2011
Induction of acute GVHD by sex-mismatched H-Y antigens in the absence of functional radiosensitive host hematopoietic–derived antigen-presenting cells
Toubai T, Tawara I, Sun Y, Liu C, Nieves E, Evers R, Friedman T, Korngold R, Reddy P. Induction of acute GVHD by sex-mismatched H-Y antigens in the absence of functional radiosensitive host hematopoietic–derived antigen-presenting cells. Blood 2011, 119: 3844-3853. PMID: 22101894, PMCID: PMC3335388, DOI: 10.1182/blood-2011-10-384057.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsAntigen-Presenting CellsBone Marrow TransplantationCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCells, CulturedDendritic CellsEndothelial CellsFemaleGraft vs Host DiseaseHematopoiesisHistocompatibilityH-Y AntigenIsoantigensMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, Mutant StrainsRadiation ToleranceThymectomyConceptsAcute GVHDT cellsAg presentationAlloreactive donor T cellsAllogeneic BM transplantationDonor T cellsMinor histocompatibility AgAntigen-presenting cellsGvH responseGVHD lethalityBM transplantationHistocompatibility AgClinical dataGVHDY antigenAPCY AgPresentationCellsTransplantationAbsenceInfusionAntigenRecipientsManipulating the Bioenergetics of Alloreactive T Cells Causes Their Selective Apoptosis and Arrests Graft-Versus-Host Disease
Gatza E, Wahl D, Opipari A, Sundberg T, Reddy P, Liu C, Glick G, Ferrara J. Manipulating the Bioenergetics of Alloreactive T Cells Causes Their Selective Apoptosis and Arrests Graft-Versus-Host Disease. Science Translational Medicine 2011, 3: 67ra8. PMID: 21270339, PMCID: PMC3364290, DOI: 10.1126/scitranslmed.3001975.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBenzodiazepinesBone Marrow CellsBone Marrow TransplantationFemaleGraft vs Host DiseaseIsoantigensLactatesLymphocyte ActivationMetabolomeMiceMice, Inbred BALB CMice, Inbred C57BLMitochondrial Proton-Translocating ATPasesOxidative PhosphorylationOxygen ConsumptionReactive Oxygen SpeciesT-LymphocytesConceptsAlloreactive T cellsT cellsHost diseaseBM transplantationAerobic glycolysisAdenosine triphosphateAccumulation of acylcarnitinesBone marrow cellsFatty acid oxidationGraft-VersusLymphocyte reconstitutionImmune activationBMT modelBM cellsImmune disordersHematopoietic engraftmentTherapeutic strategiesOxidative phosphorylationSmall molecule inhibitorsMarrow cellsSuperoxide productionSufficient adenosine triphosphateMitochondrial membrane potentialMetabolic adaptationAcid oxidation
2008
Organ-derived dendritic cells have differential effects on alloreactive T cells
Kim T, Terwey T, Zakrzewski J, Suh D, Kochman A, Chen M, King C, Borsotti C, Grubin J, Smith O, Heller G, Liu C, Murphy G, Alpdogan O, van den Brink M. Organ-derived dendritic cells have differential effects on alloreactive T cells. Blood 2008, 111: 2929-2940. PMID: 18178870, PMCID: PMC2254543, DOI: 10.1182/blood-2007-06-096602.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell ProliferationDendritic CellsGene Expression ProfilingGraft vs Host DiseaseHumansIntegrinsIsoantigensLigandsLipopolysaccharidesLiverLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLOligonucleotide Array Sequence AnalysisOrgan SpecificityPhenotypeReceptors, Lymphocyte HomingSelectinsSurvival RateT-LymphocytesUp-RegulationConceptsAlloreactive T cellsBone marrow transplantationDendritic cellsT cellsGVHD mortalityLymph nodesAlloreactive donor T cellsGut-draining lymph nodesLiver-derived dendritic cellsNaive allogeneic T cellsMurine bone marrow transplantationPathophysiology of GVHDTarget organ liverDonor T cellsInduction of graftAllogeneic T cellsPeripheral lymph nodesGut-homing phenotypeMurine BMT modelHost diseaseAdoptive transferHoming moleculesMarrow transplantationStimulatory capacityBMT model
2005
A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses
Reddy P, Maeda Y, Liu C, Krijanovski O, Korngold R, Ferrara J. A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses. Nature Medicine 2005, 11: 1244-1249. PMID: 16227991, DOI: 10.1038/nm1309.Peer-Reviewed Original ResearchConceptsBone marrow transplantationAllogeneic bone marrow transplantationGVL responseLeukemia responseAlloantigen expressionInduction of graftAntigen-presenting cellsHost diseaseSerious complicationsDonor APCsMarrow transplantationTumor burdenTumor modelGraftAPCHost originPotent formResponseImmunotherapyCellsComplicationsTransplantationAcuityExpressionTumors
2003
LPAM (α4β7 integrin) is an important homing integrin on alloreactive T cells in the development of intestinal graft-versus-host disease
Petrovic A, Alpdogan O, Willis L, Eng J, Greenberg A, Kappel B, Liu C, Murphy G, Heller G, van den Brink M. LPAM (α4β7 integrin) is an important homing integrin on alloreactive T cells in the development of intestinal graft-versus-host disease. Blood 2003, 103: 1542-1547. PMID: 14563643, DOI: 10.1182/blood-2003-03-0957.Peer-Reviewed Original ResearchConceptsDonor T cellsT cellsMurine allogeneic bone marrow transplantation modelAllogeneic bone marrow transplantation modelAlloreactive donor T cellsGut-associated lymphoid tissueAdhesion moleculesMucosal addressin cell adhesion moleculeGVHD target organsMesenteric lymph nodesAlloreactive T cellsBone marrow transplantation modelMucosal lymphoid organsHigh endothelial venulesGVHD morbidityGVT activityIntestinal graftIntestinal GVHDLess graftLess GVHDHost diseaseLymph nodesDisease morbidityLymphoid organsLymphoid tissue
2002
Acute graft-versus-host disease does not require alloantigen expression on host epithelium
Teshima T, Ordemann R, Reddy P, Gagin S, Liu C, Cooke K, Ferrara J. Acute graft-versus-host disease does not require alloantigen expression on host epithelium. Nature Medicine 2002, 8: 575-581. PMID: 12042807, DOI: 10.1038/nm0602-575.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsHost antigen-presenting cellsAlloantigen expressionAcute GVHDHost diseaseTarget epitheliaMajor histocompatibility complex class ICD8-mediated GVHDBone marrow chimerasHistocompatibility complex class IClass II alloantigensTumor necrosis factorComplex class IAcute graftInflammatory cytokinesEffector mechanismsGVHDNecrosis factorMouse modelAntigen specificityTissue damageClass IHost epitheliumEpitheliumGraft