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Oligo Synthesis Resource

About Us

The Keck Oligonucleotide Synthesis facility provides high quality, timely DNA and RNA synthesis in individual tubes or plates. Synthesis is carried out on our Dr. Oligo 192 and Applied Biosystems 394 synthesizers. We routinely perform a wide variety of complex specialty syntheses, emphasizing quality and efficiency. Our services include:

DISCLAIMER: The Keck Oligo Synthesis Section warrants that its products shall conform to the description provided on the product’s accompanying literature or analytical data. ALL PRODUCT CLAIMS, REGARDLESS OF THEIR NATURE, MUST BE BROUGHT TO OUR ATTENTION WITHIN 60 DAYS OF DELIVERY. Due to the highly complex, customized and experimental nature of some modified oligos, we cannot guarantee the purity and yield of all modified products. Although we will do our best to ensure that the highest quality product is achieved, THE KECK OLIGO SECTION SHALL NOT IN ANY EVENT BE LIABLE FOR INCIDENTAL, CONSEQUENTIAL OR SPECIAL DAMAGES OF ANY KIND RESULTING FROM ANY USE OR FAILURE OF THE PRODUCTS NOR SHALL ITS LIABILITY IN ANY CASE EXCEED THE PURCHASE PRICE OF THE PRODUCT.

Note to our Users

Please see our Price Schedule for revised pricing effective 7/1/2022.

Price Reduction

Beginning 6/1/23, we will no longer be charging a delivery fee for Yale customers and for non-Yale customers, FedEx shipping will be free of charge.

Custom Cloning Service

We are now offering a custom cloning service! Utilizing the BioXp™3200 System, dsDNA fragments from 350-1.8 kb can be cloned into the vector of your choice. Please inquire at or click here for more details.

Higher Yields!

For all un-modified normal DNA oligos, a new 100 nmole synthesis scale has replaced our current 40 nmole scale at no additional cost… higher yields and free desalting for the same low price!

New 25 NMOLE Service!

$0.20/base desalted <65 bases

$0.18/base desalted <65 bases in a 96-well plate

Free Desalting!

Normal, un-modified DNA oligos <100 bases synthesized at the 25 and 40 nmole scales are provided salt-free at no charge!

Lower Pricing

30%-60% discount on common specialty modifications such as 5'-FAM and 5-Me-dC!

Download the Request A Quote Form