2019
Donor T Cell Independent Mechanism May Contribute to Enhancing Steroid Refractory Gvhd in Murine Models
Toubai T, Rossi C, Tawara I, Liu C, Suto M, Matsuki E, Zajac C, Oravecz-Wilson K, Peltier D, Sun Y, Fujiwara H, Wu J, Riwes M, Heing I, Kim S, Reddy P. Donor T Cell Independent Mechanism May Contribute to Enhancing Steroid Refractory Gvhd in Murine Models. Transplantation And Cellular Therapy 2019, 25: s292-s293. DOI: 10.1016/j.bbmt.2018.12.669.Peer-Reviewed Original ResearchGVHD clinical scoresSR-GVHDSteroid-refractory GVHDDonor T cellsSplenic T cellsT cellsSteroid-refractoryClinical scoresRefractory GVHDMurine modelGut epithelial cellsWeight lossHistopathological scoresEpithelial cellsT cell-independent mechanismExhausted T cellsGVHD target organsMemory T cellsTarget organsT-cell characteristicsSerum inflammatory cytokinesResponse to DEXBody weight lossDevelopment of therapiesProgressive weight loss
2015
RIG-I-Induced Type I IFNs Promote Regeneration of the Intestinal Stem Cell Compartment during Acute Tissue Damage
Fischer J, Bscheider M, Eisenkolb G, Wintges A, Lindemans C, Heidegger S, Monette S, Calafiore M, Rodriguez K, Lieberman S, Liu C, Peschel C, Docampo M, Velardi E, Jenq R, Hanash A, Dudakov J, Haas T, van den Brink M, Poeck H. RIG-I-Induced Type I IFNs Promote Regeneration of the Intestinal Stem Cell Compartment during Acute Tissue Damage. Blood 2015, 126: 3072. DOI: 10.1182/blood.v126.23.3072.3072.Peer-Reviewed Original ResearchTotal body irradiationEpithelial regenerationAllogeneic hematopoietic stem cell transplantationHematopoietic stem cell transplantationAcute intestinal injuryEpithelial cellsIntestinal barrier damageStem cell transplantationAcute tissue damageType I IFNsType I IFNActivation of RIGInnovative therapeutic strategiesIntestinal epithelial cellsRegenerative functionMechanism of actionHost diseaseIntestinal injuryBody irradiationBarrier damageCell transplantationDeficient miceViral challengePreclinical modelsWorse graft