Publications

2023

Biotypes of Central Nervous System Complications in People With Human Immunodeficiency Virus: Virology, Immunology, and Neuropathology.Joseph SB, Gianella S, Burdo TH, Cinque P, Gisslen M, Letendre S, Nath A, Morgello S, Ndhlovu LC, Spudich S. J Infect Dis. 2023 Mar 17. PMID: 36930640.
Immunological, Cognitive, and Psychiatric Outcomes After Initiating Efavirenz- and Dolutegravir-based Antiretroviral Therapy During Acute Human Immunodeficiency Virus Infection.Chan P, Yoon B, Colby D, Kroon E, Sacdalan C, Sriplienchan S, Pinyakorn S, Ananworanich J, Valcour V, Vasan S, Hsu D, Phanuphak N, Paul R, Spudich S. Clin Infect Dis. 2023 Feb 8. PMID: 35687498.
Rebound HIV-1 in cerebrospinal fluid after antiviral therapy interruption is mainly clonally amplified R5 T cell-tropic virus.Kincer LP, Joseph SB, Gilleece MM, Hauser BM, Sizemore S, Zhou S, Di Germanio C, Zetterberg H, Fuchs D, Deeks SG, Spudich S, Gisslen M, Price RW, Swanstrom R. Nat Microbiol. 2023 Feb; 2023 Jan 30. PMID: 36717718.
Brain volumetrics differ by fiebig stage in acute HIV infection.Bolzenius J, Sacdalan C, Ndhlovu LC, Sailasuta N, Trautmann L, Tipsuk S, Crowell TA, Suttichom D, Colby DJ, Phanuphak N, Chan P, Premeaux T, Kroon E, Vasan S, Hsu DC, Valcour V, Ananworanich J, Robb ML, Ake JA, Pohl KM, Sriplienchan S, Spudich S, Paul R. AIDS. 2023 Jan 30; 2023 Jan 30. PMID: 36723491.

2022

HIV-1 is Transported into the Central Nervous System by Trafficking Infected Cells.Kincer LP, Schnell G, Swanstrom R, Miller MB, Spudich S, Eron JJ, Price RW, Joseph SB. Pathog Immun. 2022; 2023 Jan 23. PMID: 36865569.
Anti-SARS-CoV-2 and Autoantibody Profiling of a COVID-19 Patient With Subacute Psychosis Who Remitted After Treatment With Intravenous Immunoglobulin.McAlpine LS, Lifland B, Check JR, Angarita GA, Ngo TT, Chen P, Dandekar R, Alvarenga BD, Browne WD, Pleasure SJ, Wilson MR, Spudich SS, Farhadian SF, Bartley CM. Biol Psychiatry. 2022 Dec 5; 2022 Dec 5. PMID: 36481066.
Individual Differences in CD4/CD8 T-Cell Ratio Trajectories and Associated Risk Profiles Modeled From Acute HIV Infection.Paul R, Cho K, Bolzenius J, Sacdalan C, Ndhlovu LC, Trautmann L, Krebs S, Tipsuk S, Crowell TA, Suttichom D, Colby DJ, Premeaux TA, Phanuphak N, Chan P, Kroon E, Vasan S, Hsu D, Carrico A, Valcour V, Ananworanich J, Robb ML, Ake JA, Sriplienchan S, Spudich S. Psychosom Med. 2022 Oct 1; 2022 Jul 6. PMID: 36162059.
Correlation between CD4/CD8 ratio and neurocognitive performance during early HIV infection.Le LT, Price RW, Gisslén M, Zetterberg H, Emu B, Fabre R, Christian P, Andersen S, Spudich S, Vassallo M. HIV Med. 2022 Sep 22; 2022 Sep 22. PMID: 36134890.
Neuropathogenesis of HIV-1: insights from across the spectrum of acute through long-term treated infection.Killingsworth L, Spudich S. Semin Immunopathol. 2022 Sep; 2022 Jul 26. PMID: 35882661.
Cerebrospinal Fluid Viral Load Across the Spectrum of Untreated Human Immunodeficiency Virus Type 1 (HIV-1) Infection: A Cross-Sectional Multicenter Study.Ulfhammer G, Edén A, Antinori A, Brew BJ, Calcagno A, Cinque P, De Zan V, Hagberg L, Lin A, Nilsson S, Oprea C, Pinnetti C, Spudich S, Trunfio M, Winston A, Price RW, Gisslén M. Clin Infect Dis. 2022 Aug 31. PMID: 34747481.
Investigating vascular diseases in people living with HIV by nuclear imaging.Chan P, Spudich S. J Nucl Cardiol. 2022 Aug; 2021 Apr 21. PMID: 33884573.
HIV viral transcription and immune perturbations in the CNS of people with HIV despite ART.Farhadian SF, Lindenbaum O, Zhao J, Corley MJ, Im Y, Walsh H, Vecchio A, Garcia-Milian R, Chiarella J, Chintanaphol M, Calvi R, Wang G, Ndhlovu LC, Yoon J, Trotta D, Ma S, Kluger Y, Spudich S. JCI Insight. 2022 Jul 8; 2022 Jul 8. PMID: 35801589.
Infection and inflammation: New perspectives on Alzheimer's disease.Whitson HE, Colton C, El Khoury J, Gate D, Goate A, Heneka MT, Kaddurah-Daouk R, Klein RS, Shinohara ML, Sisodia S, Spudich SS, Stevens B, Tanzi R, Ting JP, Garden G. Brain Behav Immun Health. 2022 Jul; 2022 Apr 22. PMID: 36118272.
Single-cell multiomics reveals persistence of HIV-1 in expanded cytotoxic T cell clones.Collora JA, Liu R, Pinto-Santini D, Ravindra N, Ganoza C, Lama JR, Alfaro R, Chiarella J, Spudich S, Mounzer K, Tebas P, Montaner LJ, van Dijk D, Duerr A, Ho YC. Immunity. 2022 Jun 14; 2022 Mar 22. PMID: 35320704.
HIV Compartmentalization in the CNS and Its Impact in Treatment Outcomes and Cure Strategies.Chan P, Spudich S. Curr HIV/AIDS Rep. 2022 Jun; 2022 May 10. PMID: 35536438.
HIV Disease Dynamics and Markers of Inflammation and CNS Injury During Primary HIV Infection and Their Relationship to Cognitive Performance.Longino AA, Paul R, Wang Y, Lama JR, Brandes P, Ruiz E, Correa C, Keating S, Spudich SS, Pilcher C, Vecchio A, Pasalar S, Bender Ignacio RA, Valdez R, Dasgupta S, Robertson K, Duerr A. J Acquir Immune Defic Syndr. 2022 Feb 1. PMID: 34629415.
Nervous system consequences of COVID-19.Spudich S, Nath A. Science. 2022 Jan 21; 2022 Jan 20. PMID: 35050660.

2021

Cerebrospinal fluid CD4+ T cell infection in humans and macaques during acute HIV-1 and SHIV infection.Sharma V, Creegan M, Tokarev A, Hsu D, Slike BM, Sacdalan C, Chan P, Spudich S, Ananworanich J, Eller MA, Krebs SJ, Vasan S, Bolton DL. PLoS Pathog. 2021 Dec; 2021 Dec 7. PMID: 34874976.
Preliminary In Vivo Evidence of Reduced Synaptic Density in Human Immunodeficiency Virus (HIV) Despite Antiretroviral Therapy.Weiss JJ, Calvi R, Naganawa M, Toyonaga T, Farhadian SF, Chintanaphol M, Chiarella J, Zheng MQ, Ropchan J, Huang Y, Pietrzak RH, Carson RE, Spudich S. Clin Infect Dis. 2021 Oct 20. PMID: 34050746.
Central Nervous System Safety During Brief Analytic Treatment Interruption of Antiretroviral Therapy Within 4 Human Immunodeficiency Virus Remission Trials: An Observational Study in Acutely Treated People Living With Human Immunodeficiency Virus.Hellmuth J, Muccini C, Colby DJ, Kroon E, de Souza M, Crowell TA, Chan P, Sacdalan C, Intasan J, Benjapornpong K, Tipsuk S, Puttamaswin S, Chomchey N, Valcour V, Sarnecki M, Tomaka F, Krebs SJ, Slike BM, Jagodzinski LL, Dumrongpisutikul N, Sailasuta N, Samboju V, Michael NL, Robb ML, Vasan S, Ananworanich J, Phanuphak P, Phanuphak N, Paul R, Spudich S. Clin Infect Dis. 2021 Oct 5. PMID: 32916708.
Prior Stroke and Age Predict Acute Ischemic Stroke Among Hospitalized COVID-19 Patients: A Derivation and Validation Study.Peng TJ, Jasne AS, Simonov M, Abdelhakim S, Kone G, Cheng YK, Rethana M, Tarasaria K, Herman AL, Baker AD, Yaghi S, Frontera JA, Sansing LH, Falcone GJ, Spudich S, Schindler J, Sheth KN, Sharma R. Front Neurol. 2021; 2021 Oct 4. PMID: 34675873.
Remission of Subacute Psychosis in a COVID-19 Patient With an Antineuronal Autoantibody After Treatment With Intravenous Immunoglobulin.McAlpine LS, Lifland B, Check JR, Angarita GA, Ngo TT, Pleasure SJ, Wilson MR, Spudich SS, Farhadian SF, Bartley CM. Biol Psychiatry. 2021 Aug 15; 2021 Apr 12. PMID: 34001372.
Abrupt and altered cell-type specific DNA methylation profiles in blood during acute HIV infection persists despite prompt initiation of ART.Corley MJ, Sacdalan C, Pang APS, Chomchey N, Ratnaratorn N, Valcour V, Kroon E, Cho KS, Belden AC, Colby D, Robb M, Hsu D, Spudich S, Paul R, Vasan S, Ndhlovu LC. PLoS Pathog. 2021 Aug; 2021 Aug 13. PMID: 34388205.
VZV myelitis with secondary HIV CSF escape.Weiss JJ, Spudich S, Barakat L. BMJ Case Rep. 2021 Jun 29; 2021 Jun 29. PMID: 34187795.
Ischemic Stroke, Inflammation, and Endotheliopathy in COVID-19 Patients.McAlpine LS, Zubair AS, Maran I, Chojecka P, Lleva P, Jasne AS, Navaratnam D, Matouk C, Schindler J, Sheth KN, Chun H, Lee AI, Spudich S, Sharma R, Sansing LH. Stroke. 2021 Jun; 2021 May 10. PMID: 33966492.
Neuropathogenesis of acute coronavirus disease 2019.Farhadian SF, Seilhean D, Spudich S. Curr Opin Neurol. 2021 Jun 1. PMID: 33852526.
Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms.Song E, Bartley CM, Chow RD, Ngo TT, Jiang R, Zamecnik CR, Dandekar R, Loudermilk RP, Dai Y, Liu F, Sunshine S, Liu J, Wu W, Hawes IA, Alvarenga BD, Huynh T, McAlpine L, Rahman NT, Geng B, Chiarella J, Goldman-Israelow B, Vogels CBF, Grubaugh ND, Casanovas-Massana A, Phinney BS, Salemi M, Alexander JR, Gallego JA, Lencz T, Walsh H, Wapniarski AE, Mohanty S, Lucas C, Klein J, Mao T, Oh J, Ring A, Spudich S, Ko AI, Kleinstein SH, Pak J, DeRisi JL, Iwasaki A, Pleasure SJ, Wilson MR, Farhadian SF. Cell Rep Med. 2021 May 18; 2021 May 3. PMID: 33969321.
Compartmentalization of cerebrospinal fluid inflammation across the spectrum of untreated HIV-1 infection, central nervous system injury and viral suppression.Gisslen M, Keating SM, Spudich S, Arechiga V, Stephenson S, Zetterberg H, Di Germanio C, Blennow K, Fuchs D, Hagberg L, Norris PJ, Peterson J, Shacklett BL, Yiannoutsos CT, Price RW. PLoS One. 2021; 2021 May 13. PMID: 33983973.
Cognitive trajectories after treatment in acute HIV infection.Chan P, Kerr SJ, Kroon E, Colby D, Sacdalan C, Hellmuth J, Reiss P, Vasan S, Ananworanich J, Valcour V, Spudich S, Paul R. AIDS. 2021 May 1. PMID: 33534200.
Minimal detection of cerebrospinal fluid escape after initiation of antiretroviral therapy in acute HIV-1 infection.Handoko R, Chan P, Jagodzinski L, Pinyakorn S, Ubolyam S, Phanuphak N, Sacdalan C, Kroon E, Dumrongpisutikul N, Paul R, Valcour V, Ananworanich J, Vasan S, Spudich S. AIDS. 2021 Apr 1. PMID: 33306551.
Coronavirus disease 2019 and neurodegenerative disease: what will the future bring?McAlpine LS, Fesharaki-Zadeh A, Spudich S. Curr Opin Psychiatry. 2021 Mar 1. PMID: 33395100.

2020

Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement.Song E, Bartley CM, Chow RD, Ngo TT, Jiang R, Zamecnik CR, Dandekar R, Loudermilk RP, Dai Y, Liu F, Hawes IA, Alvarenga BD, Huynh T, McAlpine L, Rahman NT, Geng B, Chiarella J, Goldman-Israelow B, Vogels CBF, Grubaugh ND, Casanovas-Massana A, Phinney BS, Salemi M, Alexander J, Gallego JA, Lencz T, Walsh H, Lucas C, Klein J, Mao T, Oh J, Ring A, Spudich S, Ko AI, Kleinstein SH, DeRisi JL, Iwasaki A, Pleasure SJ, Wilson MR, Farhadian SF. bioRxiv. 2020 Dec 9; 2020 Dec 9. PMID: 32935102.
Lessons from a neurology consult service for patients with COVID-19.McAlpine LS, Zubair AS, Moeller J, Baehring J, Spudich S. Lancet Neurol. 2020 Oct; 2020 Sep 16. PMID: 32949536.
Assessment of Brain Injury Using Portable, Low-Field Magnetic Resonance Imaging at the Bedside of Critically Ill Patients.Sheth KN, Mazurek MH, Yuen MM, Cahn BA, Shah JT, Ward A, Kim JA, Gilmore EJ, Falcone GJ, Petersen N, Gobeske KT, Kaddouh F, Hwang DY, Schindler J, Sansing L, Matouk C, Rothberg J, Sze G, Siner J, Rosen MS, Spudich S, Kimberly WT. JAMA Neurol. 2020 Sep 8; 2020 Sep 8. PMID: 32897296.
A randomized trial of vorinostat with treatment interruption after initiating antiretroviral therapy during acute HIV-1 infection.Kroon EDMB, Ananworanich J, Pagliuzza A, Rhodes A, Phanuphak N, Trautmann L, Mitchell JL, Chintanaphol M, Intasan J, Pinyakorn S, Benjapornpong K, Chang JJ, Colby DJ, Chomchey N, Fletcher JLK, Eubanks K, Yang H, Kapson J, Dantanarayana A, Tennakoon S, Gorelick RJ, Maldarelli F, Robb ML, Kim JH, Spudich S, Chomont N, Phanuphak P, Lewin SR, de Souza MS. J Virus Erad. 2020 Sep; 2020 Jul 18. PMID: 33251022.
Determinants of suboptimal CD4(+) T cell recovery after antiretroviral therapy initiation in a prospective cohort of acute HIV-1 infection.Handoko R, Colby DJ, Kroon E, Sacdalan C, de Souza M, Pinyakorn S, Prueksakaew P, Munkong C, Ubolyam S, Akapirat S, Chiarella J, Krebs S, Sereti I, Valcour V, Paul R, Michael NL, Phanuphak N, Ananworanich J, Spudich S. J Int AIDS Soc. 2020 Sep. PMID: 32949118.
Stroke Code Presentations, Interventions, and Outcomes Before and During the COVID-19 Pandemic.Jasne AS, Chojecka P, Maran I, Mageid R, Eldokmak M, Zhang Q, Nystrom K, Vlieks K, Askenase M, Petersen N, Falcone GJ, Wira CR 3rd, Lleva P, Zeevi N, Narula R, Amin H, Navaratnam D, Loomis C, Hwang DY, Schindler J, Hebert R, Matouk C, Krumholz HM, Spudich S, Sheth KN, Sansing LH, Sharma R. Stroke. 2020 Sep; 2020 Jul 31. PMID: 32755347.
Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019: A Review.Zubair AS, McAlpine LS, Gardin T, Farhadian S, Kuruvilla DE, Spudich S. JAMA Neurol. 2020 Aug 1. PMID: 32469387.
Cognitive disorders in people living with HIV.Winston A, Spudich S. Lancet HIV. 2020 Jul. PMID: 32621876.
Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19.Farhadian S, Glick LR, Vogels CBF, Thomas J, Chiarella J, Casanovas-Massana A, Zhou J, Odio C, Vijayakumar P, Geng B, Fournier J, Bermejo S, Fauver JR, Alpert T, Wyllie AL, Turcotte C, Steinle M, Paczkowski P, Dela Cruz C, Wilen C, Ko AI, MacKay S, Grubaugh ND, Spudich S, Barakat LA. BMC Neurol. 2020 Jun 18; 2020 Jun 18. PMID: 32552792.
Single-cell transcriptional landscapes reveal HIV-1-driven aberrant host gene transcription as a potential therapeutic target.Liu R, Yeh YJ, Varabyou A, Collora JA, Sherrill-Mix S, Talbot CC Jr, Mehta S, Albrecht K, Hao H, Zhang H, Pollack RA, Beg SA, Calvi RM, Hu J, Durand CM, Ambinder RF, Hoh R, Deeks SG, Chiarella J, Spudich S, Douek DC, Bushman FD, Pertea M, Ho YC. Sci Transl Med. 2020 May 13. PMID: 32404504.
Resting-state neural signatures of depressive symptoms in acute HIV.Philippi CL, Reyna L, Nedderman L, Chan P, Samboju V, Chang K, Phanuphak N, Ratnaratorn N, Hellmuth J, Benjapornpong K, Dumrongpisutikul N, Pothisri M, Robb ML, Ananworanich J, Spudich S, Valcour V, Paul R. J Neurovirol. 2020 Apr; 2020 Jan 27. PMID: 31989446.
Regional brain volumetric changes despite 2 years of treatment initiated during acute HIV infection.Kallianpur KJ, Jahanshad N, Sailasuta N, Benjapornpong K, Chan P, Pothisri M, Dumrongpisutikul N, Laws E, Ndhlovu LC, Clifford KM, Paul R, Jagodzinski L, Krebs S, Ananworanich J, Spudich S, Valcour V. AIDS. 2020 Mar 1. PMID: 31725432.
Feasibility and safety of research sigmoid colon biopsy in a cohort of Thai men who have sex with men with acute HIV-1.Chintanaphol M, Sacdalan C, Pinyakorn S, Rerknimitr R, Ridtitid W, Prueksapanich P, Sereti I, Schuetz A, Crowell TA, Colby DJ, Robb ML, Phanuphak N, Ananworanich J, Spudich SS, Kroon E. J Virus Erad. 2020 Feb 20; 2020 Feb 20. PMID: 32175085.
Neuropsychiatric outcomes before and after switching to dolutegravir-based therapy in an acute HIV cohort.Chan P, Goh O, Kroon E, Colby D, Sacdalan C, Pinyakorn S, Prueksakaew P, Reiss P, Ananworanich J, Valcour V, Spudich S, Paul R. AIDS Res Ther. 2020 Jan 7; 2020 Jan 7. PMID: 31907064.
Liver function test abnormalities in a longitudinal cohort of Thai individuals treated since acute HIV infection.Peluso MJ, Colby DJ, Pinyakorn S, Ubolyam S, Intasan J, Trichavaroj R, Chomchey N, Prueksakaew P, Slike BM, Krebs SJ, Jian N, Robb ML, Phanuphak P, Phanuphak N, Spudich S, Ananworanich J, Kroon E. J Int AIDS Soc. 2020 Jan. PMID: 31953919.

2019

Exosomal MicroRNAs Associate With Neuropsychological Performance in Individuals With HIV Infection on Antiretroviral Therapy.OʼMeara T, Kong Y, Chiarella J, Price RW, Chaudhury R, Liu X, Spudich S, Robertson K, Emu B, Lu L. J Acquir Immune Defic Syndr. 2019 Dec 15. PMID: 31714431.
Markers of CNS Injury in Adults Living With HIV With CSF HIV Not Detected vs Detected <20 Copies/mL.Farhadian SF, Mistry H, Kirchwey T, Chiarella J, Calvi R, Chintanaphol M, Patel P, Landry ML, Robertson K, Spudich SS. Open Forum Infect Dis. 2019 Dec; 2019 Dec 14. PMID: 31893212.
Defining cerebrospinal fluid HIV RNA escape: editorial review AIDS.Winston A, Antinori A, Cinque P, Fox HS, Gisslen M, Henrich TJ, Letendre S, Persaud D, Price RW, Spudich S. AIDS. 2019 Dec 1. PMID: 31790376.
Potential for early antiretroviral therapy to reduce central nervous system HIV-1 persistence.Spudich S, Peterson J, Fuchs D, Price RW, Gisslen M. AIDS. 2019 Dec 1. PMID: 31789814.
HIV persistence in the central nervous system during antiretroviral therapy: evidence and implications.Spudich S, Clements JE. AIDS. 2019 Dec 1. PMID: 31789813.
Very Early Initiation of Antiretroviral Therapy During Acute HIV Infection Is Associated With Normalized Levels of Immune Activation Markers in Cerebrospinal Fluid but Not in Plasma.Hellmuth J, Slike BM, Sacdalan C, Best J, Kroon E, Phanuphak N, Fletcher JLK, Prueksakaew P, Jagodzinski LL, Valcour V, Robb M, Ananworanich J, Allen IE, Krebs SJ, Spudich S. J Infect Dis. 2019 Nov 6. PMID: 30668739.
Trajectory Analysis of Cognitive Outcomes in Children With Perinatal HIV.Patel PB, Apornpong T, Puthanakit T, Thongpibul K, Kosalaraksa P, Hansudewechakul R, Kanjanavanit S, Ngampiyaskul C, Luesomboon W, Wongsawat J, Sun LP, Chettra K, Saphonn V, Mellins CA, Malee K, Spudich S, Ananworanich J, Kerr SJ, Paul R. Pediatr Infect Dis J. 2019 Oct. PMID: 31568142.
Neurosyphilis During Acute HIV Infection: A CNS Immunologic and Virologic Characterization.Chan P, Dumrongpisutikul N, Subra C, Colby DJ, Kroon E, Fletcher J, Sacdalan C, Phanuphak N, Valcour V, Ananworanich J, Trautmann L, Spudich S. J Acquir Immune Defic Syndr. 2019 Oct 1. PMID: 31180994.
Human Immunodeficiency Virus Type 1 RNA Detected in the Central Nervous System (CNS) After Years of Suppressive Antiretroviral Therapy Can Originate from a Replicating CNS Reservoir or Clonally Expanded Cells.Joseph SB, Kincer LP, Bowman NM, Evans C, Vinikoor MJ, Lippincott CK, Gisslén M, Spudich S, Menezes P, Robertson K, Archin N, Kashuba A, Eron JJ, Price RW, Swanstrom R. Clin Infect Dis. 2019 Sep 27. PMID: 30561541.
Deep Sequencing Reveals Central Nervous System Compartmentalization in Multiple Transmitted/Founder Virus Acute HIV-1 Infection.Tovanabutra S, Sirijatuphat R, Pham PT, Bonar L, Harbolick EA, Bose M, Song H, Chang D, Oropeza C, O'Sullivan AM, Balinang J, Kroon E, Colby DJ, Sacdalan C, Hellmuth J, Chan P, Prueksakaew P, Pinyakorn S, Jagodzinski LL, Sutthichom D, Pattamaswin S, de Souza M, Gramzinski RA, Kim JH, Michael NL, Robb ML, Phanuphak N, Ananworanich J, Valcour V, Kijak GH, Sanders-Buell E, Spudich S. Cells. 2019 Aug 15; 2019 Aug 15. PMID: 31443253.
Persistent HIV-infected cells in cerebrospinal fluid are associated with poorer neurocognitive performance.Spudich S, Robertson KR, Bosch RJ, Gandhi RT, Cyktor JC, Mar H, Macatangay BJ, Lalama CM, Rinaldo C, Collier AC, Godfrey C, Eron JJ, McMahon D, Jacobs JL, Koontz D, Hogg E, Vecchio A, Mellors JW. J Clin Invest. 2019 Jul 15; 2019 Jul 15. PMID: 31305262.
Switch to dolutegravir is well tolerated in Thais with HIV infection.Goh OQ, Colby DJ, Pinyakorn S, Sacdalan C, Kroon E, Chan P, Chomchey N, Kanaprach R, Prueksakaew P, Suttichom D, Trichavaroj R, Spudich S, Robb ML, Phanuphak P, Phanuphak N, Ananworanich J. J Int AIDS Soc. 2019 Jul. PMID: 31294931.
Slowly progressive fatal PML-IRIS following antiretroviral initiation at CD4+ nadir of 350 cells/mm(3) despite CD4+ cell count rise to 900 cells/mm(3).Sandhu MR, Rutledge R, Grant M, Mahajan A, Spudich S. Int J STD AIDS. 2019 Jul; 2019 May 2. PMID: 31046614.
Treatment of Central Nervous System Manifestations of HIV in the Current Era.Handoko R, Spudich S. Semin Neurol. 2019 Jun; 2019 Aug 2. PMID: 31378874.
Predicting Efavirenz Concentrations in the Brain Tissue of HIV-Infected Individuals and Exploring their Relationship to Neurocognitive Impairment.Srinivas N, Joseph SB, Robertson K, Kincer LP, Menezes P, Adamson L, Schauer AP, Blake KH, White N, Sykes C, Luciw P, Eron JJ, Forrest A, Price RW, Spudich S, Swanstrom R, Kashuba ADM. Clin Transl Sci. 2019 May; 2019 Feb 27. PMID: 30675981.
Recommendations for analytical antiretroviral treatment interruptions in HIV research trials-report of a consensus meeting.Julg B, Dee L, Ananworanich J, Barouch DH, Bar K, Caskey M, Colby DJ, Dawson L, Dong KL, Dubé K, Eron J, Frater J, Gandhi RT, Geleziunas R, Goulder P, Hanna GJ, Jefferys R, Johnston R, Kuritzkes D, Li JZ, Likhitwonnawut U, van Lunzen J, Martinez-Picado J, Miller V, Montaner LJ, Nixon DF, Palm D, Pantaleo G, Peay H, Persaud D, Salzwedel J, Salzwedel K, Schacker T, Sheikh V, Søgaard OS, Spudich S, Stephenson K, Sugarman J, Taylor J, Tebas P, Tiemessen CT, Tressler R, Weiss CD, Zheng L, Robb ML, Michael NL, Mellors JW, Deeks SG, Walker BD. Lancet HIV. 2019 Apr; 2019 Mar 15. PMID: 30885693.
Cerebrospinal Fluid Concentrations of the Synaptic Marker Neurogranin in Neuro-HIV and Other Neurological Disorders.Yilmaz A, Fuchs D, Price RW, Spudich S, Blennow K, Zetterberg H, Gisslén M. Curr HIV/AIDS Rep. 2019 Feb. PMID: 30649659.
CSF concentrations of soluble TREM2 as a marker of microglial activation in HIV-1 infection.Gisslén M, Heslegrave A, Veleva E, Yilmaz A, Andersson LM, Hagberg L, Spudich S, Fuchs D, Price RW, Zetterberg H. Neurol Neuroimmunol Neuroinflamm. 2019 Jan; 2018 Nov 7. PMID: 30568991.

2018

Residency Training: Progressive gait difficulty and incontinence in a 40-year-old man with HIV.Silverman A, O'Meara T, Le L, Robertson K, Spudich S. Neurology. 2018 Dec 4. PMID: 30510020.
Longitudinal Trajectories of Brain Volume and Cortical Thickness in Treated and Untreated Primary Human Immunodeficiency Virus Infection.Sanford R, Ances BM, Meyerhoff DJ, Price RW, Fuchs D, Zetterberg H, Spudich S, Collins DL. Clin Infect Dis. 2018 Nov 13. PMID: 29697762.
Brief Report: Safety and Tolerability of Inguinal Lymph Node Biopsy in Individuals With Acute HIV Infection in Thailand.Chintanaphol M, Sacdalan C, Chottanapund S, Pinyakorn S, Buranapraditkun S, Crowell TA, Kroon E, Manasnayakorn S, Chipman JG, Schacker TW, Michael N, Phanuphak N, Spudich SS, Colby DJ, Ananworanich J. J Acquir Immune Defic Syndr. 2018 Oct 1. PMID: 30212436.
Normalization of Soluble CD163 Levels After Institution of Antiretroviral Therapy During Acute HIV Infection Tracks with Fewer Neurological Abnormalities.D'Antoni ML, Byron MM, Chan P, Sailasuta N, Sacdalan C, Sithinamsuwan P, Tipsuk S, Pinyakorn S, Kroon E, Slike BM, Krebs SJ, Khadka VS, Chalermchai T, Kallianpur KJ, Robb M, Spudich S, Valcour V, Ananworanich J, Ndhlovu LC. J Infect Dis. 2018 Sep 22. PMID: 29868826.
Single-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV.Farhadian SF, Mehta SS, Zografou C, Robertson K, Price RW, Pappalardo J, Chiarella J, Hafler DA, Spudich SS. JCI Insight. 2018 Sep 20; 2018 Sep 20. PMID: 30232286.
Distribution of Human Immunodeficiency Virus (HIV) Ribonucleic Acid in Cerebrospinal Fluid and Blood Is Linked to CD4/CD8 Ratio During Acute HIV.Chan P, Patel P, Hellmuth J, Colby DJ, Kroon E, Sacdalan C, Pinyakorn S, Jagodzinski L, Krebs S, Ananworanich J, Valcour V, Spudich S. J Infect Dis. 2018 Aug 14. PMID: 29741638.
Structural and functional brain imaging in acute HIV.Samboju V, Philippi CL, Chan P, Cobigo Y, Fletcher JLK, Robb M, Hellmuth J, Benjapornpong K, Dumrongpisutikul N, Pothisri M, Paul R, Ananworanich J, Spudich S, Valcour V. Neuroimage Clin. 2018; 2018 Jul 27. PMID: 30101063.
Central Nervous System Inflammation and Infection during Early, Nonaccelerated Simian-Human Immunodeficiency Virus Infection in Rhesus Macaques.Hsu DC, Sunyakumthorn P, Wegner M, Schuetz A, Silsorn D, Estes JD, Deleage C, Tomusange K, Lakhashe SK, Ruprecht RM, Lombardini E, Im-Erbsin R, Kuncharin Y, Phuang-Ngern Y, Inthawong D, Chuenarom W, Burke R, Robb ML, Ndhlovu LC, Ananworanich J, Valcour V, O'Connell RJ, Spudich S, Michael NL, Vasan S. J Virol. 2018 Jun 1; 2018 May 14. PMID: 29563297.
Acute Retroviral Syndrome Is Associated With High Viral Burden, CD4 Depletion, and Immune Activation in Systemic and Tissue Compartments.Crowell TA, Colby DJ, Pinyakorn S, Fletcher JLK, Kroon E, Schuetz A, Krebs SJ, Slike BM, Leyre L, Chomont N, Jagodzinski LL, Sereti I, Utay NS, Dewar R, Rerknimitr R, Chomchey N, Trichavaroj R, Valcour VG, Spudich S, Michael NL, Robb ML, Phanuphak N, Ananworanich J. Clin Infect Dis. 2018 May 2. PMID: 29228130.
Global Health Neurology: HIV/AIDS.Patel PB, Spudich SS. Semin Neurol. 2018 Apr; 2018 May 23. PMID: 29791950.
Anti-Human Immunodeficiency Virus Antibodies in the Cerebrospinal Fluid: Evidence of Early Treatment Impact on Central Nervous System Reservoir?Burbelo PD, Price RW, Hagberg L, Hatano H, Spudich S, Deeks SG, Gisslén M. J Infect Dis. 2018 Mar 13. PMID: 29401308.

2017

Neurological Complications of HIV Infection.Farhadian S, Patel P, Spudich S. Curr Infect Dis Rep. 2017 Nov 21; 2017 Nov 21. PMID: 29164407.
Depression and Anxiety are Common in Acute HIV Infection and Associate with Plasma Immune Activation.Hellmuth J, Colby D, Valcour V, Suttichom D, Spudich S, Ananworanich J, Prueksakaew P, Sailasuta N, Allen I, Jagodzinski LL, Slike B, Ochi D, Paul R. AIDS Behav. 2017 Nov. PMID: 28484888.
An explanatory factor analysis of a brief self-report scale to detect neurocognitive impairment among HIV-positive men who have sex with men and transgender women in Peru.Weikum D, Shrestha R, Ferro EG, Vagenas P, Copenhaver M, Spudich S, Alpert MD, Cabello R, Lama JR, Sanchez J, Altice FL. AIDS Care. 2017 Oct; 2017 Apr 27. PMID: 28449599.
Neurofilament light chain protein as a marker of neuronal injury: review of its use in HIV-1 infection and reference values for HIV-negative controls.Yilmaz A, Blennow K, Hagberg L, Nilsson S, Price RW, Schouten J, Spudich S, Underwood J, Zetterberg H, Gisslén M. Expert Rev Mol Diagn. 2017 Aug; 2017 Jun 14. PMID: 28598205.
CROI 2017: Neurologic Complications of HIV Infection.Spudich SS, Ances BM. Top Antivir Med. 2017 May/Jun. PMID: 28598791.
High Number of Activated CD8+ T Cells Targeting HIV Antigens Are Present in Cerebrospinal Fluid in Acute HIV Infection.Kessing CF, Spudich S, Valcour V, Cartwright P, Chalermchai T, Fletcher JL, Takata H, Nichols C, Josey BJ, Slike B, Krebs SJ, Sailsuta N, Lerdlum S, Jagodzinski L, Tipsuk S, Suttichom D, Rattanamanee S, Zetterberg H, Hellmuth J, Phanuphak N, Robb ML, Michael NL, Ananworanich J, Trautmann L. J Acquir Immune Defic Syndr. 2017 May 1. PMID: 28177966.
Blood-Brain Barrier Disruption Is Initiated During Primary HIV Infection and Not Rapidly Altered by Antiretroviral Therapy.Rahimy E, Li FY, Hagberg L, Fuchs D, Robertson K, Meyerhoff DJ, Zetterberg H, Price RW, Gisslén M, Spudich S. J Infect Dis. 2017 Apr 1. PMID: 28368497.

2016

Highlights of the Global HIV-1 CSF Escape Consortium Meeting, 9 June 2016, Bethesda, MD, USA.Joseph J, Cinque P, Colosi D, Dravid A, Ene L, Fox H, Gabuzda D, Gisslen M, Beth Joseph S, Letendre S, Mukerji SS, Nath A, Perez-Valero I, Persaud D, Price RW, Rao VR, Sacktor N, Swanstrom R, Winston A, Wojna V, Wright E, Spudich S. J Virus Erad. 2016 Oct 5; 2016 Oct 5. PMID: 27781109.
HIV-Associated Neurologic Disorders and Central Nervous System Opportunistic Infections in HIV.Le LT, Spudich SS. Semin Neurol. 2016 Aug; 2016 Sep 19. PMID: 27643907.
Cognitive Impairment and Persistent CNS Injury in Treated HIV.Chan P, Hellmuth J, Spudich S, Valcour V. Curr HIV/AIDS Rep. 2016 Aug. PMID: 27188299.
Immune Activation and HIV-Specific CD8(+) T Cells in Cerebrospinal Fluid of HIV Controllers and Noncontrollers.Ganesh A, Lemongello D, Lee E, Peterson J, McLaughlin BE, Ferre AL, Gillespie GM, Fuchs D, Deeks SG, Hunt PW, Price RW, Spudich SS, Shacklett BL. AIDS Res Hum Retroviruses. 2016 Aug; 2016 May 2. PMID: 27019338.
Putamen volume and its clinical and neurological correlates in primary HIV infection.Wright PW, Pyakurel A, Vaida FF, Price RW, Lee E, Peterson J, Fuchs D, Zetterberg H, Robertson KR, Walter R, Meyerhoff DJ, Spudich SS, Ances BM. AIDS. 2016 Jul 17. PMID: 27045376.
Neurologic signs and symptoms frequently manifest in acute HIV infection.Hellmuth J, Fletcher JL, Valcour V, Kroon E, Ananworanich J, Intasan J, Lerdlum S, Narvid J, Pothisri M, Allen I, Krebs SJ, Slike B, Prueksakaew P, Jagodzinski LL, Puttamaswin S, Phanuphak N, Spudich S. Neurology. 2016 Jul 12; 2016 Jun 10. PMID: 27287217.
CROI 2016: Neurologic Complications of HIV Infection.Spudich SS, Ances BM. Top Antivir Med. 2016 May-Jun. PMID: 27398860.
Immune activation in the central nervous system throughout the course of HIV infection.Spudich SS. Curr Opin HIV AIDS. 2016 Mar. PMID: 26760827.
Virological and immunological characteristics of HIV-infected individuals at the earliest stage of infection.Ananworanich J, Sacdalan CP, Pinyakorn S, Chomont N, de Souza M, Luekasemsuk T, Schuetz A, Krebs SJ, Dewar R, Jagodzinski L, Ubolyam S, Trichavaroj R, Tovanabutra S, Spudich S, Valcour V, Sereti I, Michael N, Robb M, Phanuphak P, Kim JH, Phanuphak N. J Virus Erad. 2016. PMID: 26889497.
Plasma Concentration of the Neurofilament Light Protein (NFL) is a Biomarker of CNS Injury in HIV Infection: A Cross-Sectional Study.Gisslén M, Price RW, Andreasson U, Norgren N, Nilsson S, Hagberg L, Fuchs D, Spudich S, Blennow K, Zetterberg H. EBioMedicine. 2016 Jan; 2015 Nov 22. PMID: 26870824.

2015

Neuropsychological Impairment in Acute HIV and the Effect of Immediate Antiretroviral Therapy.Kore I, Ananworanich J, Valcour V, Fletcher JL, Chalermchai T, Paul R, Reynolds J, Tipsuk S, Ubolyam S, Rattanamanee S, Jagodzinski L, Kim J, Spudich S. J Acquir Immune Defic Syndr. 2015 Dec 1. PMID: 26509933.
Absence of Cerebrospinal Fluid Signs of Neuronal Injury Before and After Immediate Antiretroviral Therapy in Acute HIV Infection.Peluso MJ, Valcour V, Ananworanich J, Sithinamsuwan P, Chalermchai T, Fletcher JL, Lerdlum S, Chomchey N, Slike B, Sailasuta N, Gisslén M, Zetterberg H, Spudich S. J Infect Dis. 2015 Dec 1; 2015 May 20. PMID: 25995196.
Neurological Response to cART vs. cART plus Integrase Inhibitor and CCR5 Antagonist Initiated during Acute HIV.Valcour VG, Spudich SS, Sailasuta N, Phanuphak N, Lerdlum S, Fletcher JL, Kroon ED, Jagodzinski LL, Allen IE, Adams CL, Prueksakaew P, Slike BM, Hellmuth JM, Kim JH, Ananworanich J. PLoS One. 2015; 2015 Nov 10. PMID: 26555069.
Phenotypic Correlates of HIV-1 Macrophage Tropism.Arrildt KT, LaBranche CC, Joseph SB, Dukhovlinova EN, Graham WD, Ping LH, Schnell G, Sturdevant CB, Kincer LP, Mallewa M, Heyderman RS, Rie AV, Cohen MS, Spudich S, Price RW, Montefiori DC, Swanstrom R. J Virol. 2015 Nov; 2015 Sep 2. PMID: 26339058.
CNS reservoirs for HIV: implications for eradication.Hellmuth J, Valcour V, Spudich S. J Virus Erad. 2015 Apr. PMID: 26430703.
Neurosyphilis and the impact of HIV infection.Ho EL, Spudich SS. Sex Health. 2015 Apr. PMID: 25890619.
Compartmentalized replication of R5 T cell-tropic HIV-1 in the central nervous system early in the course of infection.Sturdevant CB, Joseph SB, Schnell G, Price RW, Swanstrom R, Spudich S. PLoS Pathog. 2015 Mar; 2015 Mar 26. PMID: 25811757.
CROI 2015: Neurologic Complications of HIV Infection.Spudich SS, Ances BM. Top Antivir Med. 2015 Mar-Apr. PMID: 25965311.