2022
Blood Transcriptomes of SARS-CoV-2–Infected Kidney Transplant Recipients Associated with Immune Insufficiency Proportionate to Severity
Sun Z, Zhang Z, Banu K, Al Azzi Y, Reghuvaran A, Fredericks S, Planoutene M, Hartzell S, Kim Y, Pell J, Tietjen G, Asch W, Kulkarni S, Formica R, Rana M, Maltzman JS, Zhang W, Akalin E, Heeger PS, Cravedi P, Menon MC. Blood Transcriptomes of SARS-CoV-2–Infected Kidney Transplant Recipients Associated with Immune Insufficiency Proportionate to Severity. Journal Of The American Society Of Nephrology 2022, 33: 2108-2122. PMID: 36041788, PMCID: PMC9678030, DOI: 10.1681/asn.2022010125.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseCOVID-19CytokinesHumansImmunosuppressive AgentsKidney TransplantationRNASARS-CoV-2TranscriptomeTransplant RecipientsConceptsKidney transplant recipientsImmune activation pathwaysImmunosuppressant useKTR cohortAcute illnessBlood transcriptomeAcute casesT cellsCOVID-19Most kidney transplant recipientsPost-acute COVID-19Adaptive immune system activationManagement of immunosuppressionReinstitution of immunosuppressionAcute COVID-19Serum inflammatory cytokinesCOVID-19 severity scoreCOVID-19 infectionImmune system activationUpregulation of neutrophilActivation pathwayTransplant recipientsChart reviewImmune signaturesLymphocyte count
2021
Impact of Low-Dose Fluconazole on Tacrolimus Dosing in Renal Transplant
Johnston JP, Cohen EA, Casal GH, Asch WS, Reardon DP. Impact of Low-Dose Fluconazole on Tacrolimus Dosing in Renal Transplant. Journal Of Pharmacy Practice 2021, 35: 701-706. PMID: 33759619, DOI: 10.1177/08971900211000702.Peer-Reviewed Original ResearchConceptsLow-dose fluconazoleRenal transplant patientsAdverse drug reactionsTAC levelsTransplant patientsGraft rejectionDrug reactionsTherapeutic levelsSingle-center retrospective chart reviewPost-operative day 10Azole antifungal therapySubtherapeutic tacrolimus levelsTAC dose adjustmentRenal transplant recipientsTotal daily doseRetrospective chart reviewTacrolimus dosingTacrolimus levelsRenal transplantTransplant recipientsChart reviewSecondary outcomesDaily doseDose adjustmentPrimary outcome
2016
Belatacept and Eculizumab for Treatment of Calcineurin Inhibitor-induced Thrombotic Microangiopathy After Kidney Transplantation: Case Report
Merola J, Yoo PS, Schaub J, Smith JD, Rodriguez-Davalos MI, Tichy E, Mulligan DC, Asch W, Formica R, Kashgarian M, Kulkarni S. Belatacept and Eculizumab for Treatment of Calcineurin Inhibitor-induced Thrombotic Microangiopathy After Kidney Transplantation: Case Report. Transplantation Proceedings 2016, 48: 3106-3108. PMID: 27932157, DOI: 10.1016/j.transproceed.2016.04.005.Peer-Reviewed Original ResearchConceptsCalcineurin inhibitorsHemolytic uremic syndromeThrombotic microangiopathyKidney transplantationUremic syndromeMinimization of CNIsAtypical hemolytic uremic syndromeWithdrawal of tacrolimusEarly graft lossFavorable clinical courseGraft dysfunctionGraft lossImmunosuppression strategiesUsual therapyClinical courseCase reportCTLA-4Endothelial reactionFrequent causeChallenging causeUncontrolled activationMonoclonal antibodiesCellular destructionMicroangiopathyComponent C5
2015
Renal cancer in kidney transplanted patients
Frascà GM, Sandrini S, Cosmai L, Porta C, Asch W, Santoni M, Salviani C, D’Errico A, Malvi D, Balestra E, Gallieni M. Renal cancer in kidney transplanted patients. Journal Of Nephrology 2015, 28: 659-668. PMID: 26202137, DOI: 10.1007/s40620-015-0219-8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCalcineurin inhibitorsRenal cancerNative kidneysKidney diseaseWithdrawal of CNIsChronic allograft nephropathyAutosomal dominant polycystic kidney diseaseDominant polycystic kidney diseaseGeneral risk factorsCystic kidney diseasePolycystic kidney diseaseAllograft nephropathyImmunosuppressive therapyRapamycin inhibitorsUltrasound evaluationDialysis treatmentRisk factorsCystic diseaseGeneral populationPatientsMalignancy susceptibilityCancer developmentMammalian targetCancerKidney
2014
Oncologic Issues and Kidney Transplantation: A Review of Frequency, Mortality, and Screening
Asch WS, Bia MJ. Oncologic Issues and Kidney Transplantation: A Review of Frequency, Mortality, and Screening. Advances In Kidney Disease And Health 2014, 21: 106-113. PMID: 24359993, DOI: 10.1053/j.ackd.2013.07.003.BooksMeSH KeywordsAnus NeoplasmsBreast NeoplasmsCarcinoma, Renal CellColorectal NeoplasmsEarly Detection of CancerFemaleHumansImmunocompromised HostImmunosuppressive AgentsKidney Failure, ChronicKidney NeoplasmsKidney TransplantationLymphoproliferative DisordersNeoplasmsSkin NeoplasmsUterine Cervical NeoplasmsConceptsStandard incidence ratioKidney transplantationKidney transplant recipientsDevelopment of malignancyReview of frequencyTransplant recipientsIncidence ratiosCommon malignancyTreatment recommendationsTumor surveillanceOncologic issuesGeneral populationTumor growthMalignancyOncogenic virusesCurrent preventionTransplantationRiskEarly ageImmunosuppressantsReviewCancerMortalityRecipientsPrevention