Morten Lee
About
Research
Publications
2026
Real-world period prevalence of psoriatic disease 2015-2025: A cross-sectional study in the Epic Cosmos database
Lee M, Canavan M, Cohen J. Real-world period prevalence of psoriatic disease 2015-2025: A cross-sectional study in the Epic Cosmos database. Journal Of The American Academy Of Dermatology 2026, 95: 181-183. PMID: 41903709, DOI: 10.1016/j.jaad.2026.03.067.Peer-Reviewed Original Research
2025
Transforming malignant tumors into vulnerable phenotypes via nanoscale coordination polymer mediated cell senescence and photodynamic therapy
Zhen W, Jiang X, Li E, Germanas T, Lee M, Luo T, Ma X, Wang C, Chen Y, Weichselbaum R, Lin W. Transforming malignant tumors into vulnerable phenotypes via nanoscale coordination polymer mediated cell senescence and photodynamic therapy. Biomaterials 2025, 322: 123355. PMID: 40279766, PMCID: PMC12140873, DOI: 10.1016/j.biomaterials.2025.123355.Peer-Reviewed Original ResearchSpatial Transcriptomics Reveals Differential Inflammatory Pathways in Discoid Lupus Erythematosus and Lichen Planus
Kidacki M, Cho C, Lopez-Giraldez F, Breidbart R, Jaiswal A, Lee M, Chowdhury S, Damsky W, Chen L, Vesely M. Spatial Transcriptomics Reveals Differential Inflammatory Pathways in Discoid Lupus Erythematosus and Lichen Planus. Journal Of Investigative Dermatology 2025, 145: 2344-2348.e7. PMID: 40113031, PMCID: PMC12353771, DOI: 10.1016/j.jid.2025.02.148.Peer-Reviewed Original ResearchThis study investigates immune pathway differences in discoid lupus and lichen planus, showing stronger type 2 inflammation in lichen planus, potentially explaining symptomatic itch.
2024
STING activation disrupts tumor vasculature to overcome the EPR limitation and increase drug deposition
Jiang X, Luo T, Yang K, Lee M, Liu J, Tillman L, Zhen W, Weichselbaum R, Lin W. STING activation disrupts tumor vasculature to overcome the EPR limitation and increase drug deposition. Science Advances 2024, 10: eado0082. PMID: 39018400, PMCID: PMC466951, DOI: 10.1126/sciadv.ado0082.Peer-Reviewed Original Research
2023
Nanoscale coordination polymer synergizes photodynamic therapy and toll-like receptor activation for enhanced antigen presentation and antitumor immunity
Jiang X, Liu J, Lee M, Peng C, Luo T, Tillman L, Weichselbaum R, Lin W. Nanoscale coordination polymer synergizes photodynamic therapy and toll-like receptor activation for enhanced antigen presentation and antitumor immunity. Biomaterials 2023, 302: 122334. PMID: 37776767, PMCID: PMC10841466, DOI: 10.1016/j.biomaterials.2023.122334.Peer-Reviewed Original ResearchCo-delivery of three synergistic chemotherapeutics in a core-shell nanoscale coordination polymer for the treatment of pancreatic cancer
Jiang X, Lee M, Luo T, Tillman L, Lin W. Co-delivery of three synergistic chemotherapeutics in a core-shell nanoscale coordination polymer for the treatment of pancreatic cancer. Biomaterials 2023, 301: 122235. PMID: 37441902, PMCID: PMC10528488, DOI: 10.1016/j.biomaterials.2023.122235.Peer-Reviewed Original ResearchPharmacological ascorbate potentiates combination nanomedicines and reduces cancer cell stemness to prevent post-surgery recurrence and systemic metastasis
Jiang X, Liu J, Mao J, Han W, Fan Y, Luo T, Xia J, Lee M, Lin W. Pharmacological ascorbate potentiates combination nanomedicines and reduces cancer cell stemness to prevent post-surgery recurrence and systemic metastasis. Biomaterials 2023, 295: 122037. PMID: 36773429, PMCID: PMC9998353, DOI: 10.1016/j.biomaterials.2023.122037.Peer-Reviewed Original ResearchA Three‐in‐One Nanoscale Coordination Polymer for Potent Chemo‐Immunotherapy
Liu J, Jiang X, Feng X, Lee M, Li Y, Mao J, Weichselbaum R, Lin W. A Three‐in‐One Nanoscale Coordination Polymer for Potent Chemo‐Immunotherapy. Small Methods 2023, 7: e2201437-e2201437. PMID: 36638256, PMCID: PMC10192092, DOI: 10.1002/smtd.202201437.Peer-Reviewed Original Research
2022
Two-Stage SN38 Release from a Core–Shell Nanoparticle Enhances Tumor Deposition and Antitumor Efficacy for Synergistic Combination with Immune Checkpoint Blockade
Jiang X, Lee M, Xia J, Luo T, Liu J, Rodriguez M, Lin W. Two-Stage SN38 Release from a Core–Shell Nanoparticle Enhances Tumor Deposition and Antitumor Efficacy for Synergistic Combination with Immune Checkpoint Blockade. ACS Nano 2022, 16: 21417-21430. PMID: 36382721, PMCID: PMC9798857, DOI: 10.1021/acsnano.2c09788.Peer-Reviewed Original ResearchTLR3 agonist nanoscale coordination polymer synergizes with immune checkpoint blockade for immunotherapy of cancer
Li Y, Jiang X, Luo T, Xia J, Lee M, Weichselbaum R, Lin W. TLR3 agonist nanoscale coordination polymer synergizes with immune checkpoint blockade for immunotherapy of cancer. Biomaterials 2022, 290: 121831. PMID: 36240687, DOI: 10.1016/j.biomaterials.2022.121831.Peer-Reviewed Original Research