Ketone body beta-hydroxy butyrate deactivates NLRP3 inflammasome in myeloid cells (CAM1P.153)
Goldberg E, Youm Y, Nguyen K, Alnemri E, Dixit V. Ketone body beta-hydroxy butyrate deactivates NLRP3 inflammasome in myeloid cells (CAM1P.153). The Journal Of Immunology 2015, 194: 48.10-48.10. DOI: 10.4049/jimmunol.194.supp.48.10.Peer-Reviewed Original ResearchBeta-hydroxy butyrateInflammasome activationMyeloid cellsNLRP3-dependent inflammasome activationAnti-inflammatory interventionsNLRP3-dependent ILMyeloid lineage cellsShort-chain fatty acidsDependent inflammasome activationKetone body productionFatty acid oxidationBone lossChronic inflammationAge-related diseasesAged miceNLRP3 inflammasomeSterile inflammationChronic diseasesFunctional declineMetabolic diseasesCognitive declineCalorie restrictionChain fatty acidsInflammationLineage cells