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Livia Tomasini working with fibroblast from patients with Autism spectrum disorders at Professor Vaccarino's Laboratory of Developmental Neurobiology.
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Livia Tomasini working with fibroblast from patients with Autism spectrum disorders at Professor Vaccarino's Laboratory of Developmental Neurobiology.
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Induced pluripotent stem cells derived from a skin sample differentiated into neuronal cells expressing the transcription factors Tbr1 (red) and Ctip2 (green) –blue are undifferentiated progenitors.
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Jessica Mariani Ph.D. and M Vittoria Simonini Ph.D. working in Professor Vaccarino's Laboratory of Developmental Neurobiology analyze immunofluorescent staining showing neuronal differentiation from induced pluripotent stem cells.
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Ying Zhang, Ph.D. analyzes DNA libraries for high throughput DNA sequencing at Professor Sherman Weissman's Laboratory of Genetics.
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Ying Zhang, Ph.D. analyzes DNA libraries for high throughput DNA sequencing at Professor Sherman Weissman's Laboratory of Genetics.
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Induced pluripotent stem cells derived from a skin sample differentiated into neuronal progenitors expressing Nestin (green) and the transcription factor Pax6.
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Anna Szekely, M.D., neurogeneticist, interacts with a child participating as a control in the project of creating induced pluripotent stem cells from skin cells at the Child Study Center.
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Anita Huttner, M.D., Assistant Professor of Pathology, Flora Vaccarino, M.D., Director of the program in Neurodevelopment and Regeneration, and Alexej Abyzov, Ph.D., laboratory of Mark Gerstein, Ph.D., discuss CNV/SV variation assessed by Read Depth Analysis and Paired-end Mapping from DNA sequencing data.
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Induced pluripotent stem cells derived from a skin sample differentiated into neuronal progenitors expressing brain lipid binding protein (BLBP) (red) surrounded by βIII tubulin-expressing neuronal cells.
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Lior Rosenberg Belmaker, Ph.D., at Professor Vaccarino's Laboratory of Developmental Neurobiology generates induced pluripotent cells and neurons from skin cells of children with Autism and their family members. These cells will enable the study of the mechanism underling Autism disorder.
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Flora Vaccarino, M.D., Director of Director of the program in Neurodevelopment and Regeneration, interacts with the members of the program during a meeting.
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Induced pluripotent stem cells derived from a skin sample differentiated into neuronal progenitors expressing the transcription factors Tbr2 (red) and the cell adhesion molecule N-Cadherin –blue are undifferentiated progenitors.
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Xinghua Pan, Ph.D, M.D., laboratory of Sherman Weissman, M.D., generating reagents for nucleic acid amplification to analyze transcriptome for low quantity of induced pluripotent stem cells.
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Xinghua Pan, Ph.D, M.D., laboratory of Sherman Weissman, M.D., generating reagents for nucleic acid amplification to analyze transcriptome for low quantity of induced pluripotent stem cells.
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Induced pluripotent stem cells derived from a skin sample differentiated into neuronal progenitors expressing the transcription factors Tbr2 (red) and the cell adhesion molecule N-Cadherin –blue are undifferentiated progenitors.
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M. Vittoria Simonini Ph.D. and Jessica Mariani Ph.D., laboratory of Flora Vaccarino, M.D., generate neuronal progenitors derived from induced pluripotent stem cells.
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M Vittoria Simonini Ph.D. and Jessica Mariani Ph.D., laboratory of Flora Vaccarino, M.D., generate neuronal progenitors derived from induced pluripotent stem cells.

Program in Neurodevelopment and Regeneration

Our scientific goals include:

Studying the dynamics of human early brain development
Correlating cellular and functional events in neural development with underlying changes in genomic sequence, epigenomic imprinting and regulation of gene expression
Developing cellular models of biological mechanisms underpinning neuropsychiatric disorders of genetic and non-genetic origins
Understanding genomic mosaicism and its implications for normal and abnormal development