2009
Methylation of TFPI2 in Stool DNA: A Potential Novel Biomarker for the Detection of Colorectal Cancer
Glöckner S, Dhir M, Yi JM, McGarvey KE, Van Neste L, Louwagie J, Chan TA, Kleeberger W, de Bruïne A, Smits KM, Bakker C, Jonkers DM, Stockbrügger R, Meijer GA, Oort FA, Iacobuzio-Donahue C, Bierau K, Herman JG, Baylin SB, Van Engeland M, Schuebel KE, Ahuja N. Methylation of TFPI2 in Stool DNA: A Potential Novel Biomarker for the Detection of Colorectal Cancer. Cancer Research 2009, 69: 4691-4699. PMID: 19435926, PMCID: PMC3062162, DOI: 10.1158/0008-5472.can-08-0142.Peer-Reviewed Original ResearchConceptsTissue factor pathway inhibitor-2Colorectal cancerStool DNATFPI2 methylationStage INonmetastatic colorectal cancerHuman colorectal cancerPotential novel biomarkersCRC patientsNoncancer controlsColorectal carcinogenesisNovel biomarkersUseful adjunctPotential tumor suppressor geneNoninvasive strategyTumor suppressor geneEarly detectionAberrant DNA methylationPatientsFrequent eventCancerAberrant methylationSuppressor geneBiomarkers
2007
Comparing the DNA Hypermethylome with Gene Mutations in Human Colorectal Cancer
Schuebel KE, Chen W, Cope L, Glöckner SC, Suzuki H, Yi JM, Chan TA, Van Neste L, Van Criekinge W, van den Bosch S, van Engeland M, Ting AH, Jair K, Yu W, Toyota M, Imai K, Ahuja N, Herman JG, Baylin SB. Comparing the DNA Hypermethylome with Gene Mutations in Human Colorectal Cancer. PLOS Genetics 2007, 3: e157. PMID: 17892325, PMCID: PMC1988850, DOI: 10.1371/journal.pgen.0030157.Peer-Reviewed Original ResearchConceptsTranscriptome-wide approachCpG island DNA hypermethylationHuman colorectal cancer samplesHuman cancer genomesTumor-specific hypermethylationEpigenetic screensTranscriptional silencingIndividual genesCancer genomesEpigenetic changesDNA hypermethylationGene mutationsGenesHypermethylationCell linesIndividual tumorsHuman colorectal cancerColorectal cancer samplesCancer samplesMutationsColorectal cancerCancer biomarkersGenomeSilencingPromoter