Shaoning Jiang
Research Scientist in PathologyCards
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About
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Research Scientist in Pathology
Biography
Dr. Jiang completed her PhD degree in Molecular and cellular Pathology at the University of Alabama at Birmingham (UAB) and received postdoctoral training at UAB and University of Oklahoma health Science Center (OUHSC). Before joining Yale Pathology, Dr. Jiang has started her independent research as an assistant professor at OUHSC in the research areas of diabetes and obesity, focusing on epigenetic mechanisms linking inflammation and energy metabolism in the context of developmental origins of obesity and obesity-related metabolic disorders.
Open position:
A postdoctoral Associate position is currently available for a recent NIH R01 funded project studying cell-type specific functions of microRNAs in regulating beige and brown fat adipogenesis and crosstalk of adipose stem cells and macrophages. Please send a Curriculum Vitae, and names / contact information for three references to Dr. Shaoning Jiang (shaoning.jiang@yale.edu).
Appointments
Pathology
Research ScientistPrimary
Other Departments & Organizations
Education & Training
- Postdoc fellow
- University of Oklahoma Health Science Center
- Postdoc fellow
- University of Alabama at Birmingham
- PhD
- University of Alabama at Birmingham, Pathology
- MM
- Peking University Health Science Center, Gastroenterology
- MD
- Peking University Health Science Center, Medicine
Research
Overview
My main research interest has been studying epigenetic mechanisms linking inflammation and energy metabolism in the pathogenesis of diabetes and obesity and related metabolic disorders. Specifically, my research has focused on two main directions:
1) Macrophages, microRNAs, and adipose stem cells crosstalk in the regulation of brown/beige adipogenesis in obesity. This project studies a bone marrow-derived microRNA cluster of miR-130b and miR-301b, which suppresses adipose tissue stem cells beige differentiation and energy metabolism. By in vivo approaches using a global and a macrophage-specific knockout mouse model for miRNA-130b/301b and in vitro culture of bone marrow and adipose stem cells, the goal is to further delineate cell subtype-specific actions and explore therapeutic potential of extracellular vesicle (EV)-mediated miR-130b/301b inhibition in obesity and related metabolic disorders.
2) Epigenetic mechanisms of developmental programming of metabolic diseases in maternal obesity and diabetes. Adverse intrauterine environment, including diabetes and obesity, impacts fetal development and growth and predispose offspring to type 2 diabetes, obesity, and other metabolic diseases later in life, which has been known as “Developmental Origins of Health and Disease (DoHad)”. The overall aim of my research is to better understand the molecular mechanisms of DoHad and explore new therapeutic options for early prevention of metabolic diseases at the time of their origin, focusing on a) Roles of AMP-activated protein kinase (AMPK) and epigenetic pathways in placenta and fetal development and offspring long-term health in response to maternal overnutrition (obesity and diabetes); b) Effects of maternal overnutrition on peroxisomal and mitochondrial programming during fetal development, and how those alterations impact adipose tissue development and offspring obesity and fatty liver diseases later in life.
Research at a Glance
Yale Co-Authors
Publications Timeline
Wenyi Luo, MD, PhD
Publications
2023
AMPK Regulates DNA Methylation of PGC-1α and Myogenic Differentiation in Human Mesenchymal Stem Cells.
Wu J, Gulati S, Teague AM, Kim Y, Tryggestad JB, Jiang S. AMPK Regulates DNA Methylation of PGC-1α and Myogenic Differentiation in Human Mesenchymal Stem Cells. Stem Cells Dev 2023, 32: 131-139. PMID: 36594575, DOI: 10.1089/scd.2022.0226.Peer-Reviewed Original Research
2022
miR-130b/301b Is a Negative Regulator of Beige Adipogenesis and Energy Metabolism In Vitro and In Vivo.
Luo W, Kim Y, Jensen M, Herlea-Pana O, Wang W, Rudolph M, Friedman J, Chernausek S, Jiang S. miR-130b/301b Is a Negative Regulator of Beige Adipogenesis and Energy Metabolism In Vitro and In Vivo. Diabetes 2022, 71: 2360-2371. PMID: 36001751, PMCID: PMC9630090, DOI: 10.2337/db22-0205.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBeige adipogenesisMiR-301bMiR-130bPeroxisome proliferator-activated receptor γ coactivator 1αProliferator-activated receptor γ coactivator 1αImproved glucose toleranceReceptor γ coactivator 1αLess weight gainPotential therapeutic targetCold-induced energy expenditureΓ coactivator 1αMitochondrial biogenesisMetabolic complicationsVisceral adiposityGlucose toleranceThermogenic brownCounteract obesityMetabolic disordersTherapeutic targetAdipose tissueBeige phenotypeMetabolic diseasesAdipose progenitor cellsBeige adipocytesCoactivator 1α
2021
AMPK activates Parkin independent autophagy and improves post sepsis immune defense against secondary bacterial lung infections.
Bone NB, Becker EJ Jr, Husain M, Jiang S, Zmijewska AA, Park DW, Chacko B, Darley-Usmar V, Grégoire M, Tadie JM, Thannickal VJ, Zmijewski JW. AMPK activates Parkin independent autophagy and improves post sepsis immune defense against secondary bacterial lung infections. Sci Rep 2021, 11: 12387. PMID: 34117280, DOI: 10.1038/s41598-021-90573-0.Peer-Reviewed Original Research
2020
Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis.
Jiang S, Teague AM, Tryggestad JB, Lyons TJ, Chernausek SD. Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis. Mol Med 2020, 26: 76. PMID: 32762639, DOI: 10.1186/s10020-020-00205-y.Peer-Reviewed Original ResearchRole of metformin in epigenetic regulation of placental mitochondrial biogenesis in maternal diabetes.
Jiang S, Teague AM, Tryggestad JB, Jensen ME, Chernausek SD. Role of metformin in epigenetic regulation of placental mitochondrial biogenesis in maternal diabetes. Sci Rep 2020, 10: 8314. PMID: 32433500, DOI: 10.1038/s41598-020-65415-0.Peer-Reviewed Original Research
2019
Macrophage-Derived microRNA-155 Increases in Obesity and Influences Adipocyte Metabolism by Targeting Peroxisome Proliferator-Activated Receptor Gamma.
Tryggestad JB, Teague AM, Sparling DP, Jiang S, Chernausek SD. Macrophage-Derived microRNA-155 Increases in Obesity and Influences Adipocyte Metabolism by Targeting Peroxisome Proliferator-Activated Receptor Gamma. Obesity (Silver Spring) 2019, 27: 1856-1864. PMID: 31531958, DOI: 10.1002/oby.22616.Peer-Reviewed Original Research
2018
Metformin reverses established lung fibrosis in a bleomycin model.
Rangarajan S, Bone NB, Zmijewska AA, Jiang S, Park DW, Bernard K, Locy ML, Ravi S, Deshane J, Mannon RB, Abraham E, Darley-Usmar V, Thannickal VJ, Zmijewski JW. Metformin reverses established lung fibrosis in a bleomycin model. Nat Med 2018, 24: 1121-1127. PMID: 29967351, DOI: 10.1038/s41591-018-0087-6.Peer-Reviewed Original Research
2017
Effects of maternal diabetes and fetal sex on human placenta mitochondrial biogenesis.
Jiang S, Teague AM, Tryggestad JB, Aston CE, Lyons T, Chernausek SD. Effects of maternal diabetes and fetal sex on human placenta mitochondrial biogenesis. Placenta 2017, 57: 26-32. PMID: 28864016, DOI: 10.1016/j.placenta.2017.06.001.Peer-Reviewed Original ResearchRole of microRNA-130b in placental PGC-1α/TFAM mitochondrial biogenesis pathway.
Jiang S, Teague AM, Tryggestad JB, Chernausek SD. Role of microRNA-130b in placental PGC-1α/TFAM mitochondrial biogenesis pathway. Biochem Biophys Res Commun 2017, 487: 607-612. PMID: 28433632, DOI: 10.1016/j.bbrc.2017.04.099.Peer-Reviewed Original Research
2016
Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA.
Tryggestad JB, Vishwanath A, Jiang S, Mallappa A, Teague AM, Takahashi Y, Thompson DM, Chernausek SD. Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA. Clin Sci (Lond) 2016, 130: 1955-67. PMID: 27562513, DOI: 10.1042/CS20160305.Peer-Reviewed Original Research
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