James Jeanne, PhD

Assistant Professor in Neuroscience; Assistant Professor, Neuroscience

Departments & Organizations

Interdepartmental Neuroscience Program

Swartz Program in Theoretical Neurobiology


Jamie received a B.S.E. in Electrical Engineering from Princeton University in 2005 and a Ph.D. in Computational Neuroscience from UC San Diego in 2012. As a graduate student with Dr. Timothy Gentner and Dr. Tatyana Sharpee, he investigated plasticity in neural population codes in the auditory cortex of the European Starling, a common species of songbird with an exceptional capacity for learning. As a postdoctoral fellow with Dr. Rachel Wilson at Harvard Medical School, he studied the functional roles of convergent and divergent neural circuit motifs in the olfactory system of the fruit fly. Subsequently, using 2-photon optogenetic circuit mapping, he has begun to reveal the functional organization of higher-order olfactory circuits. He joined the Department of Neuroscience at Yale School of Medicine in the Fall of 2017.

The Jeanne Lab is broadly interested in understanding how neural circuits implement the computations that support behavior. We study the fruit fly because of its tractability: the brain contains only 100,000 neurons, neural circuits are stereotyped from fly to fly (down to the level of individual neurons), and large libraries of genetic driver lines enable precise targeting of individual neurons for physiology experiments. Current research aims to understand the circuit and computational mechanisms of sensory processing, working memory, and decision making.

Education & Training

PhD University of California, San Diego, Neuroscience (2012)
BS Princeton University, Electrical Engineering (2005)
Postdoctoral Fellow Harvard Medical School

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Contact Info

James Jeanne, PhD
Mailing Address
333 Cedar Street
New Haven, CT 06510

Jeanne Lab

2-photon optogenetic stimulation of an olfactory neuron in the Drosophila brain

2-photon optogenetic stimulation of an olfactory neuron in the Drosophila brain. A whole-cell patch clamp recording was made from a single antennal lobe projection neuron (second-order olfactory neuron, filled with red dye). The dendrites of this neuron innervate one olfactory glomerulus (lower right) and the axon projects up and out of the antennal lobe (top). The cell body is not visible. This neuron expresses ReaChR (a red-shifted channelrhodopsin) and 7x7x8 micron "voxels" were stimulated using 2-photon excitation. The voltage response of the neuron to stimulation of each voxel is superimposed in white. Only voxels within the glomerulus elicit spikes in the neuron. The green background is a neuropil counterstain showing other olfactory glomeruli.