2020
The Foundational Role of Cardiovascular Imaging in the Characterization of Mental Stress–Induced Myocardial Ischemia in Patients with Coronary Artery Disease
Meadows JL, Shah S, Burg MM, Pfau S, Soufer R. The Foundational Role of Cardiovascular Imaging in the Characterization of Mental Stress–Induced Myocardial Ischemia in Patients with Coronary Artery Disease. Current Cardiology Reports 2020, 22: 162. PMID: 33037938, DOI: 10.1007/s11886-020-01407-w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCoronary artery diseaseArtery diseaseMyocardial ischemiaMental Stress–Induced Myocardial IschemiaNon-obstructive coronary artery diseaseStable coronary artery diseaseHalf of patientsEpicardial coronary stenosisMental stress testingMyocardial oxygen demandUnderstanding of pathophysiologyCoronary macroAnginal symptomsCardiac eventsAdverse prognosisEarly mortalityIschemic phenomenaCoronary perfusionCoronary stenosisCoronary microvasculatureInvasive studiesClinical careMyocardial perfusionStress-mediated changesCardiac response
2016
Post-traumatic Stress Disorder and Cardiovascular Disease
Burg MM, Soufer R. Post-traumatic Stress Disorder and Cardiovascular Disease. Current Cardiology Reports 2016, 18: 94. PMID: 27566327, DOI: 10.1007/s11886-016-0770-5.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderCardiovascular diseaseStress disorderIncident hypertension riskIncident cardiovascular diseaseAcute cardiac eventsEmergency department environmentCardiac eventsCardiovascular mortalityEarly recurrenceMilitary veteran sampleHypertension riskClinical pathwayPatient experiencePTSD treatmentPTSD onsetTrauma exposureVeteran sampleAutomobile accidentsDepartment environmentMortalityDiseaseRiskTraumaDisorders
2011
Autonomic Contribution to Endothelin-1 Increase during Laboratory Anger-Recall Stress in Patients with Coronary Artery Disease
Burg MM, Soufer A, Lampert R, Collins D, Soufer R. Autonomic Contribution to Endothelin-1 Increase during Laboratory Anger-Recall Stress in Patients with Coronary Artery Disease. Molecular Medicine 2011, 17: 495-501. PMID: 21267513, PMCID: PMC3105151, DOI: 10.2119/molmed.2010.00083.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseEndothelin-1Parasympathetic activityArtery diseaseAutonomic contributionsChronic stable coronary artery diseaseStable coronary artery diseaseCholinergic antiinflammatory pathwayLaboratory stressCoronary plaque ruptureEndothelin-1 increaseSignificant odds ratioEndothelial cell functionCardiac eventsEndothelial dysfunctionIndwelling catheterAutonomic factorsSympathetic activityAntiinflammatory pathwayAutonomic influencesAutonomic toneOdds ratioPlaque ruptureParasympathetic withdrawalHemodynamic monitor
2008
Noninvasive Detection of Risk for Emotion Provoked Myocardial Ischemia
Burg MM, Graeber B, Vashist A, Collins D, Earley C, Liu J, Lampert R, Soufer R. Noninvasive Detection of Risk for Emotion Provoked Myocardial Ischemia. Psychosomatic Medicine 2008, 71: 14-20. PMID: 18941131, PMCID: PMC2739989, DOI: 10.1097/psy.0b013e318187c035.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngerAngiotensin-Converting Enzyme InhibitorsBlood PressureCoronary DiseaseEpinephrineFemaleHeart RateHumansImagery, PsychotherapyMaleManometryMiddle AgedMyocardial IschemiaNorepinephrinePlethysmographyPredictive Value of TestsPulsatile FlowRiskSensitivity and SpecificityStress, PsychologicalTomography, Emission-Computed, Single-PhotonVascular ResistanceConceptsPeripheral arterial tonometryCoronary artery diseasePAT ratioMyocardial ischemiaMajor adverse cardiac eventsStable coronary artery diseaseLower PAT ratioMental stress ischemiaAdverse cardiac eventsNew perfusion defectsCT myocardial perfusionSensitivity/specificityStress ischemiaArterial tonometryCardiac eventsArtery diseaseBlood pressureACE inhibitionPerfusion defectsHeart rateMyocardial perfusionPatientsEnzyme inhibitorsClinical settingIschemia
2007
The heart-brain interaction during emotionally provoked myocardial ischemia: implications of cortical hyperactivation in CAD and gender interactions.
Soufer R, Burg MM. The heart-brain interaction during emotionally provoked myocardial ischemia: implications of cortical hyperactivation in CAD and gender interactions. Cleveland Clinic Journal Of Medicine 2007, 74 Suppl 1: s59-62. PMID: 17455547, DOI: 10.3949/ccjm.74.suppl_1.s59.Peer-Reviewed Original ResearchConceptsMental stress-induced ischemiaStress-induced ischemiaMental stressMyocardial ischemiaAcute coronary syndromeRecurrent cardiac eventsSilent myocardial ischemiaRisk stratification algorithmLong-term outcomesTreatment of patientsHeart-brain interactionsDifferential pathophysiologyCoronary syndromeCardiac eventsRisk stratificationPoor prognosisTransient ischemiaVulnerable patientsStratification algorithmCortical hyperactivationEarly deathIschemiaDiagnostic testingClinical settingClinical goals
1995
Prognostic Implications of Mental Stress-Induced Silent Loft Ventricular Dysfunction in Patients With Stable Angina Pectoris
Jain D, Burg M, Soufer R, Zaret B. Prognostic Implications of Mental Stress-Induced Silent Loft Ventricular Dysfunction in Patients With Stable Angina Pectoris. The American Journal Of Cardiology 1995, 76: 31-35. PMID: 7793399, DOI: 10.1016/s0002-9149(99)80796-6.Peer-Reviewed Original ResearchConceptsStable angina pectorisTransient LV dysfunctionAdverse cardiac eventsCardiac eventsLV dysfunctionAngina pectorisMental stressAbnormal cardiovascular reactivityHigher cardiac eventsCohort of patientsCoronary artery diseaseGroup of patientsVentricular function monitoringMental arithmeticVentricular dysfunctionAdverse eventsBaseline characteristicsBeta blockersContinuous ambulatoryArtery diseaseRisk stratificationPrognostic implicationsStress perfusionFunction monitoringHeart rateRelationship between reverse redistribution on planar thallium scintigraphy and regional myocardial viability: a correlative PET study.
Soufer R, Dey H, Lawson A, Wackers F, Zaret B. Relationship between reverse redistribution on planar thallium scintigraphy and regional myocardial viability: a correlative PET study. Journal Of Nuclear Medicine 1995, 36: 180-7. PMID: 7830110.Peer-Reviewed Original ResearchConceptsPlanar thallium scintigraphyCardiac eventsThallium scintigraphyReverse redistributionChronic coronary artery diseasePET viabilityAbnormal regional wall motionPlanar thallium imagesMyocardial Infarction trialPercent of patientsFuture cardiac eventsFuture cardiovascular eventsCoronary artery diseaseFavorable clinical outcomeMyocardial metabolic activityRegional wall motion analysisRegional wall motionPercent of segmentsWall motion analysisPET criteriaCardiovascular eventsReperfusion therapyArtery diseaseClinical outcomesPrognostic value