Projects

The Vaccarino Lab performs its research in four main project areas.

Somatic mosaicism

Somatic mosaicism is the accumulation of mutations in DNA sequence or copy number in cellular genomes after fertilization (typically in the form of copy number variations, single nucleotide...

Induced Pluripotent Stem Cells & Developmental Disorders

In our lab we produce iPSC from skin fibroblasts of ASD patients and control subjects and use them to study differences in human embryonic neuronal development between these two populations.

The Role of Fibroblast Growth Factor Receptors in the Morphogenesis and Maturation of the Neocortex

Our studies have shown that Fgf signaling regulates the surface expansion of the cerebral cortex and the hippocampus.


Cortico-basal ganglia interactions in movement disorders: Tourette Syndrome

Using stereology, we showed a decrease in number of GABAergic and cholinergic interneurons in postmortem basal ganglia tissue from subjects with Tourette.


Research Funding

Women's Health Research at Yale
Women’s Health Research at Yale funds promising new approaches to understanding sex and gender differences. They bring together Yale faculty from different fields to answer real-world health questions and train the next generation of researchers and clinicians committed to advancing women’s health. They share their findings with the public and policymakers, so that everybody can make more informed health decisions. To learn more about Women's Health Research at Yale, their mission, funding opportunities, community partners and affiliates, please visit their website for more information.