2024
Buprenorphine for Opioid Use Disorder—An Essential Medical Treatment
Weimer M, Morford K. Buprenorphine for Opioid Use Disorder—An Essential Medical Treatment. JAMA Internal Medicine 2024, 184: 1248-1249. PMID: 39186298, DOI: 10.1001/jamainternmed.2024.3977.Peer-Reviewed Original ResearchDevelopment of a Patient and Clinician Informed Website on Injection Drug Use Related Infective Endocarditis.
Chan C, Minahan-Rowley R, Biegacki E, Sue K, Weimer M. Development of a Patient and Clinician Informed Website on Injection Drug Use Related Infective Endocarditis. Substance Use & Addiction Journal 2024, 29767342241267077. PMID: 39087514, DOI: 10.1177/29767342241267077.Peer-Reviewed Original ResearchInjection drug use-related infective endocarditisSemi-structured interviewsInjection drug usePatient participationPatient websitesInjection practicesInfective endocarditisPatient education resourcesHelpfulness of informationHistory of injection drug useDrug useMixed-methods studyHealthcare cliniciansBaseline surveyOpioid use disorderPrevention strategiesInformation websitesEducational materialsCounseling patientsHospitalized adultsPromote educationWebsite sectionsCliniciansSurvey feedbackUse disorder
2023
Long-Term Treatment of Opioid Use Disorder with Medications
Wolfgang A, Weimer M, Na P, Fiellin D, Muvvala S. Long-Term Treatment of Opioid Use Disorder with Medications. 2023, 631-661. DOI: 10.1093/oxfordhb/9780197618431.013.23.ChaptersOpioid use disorderMedical diseasesUse disordersChronic medical diseasesExtended-release naltrexoneLong-term treatmentCause mortalityOUD treatmentClinical outcomesOngoing treatmentOpioid overdoseTerm treatmentMedicationsPsychosocial outcomesAddiction treatmentDisease paradigmOutcomesTreatmentEvidence-based paradigmDiseaseDisordersNegative outcomesImproved retentionRemissionRelapsingASAM Clinical Considerations: Buprenorphine Treatment of Opioid Use Disorder for Individuals Using High-potency Synthetic Opioids
Weimer M, Herring A, Kawasaki S, Meyer M, Kleykamp B, Ramsey K. ASAM Clinical Considerations: Buprenorphine Treatment of Opioid Use Disorder for Individuals Using High-potency Synthetic Opioids. Journal Of Addiction Medicine 2023, 17: 632-639. PMID: 37934520, DOI: 10.1097/adm.0000000000001202.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHigh potency synthetic opioidsOpioid use disorderBuprenorphine initiationBuprenorphine treatmentTreatment needsUse disordersClinical considerationsExpert consensusSynthetic opioidsTreatment of OUDProspective researchOpioid agonist treatmentLong-term treatmentDrug supplyPatients' treatment needsOpioid withdrawalBuprenorphine doseOUD treatmentAgonist treatmentDosing frequencyClinical questionsFrontline cliniciansClinical practiceTreatment settingsIndividualized strategiesLow-dose Initiation of Buprenorphine in Hospitalized Patients Using Buccal Buprenorphine: A Case Series
Adams K, Cohen S, Guerra M, Weimer M. Low-dose Initiation of Buprenorphine in Hospitalized Patients Using Buccal Buprenorphine: A Case Series. Journal Of Addiction Medicine 2023, 17: 474-476. PMID: 37579114, DOI: 10.1097/adm.0000000000001146.Peer-Reviewed Original ResearchConceptsOpioid use disorderBuprenorphine initiationSublingual buprenorphineChronic painBuccal buprenorphineCase seriesClinical Opiate Withdrawal Scale (COWS) scoresAddiction medicine serviceLow dose initiationSevere opioid withdrawalHistory of heroinOutpatient opioidsOpioid withdrawalAcute painFentanyl useHospitalized patientsMedian lengthPrescription refillsMedian numberModerate withdrawalInitiation strategiesBuprenorphineMedicine servicePatientsUse disordersPrecipitated Opioid Withdrawal Treated With Ketamine in a Hospitalized Patient: A Case Report
Christian N, Butner J, Evarts M, Weimer M. Precipitated Opioid Withdrawal Treated With Ketamine in a Hospitalized Patient: A Case Report. Journal Of Addiction Medicine 2023, 17: 488-490. PMID: 37579118, DOI: 10.1097/adm.0000000000001151.Peer-Reviewed Case Reports and Technical NotesConceptsClinical Opiate Withdrawal Scale (COWS) scoresOpioid use disorderKetamine infusionOpioid withdrawalCase reportUse disordersScale scoreSevere opioid use disorderFull opioid agonistsHours of admissionEmergency department settingFirst case reportInpatient hospital settingLife-saving medicationsReceptor-mediated signalingLack of evidenceMale patientsFentanyl useOpioid agonistsEmergency departmentComplete resolutionDepartment settingClinical dilemmaAppropriate treatmentHospital setting
2022
Top Ten Tips Palliative Care Clinicians Should Know About Buprenorphine
Neale KJ, Weimer MB, Davis MP, Jones KF, Kullgren JG, Kale SS, Childers J, Broglio K, Merlin JS, Peck S, Francis SY, Bango J, Jones CA, Sager Z, Ho JJ. Top Ten Tips Palliative Care Clinicians Should Know About Buprenorphine. Journal Of Palliative Medicine 2022, 26: 120-130. PMID: 36067137, DOI: 10.1089/jpm.2022.0399.Commentaries, Editorials and LettersConceptsPalliative carePain managementPartial mu-opioid receptor agonistSerious illnessMu-opioid receptor agonistTop Ten TipsOpioid use disorderLife-limiting illnessPC cliniciansCare cliniciansOpioid misuseBuprenorphine useReceptor agonistNurse practitionersUse disordersPopulation-wide trendsIllnessBuprenorphineCliniciansPatientsAgonistsPharmacistsPhysiciansCareSocial workersManagement of opioid use disorder and associated conditions among hospitalized adults: A Consensus Statement from the Society of Hospital Medicine
Calcaterra SL, Martin M, Bottner R, Englander H, Weinstein Z, Weimer MB, Lambert E, Herzig SJ. Management of opioid use disorder and associated conditions among hospitalized adults: A Consensus Statement from the Society of Hospital Medicine. Journal Of Hospital Medicine 2022, 17: 744-756. PMID: 35880813, PMCID: PMC9474708, DOI: 10.1002/jhm.12893.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsOpioid use disorderConsensus statementHospitalized adultsOpioid withdrawalUse disordersTreatment of OUDDraft statementManagement of OUDHospital medicineAcute pain managementNumber of hospitalizationsHospital-based cliniciansFinal consensus statementOpioid-related overdoseHospital dischargeOpioid usePain managementWorking GroupCare transitionsInpatient settingObservational studyExpert consensusGuidance statementsPatientsSystematic reviewManagement of opioid use disorder, opioid withdrawal, and opioid overdose prevention in hospitalized adults: A systematic review of existing guidelines
Calcaterra SL, Bottner R, Martin M, Englander H, Weinstein ZM, Weimer MB, Lambert E, Ronan MV, Huerta S, Zaman T, Ullal M, Peterkin AF, Torres‐Lockhart K, Buresh M, O'Brien MT, Snyder H, Herzig SJ. Management of opioid use disorder, opioid withdrawal, and opioid overdose prevention in hospitalized adults: A systematic review of existing guidelines. Journal Of Hospital Medicine 2022, 17: 679-692. PMID: 35880821, PMCID: PMC9474657, DOI: 10.1002/jhm.12908.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsOpioid overdose preventionOpioid withdrawalOpioid useOUD treatmentOverdose preventionShort-acting opioid analgesicsOpioid use disorder managementAcute pain managementUse of methadoneOpioid use disorderEvaluation II (AGREE II) instrumentAppraisal of GuidelinesOpioid withdrawal managementUse of multimodalOpioid overdose reversalMethadone initiationNonopioid therapyHospitalized adultsBuprenorphine treatmentOpioid analgesicsPain managementTreatment guidelinesDiagnostic Statistical ManualOvid MEDLINEEdition criteriaClinical Management of Opioid Withdrawal
Torres‐Lockhart K, Lu TY, Weimer MB, Stein MR, Cunningham CO. Clinical Management of Opioid Withdrawal. Addiction 2022, 117: 2540-2550. PMID: 35112746, DOI: 10.1111/add.15818.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsOpioid use disorderOpioid withdrawal managementOpioid withdrawalClinical managementWithdrawal managementLong-term treatmentAppropriate clinical managementPatient-centered approachRelapse prevention strategiesHarm reduction strategiesHigh-risk timeOUD treatmentAppropriate diagnosisOpioid overdoseUse disordersPrevention strategiesTreatment settingsNarrative reviewWithdrawalTreatmentComplex casesManagementRelapsePatientsOverdosePerioperative Buprenorphine Management A Multidisciplinary Approach
Hickey T, Abelleira A, Acampora G, Becker WC, Falker CG, Nazario M, Weimer MB. Perioperative Buprenorphine Management A Multidisciplinary Approach. Medical Clinics Of North America 2022, 106: 169-185. PMID: 34823729, DOI: 10.1016/j.mcna.2021.09.001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAcetaminophenAgedAnalgesics, Non-NarcoticAnalgesics, OpioidAnti-Inflammatory Agents, Non-SteroidalArthroplasty, Replacement, HipBuprenorphineCombined Modality TherapyDrug CompoundingFemaleHumansInterdisciplinary CommunicationMaleOpiate Substitution TreatmentOpioid-Related DisordersPainPain ManagementPain, PostoperativePerioperative CareReceptors, Opioid, muConceptsOpioid use disorderBuprenorphine treatmentMu-opioid receptor availabilityAgonist opioid treatmentMultimodal analgesic strategyAnti-inflammatory drugsLong-term buprenorphine treatmentAnalgesic strategiesNonopioid adjunctsOpioid treatmentPerioperative strategiesHospital dischargePerioperative managementBuprenorphine formulationsSimultaneous administrationRegional anesthesiaEffective treatmentUse disordersReceptor availabilityMultidisciplinary approachBuprenorphinePatientsTreatmentPainAnesthesiaCardiac Surgeons’ Practices and Attitudes toward Addiction Care for Patients with Substance use Disorders
Tiako M, Mszar R, Brooks C, Bin Mahmood SU, Mori M, Vallabhajosyula P, Geirsson A, Weimer MB. Cardiac Surgeons’ Practices and Attitudes toward Addiction Care for Patients with Substance use Disorders. Substance Abuse 2022, 43: 206-211. PMID: 34038333, DOI: 10.1080/08897077.2021.1917475.Peer-Reviewed Original ResearchConceptsSubstance use disordersUse disordersCardiac surgeonsSurgeon's practiceAddiction careInjection drug useOpioid use disorderMultivariable logistic regressionCare of patientsQuarter of surgeonsMost hospital settingsMinority of surgeonsMost patientsInfective endocarditisHospital settingAddiction specialistsPatientsMost surgeonsIDUsAddiction servicesLogistic regressionMOUDHealth systemSurgeonsLack of educationInfectious Complications of Injection Drug Use
Marks LR, Nolan NS, Liang SY, Durkin MJ, Weimer MB. Infectious Complications of Injection Drug Use. Medical Clinics Of North America 2022, 106: 187-200. PMID: 34823730, DOI: 10.1016/j.mcna.2021.08.006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInjection drug useInjection drug use-related infective endocarditisHuman immunodeficiency virusHepatitis C virusInfectious complicationsDrug useCommon infectious complicationOpioid use disorderCommon risk factorsCause of deathOpioid overdose epidemicViral hepatitisInfective endocarditisImmunodeficiency virusClinical syndromeHIV outbreakInfectious disease epidemicsC virusRisk factorsIntravenous administrationOverdose epidemicUse disordersModel of treatmentMedical careInfectious diseases
2021
Low Dose Initiation of Buprenorphine: A Narrative Review and Practical Approach
Cohen SM, Weimer MB, Levander XA, Peckham AM, Tetrault JM, Morford KL. Low Dose Initiation of Buprenorphine: A Narrative Review and Practical Approach. Journal Of Addiction Medicine 2021, 16: 399-406. PMID: 34954746, DOI: 10.1097/adm.0000000000000945.Peer-Reviewed Original ResearchConceptsLow dose initiationFull opioid agonistsDose initiationOpioid withdrawal symptomsOpioid agonistsBuprenorphine doseWithdrawal symptomsHigh potency synthetic opioidsOpioid use disorderAppropriate clinical situationsMu-opioid receptorsBuprenorphine initiationOpioid withdrawalStarting doseOutpatient settingCare coordinationDose changesOverdose deathsCurrent evidenceUse disordersBuprenorphineTherapeutic levelsClinical situationsSynthetic opioidsNarrative reviewRemoving One Barrier to Opioid Use Disorder Treatment
Weimer MB, Wakeman SE, Saitz R. Removing One Barrier to Opioid Use Disorder Treatment. JAMA 2021, 325: 1147-1148. PMID: 33630020, DOI: 10.1001/jama.2021.0958.Commentaries, Editorials and LettersAdapting inpatient addiction medicine consult services during the COVID-19 pandemic
Harris MTH, Peterkin A, Bach P, Englander H, Lapidus E, Rolley T, Weimer MB, Weinstein ZM. Adapting inpatient addiction medicine consult services during the COVID-19 pandemic. Addiction Science & Clinical Practice 2021, 16: 13. PMID: 33627183, PMCID: PMC7903401, DOI: 10.1186/s13722-021-00221-1.Commentaries, Editorials and LettersMeSH KeywordsBritish ColumbiaBuprenorphineConnecticutCOVID-19Cross-Cultural ComparisonDelivery of Health CareForecastingHealth Plan ImplementationHealth Services AccessibilityHumansMassachusettsOpioid-Related DisordersOregonPatient AdmissionPatient Care TeamPatient DischargeRemote ConsultationSubstance-Related DisordersTelemedicineConceptsUse disordersCOVID-19 isolation unitsYale-New Haven HospitalHigh-risk patientsNovel coronavirus disease 2019 (COVID-19) pandemicSt. Paul's HospitalAddiction medicine consult serviceOpioid use disorderBoston Medical CenterCoronavirus disease 2019 (COVID-19) pandemicNew Haven HospitalTelephone-based consultationsAlcohol use disorderDisease 2019 pandemicHealth care systemPublic health crisisHospitalized patientsPaul's HospitalOutpatient settingCare coordinationPatient visitsVulnerable patientsConsult serviceBenzodiazepine taperMedical CenterSafe Pain Management with Opioids in Posttransplant Patients
Weimer M. Safe Pain Management with Opioids in Posttransplant Patients. 2021, 723-745. DOI: 10.1007/978-3-030-53626-8_45.ChaptersPrescription opioid useOpioid usePain managementLong-term prescription opioid useSevere opioid use disorderHematopoietic cell transplantation patientsSafe pain managementEffective pain managementCell transplantation patientsOpioid use disorderPalliative care providersAnti-inflammatory drugsOpioid prescribingPosttransplant patientsTransplantation patientsMore patientsHCT treatmentPrescription opioidsSafer opioidsTreatment optionsMost oncologistsTransplant providersConcerns of toxicityPotent opioidsCare providers
2019
Treatment of Opioid Use Disorder in the Acute Hospital Setting: a Critical Review of the Literature (2014–2019)
Weimer M, Morford K, Donroe J. Treatment of Opioid Use Disorder in the Acute Hospital Setting: a Critical Review of the Literature (2014–2019). Current Addiction Reports 2019, 6: 339-354. DOI: 10.1007/s40429-019-00267-x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsOpioid use disorderAddiction medicine consult serviceHospitalized patientsUse disordersInitiation of MOUDPurpose of ReviewPatientsConcomitant medical conditionsAcute hospital settingHealth care utilizationIntravenous opioid useTreatment of patientsAcute care hospitalsHealth care outcomesHospital initiationRecent FindingsManagementInfectious complicationsOpioid withdrawalOpioid useCare hospitalCare utilizationOutpatient settingPatient outcomesConsult serviceHospital careCare model
2016
Primary Care-Based Models for the Treatment of Opioid Use Disorder: A Scoping Review.
Korthuis PT, McCarty D, Weimer M, Bougatsos C, Blazina I, Zakher B, Grusing S, Devine B, Chou R. Primary Care-Based Models for the Treatment of Opioid Use Disorder: A Scoping Review. Annals Of Internal Medicine 2016, 166: 268-278. PMID: 27919103, PMCID: PMC5504692, DOI: 10.7326/m16-2149.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsOpioid use disorderMedication-assisted treatmentPrimary care settingCare settingsUse disordersPrimary care-based modelU.S. primary care settingsDiverse health care settingsPrimary care variesHealth care settingsOUD treatmentCare modelCare variesPsychosocial servicesHealthcare ResearchUnique milieuCareScoping ReviewTreatmentDisordersCommunity educationLiterature reviewReportSettingBuprenorphineA Chronic Opioid Therapy Dose Reduction Policy in Primary Care
Weimer MB, Hartung DM, Ahmed S, Nicolaidis C. A Chronic Opioid Therapy Dose Reduction Policy in Primary Care. Substance Abuse 2016, 37: 141-147. PMID: 26685018, DOI: 10.1080/08897077.2015.1129526.Peer-Reviewed Original ResearchConceptsHigh-dose opioidsChronic opioid therapyOpioid therapyOpioid doseDose taperAcademic primary care clinicHigh-dose opioid therapyHigher opioid doseIntervention of educationOpioid dose reductionTotal opioid doseRetrospective cohort studyCharacteristics of patientsPrimary care clinicsOpioid use disorderMedication-assisted treatmentAverage daily doseOnly significant associationMorphine equivalentsOpioid dosesCohort studyPatient characteristicsDaily doseCare clinicsChronic pain