Abstracts

Conference on Retroviruses and Opportunistic Infections (CROI)

Single-cell Genomic Analysis of Blood and CSF T Cells in HIV+ and HIV- Adults. Farhadian, S, Lindenbaum, O, Zhao J, Garcia-Milian R, Charella J, Chintanaphol M, Calvi R, Kluger Y, Spudich S. Oral Abstract 27.

PET Imaging of Synaptic Density in HIV: Preliminary Findings from a Pilot Study. Weiss J, Calvi R, Naganawa M, Toyonaga T, Farhadian S, Chintanaphol M, Charella J, Zheng M, Ropchan J, Huang Y, Carson R, Spudich S. Oral Abstract 29.

HIV DNA Detected in Immune Cell Subsets in CSF During ART. Farhadian S, Cyktor J, Naqvi A, Corley M, Chiarella J, Calvi R, Chintanaphol M, Lyon G, Trotta D, Mellors J, Spudich S. Oral Abstract 31.

Single-cell Atlas and Clonal Expansion Dynamics of CD4+ T Cells During HIV Infection. Collora J, Pinto-Santini D, Pasalar S, Alfaro R, Canoza C, Chiarella J, Calvi R, Lama J, Spudich S, Duerr A, Ho Y. Abstract 361.

Neuroinflammation and Reactive Gliosis During Longterm cART Initiated in Acute HIV. Sailasuta N, Chan P, Sacdalan C, Tipsuk S, Suttichom D, Phanuphak N, Martin S, Ratnaratorn N, Pothirsri M, Dumrongpisutikul N, Ananworanich J, Valcour V, Vasan S, Spudich S, Paul R. Abstract 391.

Clinical and Laboratory Outcomes 24 Weeks After Starting DTG Versus EFV in Acute HIV. Chan P, Goh O, Colby D, Sacdalan C, MucciniC, Phanuphak N, Pinyakorn S, Phanuphak P, Chomchey N, Paul R, Vasan S, Spudich S, Ananworanich J, Kroon E. Abstract 475.

A Randomized Trial of Adjunctive Telmisartan to Reduce CNS Inflammation in Acute HIV. Peluso M, Kroon E, Chan P, Tipsuk S, Sacdalan C, Chiarella J, Gisslen M, Zetterberg H, Gorelick R, Suttichom D, Sailasuta N, Paul R, Ananworanich J, Spudich S. Abstract 406.

Inflammatory Markers Show Dynamic Changes in Acute HIV and Predict Cognitive Outcomes. Longino A, Lama J, Brandes P, Ruiz E, Correa C, Spudich S, Pilcher C, Robertson K, Ignacio R, Duerr A. Abstract 407.

Infiltration of bNAB VRC01 into the Cerebrospinal Fluid in Humans in the RV397 Study. Prabhakaran M, Narpala S, Gama L, Colby D, Chan P, Sacdalan C, Benjapornpong K, Ananworanich J, Phanuphak N, Pinyakorn S, Crowell T, Spudich S, McDermott A. Abstract 453.

A Cross-sectional Analysis of Antiretroviral Regimen Activity in Cerebrospinal Fluid. Fletcher C, McCarthy C, Bosch R, Spudich S, Podany A, Avedissian S, Winchester L, Mykris T, Weinhold J, Macatangay B, Cyktor J, Eron J, Mellors J, Gandhi R, McMahon D. Abstract 455.

Single-cell Atlas and Clonal Expansion Dynamics of CD4+ T Cells during HIV Infection. Collora J, Pinto-Santini D, Pasalar S, Alfaro R, Ganoza C, Chiarella J, Calvi R, Lama J, Spudich S, Duerr A, Ho Y. Abstract 361.

Plasma and CSF SCD30 Dynamics Before and After ART Initiated in Acute HIV. Peluso M, Silke B, Chan P, Sacdalan C, Akapirat S, Jagodzinski L, Valcour V, Phanuphak N, Kroon E, Ananworanich J, Vasan S, Henrich T, Spudich S, Krebs S. Abstract 431.

Quantitation of Cerebrospinal Fluid Pleocytosis and HIV-1 RNA During Acute Infection. Chan P, Muccini C, Sacdalan C, Kroon E, Colby D, Chomchey N, Prueksakaew P, Pinyakorn S, Phanuphak N, Jagodzinski L, Valcour V, Vasan S, Ananworanich J, Spudich S. Abstract 432.

Evolution of Immune Activation Biomarkers in CSF in Fiebig I-V Acute HIV Infection. Weiss J, Chan P, Scadalan C, Kroon E, Akapirat S, Chiarella J, Valcour V, Phanuphak N, Jian N, Vasan S, Ananworanich J, Silke B, Krebs S, Spudich S. Abstract 433.

Conference on Retroviruses and Opportunistic Infections (CROI)

"CSF HIV RNA detected at <20 copies/mL associates with blood brain barrier measures." Farhadian S, Chiarella J, Calvi R, Mistry H, Kirchwey T, Chintanaphol M, Patel P, Landry ML, S Spudich.

"Neuropsychiatric outcomes before and after switching to dolutegravir-based therapy." P Chan, O Goh, E Kroon, D Colby, C Sacdalan, S Pinyakorn, S Tipsuk, N Phanuphak, P Phanuphak, J Ananworanich, V Valcour, S Spudich, R Paul, on behalf of RV254/SEARCH 010 Research Team.

"Resting-state connectivity associates with depression symptom sin acute HIV." C Philippi, L Reyna, P Chan, N Phanuphak, N Ratnaratorn, J Hellmuth, K Benjapornpong, N Dumrongpisutikul, M Pothisri, J Ananworanich, S Spudich, V Valcour, R Paul, for the SEARCH 010/RV254 and RV304 protocol team.

"CSF HIV-specific T cells persist during ART and associate with lower CNS inflammation." C Subra, F Fatmi, S buranapraditkun, P Chan, C Sacdalan, K Tangnaree, M Rolland, S Krebs, N Sailasuta, S Tovanabutra, N Michale, J Ananworanich, S Spudich, L Trautmann, on behalf of the SEARCH010/RV254 Study group.

"CSF escape not detected in acute HIV infection." R Handoko, P Chan, L Jagodzinski, S Pinyakorn, N Phanuphak, C Sacdalan, E Kroon, C Munkong, N Dumrongpisutikul, R O'Connell, R Gramzinski, V Valcour, J Ananworanich, S Spudich, on behalf of the SEARCH010/RV254 Study Team.

"Early ART in acute HIV limits detrimental CX3CR1 monocytes linked to CNS dysfunction." M D'Antoni, P Chan, D Clements, Y Chinvarun, V Khadka, S Tipsuk, R Paul, N Chomchey, D Colby, J Ananworanich, R Gramzinski, S Spudich, L Ndhlovu and the RV254/SEARCH 010;SEARCH013 and SEARCH 011 study groups.

"Effect of Telmisartan given at ART initiation in AHI on immune cells in lymph nodes." S Buranapraditkun, H Takata, E Kroon, S Chottanapund, C Sacdalan, S Tipsuk, K Benjapornpong, B Nuntapinit, T Schacker, N Chomont, M Robb, J Ananworanich, S Spudich, L Trautmann, on behalf of the SEARCH018/RV408 study group.

"HIV-1 persists in CSF cells in half of individuals on long-term ART." S Spudich, R Gandhi, J Cyktor, C Lalama, R Bosch, B Macatangay, C Rinaldo, K Robertson, AC Collier, C Godfrey, E Hogg, J Eron, D McMahon, JW Mellors (ORAL PRESENTATION)

"Longitudinal trajectory of brain volume and cortical thickness in primary infection." Sanford R, Ances BM, Meyerhoff DJ, Price RW, Fuchs D, Zetterberg H, S Spudich, Collins DL (ORAL PRESENTATION)

"Determinants of immunological non-response after initiation of ART in Acute HIV." R Handoko, D Colby, E Kroon, M de Souza, S Pinyakorn, P Prueksakaew, J Chiarella, S Krebs, I Sereti, V Valcour, NL Michael, N Phanuphak, J Ananworanich, S Spudich.

"Intact structural and functional brain imaging in acute HIV." V Samboju, C Phillippi, P Chan, Y Cobigo, JL Fletcher, ML Robb, J Hellmuth, K Benjapornpong, N Dumrongpisutikul, M Pothisri, R Paul, J Ananworanich, S Spudich, V Valcour.

"Cerebral Glutathione metabolism in acute HIV infection and response to ART." N Sailasuta, J Daniels, P Chan, C Sacdalan, ML Robb, S Tipsuk, J Ananworanich, D Suttichom, R Paul, N Ratnaratorn, M Pothisri, N Dumrongpisutikul, S Spudich, V Valcour.

"CSF and blood HIV RNA relationship in acute HIV in linked to CD4/CD8 ratio." P Chan, Payal Patel, J Hellmuth, D Colby, E Kroon, C Sacdalan, JL Fletcher, S Pinyakorn, L Jagodzinski, S Krebs, NL Michael, J Ananworanich, V Valcour, S Spudich.

"Longitudinal cognitive outcomes after treatment in acute HIV infection." P Chan, U Tokac, J Hellmuth, E Kroon, D Colby, C Sacdalan, JL Fletcher, S Tipsuk, S Pinyakorn, ML Robb, J Ananworanich, V Valcour, S Spudich, R Paul. (ORAL PRESENTATION)

"Neurologic stability with brief analytic treatment interruption after early ART." J Hellmuth, D Colby, E Kroon, C Sacdalan, P Chan, J Intasan, V Valcour, T Crowell, L Jagodzinski, K Benjapornpong, NL Michael, J Ananworanich, R Paul, Spudich.