2016
Energy sources identify metabolic phenotypes in pancreatic cancer
Liang C, Qin Y, Zhang B, Ji S, Shi S, Xu W, Liu J, Xiang J, Liang D, Hu Q, Liu L, Liu C, Luo G, Ni Q, Xu J, Yu X. Energy sources identify metabolic phenotypes in pancreatic cancer. Acta Biochimica Et Biophysica Sinica 2016, 48: 969-979. PMID: 27649892, DOI: 10.1093/abbs/gmw097.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaWarburg phenotypeMetabolic phenotypeInducing different metabolic phenotypesCancer metabolic reprogrammingPancreatic ductal adenocarcinoma treatmentHallmarks of cancerStratified pancreatic ductal adenocarcinomaIndividual metabolic phenotypeMetabolic reprogrammingMetabolic pathwaysMetabolic typeDuctal adenocarcinomaMalignant tumorsHeterogeneous diseasePhenotypeTherapeutic approachesEnergy metabolismMetabolic featuresMetabolic diseasesMetabolic inhibitorsNutritional substratesMetabolite detectionDiseaseGlutaminolysis
2009
Gamma irradiation alters the phenotype and function of CD4+CD25+ regulatory T cells
Cao M, Cabrera R, Xu Y, Liu C, Nelson D. Gamma irradiation alters the phenotype and function of CD4+CD25+ regulatory T cells. Cell Biology International 2009, 33: 565-571. PMID: 19268553, PMCID: PMC2683182, DOI: 10.1016/j.cellbi.2009.02.007.Peer-Reviewed Original ResearchConceptsRegulatory T cellsT cellsSuppression of TregsT cell proliferationDose-dependent reductionTreg expressionTreg proliferationEffector cellsImmunologic balanceSuppressive capacityTregsGy/minDose gamma irradiationFlow cytometryThymidine incorporationUpregulated BaxCell proliferationCancer therapyHigh-dose gamma irradiationApoptosis inductionDifferent dosagesFunction changesGamma irradiationPhenotypeIrradiation alters
2008
Organ-derived dendritic cells have differential effects on alloreactive T cells
Kim T, Terwey T, Zakrzewski J, Suh D, Kochman A, Chen M, King C, Borsotti C, Grubin J, Smith O, Heller G, Liu C, Murphy G, Alpdogan O, van den Brink M. Organ-derived dendritic cells have differential effects on alloreactive T cells. Blood 2008, 111: 2929-2940. PMID: 18178870, PMCID: PMC2254543, DOI: 10.1182/blood-2007-06-096602.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell ProliferationDendritic CellsGene Expression ProfilingGraft vs Host DiseaseHumansIntegrinsIsoantigensLigandsLipopolysaccharidesLiverLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLOligonucleotide Array Sequence AnalysisOrgan SpecificityPhenotypeReceptors, Lymphocyte HomingSelectinsSurvival RateT-LymphocytesUp-RegulationConceptsAlloreactive T cellsBone marrow transplantationDendritic cellsT cellsGVHD mortalityLymph nodesAlloreactive donor T cellsGut-draining lymph nodesLiver-derived dendritic cellsNaive allogeneic T cellsMurine bone marrow transplantationPathophysiology of GVHDTarget organ liverDonor T cellsInduction of graftAllogeneic T cellsPeripheral lymph nodesGut-homing phenotypeMurine BMT modelHost diseaseAdoptive transferHoming moleculesMarrow transplantationStimulatory capacityBMT model
2004
An immunomodulatory role for CD4+CD25+ regulatory T lymphocytes in hepatitis C virus infection
Cabrera R, Tu Z, Xu Y, Firpi R, Rosen H, Liu C, Nelson D. An immunomodulatory role for CD4+CD25+ regulatory T lymphocytes in hepatitis C virus infection. Hepatology 2004, 40: 1062-1071. PMID: 15486925, DOI: 10.1002/hep.20454.Peer-Reviewed Original ResearchMeSH KeywordsAntibodiesAntibody FormationAntigens, CDCase-Control StudiesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell CommunicationEpitopesHepatitis CHepatitis C AntigensHumansImmune SystemInterleukin-10PhenotypeReceptors, Interleukin-2Transforming Growth Factor betaTransforming Growth Factor beta1ConceptsHepatitis C virus infectionPeripheral blood mononuclear cellsC virus infectionRegulatory T lymphocytesBlood mononuclear cellsT lymphocytesMononuclear cellsVirus infectionHCV-specific T-cell responsesCell-cell contact mannerT cell immune responsesHCV RNA titersT cell frequenciesIL-10 productionT cell responsesCell immune responsesInterferon-gamma productionLiver inflammatory activityNormal control subjectsT cell proliferationInterferon gamma activityGrowth factor betaIL-10Intracellular cytokinesInflammatory activity