezot JD, Gardus J, Yang J, Planeta B, Nabulsi N, Ogden RT, Labaree DC, Huang YH, Mann JJ, Gasparini F, Lin X, Javitch JA, Parsey RV, Carson RE, Esterlis I. J Cereb Blood Flow Metab. 2017 Aug; 2016 Jan 1. PMID: 27742888.
(18)F-Labeled indole-based analogs as highly selective radioligands for imaging sigma-2 receptors in the brain.Wang L, Ye J, He Y, Deuther-Conrad W, Zhang J, Zhang X, Cui M, Steinbach J, Huang Y, Brust P, Jia H. Bioorg Med Chem. 2017 Jul 15; 2017 May 10. PMID: 28549890.
Direct reconstruction of parametric images for brain PET with event-by-event motion correction: evaluation in two tracers across count levels.Germino M, Gallezot JD, Yan J, Carson RE. Phys Med Biol. 2017 Jul 7; 2017 May 15. PMID: 28504644.
Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study.Abdallah CG, Hannestad J, Mason GF, Holmes SE, DellaGioia N, Sanacora G, Jiang L, Matuskey D, Satodiya R, Gasparini F, Lin X, Javitch J, Planeta B, Nabulsi N, Carson RE, Esterlis I. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Jul; 2017 Apr 6. PMID: 28993818.
PET Imaging for Early Detection of Alzheimer's Disease: From Pathologic to Physiologic Biomarkers.Bao W, Jia H, Finnema S, Cai Z, Carson RE, Huang YH. PET Clin. 2017 Jul; 2017 May 2. PMID: 28576171.
Data-driven event-by-event respiratory motion correction using TOF PET list-mode centroid of distribution.Ren S, Jin X, Chan C, Jian Y, Mulnix T, Liu C, Carson RE. Phys Med Biol. 2017 Jun 21; 2017 May 18. PMID: 28520558.
PET Imaging Evaluation of Four σ(1) Radiotracers in Nonhuman Primates.Baum E, Cai Z, Bois F, Holden D, Lin SF, Lara-Jaime T, Kapinos M, Chen Y, Deuther-Conrad W, Fischer S, Dukic-Stefanovic S, Bunse P, Wünsch B, Brust P, Jia H, Huang Y. J Nucl Med. 2017 Jun; 2017 Feb 23. PMID: 28232607.
PET imaging of α(7) nicotinic acetylcholine receptors: a comparative study of [(18)F]ASEM and [(18)F]DBT-10 in nonhuman primates, and further evaluation of [(18)F]ASEM in humans.Hillmer AT, Li S, Zheng MQ, Scheunemann M, Lin SF, Nabulsi N, Holden D, Pracitto R, Labaree D, Ropchan J, Teodoro R, Deuther-Conrad W, Esterlis I, Cosgrove KP, Brust P, Carson RE, Huang Y. Eur J Nucl Med Mol Imaging. 2017 Jun; 2017 Jan 24. PMID: 28120003.
1-(4-[(18)F]Fluorobenzyl)-4-[(tetrahydrofuran-2-yl)methyl]piperazine: A Novel Suitable Radioligand with Low Lipophilicity for Imaging σ(1) Receptors in the Brain.He Y, Xie F, Ye J, Deuther-Conrad W, Cui B, Wang L, Lu J, Steinbach J, Brust P, Huang Y, Lu J, Jia H. J Med Chem. 2017 May 25; 2017 May 8. PMID: 28409931.
A multi species evaluation of the radiation dosimetry of [(11)C]erlotinib, the radiolabeled analog of a clinically utilized tyrosine kinase inhibitor.Petrulli JR, Hansen SB, Abourbeh G, Yaqub M, Bahce I, Holden D, Huang Y, Nabulsi NB, Contessa JN, Mishani E, Lammertsma AA, Morris ED. Nucl Med Biol. 2017 Apr; 2017 Jan 2. PMID: 28126682.
Systemic inflammation enhances stimulant-induced striatal dopamine elevation.Petrulli JR, Kalish B, Nabulsi NB, Huang Y, Hannestad J, Morris ED. Transl Psychiatry. 2017 Mar 28; 2017 Mar 28. PMID: 28350401.
Regional and source-based patterns of [(11)C]-(+)-PHNO binding potential reveal concurrent alterations in dopamine D(2) and D(3) receptor availability in cocaine-use disorder.Worhunsky PD, Matuskey D, Gallezot JD, Gaiser EC, Nabulsi N, Angarita GA, Calhoun VD, Malison RT, Potenza MN, Carson RE. Neuroimage. 2017 Mar 1; 2017 Jan 19. PMID: 28110088.
Erratum to: The need of standardization and of large clinical studies in an emerging indication of [18 F]FDG PET: the autoimmune encephalitis.Morbelli S, Arbizu J, Booij J, Chen MK, Chetelat G, Cross DJ, Djekidel M, Drzezga A, Ekmekcioglu O, Garibotto V, Hesse S, Ishii K, Jafari L, Lammertsma AA, Law I, Mathews D, Minoshima S, Mosci K, Pagani M, Pappata S, Silverman DH, Signore A, Van De Giessen E, Villemagne V, Barthel H. Eur J Nucl Med Mol Imaging. 2017 Mar. PMID: 27987029.
The need of standardization and of large clinical studies in an emerging indication of [(18)F]FDG PET: the autoimmune encephalitis.Morbelli S, Arbizu J, Booij J, Chen MK, Chetelat G, Cross DJ, Djekidel M, Drzezga A, Ekmekcioglu O, Garibotto V, Hesse S, Ishii K, Jafari L, Lammertsma AA, Law I, Mathews D, Minoshima S, Mosci K, Pagani M, Pappata S, Silverman DH, Signore A, Van De Giessen E, Villemagne V, Barthel H. Eur J Nucl Med Mol Imaging. 2017 Mar; 2016 Dec 6. PMID: 27924371.
Determination of receptor occupancy in the presence of mass dose: [(11)C]GSK189254 PET imaging of histamine H(3) receptor occupancy by PF-03654746.Gallezot JD, Planeta B, Nabulsi N, Palumbo D, Li X, Liu J, Rowinski C, Chidsey K, Labaree D, Ropchan J, Lin SF, Sawant-Basak A, McCarthy TJ, Schmidt AW, Huang Y, Carson RE. J Cereb Blood Flow Metab. 2017 Mar; 2016 Jul 20. PMID: 27207170.
A framework for designing dynamic lp-ntPET studies to maximize the sensitivity to transient neurotransmitter responses to drugs: Application to dopamine and smoking.Wang S, Kim S, Cosgrove KP, Morris ED. Neuroimage. 2017 Feb 1; 2016 Oct 13. PMID: 27743899.
Quantitative projection of human brain penetration of the H(3) antagonist PF-03654746 by integrating rat-derived brain partitioning and PET receptor occupancy.Sawant-Basak A, Chen L, Shaffer CL, Palumbo D, Schmidt A, Tseng E, Spracklin DK, Gallezot JD, Labaree D, Nabulsi N, Huang Y, Carson RE, McCarthy T. Xenobiotica. 2017 Feb; 2016 Jun 29. PMID: 27353353.
Fluorine-18-Labeled Antagonist for PET Imaging of Kappa Opioid Receptors.Cai Z, Li S, Pracitto R, Navarro A, Shirali A, Ropchan J, Huang Y. ACS Chem Neurosci. 2017 Jan 18; 2016 Oct 20. PMID: 27741398.
The Search for a Subtype-Selective PET Imaging Agent for the GABA(A) Receptor Complex: Evaluation of the Radiotracer [(11)C]ADO in Nonhuman Primates.Lin SF, Bois F, Holden D, Nabulsi N, Pracitto R, Gao H, Kapinos M, Teng JK, Shirali A, Ropchan J, Carson RE, Elmore CS, Vasdev N, Huang Y. Mol Imaging. 2017 Jan-Dec. PMID: 28929924.

2016

Optimized and Automated Radiosynthesis of [(18)F]DHMT for Translational Imaging of Reactive Oxygen Species with Positron Emission Tomography.Zhang W, Cai Z, Li L, Ropchan J, Lim K, Boutagy NE, Wu J, Stendahl JC, Chu W, Gropler R, Sinusas AJ, Liu C, Huang Y. Molecules. 2016 Dec 9; 2016 Dec 9. PMID: 27941676.
Evaluation of pancreatic VMAT2 binding with active and inactive enantiomers of (18)F-FP-DTBZ in baboons.Naganawa M, Lin SF, Lim K, Labaree D, Ropchan J, Harris P, Huang Y, Ichise M, Carson RE, Cline GW. Nucl Med Biol. 2016 Dec; 2016 Sep 2. PMID: 27673755.
Quantification of myocardial blood flow with (82)Rb: Validation with (15)O-water using time-of-flight and point-spread-function modeling.Germino M, Ropchan J, Mulnix T, Fontaine K, Nabulsi N, Ackah E, Feringa H, Sinusas AJ, Liu C, Carson RE. EJNMMI Res. 2016 Dec; 2016 Aug 1. PMID: 27650280.
Erratum to: Toxicity and radiation dosimetry studies of the serotonin transporter radioligand [(18)F]AFM in rats and monkeys.Huang YY, Cheng CY, Huang WS, Ma KH, Tseng TW, Chou TK, Huang Y, Shiue CY. EJNMMI Res. 2016 Dec; 2016 Sep 6. PMID: 27600887.
Elevated Dopamine D(2/3) Receptor Availability in Obese Individuals: A PET Imaging Study with [(11)C](+)PHNO.Gaiser EC, Gallezot JD, Worhunsky PD, Jastreboff AM, Pittman B, Kantrovitz L, Angarita GA, Cosgrove KP, Potenza MN, Malison RT, Carson RE, Matuskey D. Neuropsychopharmacology. 2016 Dec; 2016 Jul 4. PMID: 27374277.
Imaging of cerebral α4β2* nicotinic acetylcholine receptors with (-)-[(18)F]Flubatine PET: Implementation of bolus plus constant infusion and sensitivity to acetylcholine in human brain.Hillmer AT, Esterlis I, Gallezot JD, Bois F, Zheng MQ, Nabulsi N, Lin SF, Papke RL, Huang Y, Sabri O, Carson RE, Cosgrove KP. Neuroimage. 2016 Nov 1; 2016 Jul 15. PMID: 27426839.
Preferential binding to dopamine D3 over D2 receptors by cariprazine in patients with schizophrenia using PET with the D3/D2 receptor ligand [(11)C]-(+)-PHNO.Girgis RR, Slifstein M, D'Souza D, Lee Y, Periclou A, Ghahramani P, Laszlovszky I, Durgam S, Adham N, Nabulsi N, Huang Y, Carson RE, Kiss B, Kapás M, Abi-Dargham A, Rakhit A. Psychopharmacology (Berl). 2016 Oct; 2016 Aug 15. PMID: 27525990.
Preclinical Evaluation of 18F-PF-05270430, a Novel PET Radioligand for the Phosphodiesterase 2A Enzyme.Chen L, Nabulsi N, Naganawa M, Zasadny K, Skaddan MB, Zhang L, Najafzadeh S, Lin SF, Helal CJ, Boyden TL, Chang C, Ropchan J, Carson RE, Villalobos A, Huang Y. J Nucl Med. 2016 Sep; 2016 May 19. PMID: 27199356.
First-in-Human Assessment of the Novel PDE2A PET Radiotracer 18F-PF-05270430.Naganawa M, Waterhouse RN, Nabulsi N, Lin SF, Labaree D, Ropchan J, Tarabar S, DeMartinis N, Ogden A, Banerjee A, Huang Y, Carson RE. J Nucl Med. 2016 Sep; 2016 Apr 21. PMID: 27103022.
PET imaging reveals sex differences in kappa opioid receptor availability in humans, in vivo.Vijay A, Wang S, Worhunsky P, Zheng MQ, Nabulsi N, Ropchan J, Krishnan-Sarin S, Huang Y, Morris ED. Am J Nucl Med Mol Imaging. 2016; 2016 Aug 20. PMID: 27648372.
Imaging synaptic density in the living human brain.Finnema SJ, Nabulsi NB, Eid T, Detyniecki K, Lin SF, Chen MK, Dhaher R, Matuskey D, Baum E, Holden D, Spencer DD, Mercier J, Hannestad J, Huang Y, Carson RE. Sci Transl Med. 2016 Jul 20. PMID: 27440727.
Event-by-Event Continuous Respiratory Motion Correction for Dynamic PET Imaging.Yu Y, Chan C, Ma T, Liu Y, Gallezot JD, Naganawa M, Kelada OJ, Germino M, Sinusas AJ, Carson RE, Liu C. J Nucl Med. 2016 Jul; 2016 Feb 23. PMID: 26912437.
Dopamine D3 Receptor Availability Is Associated with Inflexible Decision Making.Groman SM, Smith NJ, Petrullli JR, Massi B, Chen L, Ropchan J, Huang Y, Lee D, Morris ED, Taylor JR. J Neurosci. 2016 Jun 22. PMID: 27335404.
Reduced Brain Cannabinoid Receptor Availability in Schizophrenia.Ranganathan M, Cortes-Briones J, Radhakrishnan R, Thurnauer H, Planeta B, Skosnik P, Gao H, Labaree D, Neumeister A, Pittman B, Surti T, Huang Y, Carson RE, D'Souza DC. Biol Psychiatry. 2016 Jun 15; 2015 Aug 29. PMID: 26432420.
OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding.Pittenger C, Adams TG Jr, Gallezot JD, Crowley MJ, Nabulsi N, James Ropchan, Gao H, Kichuk SA, Simpson R, Billingslea E, Hannestad J, Bloch M, Mayes L, Bhagwagar Z, Carson RE. J Affect Disord. 2016 May 15; 2016 Feb 9. PMID: 26919057.
Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain.Nabulsi NB, Mercier J, Holden D, Carré S, Najafzadeh S, Vandergeten MC, Lin SF, Deo A, Price N, Wood M, Lara-Jaime T, Montel F, Laruelle M, Carson RE, Hannestad J, Huang Y. J Nucl Med. 2016 May; 2016 Feb 4. PMID: 26848175.
Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging.Han L, Kong DK, Zheng MQ, Murikinati S, Ma C, Yuan P, Li L, Tian D, Cai Q, Ye C, Holden D, Park JH, Gao X, Thomas JL, Grutzendler J, Carson RE, Huang Y, Piepmeier JM, Zhou J. ACS Nano. 2016 Apr 26; 2016 Mar 16. PMID: 26967254.
Age-related changes in binding of the D2/3 receptor radioligand [(11)C](+)PHNO in healthy volunteers.Matuskey D, Worhunksy P, Correa E, Pittman B, Gallezot JD, Nabulsi N, Ropchan J, Sreeram V, Gudepu R, Gaiser E, Cosgrove K, Ding YS, Potenza MN, Huang Y, Malison RT, Carson RE. Neuroimage. 2016 Apr 15; 2016 Feb 11. PMID: 26876475.
Nicotine and Nicotine Abstinence Do Not Interfere with GABAA Receptor Neuroadaptations During Alcohol Abstinence.Hillmer AT, Kloczynski T, Sandiego CM, Pittman B, Anderson JM, Labaree D, Gao H, Huang Y, Deluliis G, O'Malley SS, Carson RE, Cosgrove KP. Alcohol Clin Exp Res. 2016 Apr; 2016 Mar 12. PMID: 26971694.
Neuroprotective effects of stemazole in the MPTP-induced acute model of Parkinson's disease: Involvement of the dopamine system.Guo Z, Xu S, Du N, Liu J, Huang Y, Han M. Neurosci Lett. 2016 Mar 11; 2016 Jan 28. PMID: 26827716.
Determining the Minimal Required Radioactivity of 18F-FDG for Reliable Semiquantification in PET/CT Imaging: A Phantom Study.Chen MK, Menard DH 3rd, Cheng DW. J Nucl Med Technol. 2016 Mar; 2016 Jan 14. PMID: 26769598.
Comparative evaluation of two glycine transporter 1 radiotracers [11C]GSK931145 and [18F]MK-6577 in baboons.Zheng MQ, Lin SF, Holden D, Naganawa M, Ropchan JR, Najafzaden S, Kapinos M, Tabriz M, Carson RE, Hamill TG, Huang Y. Synapse. 2016 Mar; 2016 Jan 6. PMID: 26671330.
PET imaging evaluation of [(18)F]DBT-10, a novel radioligand specific to α7 nicotinic acetylcholine receptors, in nonhuman primates.Hillmer AT, Zheng MQ, Li S, Scheunemann M, Lin SF, Holden D, Labaree D, Ropchan J, Teodoro R, Deuther-Conrad W, Carson RE, Brust P, Huang Y. Eur J Nucl Med Mol Imaging. 2016 Mar; 2015 Oct 12. PMID: 26455500.
Brivaracetam, a selective high-affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of action.Nicolas JM, Hannestad J, Holden D, Kervyn S, Nabulsi N, Tytgat D, Huang Y, Chanteux H, Staelens L, Matagne A, Mathy FX, Mercier J, Stockis A, Carson RE, Klitgaard H. Epilepsia. 2016 Feb; 2015 Dec 10. PMID: 26663401.
Receptor Occupancy of the κ-Opioid Antagonist LY2456302 Measured with Positron Emission Tomography and the Novel Radiotracer 11C-LY2795050.Naganawa M, Dickinson GL, Zheng MQ, Henry S, Vandenhende F, Witcher J, Bell R, Nabulsi N, Lin SF, Ropchan J, Neumeister A, Ranganathan M, Tauscher J, Huang Y, Carson RE. J Pharmacol Exp Ther. 2016 Feb; 2015 Dec 1. PMID: 26628406.

2015

How Imaging Glutamate, γ-Aminobutyric Acid, and Dopamine Can Inform the Clinical Treatment of Alcohol Dependence and Withdrawal.Hillmer AT, Mason GF, Fucito LM, O'Malley SS, Cosgrove KP. Alcohol Clin Exp Res. 2015 Dec; 2015 Oct 28. PMID: 26510169.
Measurement of Bmax and Kd with the glycine transporter 1 radiotracer ¹⁸F-MK6577 using a novel multi-infusion paradigm.Xia Y, Zheng MQ, Holden D, Lin SF, Kapinos M, Ropchan J, Gallezot JD, Huang Y, Carson RE. J Cereb Blood Flow Metab. 2015 Dec; 2015 Jul 22. PMID: 26198176.
A Promising PET Tracer for Imaging of α₇ Nicotinic Acetylcholine Receptors in the Brain: Design, Synthesis, and in Vivo Evaluation of a Dibenzothiophene-Based Radioligand.Teodoro R, Scheunemann M, Deuther-Conrad W, Wenzel B, Fasoli FM, Gotti C, Kranz M, Donat CK, Patt M, Hillmer A, Zheng MQ, Peters D, Steinbach J, Sabri O, Huang Y, Brust P. Molecules. 2015 Oct 9; 2015 Oct 9. PMID: 26473809.
Imaging robust microglial activation after lipopolysaccharide administration in humans with PET.Sandiego CM, Gallezot JD, Pittman B, Nabulsi N, Lim K, Lin SF, Matuskey D, Lee JY, O'Connor KC, Huang Y, Carson RE, Hannestad J, Cosgrove KP. Proc Natl Acad Sci U S A. 2015 Oct 6; 2015 Sep 18. PMID: 26385967.
A preliminary study of dopamine D2/3 receptor availability and social status in healthy and cocaine dependent humans imaged with [(11)C](+)PHNO.Matuskey D, Gaiser EC, Gallezot JD, Angarita GA, Pittman B, Nabulsi N, Ropchan J, MaCleod P, Cosgrove KP, Ding YS, Potenza MN, Carson RE, Malison RT. Drug Alcohol Depend. 2015 Sep 1; 2015 Jun 30. PMID: 26164205.
Test-retest reproducibility of the metabotropic glutamate receptor 5 ligand [¹⁸F]FPEB with bolus plus constant infusion in humans.Park E, Sullivan JM, Planeta B, Gallezot JD, Lim K, Lin SF, Ropchan J, McCarthy TJ, Ding YS, Morris ED, Williams WA, Huang Y, Carson RE. Eur J Nucl Med Mol Imaging. 2015 Sep; 2015 Jun 5. PMID: 26044120.
Imaging the cannabinoid CB1 receptor in humans with [11C]OMAR: assessment of kinetic analysis methods, test-retest reproducibility, and gender differences.Normandin MD, Zheng MQ, Lin KS, Mason NS, Lin SF, Ropchan J, Labaree D, Henry S, Williams WA, Carson RE, Neumeister A, Huang Y. J Cereb Blood Flow Metab. 2015 Aug; 2015 Apr 1. PMID: 25833345.
Evaluation of [(18)F]-(-)-norchlorofluorohomoepibatidine ([(18)F]-(-)-NCFHEB) as a PET radioligand to image the nicotinic acetylcholine receptors in non-human primates.Bois F, Gallezot JD, Zheng MQ, Lin SF, Esterlis I, Cosgrove KP, Carson RE, Huang Y. Nucl Med Biol. 2015 Jun; 2014 Aug 8. PMID: 25858513.
(11)C-PBR28 imaging in multiple sclerosis patients and healthy controls: test-retest reproducibility and focal visualization of active white matter areas.Park E, Gallezot JD, Delgadillo A, Liu S, Planeta B, Lin SF, O'Connor KC, Lim K, Lee JY, Chastre A, Chen MK, Seneca N, Leppert D, Huang Y, Carson RE, Pelletier D. Eur J Nucl Med Mol Imaging. 2015 Jun; 2015 Apr 2. PMID: 25833352.
Imaging human brown adipose tissue under room temperature conditions with (11)C-MRB, a selective norepinephrine transporter PET ligand.Hwang JJ, Yeckel CW, Gallezot JD, Aguiar RB, Ersahin D, Gao H, Kapinos M, Nabulsi N, Huang Y, Cheng D, Carson RE, Sherwin R, Ding YS. Metabolism. 2015 Jun; 2015 Mar 5. PMID: 25798999.
Synthesis of [(18)F]FMISO in a flow-through microfluidic reactor: Development and clinical application.Zheng MQ, Collier L, Bois F, Kelada OJ, Hammond K, Ropchan J, Akula MR, Carlson DJ, Kabalka GW, Huang Y. Nucl Med Biol. 2015 Jun; 2015 Feb 7. PMID: 25779036.
Opposing relationships of BMI with BOLD and dopamine D2/3 receptor binding potential in the dorsal striatum.Cosgrove KP, Veldhuizen MG, Sandiego CM, Morris ED, Small DM. Synapse. 2015 Apr; 2015 Mar 11. PMID: 25664726.
Deficits in prefrontal cortical and extrastriatal dopamine release in schizophrenia: a positron emission tomographic functional magnetic resonance imaging study.Slifstein M, van de Giessen E, Van Snellenberg J, Thompson JL, Narendran R, Gil R, Hackett E, Girgis R, Ojeil N, Moore H, D'Souza D, Malison RT, Huang Y, Lim K, Nabulsi N, Carson RE, Lieberman JA, Abi-Dargham A. JAMA Psychiatry. 2015 Apr. PMID: 25651194.
Reference region modeling approaches for amphetamine challenge studies with [11C]FLB 457 and PET.Sandiego CM, Gallezot JD, Lim K, Ropchan J, Lin SF, Gao H, Morris ED, Cosgrove KP. J Cereb Blood Flow Metab. 2015 Mar 31; 2015 Mar 31. PMID: 25564239.
Comparison of standardized uptake values with volume of distribution for quantitation of [(11)C]PBR28 brain uptake.Yoder KK, Territo PR, Hutchins GD, Hannestad J, Morris ED, Gallezot JD, Normandin MD, Cosgrove KP. Nucl Med Biol. 2015 Mar; 2014 Nov 15. PMID: 25487553.
Test-retest reliability of the novel 5-HT1B receptor PET radioligand [11C]P943.Saricicek A, Chen J, Planeta B, Ruf B, Subramanyam K, Maloney K, Matuskey D, Labaree D, Deserno L, Neumeister A, Krystal JH, Gallezot JD, Huang Y, Carson RE, Bhagwagar Z. Eur J Nucl Med Mol Imaging. 2015 Mar; 2014 Nov 27. PMID: 25427881.
Test-retest reproducibility of binding parameters in humans with 11C-LY2795050, an antagonist PET radiotracer for the κ opioid receptor.Naganawa M, Zheng MQ, Henry S, Nabulsi N, Lin SF, Ropchan J, Labaree D, Najafzadeh S, Kapinos M, Tauscher J, Neumeister A, Carson RE, Huang Y. J Nucl Med. 2015 Feb; 2015 Jan 15. PMID: 25593119.
Further evaluation of [11C]MP-10 as a radiotracer for phosphodiesterase 10A: PET imaging study in rhesus monkeys and brain tissue metabolite analysis.Lin SF, Labaree D, Chen MK, Holden D, Gallezot JD, Kapinos M, Teng JK, Najafzadeh S, Plisson C, Rabiner EA, Gunn RN, Carson RE, Huang Y. Synapse. 2015 Feb; 2014 Dec 11. PMID: 25450608.
In vivo ketamine-induced changes in [¹¹C]ABP688 binding to metabotropic glutamate receptor subtype 5.DeLorenzo C, DellaGioia N, Bloch M, Sanacora G, Nabulsi N, Abdallah C, Yang J, Wen R, Mann JJ, Krystal JH, Parsey RV, Carson RE, Esterlis I. Biol Psychiatry. 2015 Feb 1; 2014 Jul 10. PMID: 25156701.
Applications of the line-of-response probability density function resolution model in PET list mode reconstruction.Jian Y, Yao R, Mulnix T, Jin X, Carson RE. Phys Med Biol. 2015 Jan 7; 2014 Dec 9. PMID: 25490063.
Evaluation of bias and variance in low-count OSEM list mode reconstruction.Jian Y, Planeta B, Carson RE. Phys Med Biol. 2015 Jan 7; 2014 Dec 5. PMID: 25479254.
Imaging Tobacco Smoking with PET and SPECT.Cosgrove KP, Esterlis I, Sandiego C, Petrulli R, Morris ED. Curr Top Behav Neurosci. 2015. PMID: 25638332.
What is the role of dosimetry in patients with advanced thyroid cancer?Chen MK, Cheng DW. Curr Opin Oncol. 2015 Jan. PMID: 25319079.

2014

Radiolabeling of poly(lactic-co-glycolic acid) (PLGA) nanoparticles with biotinylated F-18 prosthetic groups and imaging of their delivery to the brain with positron emission tomography.Sirianni RW, Zheng MQ, Patel TR, Shafbauer T, Zhou J, Saltzman WM, Carson RE, Huang Y. Bioconjug Chem. 2014 Dec 17; 2014 Dec 1. PMID: 25322194.
Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal.Cosgrove KP, McKay R, Esterlis I, Kloczynski T, Perkins E, Bois F, Pittman B, Lancaster J, Glahn DC, O'Malley S, Carson RE, Krystal JH. Proc Natl Acad Sci U S A. 2014 Dec 16; 2014 Dec 1. PMID: 25453062.
Preclinical to clinical translation of CNS transporter occupancy of TD-9855, a novel norepinephrine and serotonin reuptake inhibitor.Smith JA, Bourdet DL, Daniels OT, Ding YS, Gallezot JD, Henry S, Kim KH, Kshirsagar S, Martin WJ, Obedencio GP, Stangeland E, Tsuruda PR, Williams W, Carson RE, Patil ST. Int J Neuropsychopharmacol. 2014 Dec 13; 2014 Dec 13. PMID: 25522383.
Sex differences in the brain's dopamine signature of cigarette smoking.Cosgrove KP, Wang S, Kim SJ, McGovern E, Nabulsi N, Gao H, Labaree D, Tagare HD, Sullivan JM, Morris ED. J Neurosci. 2014 Dec 10. PMID: 25505336.
Preparation of the metabotropic glutamate receptor 5 (mGluR5) PET tracer [(18)F]FPEB for human use: An automated radiosynthesis and a novel one-pot synthesis of its radiolabeling precursor.Lim K, Labaree D, Li S, Huang Y. Appl Radiat Isot. 2014 Dec; 2014 Sep 18. PMID: 25305528.
Reductions in brain 5-HT1B receptor availability in primarily cocaine-dependent humans.Matuskey D, Bhagwagar Z, Planeta B, Pittman B, Gallezot JD, Chen J, Wanyiri J, Najafzadeh S, Ropchan J, Geha P, Huang Y, Potenza MN, Neumeister A, Carson RE, Malison RT. Biol Psychiatry. 2014 Nov 15; 2013 Nov 28. PMID: 24433854.
Association of in vivo κ-opioid receptor availability and the transdiagnostic dimensional expression of trauma-related psychopathology.Pietrzak RH, Naganawa M, Huang Y, Corsi-Travali S, Zheng MQ, Stein MB, Henry S, Lim K, Ropchan J, Lin SF, Carson RE, Neumeister A. JAMA Psychiatry. 2014 Nov. PMID: 25229257.
The effects of chronic alcohol self-administration on serotonin-1A receptor binding in nonhuman primates.Hillmer AT, Wooten DW, Tudorascu DL, Barnhart TE, Ahlers EO, Resch LM, Larson JA, Converse AK, Moore CF, Schneider ML, Christian BT. Drug Alcohol Depend. 2014 Nov 1; 2014 Aug 29. PMID: 25220896.
Kinetic modeling of (11)C-LY2795050, a novel antagonist radiotracer for PET imaging of the kappa opioid receptor in humans.Naganawa M, Zheng MQ, Nabulsi N, Tomasi G, Henry S, Lin SF, Ropchan J, Labaree D, Tauscher J, Neumeister A, Carson RE, Huang Y. J Cereb Blood Flow Metab. 2014 Nov; 2014 Sep 3. PMID: 25182664.
Evaluation of the sensitivity of the novel α4β2* nicotinic acetylcholine receptor PET radioligand 18F-(-)-NCFHEB to increases in synaptic acetylcholine levels in rhesus monkeys.Gallezot JD, Esterlis I, Bois F, Zheng MQ, Lin SF, Kloczynski T, Krystal JH, Huang Y, Sabri O, Carson RE, Cosgrove KP. Synapse. 2014 Nov; 2014 Jul 28. PMID: 25043426.
Relationship between glycine transporter 1 inhibition as measured with positron emission tomography and changes in cognitive performances in nonhuman primates.Castner SA, Murthy NV, Ridler K, Herdon H, Roberts BM, Weinzimmer DP, Huang Y, Zheng MQ, Rabiner EA, Gunn RN, Carson RE, Williams GV, Laruelle M. Neuropsychopharmacology. 2014 Nov; 2014 Feb 3. PMID: 24487737.
Synthesis and evaluation of a 18F-labeled spirocyclic piperidine derivative as promising σ1 receptor imaging agent.Chen YY, Wang X, Zhang JM, Deuther-Conrad W, Zhang XJ, Huang Y, Li Y, Ye JJ, Cui MC, Steinbach J, Brust P, Liu BL, Jia HM. Bioorg Med Chem. 2014 Oct 1; 2014 Aug 12. PMID: 25189691.
Evaluation of the agonist PET radioligand [¹¹C]GR103545 to image kappa opioid receptor in humans: kinetic model selection, test-retest reproducibility and receptor occupancy by the antagonist PF-04455242.Naganawa M, Jacobsen LK, Zheng MQ, Lin SF, Banerjee A, Byon W, Weinzimmer D, Tomasi G, Nabulsi N, Grimwood S, Badura LL, Carson RE, McCarthy TJ, Huang Y. Neuroimage. 2014 Oct 1; 2014 May 17. PMID: 24844744.
Cannabinoid type 1 receptor availability in the amygdala mediates threat processing in trauma survivors.Pietrzak RH, Huang Y, Corsi-Travali S, Zheng MQ, Lin SF, Henry S, Potenza MN, Piomelli D, Carson RE, Neumeister A. Neuropsychopharmacology. 2014 Oct; 2014 May 12. PMID: 24820537.
Biodistribution and radiation dosimetry of LMI1195: first-in-human study of a novel 18F-labeled tracer for imaging myocardial innervation.Sinusas AJ, Lazewatsky J, Brunetti J, Heller G, Srivastava A, Liu YH, Sparks R, Puretskiy A, Lin SF, Crane P, Carson RE, Lee LV. J Nucl Med. 2014 Sep; 2014 Jul 3. PMID: 24994931.
Voxelwise lp-ntPET for detecting localized, transient dopamine release of unknown timing: sensitivity analysis and application to cigarette smoking in the PET scanner.Kim SJ, Sullivan JM, Wang S, Cosgrove KP, Morris ED. Hum Brain Mapp. 2014 Sep; 2014 Apr 3. PMID: 24700424.
Assessment of patient selection criteria for quantitative imaging with respiratory-gated positron emission tomography.Bowen SR, Pierce LA, Alessio AM, Liu C, Wollenweber SD, Stearns CW, Kinahan PE. J Med Imaging (Bellingham). 2014 Jul; 2014 Sep 24. PMID: 26158039.
An Improved Antagonist Radiotracer for the κ-Opioid Receptor: Synthesis and Characterization of (11)C-LY2459989.Zheng MQ, Kim SJ, Holden D, Lin SF, Need A, Rash K, Barth V, Mitch C, Navarro A, Kapinos M, Maloney K, Ropchan J, Carson RE, Huang Y. J Nucl Med. 2014 Jul; 2014 May 22. PMID: 24854795.
Use of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography to aid in diagnosing intestinal adenocarcinoma in 2 rhesus macaques (Macaca mulatta).Caporizzo DJ, Kwiatkowski AE, Chen MK, Beck AP, Booth CJ, Zeiss C, Smith PC, Carlson Scholz JA, Wilson SR. Comp Med. 2014 Jun. PMID: 24956213.
Parametric Imaging and Test-Retest Variability of ¹¹C-(+)-PHNO Binding to D₂/D₃ Dopamine Receptors in Humans on the High-Resolution Research Tomograph PET Scanner.Gallezot JD, Zheng MQ, Lim K, Lin SF, Labaree D, Matuskey D, Huang Y, Ding YS, Carson RE, Malison RT. J Nucl Med. 2014 Jun; 2014 Apr 14. PMID: 24732151.
Dopamine D₃ receptor alterations in cocaine-dependent humans imaged with [¹¹C](+)PHNO.Matuskey D, Gallezot JD, Pittman B, Williams W, Wanyiri J, Gaiser E, Lee DE, Hannestad J, Lim K, Zheng MQ, Lin SF, Labaree D, Potenza MN, Carson RE, Malison RT, Ding YS. Drug Alcohol Depend. 2014 Jun 1; 2014 Mar 20. PMID: 24717909.
How to design PET experiments to study neurochemistry: application to alcoholism.Morris ED, Lucas MV, Petrulli JR, Cosgrove KP. Yale J Biol Med. 2014 Mar; 2014 Mar 5. PMID: 24600335.
Imaging nicotine- and amphetamine-induced dopamine release in rhesus monkeys with [(11)C]PHNO vs [(11)C]raclopride PET.Gallezot JD, Kloczynski T, Weinzimmer D, Labaree D, Zheng MQ, Lim K, Rabiner EA, Ridler K, Pittman B, Huang Y, Carson RE, Morris ED, Cosgrove KP. Neuropsychopharmacology. 2014 Mar; 2013 Oct 15. PMID: 24220025.
Electron density sharpening as a general technique in crystallographic studies.Liu C, Xiong Y. J Mol Biol. 2014 Feb 20; 2013 Nov 21. PMID: 24269527.
Evaluation of frame-based and event-by-event motion-correction methods for awake monkey brain PET imaging.Jin X, Mulnix T, Sandiego CM, Carson RE. J Nucl Med. 2014 Feb; 2014 Jan 16. PMID: 24434295.
Decreased norepinephrine transporter availability in obesity: Positron Emission Tomography imaging with (S,S)-[(11)C]O-methylreboxetine.Li CS, Potenza MN, Lee DE, Planeta B, Gallezot JD, Labaree D, Henry S, Nabulsi N, Sinha R, Ding YS, Carson RE, Neumeister A. Neuroimage. 2014 Feb 1; 2013 Oct 10. PMID: 24121204.
Clinical doses of atomoxetine significantly occupy both norepinephrine and serotonin transports: Implications on treatment of depression and ADHD.Ding YS, Naganawa M, Gallezot JD, Nabulsi N, Lin SF, Ropchan J, Weinzimmer D, McCarthy TJ, Carson RE, Huang Y, Laruelle M. Neuroimage. 2014 Feb 1; 2013 Aug 9. PMID: 23933039.
Imaging glutamate homeostasis in cocaine addiction with the metabotropic glutamate receptor 5 positron emission tomography radiotracer [(11)C]ABP688 and magnetic resonance spectroscopy.Martinez D, Slifstein M, Nabulsi N, Grassetti A, Urban NB, Perez A, Liu F, Lin SF, Ropchan J, Mao X, Kegeles LS, Shungu DC, Carson RE, Huang Y. Biol Psychiatry. 2014 Jan 15; 2013 Sep 12. PMID: 24035345.
Neuroprotective Effects of Jitai Tablet, a Traditional Chinese Medicine, on the MPTP-Induced Acute Model of Parkinson's Disease: Involvement of the Dopamine System.Liu J, Gao J, Tu S, Xu S, Liu Y, Shang W, Gu C, Huang Y, Han M. Evid Based Complement Alternat Med. 2014; 2014 Apr 2. PMID: 24799940.
In vivo imaging of the metabotropic glutamate receptor 1 (mGluR1) with positron emission tomography: recent advance and perspective.Li S, Huang Y. Curr Med Chem. 2014. PMID: 23992339.

2013

Quantitative analysis of [11C]-erlotinib PET demonstrates specific binding for activating mutations of the EGFR kinase domain.Petrulli JR, Sullivan JM, Zheng MQ, Bennett DC, Charest J, Huang Y, Morris ED, Contessa JN. Neoplasia. 2013 Dec. PMID: 24403856.
Tracer kinetic modeling of [(11)C]AFM, a new PET imaging agent for the serotonin transporter.Naganawa M, Nabulsi N, Planeta B, Gallezot JD, Lin SF, Najafzadeh S, Williams W, Ropchan J, Labaree D, Neumeister A, Huang Y, Carson RE. J Cereb Blood Flow Metab. 2013 Dec; 2013 Aug 7. PMID: 23921898.
Event-by-event respiratory motion correction for PET with 3D internal-1D external motion correlation.Chan C, Jin X, Fung EK, Naganawa M, Mulnix T, Carson RE, Liu C. Med Phys. 2013 Nov. PMID: 24320466.
Awake nonhuman primate brain PET imaging with minimal head restraint: evaluation of GABAA-benzodiazepine binding with 11C-flumazenil in awake and anesthetized animals.Sandiego CM, Jin X, Mulnix T, Fowles K, Labaree D, Ropchan J, Huang Y, Cosgrove K, Castner SA, Williams GV, Wells L, Rabiner EA, Carson RE. J Nucl Med. 2013 Nov; 2013 Oct 10. PMID: 24115528.
Association of posttraumatic stress disorder with reduced in vivo norepinephrine transporter availability in the locus coeruleus.Pietrzak RH, Gallezot JD, Ding YS, Henry S, Potenza MN, Southwick SM, Krystal JH, Carson RE, Neumeister A. JAMA Psychiatry. 2013 Nov. PMID: 24048210.
Evaluation of motion correction methods in human brain PET imaging--a simulation study based on human motion data.Jin X, Mulnix T, Gallezot JD, Carson RE. Med Phys. 2013 Oct. PMID: 24089924.
The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: a [¹¹C]PBR28 PET study.Hannestad J, DellaGioia N, Gallezot JD, Lim K, Nabulsi N, Esterlis I, Pittman B, Lee JY, O'Connor KC, Pelletier D, Carson RE. Brain Behav Immun. 2013 Oct; 2013 Jul 9. PMID: 23850810.
Direct, quantitative, and noninvasive imaging of the transport of active agents through intact brain with positron emission tomography.Sirianni RW, Zheng MQ, Saltzman WM, Huang Y, Carson RE. Mol Imaging Biol. 2013 Oct. PMID: 23624949.
Determination of the in vivo selectivity of a new κ-opioid receptor antagonist PET tracer 11C-LY2795050 in the rhesus monkey.Kim SJ, Zheng MQ, Nabulsi N, Labaree D, Ropchan J, Najafzadeh S, Carson RE, Huang Y, Morris ED. J Nucl Med. 2013 Sep; 2013 Aug 5. PMID: 23918735.
List-mode reconstruction for the Biograph mCT with physics modeling and event-by-event motion correction.Jin X, Chan C, Mulnix T, Panin V, Casey ME, Liu C, Carson RE. Phys Med Biol. 2013 Aug 21; 2013 Jul 29. PMID: 23892635.
Creating dynamic images of short-lived dopamine fluctuations with lp-ntPET: dopamine movies of cigarette smoking.Morris ED, Kim SJ, Sullivan JM, Wang S, Normandin MD, Constantinescu CC, Cosgrove KP. J Vis Exp. 2013 Aug 6; 2013 Aug 6. PMID: 23963311.
Studies of the metabotropic glutamate receptor 5 radioligand [¹¹C]ABP688 with N-acetylcysteine challenge in rhesus monkeys.Sandiego CM, Nabulsi N, Lin SF, Labaree D, Najafzadeh S, Huang Y, Cosgrove K, Carson RE. Synapse. 2013 Aug; 2013 Mar 27. PMID: 23424090.
Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma.Zhou J, Patel TR, Sirianni RW, Strohbehn G, Zheng MQ, Duong N, Schafbauer T, Huttner AJ, Huang Y, Carson RE, Zhang Y, Sullivan DJ Jr, Piepmeier JM, Saltzman WM. Proc Natl Acad Sci U S A. 2013 Jul 16; 2013 Jul 1. PMID: 23818631.
Limitations of SRTM, Logan graphical method, and equilibrium analysis for measuring transient dopamine release with [(11)C]raclopride PET.Sullivan JM, Kim SJ, Cosgrove KP, Morris ED. Am J Nucl Med Mol Imaging. 2013; 2013 Apr 9. PMID: 23638336.
Determination of in vivo Bmax and Kd for 11C-GR103545, an agonist PET tracer for κ-opioid receptors: a study in nonhuman primates.Tomasi G, Nabulsi N, Zheng MQ, Weinzimmer D, Ropchan J, Blumberg L, Brown-Proctor C, Ding YS, Carson RE, Huang Y. J Nucl Med. 2013 Apr; 2013 Feb 19. PMID: 23424192.
Kinetic analysis of the metabotropic glutamate subtype 5 tracer [(18)F]FPEB in bolus and bolus-plus-constant-infusion studies in humans.Sullivan JM, Lim K, Labaree D, Lin SF, McCarthy TJ, Seibyl JP, Tamagnan G, Huang Y, Carson RE, Ding YS, Morris ED. J Cereb Blood Flow Metab. 2013 Apr; 2012 Dec 19. PMID: 23250105.
Cerebral blood flow with [15O]water PET studies using an image-derived input function and MR-defined carotid centerlines.Fung EK, Carson RE. Phys Med Biol. 2013 Mar 21; 2013 Feb 27. PMID: 23442733.
Test-retest reproducibility of [11C]-(+)-propyl-hexahydro-naphtho-oxazin positron emission tomography using the bolus plus constant infusion paradigm.Lee DE, Gallezot JD, Zheng MQ, Lim K, Ding YS, Huang Y, Carson RE, Morris ED, Cosgrove KP. Mol Imaging. 2013 Mar-Apr. PMID: 23415395.
Synthesis and evaluation of 11C-LY2795050 as a κ-opioid receptor antagonist radiotracer for PET imaging.Zheng MQ, Nabulsi N, Kim SJ, Tomasi G, Lin SF, Mitch C, Quimby S, Barth V, Rash K, Masters J, Navarro A, Seest E, Morris ED, Carson RE, Huang Y. J Nucl Med. 2013 Mar; 2013 Jan 25. PMID: 23353688.
Optimization of PET-MR registrations for nonhuman primates using mutual information measures: a Multi-Transform Method (MTM).Sandiego CM, Weinzimmer D, Carson RE. Neuroimage. 2013 Jan 1; 2012 Aug 25. PMID: 22926293.

2012

Direct 4-D PET list mode parametric reconstruction with a novel EM algorithm.Yan J, Planeta-Wilson B, Carson RE. IEEE Trans Med Imaging. 2012 Dec; 2012 Aug 23. PMID: 22929383.
Synthesis and characterization of two PET radioligands for the metabotropic glutamate 1 (mGlu1) receptor.Huang Y, Narendran R, Bischoff F, Guo N, Bae SA, Hwang DR, Lesage AS, Laruelle M. Synapse. 2012 Dec; 2012 Sep 29. PMID: 22927303.
Endotoxin-induced systemic inflammation activates microglia: [¹¹C]PBR28 positron emission tomography in nonhuman primates.Hannestad J, Gallezot JD, Schafbauer T, Lim K, Kloczynski T, Morris ED, Carson RE, Ding YS, Cosgrove KP. Neuroimage. 2012 Oct 15; 2012 Jul 6. PMID: 22776451.
Ex vivo and in vivo evaluation of the norepinephrine transporter ligand [11C]MRB for brown adipose tissue imaging.Lin SF, Fan X, Yeckel CW, Weinzimmer D, Mulnix T, Gallezot JD, Carson RE, Sherwin RS, Ding YS. Nucl Med Biol. 2012 Oct; 2012 May 16. PMID: 22595487.
Age effects on serotonin receptor 1B as assessed by PET.Matuskey D, Pittman B, Planeta-Wilson B, Walderhaug E, Henry S, Gallezot JD, Nabulsi N, Ding YS, Bhagwagar Z, Malison R, Carson RE, Neumeister A. J Nucl Med. 2012 Sep; 2012 Jul 31. PMID: 22851636.
In vivo imaging of endogenous pancreatic β-cell mass in healthy and type 1 diabetic subjects using 18F-fluoropropyl-dihydrotetrabenazine and PET.Normandin MD, Petersen KF, Ding YS, Lin SF, Naik S, Fowles K, Skovronsky DM, Herold KC, McCarthy TJ, Calle RA, Carson RE, Treadway JL, Cline GW. J Nucl Med. 2012 Jun; 2012 May 9. PMID: 22573821.
Affinity and selectivity of [¹¹C]-(+)-PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo.Gallezot JD, Beaver JD, Gunn RN, Nabulsi N, Weinzimmer D, Singhal T, Slifstein M, Fowles K, Ding YS, Huang Y, Laruelle M, Carson RE, Rabiner EA. Synapse. 2012 Jun; 2012 Feb 24. PMID: 22213512.
Glucose metabolism in the insula and cingulate is affected by systemic inflammation in humans.Hannestad J, Subramanyam K, Dellagioia N, Planeta-Wilson B, Weinzimmer D, Pittman B, Carson RE. J Nucl Med. 2012 Apr; 2012 Mar 13. PMID: 22414635.

2011

Recovery from chronic spinal cord contusion after Nogo receptor intervention.Wang X, Duffy P, McGee AW, Hasan O, Gould G, Tu N, Harel NY, Huang Y, Carson RE, Weinzimmer D, Ropchan J, Benowitz LI, Cafferty WB, Strittmatter SM. Ann Neurol. 2011 Nov. PMID: 22162062.
Assessing the sensitivity of [¹¹C]p943, a novel 5-HT1B radioligand, to endogenous serotonin release.Cosgrove KP, Kloczynski T, Nabulsi N, Weinzimmer D, Lin SF, Staley JK, Bhagwagar Z, Carson RE. Synapse. 2011 Oct; 2011 May 3. PMID: 21484884.
Pancreatic beta cell mass PET imaging and quantification with [11C]DTBZ and [18F]FP-(+)-DTBZ in rodent models of diabetes.Singhal T, Ding YS, Weinzimmer D, Normandin MD, Labaree D, Ropchan J, Nabulsi N, Lin SF, Skaddan MB, Soeller WC, Huang Y, Carson RE, Treadway JL, Cline GW. Mol Imaging Biol. 2011 Oct; 2010 Sep 8. PMID: 20824509.
Respiratory motion correction for quantitative PET/CT using all detected events with internal-external motion correlation.Liu C, Alessio AM, Kinahan PE. Med Phys. 2011 May. PMID: 21776808.
Evaluation of [(11)C]MRB for assessment of occupancy of norepinephrine transporters: Studies with atomoxetine in non-human primates.Gallezot JD, Weinzimmer D, Nabulsi N, Lin SF, Fowles K, Sandiego C, McCarthy TJ, Maguire RP, Carson RE, Ding YS. Neuroimage. 2011 May 1; 2010 Sep 30. PMID: 20869448.
[11C]GR103545: novel one-pot radiosynthesis with high specific activity.Nabulsi NB, Zheng MQ, Ropchan J, Labaree D, Ding YS, Blumberg L, Huang Y. Nucl Med Biol. 2011 Feb; 2010 Dec 3. PMID: 21315277.

2010

Clinically relevant doses of methylphenidate significantly occupy norepinephrine transporters in humans in vivo.Hannestad J, Gallezot JD, Planeta-Wilson B, Lin SF, Williams WA, van Dyck CH, Malison RT, Carson RE, Ding YS. Biol Psychiatry. 2010 Nov 1; 2010 Aug 5. PMID: 20691429.
Quiescent period respiratory gating for PET/CT.Liu C, Alessio A, Pierce L, Thielemans K, Wollenweber S, Ganin A, Kinahan P. Med Phys. 2010 Sep. PMID: 20964223.
High-resolution imaging of brain 5-HT 1B receptors in the rhesus monkey using [11C]P943.Nabulsi N, Huang Y, Weinzimmer D, Ropchan J, Frost JJ, McCarthy T, Carson RE, Ding YS. Nucl Med Biol. 2010 Feb; 2009 Dec 1. PMID: 20152720.
Arterial transit time effects in pulsed arterial spin labeling CBF mapping: insight from a PET and MR study in normal human subjects.Qiu M, Paul Maguire R, Arora J, Planeta-Wilson B, Weinzimmer D, Wang J, Wang Y, Kim H, Rajeevan N, Huang Y, Carson RE, Constable RT. Magn Reson Med. 2010 Feb. PMID: 19953506.
Development of effective PET and SPECT imaging agents for the serotonin transporter: has a twenty-year journey reached its destination?Huang Y, Zheng MQ, Gerdes JM. Curr Top Med Chem. 2010. PMID: 20583995.
Kinetic modeling of the serotonin 5-HT(1B) receptor radioligand [(11)C]P943 in humans.Gallezot JD, Nabulsi N, Neumeister A, Planeta-Wilson B, Williams WA, Singhal T, Kim S, Maguire RP, McCarthy T, Frost JJ, Huang Y, Ding YS, Carson RE. J Cereb Blood Flow Metab. 2010 Jan; 2009 Sep 23. PMID: 19773803.
PET imaging of the effects of age and cocaine on the norepinephrine transporter in the human brain using (S,S)-[(11)C]O-methylreboxetine and HRRT.Ding YS, Singhal T, Planeta-Wilson B, Gallezot JD, Nabulsi N, Labaree D, Ropchan J, Henry S, Williams W, Carson RE, Neumeister A, Malison RT. Synapse. 2010 Jan. PMID: 19728366.

2009

Initial Evaluation of Direct 4D Parametric Reconstruction with Human PET Data.Yan J, Planeta-Wilson B, Gallezot JD, Carson RE. IEEE Nucl Sci Symp Conf Rec (1997). 2009 Nov 1. PMID: 21278923.
Accuracy of Head Motion Compensation for the HRRT: Comparison of Methods.Jin X, Mulnix T, Planeta-Wilson B, Gallezot JD, Carson RE. IEEE Nucl Sci Symp Conf Rec (1997). 2009 Oct 24. PMID: 20607125.
A Multimodal Approach to Image-Derived Input Functions for Brain PET.Fung EK, Planeta-Wilson B, Mulnix T, Carson RE. IEEE Nucl Sci Symp Conf Rec (1997). 2009 Oct 24. PMID: 20607124.

2008

Quantitative Accuracy of HRRT List-mode Reconstructions: Effect of Low Statistics.Planeta-Wilson B, Yan J, Mulnix T, Carson RE. IEEE Nucl Sci Symp Conf Rec (1997). 2008 Oct 1. PMID: 20617118.
Direct 4D List Mode Parametric Reconstruction for PET with a Novel EM Algorithm.Yan J, Planeta-Wilson B, Carson RE. IEEE Nucl Sci Symp Conf Rec (1997). 2008. PMID: 20628540.