John D MacMicking, PhD

Associate Professor of Microbial Pathogenesis and of Immunobiology; Member, Yale Systems Biology Institute; Investigator, Howard Hughes Medical Institute

Departments & Organizations

Microbial Pathogenesis

Immunobiology: Human and Translational Immunology Program

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Immunology | Microbiology | Molecular Cell Biology, Genetics and Development

Office of Cooperative Research


Dr. MacMicking trained in synthetic organic chemistry and biochemistry at the Australian National University (B.Sc, 1st Class Honours) where he conducted thesis work within the Department of Immunology & Cell Biology formerly headed by 1996 Nobel Laureate, Peter Doherty, at the the John Curtin School of Medical Research.

He then pursued Ph.D studies within the Immunology program at Sloan-Kettering Institute-Cornell University in New York City (with Carl Nathan) before post-doctoral work as an HHMI Life Science Research Foundation Fellow at the Rockefeller University (with John McKinney). His doctoral dissertation described the first knockout of an innate immune effector protein in mammals - inducible nitric oxide synthase (iNOS) - genetically engineered between 1992-1995. It served as an early paradigm for cell-autonomous immunity to infection. At Rockefeller University he computationally identified, physically mapped and began functionally characterizing a complete IFN-inducible GTPase superfamily comprising 47 members in humans and mice as a new defense network operating against all pathogen classes. For these discoveries he has received several awards at Yale, being named a Edward Mallinckrodt Jr Foundation Fellow (2004), Searle Scholar (2005), Cancer Research Institute Investigator (2006), Burroughs-Wellcome Fund Investigator in the Pathogenesis of Infectious Disease (2008), CCFA Senior Research Awardee (2010), AAF Scholar (2014) and Kenneth Rainin Foundation Innovator (2014)

Dr. MacMicking was promoted to Associate Professor in 2010 and received Tenure in 2014. He was chosen as an HHMI Investigator in 2015 before moving to the Yale Systems Biology Institute in 2017. 

Education & Training

PhD Cornell University (1997)
BS Australian National Univ (1990)
Assistant Professor (Adjunct) The Rockefeller University
Research Associate The Rockefeller University
HHMI LSRF Fellow The Rockefeller University
Revson Biomedical Fellow The Rockefeller University

Honors & Recognition

  • Howard Hughes Medical Institute (HHMI) Investigator (2015)

  • Innovator Award, Kenneth Rainin Foundation (2014)

  • American Asthma Foundation (AAF) Scholar (2014)

  • Crohn’s and Colitis Foundation of America (CCFA) Senior Investigator Award (2010)

  • Burroughs Wellcome Fund (BWF) Investigator in the Pathogenesis of Infectious Disease Award (2008)

  • Cancer Research Institute (CRI) Investigator Award (2006)

  • Searle-Chicago Community Trust Scholar (2005)

  • Edward Mallinckrodt, Jr. Foundation Fellow (2004)

  • HHMI Life Science Research Foundation (LSRF) Fellow The Rockefeller University (1998)

  • Charles H. Revson Fellow in Biomedical ResearchThe Rockefeller University (1997)

  • Distinguished Student Commencement Speaker AwardSloan-Kettering Institute-Cornell University, New York, NY (1997)

Professional Service

  • Cellular Microbiology (2017 - Present) Editorial Board

  • American Society of Microbiology (2014 - 2016) President and President-Elect, Immunology Division

  • NIAID, NIH (2013 - 2015) Standing member, Immunity and Host Defense (IHD) Study Section


  • German Research Foundation (DFG)
 Bonn, Germany (2013)

    International Reviewer, Life Sciences 2 Programme

  • French National Research Agency (ANR) Paris, France (2012)

    International Reviewer, Programme Blanc International

  • Health Research Board of Ireland (HRB) Dublin, Ireland (2011)

    International Reviewer, Translational Medicine Fellowships Programme

  • European Research Council (ERC) Brussels, Belgium (2011)

    International Reviewer, European Union 7th Research Framework Advanced Grants Programme (FP7)

  • Medical Research Council (MRC) London, United Kingdom (2009)

    International Reviewer, Strategic Grants Programme

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Contact Info

John D MacMicking, PhD
Mailing Address
Yale UniversityHoward Hughes Medical Institute, Yale Systems Biology Institute
850 West Campus Drive, ISTC 341

West Haven, CT 06516-7389