Publications

2026

Shared genetic and neuroimmune architecture links type 1 diabetes with neurocognitive traits
Saarah P, Syeda Z, Xu Z, Dong Y, Jiang H, Shanguyhia M, Roy S, Zhu B, Zhang L, Dewan A, Asgari S, Alagpulinsa D. Shared genetic and neuroimmune architecture links type 1 diabetes with neurocognitive traits. Nature Communications 2026 PMID: 41826324, DOI: 10.1038/s41467-026-70694-8.
Peer-Reviewed Original Research
Concepts

2025

Pilot Study: Functional Survival of Human Stem Cell‐Derived Islets Microencapsulated With Alginate Incorporating CXCL12 in Non‐Human Primates Without Systemic Immunosuppression
Kawai K, Dogan F, Alagpulinsa D, Pop R, Veres A, Sobell D, Deng H, Collins S, Zhang J, Chapin M, Markmann J, Lei J, Poznansky M. Pilot Study: Functional Survival of Human Stem Cell‐Derived Islets Microencapsulated With Alginate Incorporating CXCL12 in Non‐Human Primates Without Systemic Immunosuppression. Xenotransplantation 2025, 32: e70098. PMID: 41431325, DOI: 10.1111/xen.70098.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Shared genetic and neuroimmune architecture links type 1 diabetes with neurocognitive traits
Saarah P, Syeda ZA, Xu Z, Dong Y, Jiang A, Shanguhyia M, Roy S, Zhu B, Zhang L, Dewan AT, Asgari S, Alagpulinsa DA*. Shared genetic and neuroimmune architecture links type 1 diabetes with neurocognitive traits. medRxiv. 2025. Doi: https://doi.org/10.1101/2025.09.14.25335719
Peer-Reviewed Original Research

2024

2023

Short‐term function and immune‐protection of microencapsulated adult porcine islets with alginate incorporating CXCL12 in healthy and diabetic non‐human primates without systemic immune suppression: A pilot study
Sremac M, Luo H, Deng H, Parr M, Hutcheson J, Verde P, Alagpulinsa D, Kitzmann J, Papas K, Brauns T, Markmann J, Lei J, Poznansky M. Short‐term function and immune‐protection of microencapsulated adult porcine islets with alginate incorporating CXCL12 in healthy and diabetic non‐human primates without systemic immune suppression: A pilot study. Xenotransplantation 2023, 30: e12826. PMID: 37712342, DOI: 10.1111/xen.12826.
Peer-Reviewed Original Research
MeSH Keywords and Concepts

2022

2021

209.6: Long-term Functional Survival of Human Stem Cell-derived Islets Microencapsulated in Alginate With CXCL12 in Non-human Primates Without Immunosuppression
Alagpulinsa D, Jei L, Pop R, Veres A, Deng H, Zhang J, Kawai K, Collins S, Sobell D, Chapin M, Verill D, Melton D, Markmann J, Poznansky M. 209.6: Long-term Functional Survival of Human Stem Cell-derived Islets Microencapsulated in Alginate With CXCL12 in Non-human Primates Without Immunosuppression. Transplantation 2021, 105: s16-s16. DOI: 10.1097/01.tp.0000804360.12644.62.
Peer-Reviewed Original Research
Concepts

2020

2019

2018

Harnessing CXCL12 signaling to protect and preserve functional β-cell mass and for cell replacement in type 1 diabetes
Alagpulinsa D, Cao J, Sobell D, Poznansky M. Harnessing CXCL12 signaling to protect and preserve functional β-cell mass and for cell replacement in type 1 diabetes. Pharmacology & Therapeutics 2018, 193: 63-74. PMID: 30149101, DOI: 10.1016/j.pharmthera.2018.08.011.
Peer-Reviewed Original Research
MeSH Keywords and Concepts

Publications

2026

Shared genetic and neuroimmune architecture links type 1 diabetes with neurocognitive traits

2025

Pilot Study: Functional Survival of Human Stem Cell‐Derived Islets Microencapsulated With Alginate Incorporating CXCL12 in Non‐Human Primates Without Systemic Immunosuppression

Shared genetic and neuroimmune architecture links type 1 diabetes with neurocognitive traits

2024

Genetic relations between type 1 diabetes, coronary artery disease and leukocyte counts

Association of T-cell subtypes with macrophage-specific arterial infiltration in people with HIV

Genetic relations between leukocyte counts, type 1 diabetes, and coronary artery disease

2023

Short‐term function and immune‐protection of microencapsulated adult porcine islets with alginate incorporating CXCL12 in healthy and diabetic non‐human primates without systemic immune suppression: A pilot study

2022

Cardiac strain is lower among women with HIV in relation to monocyte activation

Plasma osteopontin relates to myocardial fibrosis and steatosis and to immune activation among women with HIV

Advances in understanding the molecular basis of clonal hematopoiesis

2021

209.6: Long-term Functional Survival of Human Stem Cell-derived Islets Microencapsulated in Alginate With CXCL12 in Non-human Primates Without Immunosuppression

2020

Metabolomic and transcriptomic analyses of the anti-rheumatoid arthritis potential of xylopic acid in a bioinspired lipoprotein nanoformulation

Genomic Instability in Multiple Myeloma

2019

Amplification and overexpression of E2 ubiquitin conjugase UBE2T promotes homologous recombination in multiple myeloma

E2 ubiquitin conjugase UBE2T contributes to genome maintenance through homologous recombination in multiple myeloma

Alginate-microencapsulation of human stem cell–derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression

2018

Harnessing CXCL12 signaling to protect and preserve functional β-cell mass and for cell replacement in type 1 diabetes

2016

Flap Structure-Specific Endonuclease 1 (FEN1) May be a Key Mediator of Genome Instability in Myeloma: A Cellular Vulnerability with Potential Therapeutic Significance

A Cyclin-Dependent Kinase Inhibitor, Dinaciclib, Impairs Homologous Recombination and Sensitizes Multiple Myeloma Cells to PARP Inhibition

2015

Nuclease Activity Is Associated with Genomic Instability As Well As Survival in Myeloma; Underlying Mechanisms and Significance

A peptide nucleic acid targeting nuclear RAD51 sensitizes multiple myeloma cells to melphalan treatment

2014

A Peptide Nucleic Acid Targeting Nuclear Rad51 Sensitizes Myeloma Cells to Melphalan Chemotoxicity Both in Vitro and in Vivo

Dinaciclib, a CDK Inhibitor, Impairs Homologous Recombination and Sensitizes Multiple Myeloma Cells to PARP Inhibition

A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin