2016
Therapeutic improvements expected in the near future for schizophrenia and schizoaffective disorder: an appraisal of phase III clinical trials of schizophrenia-targeted therapies as found in US and EU clinical trial registries
Garay R, Citrome L, Samalin L, Liu C, Thomsen M, Correll C, Hameg A, Llorca P. Therapeutic improvements expected in the near future for schizophrenia and schizoaffective disorder: an appraisal of phase III clinical trials of schizophrenia-targeted therapies as found in US and EU clinical trial registries. Expert Opinion On Pharmacotherapy 2016, 17: 921-936. PMID: 26831200, DOI: 10.1517/14656566.2016.1149164.Peer-Reviewed Original ResearchConceptsCognitive impairment associated with schizophreniaSchizoaffective disorderNegative symptomsDopamine D2 receptor partial agonistTreatment of cognitive impairment associated with schizophreniaD2 receptor partial agonistTreating positive symptomsReceptor partial agonistEU clinical trial registriesAdd-on compoundsTardive dyskinesiaPositive symptomsGoal of recoverySchizophreniaPartial agonistAntipsychoticsSchizoaffectivePhase III of clinical developmentTherapeutic improvementDisordersClinical Trials RegistrySymptomsPharmacodynamic profileClinical developmentAcademic medical center
2015
Neurocognitive functioning of subjects with putative pre-psychotic states and early psychosis
Liu C, Hua M, Hwang T, Chiu C, Liu C, Hsieh M, Chien Y, Lin Y, Hwu H. Neurocognitive functioning of subjects with putative pre-psychotic states and early psychosis. Schizophrenia Research 2015, 164: 40-46. PMID: 25802138, DOI: 10.1016/j.schres.2015.03.006.Peer-Reviewed Original ResearchConceptsUltra-high riskPre-psychotic stateNeurocognitive functionWechsler Adult Intelligence Scale-Third EditionWechsler Memory Scale-Third EditionRisk of transition to psychosisWisconsin Card Sorting TestCard Sorting TestDomains of neurocognitionNeurocognitive function of patientsTransition to psychosisContinuous Performance TestVerbal fluency testTrail Making TestLevels of clinical severityFollow-up assessmentStability of changesSorting TestNeuropsychological batteryOnset of illnessNeurocognitive profileEpisode psychosisFluency testNeurocognitive deficitsFunction of subjects