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Postdoctoral Researcher at the Yale Child Study Center & Program in Neurodevelopment and Regeneration

Postdoctoral Associate

Somatic mosaicism and epigenomic regulation in human development and disorders

Flora Vaccarino, PI

A Postdoctoral Associate position is available in the Vaccarino laboratory at the Child Study Center, Yale School of Medicine. The lab is in the Sterling Hall of Medicine, in the main Yale Medical School campus.

The lab uses induced pluripotent stem cells (iPSC) and organoid technologies to investigate genomic and epigenomic underpinnings of human brain development. Over the last 10 years, the Vaccarino lab has created a unique resource, a large numbers of human iPSC lines from over 110 individuals comprising clinically characterized cohorts of patients, their first- degree family members, and independent controls. The research focuses on using this unique tool to develop and refine methods for discovery and analysis of noncoding regulatory elements and somatic mutations during human development using advanced molecular, cellular and genomic techniques.

The applicant will be supported by the laboratory’s experience in stem cell technologies and bioinformatic analyses, a library of viral vectors to perform cell type-specific tracing, and microscopic set-up to perform live cell imaging and functional activity studies. The candidate will have the opportunity to collaborate with bioinformaticians involved in the analysis of DNA structural and sequence variants. The applicant will probe the cell types harboring somatic mutations by single cell transcriptome analyses and their functional relevance using CRISPR technologies to engineer mutations in iPSCs lines. Finally, the candidate will take advantage of the superb core facilities at Yale University and will interact with experts in several other disciplines, including geneticists, physiologists, and system biologists.

  • The candidate must have a Ph.D. and/or M.D., should be an accomplished biomedical scientist with knowledge in molecular and cellular biology, bioinformatics and preferably developmental neuroscience.
  • Excellent command of the English language is required

Qualified candidates should send a CV, a statement of research interests and the names of two references to:

Vaccarino Lab website

Program in Neurodevelopment and Regeneration website