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Lab Members

Prinicipal Investigator

  • Assistant Professor

    Research Interests
    • Autoimmune Diseases
    • Cardiovascular Diseases
    • Diabetes Mellitus, Type 1
    • DNA Transposable Elements
    • Genetics
    • Hematopoiesis
    • Hematopoietic Stem Cells
    • Islets of Langerhans
    • Myocardial Infarction
    • Genomics
    • Atherosclerosis
    • Epigenomics
    • Single-Cell Analysis
    • Clonal Hematopoiesis
    David is an Assistant Professor of Comparative and Cardiovascular Medicine. His doctoral studies in Interdisciplinary Biomedical Sciences at the University of Arkansas for Medical Scinces in Little Rock, Arkansas, focused on defining and exploiting the mechanisms that maintain genome integrity in multiple myeloma, a hematologic malignancy of B lymphocytes. He completed a postdoctoral training at the Massachusetts General Hospital and Harvard Medical School in Boston, developing strategies to immunoprotect endogenous and transplanted islets to treat type 1 diabetes without systemic immunosuppression. David joined the Yale Center for Molecular and Systems Metabolism and Department of Comparative Medicine at Yale as an Assistant Professor in 2023 to establish the AlagsLab. Research in the AlagsLab integrates knowledge from genetics, developmental and molecular biology, immunology, biomedical engineering, and statistical and computational biology to understand complex traits and diseases, including hematopoiesis, T1D, and cardiovascular disease.

Postdoctoral Research Associates

  • Postdoctoral Associate

    Zehra is interested in applying modern statistical genetics and computational tools to understand the genetic basis of type 1 diabetes. She is particularly interested in using high-throughput single-cell sequencing technologies to unveil novel genetic regulatory pathways and drug targets for type1 diabetes. She is passionate about learning new computational and bioinformatics tools.

    Zehra loves to cook food and watch movies with her daughter in her free time.

Research Assistants

  • Research Assistant 1, MS

    Priscilla has a bachelor’s in biology with a computer science minor from Dillard University. She finds neuroscience and artificial intelligence research fascinating. She is expanding her interests to type 1 diabetes, which she started at Massachusetts General Hospital in the Alagpulinsa laboratory. She has always had a thing for clinical care and plans to pursue both medicine and research and believes in the concept of ‘bench to bed-side’ research.

Students

  • Yikai Dong is a master’s student in Biostatistics at Yale University. He graduated from Xi’an Jiaotong-Liverpool University with a B.S. in Bioinformatics, where he gained extensive knowledge in genetics, computational biology, and biostatistics. Yikai’s research interests include developing innovative frameworks for genetic risk prediction and utilizing deep learning techniques to identify disease heterogeneity at the single-cell level. His current project, supervised by Dr. David Alagpulinsa, involves comprehensive analysis of whole-genome sequencing data from type 1 diabetes patients to examine the prevalence and effects of clonal hematopoiesis mutations, contributing to the understanding of cardiovascular disease mechanisms.

  • Ziang (Aiden) holds a bachelor's degree in Mathematics and Statistics from the University of Alberta and is currently pursuing a master's degree in Health Informatics.

    He specializes in Bioinformatics and Computational Biology. Ziang's research interests lie in the genetic underpinnings of diseases such as Diabetes and Cardiovascular Disease.

    He is passionate about uncovering the causes of diseases and developing treatments to improve patient quality of life.