2022
Neurogenetic traits outline vulnerability to cortical disruption in Parkinson’s disease
Basaia S, Agosta F, Diez I, Bueichekú E, Uquillas F, Delgado-Alvarado M, Caballero-Gaudes C, Rodriguez-Oroz M, Stojkovic T, Kostic V, Filippi M, Sepulcre J. Neurogenetic traits outline vulnerability to cortical disruption in Parkinson’s disease. NeuroImage Clinical 2022, 33: 102941. PMID: 35091253, PMCID: PMC8800137, DOI: 10.1016/j.nicl.2022.102941.Peer-Reviewed Original ResearchConceptsParkinson's diseaseBrain circuitsGene expression patternsBrain connectivityPD-related pathologyPD participantsHuman brainHuman cortexTopological intersectionConnectivity networksCortical propagation patternsPostmortem dataGenetic traitsBrainExpression patternsSNCA geneConnectivity trajectoriesGenesCellular componentsNeuronal damageNeuronal vulnerabilityVulnerabilityParkinsonTraits
2020
Linking Lysosomal Enzyme Targeting Genes and Energy Metabolism with Altered Gray Matter Volume in Children with Persistent Stuttering
Chow H, Garnett E, Li H, Etchell A, Sepulcre J, Drayna D, Chugani D, Chang S. Linking Lysosomal Enzyme Targeting Genes and Energy Metabolism with Altered Gray Matter Volume in Children with Persistent Stuttering. Neurobiology Of Language 2020, 1: 365-380. PMID: 34041495, PMCID: PMC8138901, DOI: 10.1162/nol_a_00017.Peer-Reviewed Original ResearchGray matter volume differencesGray matter volumeParticipating genomesMatter volumeTarget genesExpression patternsPersistent stutteringGene expression dataEnergy metabolismGene expression patternsGene set enrichment analysisVolume differencesVoxel-based morphometryChildhood-onset neurodevelopmental disorderExpression dataIntracellular traffickingEnrichment analysisGene expressionGenesDevelopmental stutteringFluent peersNeuroanatomical changesStuttering casesBrain structuresAllen Institute for Brain Science