2018
Optimal Intraoperative Assessment of Gastric Margins
Celli R, Barbieri AL, Colunga M, Sinard J, Gibson JA. Optimal Intraoperative Assessment of Gastric Margins. American Journal Of Clinical Pathology 2018, 150: 353-363. PMID: 30020407, DOI: 10.1093/ajcp/aqy062.Peer-Reviewed Original ResearchConceptsIntraoperative pathology consultationGastric marginPositive marginsTumor distanceMajority of casesRepresentative sectionsR0 resectionConsecutive patientsGastroesophageal junctionTumor sizeNegative marginsPatient outcomesIntraoperative assessmentPathology consultationPatientsStrong associationMargin assessment
2017
Clinicopathologic and outcome study of sessile serrated adenomas/polyps with serrated versus intestinal dysplasia
Cenaj O, Gibson J, Odze RD. Clinicopathologic and outcome study of sessile serrated adenomas/polyps with serrated versus intestinal dysplasia. Modern Pathology 2017, 31: 633-642. PMID: 29271414, DOI: 10.1038/modpathol.2017.169.Peer-Reviewed Original ResearchConceptsSessile serrated adenomas/polypsSerrated adenomas/polypsAdenomas/polypsIntestinal dysplasiaConventional adenomasSerrated dysplasiaPrevalence of adenocarcinomaType of dysplasiaHigh-grade lesionsDysplasia-carcinoma sequenceLow-grade dysplasiaNeoplastic precursor lesionsHigh rateDysplasia subtypeControl patientsPathologic featuresMean ageMicrosatellite unstable cancersBiologic featuresInvasive carcinomaPrecursor lesionsNeoplastic lesionsPrevalence ratesOutcome studiesPatients
2015
Performing Colonic Mast Cell Counts in Patients With Chronic Diarrhea of Unknown Etiology Has Limited Diagnostic Use
Sethi A, Jain D, Roland BC, Kinzel J, Gibson J, Schrader R, Hanson JA. Performing Colonic Mast Cell Counts in Patients With Chronic Diarrhea of Unknown Etiology Has Limited Diagnostic Use. Archives Of Pathology & Laboratory Medicine 2015, 139: 225-32. PMID: 25611105, DOI: 10.5858/arpa.2013-0594-oa.Peer-Reviewed Original ResearchConceptsHigh-power fieldMC countChronic diarrheaMast cell countsUnknown etiologyMast cellsCutoff valueMastocytic enterocolitisLeft colonBiopsy resultsClinical utilityDiscriminatory cutoff valuesCell countC-kit stainConsecutive control patientsMast cell stabilizerSpecific cutoff valuesSingle high-power fieldControl patientsConsecutive patientsNormal biopsiesCell stabilizerCharacteristic analysisStudy groupSpecial stains
2012
BRAF V600E mutation in papillary thyroid microcarcinoma: a genotype–phenotype correlation
Virk RK, Van Dyke AL, Finkelstein A, Prasad A, Gibson J, Hui P, Theoharis CG, Carling T, Roman SA, Sosa JA, Udelsman R, Prasad ML. BRAF V600E mutation in papillary thyroid microcarcinoma: a genotype–phenotype correlation. Modern Pathology 2012, 26: 62-70. PMID: 22918165, DOI: 10.1038/modpathol.2012.152.Peer-Reviewed Original ResearchConceptsPapillary thyroid microcarcinomaThyroid microcarcinomaPapillary thyroid carcinomaFollicular variantThyroid carcinomaLateral cervical node metastasesOsteoclastic-type giant cellsCervical node metastasisInfiltrative tumor borderGroup of tumorsBRAF V600E mutationClassic nuclear featuresGenotype-phenotype correlationStromal calcificationLymphovascular invasionNode metastasisClinicopathologic featuresLymphocytic infiltrationAggressive featuresTumor sizeCystic changesPapillary microcarcinomaAbsence of mutationsHigh prevalenceMicrocarcinoma
2011
MUC Expression in Hyperplastic and Serrated Colonic Polyps
Gibson JA, Hahn HP, Shahsafaei A, Odze RD. MUC Expression in Hyperplastic and Serrated Colonic Polyps. The American Journal Of Surgical Pathology 2011, 35: 742-749. PMID: 21490447, DOI: 10.1097/pas.0b013e31821537a2.Peer-Reviewed Original ResearchConceptsSSA/PExpression of MUC6Hyperplastic polypsSerrated polypsSSA/PsPolyp groupRight colonMUC expressionColonic polypsSerrated colonic polypsSessile serrated adenomas/polypsSerrated adenomas/polypsTraditional serrated adenomasGoblet cell typeProgression of malignancyAdenomas/polypsIntensity of stainingDifferent anatomic locationsMicrovesicular typeSerrated carcinogenesisDifferential diagnosisMUC6 expressionAnatomic locationSerrated pathwaySerrated adenomas
2009
Mucosal Schwann Cell “Hamartoma”
Gibson JA, Hornick JL. Mucosal Schwann Cell “Hamartoma”. The American Journal Of Surgical Pathology 2009, 33: 781-787. PMID: 19065103, DOI: 10.1097/pas.0b013e31818dd6ca.Peer-Reviewed Original ResearchMeSH KeywordsActinsAgedAged, 80 and overAntigens, CD34Cell DifferentiationCell ProliferationClaudin-1Colonic PolypsColonoscopyColorectal NeoplasmsDiagnosis, DifferentialFemaleGlial Fibrillary Acidic ProteinHamartomaHumansImmunohistochemistryIncidental FindingsIntestinal MucosaMaleMembrane ProteinsMiddle AgedMucin-1Neurofibromatosis 1Neurofilament ProteinsNeuromaProto-Oncogene Proteins c-kitS100 ProteinsSchwann CellsConceptsLamina propriaHistologic featuresGanglion cellsSchwann cellsColorectal polypsNF1 patientsNeurofilament proteinDense eosinophilic cytoplasmGlial fibrillary acidic proteinSolitary colorectal polypsSimilar histologic featuresBland spindle cellsIndistinct cell bordersType 1 neurofibromatosisEpithelial membrane antigenFibrillary acidic proteinSchwann cell proliferationSmooth muscle actinUniform bland spindle cellsRare axonsMucosal biopsiesPositive axonsImmunohistochemical featuresNeural lesionsIntralesional heterogeneity